LOCUS       NM_001412635            5744 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus ST3 beta-galactoside alpha-2,3-sialyltransferase 1
            (St3gal1), transcript variant 2, mRNA.
ACCESSION   NM_001412635 XM_011245529
VERSION     NM_001412635.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5744)
  AUTHORS   Hong,Y., Walling,B.L., Kim,H.R., Serratelli,W.S., Lozada,J.R.,
            Sailer,C.J., Amitrano,A.M., Lim,K., Mongre,R.K., Kim,K.D.,
            Capece,T., Lomakina,E.B., Reilly,N.S., Vo,K., Gerber,S.A.,
            Fan,T.C., Yu,A.L., Oakes,P.W., Waugh,R.E., Jun,C.D., Reagan,P.M.
            and Kim,M.
  TITLE     ST3GAL1 and betaII-spectrin pathways control CAR T cell migration
            to target tumors
  JOURNAL   Nat Immunol 24 (6), 1007-1019 (2023)
   PUBMED   37069398
REFERENCE   2  (bases 1 to 5744)
  AUTHORS   Gonzalez-Gil,A., Porell,R.N., Fernandes,S.M., Maenpaa,E., Li,T.A.,
            Li,T., Wong,P.C., Aoki,K., Tiemeyer,M., Yu,Z.J., Orsburn,B.C.,
            Bumpus,N.N., Matthews,R.T. and Schnaar,R.L.
  TITLE     Human brain sialoglycan ligand for CD33, a microglial inhibitory
            Siglec implicated in Alzheimer's disease
  JOURNAL   J Biol Chem 298 (6), 101960 (2022)
   PUBMED   35452678
REFERENCE   3  (bases 1 to 5744)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5744)
  AUTHORS   Wang,Y., Chen,W., Zhang,W., Lee-Sundlov,M.M., Casari,C.,
            Berndt,M.C., Lanza,F., Bergmeier,W., Hoffmeister,K.M., Zhang,X.F.
            and Li,R.
  TITLE     Desialylation of O-glycans on glycoprotein Ibalpha drives receptor
            signaling and platelet clearance
  JOURNAL   Haematologica 106 (1), 220-229 (2021)
   PUBMED   31974202
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5744)
  AUTHORS   Paul,A., Crow,M., Raudales,R., He,M., Gillis,J. and Huang,Z.J.
  TITLE     Transcriptional Architecture of Synaptic Communication Delineates
            GABAergic Neuron Identity
  JOURNAL   Cell 171 (3), 522-539 (2017)
   PUBMED   28942923
REFERENCE   6  (bases 1 to 5744)
  AUTHORS   Priatel,J.J., Chui,D., Hiraoka,N., Simmons,C.J., Richardson,K.B.,
            Page,D.M., Fukuda,M., Varki,N.M. and Marth,J.D.
  TITLE     The ST3Gal-I sialyltransferase controls CD8+ T lymphocyte
            homeostasis by modulating O-glycan biosynthesis
  JOURNAL   Immunity 12 (3), 273-283 (2000)
   PUBMED   10755614
  REMARK    GeneRIF: St3gal-1 functions to protect CD8 T cells from apoptosis
REFERENCE   7  (bases 1 to 5744)
  AUTHORS   Takashima,S., Tachida,Y., Nakagawa,T., Hamamoto,T. and Tsuji,S.
  TITLE     Quantitative analysis of expression of mouse sialyltransferase
            genes by competitive PCR
  JOURNAL   Biochem Biophys Res Commun 260 (1), 23-27 (1999)
   PUBMED   10381338
REFERENCE   8  (bases 1 to 5744)
  AUTHORS   Kono,M., Ohyama,Y., Lee,Y.C., Hamamoto,T., Kojima,N. and Tsuji,S.
  TITLE     Mouse beta-galactoside alpha 2,3-sialyltransferases: comparison of
            in vitro substrate specificities and tissue specific expression
  JOURNAL   Glycobiology 7 (4), 469-479 (1997)
   PUBMED   9184827
REFERENCE   9  (bases 1 to 5744)
  AUTHORS   Lee,Y.C., Kojima,N., Wada,E., Kurosawa,N., Nakaoka,T., Hamamoto,T.
            and Tsuji,S.
  TITLE     Cloning and expression of cDNA for a new type of Gal beta 1,3GalNAc
            alpha 2,3-sialyltransferase
  JOURNAL   J Biol Chem 269 (13), 10028-10033 (1994)
   PUBMED   8144500
REFERENCE   10 (bases 1 to 5744)
  AUTHORS   Lee,Y.C., Kurosawa,N., Hamamoto,T., Nakaoka,T. and Tsuji,S.
  TITLE     Molecular cloning and expression of Gal beta 1,3GalNAc alpha
            2,3-sialyltransferase from mouse brain
  JOURNAL   Eur J Biochem 216 (2), 377-385 (1993)
   PUBMED   8375377
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC166984.7 and AC087116.13.
