LOCUS       NM_009179               4470 bp    mRNA    linear   ROD 04-AUG-2023
DEFINITION  Mus musculus ST3 beta-galactoside alpha-2,3-sialyltransferase 2
            (St3gal2), mRNA.
ACCESSION   NM_009179 NM_178048
VERSION     NM_009179.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4470)
  AUTHORS   Gonzalez-Gil A, Porell RN, Fernandes SM, Maenpaa E, Li TA, Li T,
            Wong PC, Aoki K, Tiemeyer M, Yu ZJ, Orsburn BC, Bumpus NN, Matthews
            RT and Schnaar RL.
  TITLE     Human brain sialoglycan ligand for CD33, a microglial inhibitory
            Siglec implicated in Alzheimer's disease
  JOURNAL   J Biol Chem 298 (6), 101960 (2022)
   PUBMED   35452678
REFERENCE   2  (bases 1 to 4470)
  AUTHORS   Lim H, Lee J, You B, Oh JH, Mok HJ, Kim YS, Yoon BE, Kim BG, Back
            SK, Park JS, Kim KP, Schnaar RL and Lee SJ.
  TITLE     GT1b functions as a novel endogenous agonist of toll-like receptor
            2 inducing neuropathic pain
  JOURNAL   EMBO J 39 (6), e102214 (2020)
   PUBMED   32030804
  REMARK    GeneRIF: GT1b functions as a novel endogenous agonist of toll-like
            receptor 2 inducing neuropathic pain.
REFERENCE   3  (bases 1 to 4470)
  AUTHORS   Lopez PH, Aja S, Aoki K, Seldin MM, Lei X, Ronnett GV, Wong GW and
            Schnaar RL.
  TITLE     Mice lacking sialyltransferase ST3Gal-II develop late-onset obesity
            and insulin resistance
  JOURNAL   Glycobiology 27 (2), 129-139 (2017)
   PUBMED   27683310
  REMARK    GeneRIF: t3gal2-null mice display a reduced respiratory exchange
            ratio compared to WT mice, indicating a preference for lipid
            oxidation as an energy source. Despite their altered metabolism,
            St3gal2-null mice were hyperactive. We conclude that altered
            ganglioside expression in adipose tissue results in diminished IR
            sensitivity and late-onset obesity.
REFERENCE   4  (bases 1 to 4470)
  AUTHORS   Yoo SW, Motari MG, Susuki K, Prendergast J, Mountney A, Hurtado A
            and Schnaar RL.
  TITLE     Sialylation regulates brain structure and function
  JOURNAL   FASEB J 29 (7), 3040-3053 (2015)
   PUBMED   25846372
  REMARK    GeneRIF: St3gal2/3 double-null mice displayed dysmyelination marked
            by a reduction in major myelin proteins, fewer myelinated axons, a
            decrease in myelin thickness, possibly by dysregulation of
            ganglioside-mediated oligodendroglial precursor cell proliferation.
REFERENCE   5  (bases 1 to 4470)
  AUTHORS   Orr SL, Le D, Long JM, Sobieszczuk P, Ma B, Tian H, Fang X, Paulson
            JC, Marth JD and Varki N.
  TITLE     A phenotype survey of 36 mutant mouse strains with gene-targeted
            defects in glycosyltransferases or glycan-binding proteins
  JOURNAL   Glycobiology 23 (3), 363-380 (2013)
   PUBMED   23118208
REFERENCE   6  (bases 1 to 4470)
  AUTHORS   Piao Y, Ko NT, Lim MK and Ko MS.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   7  (bases 1 to 4470)
  AUTHORS   Takashima S and Tsuji S.
  TITLE     Comparison of genomic structures of four members of
            beta-galactoside alpha2,3-sialyltransferase genes in the mouse
  JOURNAL   Cytogenet Cell Genet 89 (1-2), 101-106 (2000)
   PUBMED   10894948
REFERENCE   8  (bases 1 to 4470)
  AUTHORS   Takashima S, Tachida Y, Nakagawa T, Hamamoto T and Tsuji S.