            
            On Oct 13, 2022 this sequence version replaced XM_011245529.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422589.396555.1,
                                           SRR13422601.2188635.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-95                AC166984.7         22192-22286
            96-223              AC166984.7         45748-45875
            224-278             AC166984.7         70311-70365
            279-394             AC166984.7         74498-74613
            395-1245            AC166984.7         84561-85411
            1246-1442           AC166984.7         86291-86487
            1443-1622           AC166984.7         87507-87686
            1623-1668           AC166984.7         89267-89312
            1669-1788           AC166984.7         90590-90709
            1789-5744           AC087116.13        213900-217855       c
FEATURES             Location/Qualifiers
     source          1..5744
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 29.3 cM"
     gene            1..5744
                     /gene="St3gal1"
                     /gene_synonym="5330418N22Rik; Siat4; Siat4a; St3gal-1;
                     ST3GalI"
                     /note="ST3 beta-galactoside alpha-2,3-sialyltransferase 1"
                     /db_xref="GeneID:20442"
                     /db_xref="MGI:MGI:98304"
     exon            1..95
                     /gene="St3gal1"
                     /gene_synonym="5330418N22Rik; Siat4; Siat4a; St3gal-1;
                     ST3GalI"
                     /inference="alignment:Splign:2.1.0"
     exon            96..223
                     /gene="St3gal1"
                     /gene_synonym="5330418N22Rik; Siat4; Siat4a; St3gal-1;
                     ST3GalI"
                     /inference="alignment:Splign:2.1.0"
     exon            224..278
                     /gene="St3gal1"
                     /gene_synonym="5330418N22Rik; Siat4; Siat4a; St3gal-1;
                     ST3GalI"
                     /inference="alignment:Splign:2.1.0"
     exon            279..394
                     /gene="St3gal1"
                     /gene_synonym="5330418N22Rik; Siat4; Siat4a; St3gal-1;
                     ST3GalI"
                     /inference="alignment:Splign:2.1.0"
     exon            395..1245
                     /gene="St3gal1"
                     /gene_synonym="5330418N22Rik; Siat4; Siat4a; St3gal-1;
                     ST3GalI"
                     /inference="alignment:Splign:2.1.0"
     CDS             949..1962
                     /gene="St3gal1"
                     /gene_synonym="5330418N22Rik; Siat4; Siat4a; St3gal-1;
                     ST3GalI"
                     /EC_number="2.4.3.4"
                     /EC_number="2.4.3.2"
                     /note="sialyltransferase 4A (beta-galactoside
                     alpha-2,3-sialytransferase); ST3GAL-I sialyltransferase;
                     Gal beta1,3 GalNAc alpha2,3 sialyltransferase; ST3O;
                     SIAT4-A; ST3Gal I; ST3GalA.1; gal-NAc6S; alpha 2,3-ST 1;
                     beta-galactoside alpha-2,3-sialyltransferase 1;
                     gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase;
                     sialyltransferase 4A (beta-galactosidase
                     alpha-2,3-sialytransferase); CMP-N-acetylneuraminate:
                     [beta-galactosidase alpha-2,3] sialytransferase;
                     monosialoganglioside sialyltransferase"
                     /codon_start=1
                     /product="CMP-N-acetylneuraminate-beta-galactosamide-
                     alpha-2,3-sialyltransferase 1"
                     /protein_id="NP_001399564.1"
                     /db_xref="GeneID:20442"
                     /db_xref="MGI:MGI:98304"
                     /translation="MRRKTLKYLTFFLLFIFLTSFVLNYSNTGVPSAWFPKQMLLELS
                     ENFRRFIKSQPCTCRHCISQDKVSYWFDQRFNKTMQPLLTVHNALMEEDTYRWWLRLQ
                     RERKPNNLSDTVKELFRLVPGNVDPMLNKRLVGCRRCAVVGNSGNLKDSSYGPEIDSH
                     DFVLRMNKAPTVGFEADVGSRTTHHLVYPESFRELGENVNMVLVPFKTTDLQWVISAT
                     TTGTITHTYVPVPPKIKVKQEKILIYHPAFIKYVFDNWLQGHGRYPSTGILSIIFSIH
                     ICDEVDLYGFGADSKGNWHHYWENNPSAGAFRKTGVHDGDFEYNITTTLAAINKIRIF
                     KGR"
     exon            1246..1442
                     /gene="St3gal1"
                     /gene_synonym="5330418N22Rik; Siat4; Siat4a; St3gal-1;
                     ST3GalI"