  TITLE     Quantitative analysis of expression of mouse sialyltransferase
            genes by competitive PCR
  JOURNAL   Biochem Biophys Res Commun 260 (1), 23-27 (1999)
   PUBMED   10381338
REFERENCE   9  (bases 1 to 4470)
  AUTHORS   Kono M, Ohyama Y, Lee YC, Hamamoto T, Kojima N and Tsuji S.
  TITLE     Mouse beta-galactoside alpha 2,3-sialyltransferases: comparison of
            in vitro substrate specificities and tissue specific expression
  JOURNAL   Glycobiology 7 (4), 469-479 (1997)
   PUBMED   9184827
REFERENCE   10 (bases 1 to 4470)
  AUTHORS   Lee YC, Kojima N, Wada E, Kurosawa N, Nakaoka T, Hamamoto T and
            Tsuji S.
  TITLE     Cloning and expression of cDNA for a new type of Gal beta 1,3GalNAc
            alpha 2,3-sialyltransferase
  JOURNAL   J Biol Chem 269 (13), 10028-10033 (1994)
   PUBMED   8144500
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ174248.1, AK029246.1, AK131653.1 and BY582241.1.
            
            [WARNING] On Oct 16, 2023 this sequence was replaced by
            NM_009179.4.
            
            On or before Nov 2, 2007 this sequence version replaced
            NM_178048.3, NM_009179.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK031052.1, AK053827.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-86                CJ174248.1         2-87
            87-512              AK029246.1         1-426
            513-1178            AK029246.1         428-1093
            1179-4453           AK131653.1         2-3276
            4454-4470           BY582241.1         373-389
FEATURES             Location/Qualifiers
     source          1..4470
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 57.81 cM"
     gene            1..4470
                     /gene="St3gal2"
                     /gene_synonym="Siat5; ST3GalII"
                     /note="ST3 beta-galactoside alpha-2,3-sialyltransferase 2"
                     /db_xref="GeneID:20444"
                     /db_xref="MGI:MGI:99427"
     exon            1..241
                     /gene="St3gal2"
                     /gene_synonym="Siat5; ST3GalII"
                     /inference="alignment:Splign:2.1.0"
     exon            242..1534
                     /gene="St3gal2"
                     /gene_synonym="Siat5; ST3GalII"
                     /inference="alignment:Splign:2.1.0"
     exon            1535..1728
                     /gene="St3gal2"
                     /gene_synonym="Siat5; ST3GalII"
                     /inference="alignment:Splign:2.1.0"
     exon            1729..1908
                     /gene="St3gal2"
                     /gene_synonym="Siat5; ST3GalII"
                     /inference="alignment:Splign:2.1.0"
     exon            1909..1954
                     /gene="St3gal2"
                     /gene_synonym="Siat5; ST3GalII"
                     /inference="alignment:Splign:2.1.0"
     exon            1955..2074
                     /gene="St3gal2"
                     /gene_synonym="Siat5; ST3GalII"
                     /inference="alignment:Splign:2.1.0"
     exon            2075..4470
                     /gene="St3gal2"
                     /gene_synonym="Siat5; ST3GalII"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggtaggggt ggggggaggg gccgggctga gctgcagccg cggcgctccg ggagggcagg
       61 gccaggcaag ggcgggactg gcccgaggct ggcggactgg agagcggtga agctaacggg
      121 tccaggcgcg ggaggcggcg gcggcggcgg cggcggcggc agcggcggca gctctctgca
      181 cgggcggagg cggcggcagg agcggcaagc atggcccgcg cggcgcccag cgcagactga
      241 gggtcaggct gtggccgccc ggtgcctgac aggtgaggaa gagcctgcca ggggatcact
      301 gccaacagga gccaagggca gaacagcctc accctagaag caggggtggg cagggcagtt
      361 gccctgccaa ggccaacagt cccaggaagg agtctggagt cccaatgagg accacgtaag
      421 ctctcctgat ccacatggct tagagtctgg caccttgctg agcagcagct gttcccagct
      481 ccagacgacc ccacagcaca gagtagggga ccagcccctc tgatgggagg cagcaggcca
      541 gacgctccgc agaaggtctt gggtttttgt agccctgacg cccatgaaga tcactggttt
      601 tctttctggc cttgagtcag gctcttttcc cctggctaag gagttggacc aggacggcct
      661 gcaagtgcga agaggactcg tgcatggaat gcaggccccc tgaagcccgt gcaccctctg
      721 ctgtaatcag ggttccaggg attccccact gcaggggagc aggggctgcc ttagcgtctg
      781 ctcatgagcc acaaggaccc agactgctcc agactggacc ttttcaagcc accaaagagg
      841 ggggaccccg gagctggcag ccagcactca caagggacta gagggctgag atggactgac
      901 ctctgccttg acggggtggc agaagacgca gaatctttgt ggcccagcta gtgactgaga
      961 gagacccgag gaagttctga gcgagaggct ctggtggctc agggacggtg ggaggggggg
     1021 gctattcctg ctttcccctt ttgttgaggg aaggtgtggc aagagtcccc tgtcacgctt
     1081 cgtgccccta tgccctttct acgtgctgcc aaaacaagca ggctgcgccg tggctggccc
     1141 cgcagcgggc cgggaaagga ttggccacgg tgacagccac cccgtggcca gcacgatgaa
     1201 gtgctctctt cgggtgtggt tcctctctat ggcattcctg ctggtgttca ttatgtccct
     1261 gctcttcacc tactcgcacc acagcatggc taccttgccc tacctggact cgggggctct
     1321 gggcggcaca caccgggtga agctggtacc aggctattca ggactacagc gcctcggcaa
     1381 ggaggggctt ttggggagaa attgtgcctg cagtcgctgc atgggtgacg ccagcacctc
     1441 tgaatggttt gacagccact ttgacggcaa catctcaccc gtctggacca gagataacat
     1501 gaacctcccc ccggatgtcc agcggtggtg gatgatgcta caaccccaat tcaagtcaca
     1561 caacaccaac gaagtgctgg aaaaactgtt ccagatcgtg cctggcgaga acccctaccg
     1621 cttccgggac ccccaacagt gccggcgctg tgctgtggtc gggaactcag gcaaccttcg
     1681 gggctctggc tatggacaag aagtggacag ccacaacttt atcatgagga tgaatcaggc
     1741 accgactgtg ggctttgaga aggatgttgg cagccgaaca actcaccatt tcatgtaccc
     1801 agagagtgcc aagaacctgc ctgccaatgt cagcttcgtg ctggtcccct tcaaggccct
     1861 ggacctaatg tggattgcca gcgccctctc cacaggacag atccgattca cctatgcccc
     1921 agtgaagtcc ttccttcgag tggacaaaga gaaggtccag atttacaacc cagccttctt
     1981 caagtacatt cacgacaggt ggaccgagca ccacgggcgc tacccttcca caggaatgct
     2041 ggtgctcttc tttgcactac atgtgtgtga tgaggtgaac gtgtatgggt tcggggccga
     2101 cagtcgaggc aactggcacc actactggga gaacaaccgg tacgcgggcg agttccggaa
     2161 gacaggcgtg catgacgccg acttcgaagc ccacatcatc gacatgctgg ccaaggccag
     2221 caagatcgag gtctaccgag ggaactgagc ggccctgagc gccttcagaa ccagtcactt
     2281 ctgggtccgg caagcgccgg ttgcagccca ccaatcagac tgcgccgtcc ccagcaacca
     2341 atcagtgctg cagttgggag gagcttcttt cttagccaat cacgcaactc aaggagaatt
     2401 tccggcgccg ccgtctccac caatcatggc cttgggaggc ggcgggcctc gaccccctcc
     2461 cctaaacctg ctttggataa gaattttgat gctttttaag aggcgggtct ggggctgggc
     2521 aggagcgcct tgaactgctc atttccagct taggccgggt gggtgagtga agccatccaa
     2581 agaaatgtgg ttccggtgag acactctcca gggctttccg tggcgcacca ggtagtaggg
     2641 ggttgaattc accccctgtt gggttgatct ccctagggcc tcactagtgt caggaacggg
     2701 taggaagctt caccgggtca catgcaaggt gcttctctca catgtgccct cactcctgtc
     2761 tcctaccacc ttctcagcgt ctgtccttag gtcctgggcc tcctctccag ctcacctgtt
     2821 gattcggaga caaagtgaga ccaccctgac tcggctgctt ttgctctccc acacgtgacc
     2881 cgtgtcttta gccctaaggc gcgagagagc aacacggttg gacagttggc tggaaaggag
     2941 atccctgagc atgtaccgtt ttctttcatt gtcaccccaa agaggagcag gcagcctctt
     3001 gcttgggggt aggatttgct ttggactcat gctttagtta ccctcaagct gccagggatg
     3061 gcgatccaac caagattgct tgacaattgt ttgcggggcc tcgcgcagat ggctcggagc
     3121 tttgctgggg aggagcggat tggtggctgc cctgcatgcc tcctcctgtc cgcaccttta
     3181 ccctgcttac tcgcctgttc taacctactc tccagctcca gaagggccgc tcagtcaaga
     3241 atcaggggtt acaactggaa gctacttgca tgacttggtc acagttgagg ttcactggga
     3301 gaaagggctt cagtgaatgt ctcaggccgc agaaaacacg tccctgctgc agcgtccaca
     3361 taaatatttc ccattcttaa tgagttcaca ttaccaagca gcctggttgg gggacagtca
     3421 cacataaggg agagtgttaa gaggtttggg atgaggcaac aaccctaaaa actaatacat
     3481 ggagaacttt gctcgagtct gttccttccc agtttcaaaa gcacgggtgg aggaaaaaaa
     3541 aaaagggagg ggcgtatagc agaacctctc agggctcgaa ccatcgcaca tagtcaccgt
     3601 tccagttttt gcctgtctca tctctgctct caagctgctg tgatgagaaa cgggaaagca
     3661 atgcaattat gccaaacagt attgagaaga gtaatttatt tttcttccct ttgttttgtt
     3721 taaatcatga atccccattc tagaaaaggt aggtcccaga atctacatct ttttcttcta
     3781 gagttattta aacattcaac tttcccttcc gtttctttcc ctgaattaaa aagaacaaag
     3841 cccatagagt cactcatctg ttctgaactg caccatccta ggtgtctaag gaggtaaggg
     3901 tgtttgggag aacaacacaa ctctgatacc ctcttacggc tgaggagtct agttcatggg
     3961 ctctgttcac tgaagtcccc cctaaggact ctgagtatta tggtttaaaa aaaaaaatca
     4021 acttattatg tcaggcatgg tggcatgtgc ccttaatcct agcagttgag aggctgaggg
     4081 gcaggaaaag aagttaaagg ctagcctcag ctacatggta actttcaaac taacctgggc
     4141 tacatgagac ctttcttaag ggggaaaaaa aggagcaaaa aatctctagt gagttctctc
     4201 acgagttctg acatttttct gcttagccca atcgtgctgt gtggcccaca gcttgttgcc
     4261 agtacaaagt gctatgcaaa ggaagagttc tctgggagag ctgcggaggg cagatagtgc
     4321 ctctctgagt tttgcctgtc actaaggata aatgcttaaa cttcagtagg gtaactggaa
     4381 aacagggggg aatgttgggt ctgcacctta aactactcac taaaataggt cgtatggatc
     4441 ttagaactaa attaaaaaaa aaaaaaaacc
//