                     /inference="alignment:Splign:2.1.0"
     exon            1443..1622
                     /gene="St3gal1"
                     /gene_synonym="5330418N22Rik; Siat4; Siat4a; St3gal-1;
                     ST3GalI"
                     /inference="alignment:Splign:2.1.0"
     exon            1623..1668
                     /gene="St3gal1"
                     /gene_synonym="5330418N22Rik; Siat4; Siat4a; St3gal-1;
                     ST3GalI"
                     /inference="alignment:Splign:2.1.0"
     exon            1669..1788
                     /gene="St3gal1"
                     /gene_synonym="5330418N22Rik; Siat4; Siat4a; St3gal-1;
                     ST3GalI"
                     /inference="alignment:Splign:2.1.0"
     exon            1789..5744
                     /gene="St3gal1"
                     /gene_synonym="5330418N22Rik; Siat4; Siat4a; St3gal-1;
                     ST3GalI"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2303..2308
                     /regulatory_class="polyA_signal_sequence"
                     /gene="St3gal1"
                     /gene_synonym="5330418N22Rik; Siat4; Siat4a; St3gal-1;
                     ST3GalI"
                     /note="hexamer: AATAAA"
     polyA_site      2332
                     /gene="St3gal1"
                     /gene_synonym="5330418N22Rik; Siat4; Siat4a; St3gal-1;
                     ST3GalI"
                     /note="major polyA site"
     regulatory      5719..5724
                     /regulatory_class="polyA_signal_sequence"
                     /gene="St3gal1"
                     /gene_synonym="5330418N22Rik; Siat4; Siat4a; St3gal-1;
                     ST3GalI"
                     /note="hexamer: AATAAA"
     polyA_site      5744
                     /gene="St3gal1"
                     /gene_synonym="5330418N22Rik; Siat4; Siat4a; St3gal-1;
                     ST3GalI"
                     /note="major polyA site"
ORIGIN      
        1 agacactttc gacactttgc aaagacaaag agccctaaac cggagggagg agagaggagg
       61 aggcagagaa ggagcgtgag gtttgagctg gctgggtttg actctgctga gctagcaatg
      121 ccatcaaaga gcaactggca cctgttggat ctgtgagcca gagctgtggg gccgggcagt
      181 tgtatctgtg agccaggggc agacagtggc tcggcttcct gagatgaaga aactgaaact
      241 cagagagatt aaggacctcc cctgatgtgg cacttctggg caaggccttt tcttcatgtg
      301 ccagtcatcc caacacgtgt cacagcagag acatggtaga aatgctgtaa atactttagt
      361 aacggtggaa ttaatgcctt catgggaatt cgagatgttc agcaaaccct atgccttcca
      421 ggagatgccc tttcagtccc cattccttgg aacagcctag gagacacagc tctaattaag
      481 gattattgga ggagggcggc caagcatcct cgcatcctgc gccaagacct tttacagatt
      541 gtccaggggt tcgctcaggc tgagagtaac taactaaact tgatccccgt ttgagctggg
      601 gagaacactg ctcttcccag gtttcactca agtgtcatca agccacattc ttgactttgc
      661 ttgggttgca gaagaggtag accacgctgc ttaccaatac aggcaagact gactgcatgg
      721 cacagactac cctcgtgtgc cacacagcaa tgtcgagaac acaaacctag gcgtgtctcc
      781 aacaggctga agtttgccct agctgcttct gagatctccc tgcggactcc ctttcctgct
      841 gcctgctcct gtgtctctga gatttctgtt cagctctagg aggggggtct cctctcttcc
      901 accctcccat caacacagag gacccagcaa agggtggagg tggtgaacat gaggaggaag
      961 accctcaagt acctcacctt cttcctgctc ttcatcttcc tcacttcctt tgtcctgaat
     1021 tactccaaca cgggagtacc cagtgcctgg ttccccaagc agatgctcct ggaactctca
     1081 gagaacttcc gcaggttcat caagtcacag ccgtgcacct gcagacactg catcagccag
     1141 gacaaggtat catattggtt cgaccagcgc ttcaacaaga ctatgcagcc cctgctgaca
     1201 gtccacaacg ctctgatgga ggaggacaca taccggtggt ggctgaggct ccagcgggag
     1261 aggaaaccca acaacctgag cgacaccgtc aaggaactgt ttcgcctggt gcctggcaat
     1321 gtggatccta tgttgaacaa gaggctggtg ggctgccgac gctgtgcagt tgtaggaaac
     1381 tccggtaacc tgaaggactc ctcgtatggg cctgagatcg acagccatga ctttgtgctg
     1441 aggatgaaca aggcacccac agtgggtttt gaggcagacg ttgggagccg gaccacccac
     1501 catctcgtgt atcctgagag cttccgggag ctgggagaga atgtcaacat ggtcctggtc
     1561 cccttcaaga ccaccgacct gcagtgggtg atcagcgcca ccaccacagg caccatcact
     1621 cacacctatg tccccgtgcc cccgaagatc aaagtgaaac aagagaagat cctgatctac
     1681 cacccagcct tcatcaagta tgtctttgac aactggcttc agggccatgg gcggtatcca
     1741 tcgactggca tcctctccat catcttctcc attcatatct gtgatgaggt ggacttatat
     1801 ggttttgggg cagacagcaa aggaaattgg caccattact gggagaacaa cccatcagcg
     1861 ggtgccttcc gaaagacggg ggttcacgat ggtgacttcg agtacaacat cacaactacc
     1921 ctggcagcca tcaataaaat ccgcatcttc aaggggagat gatgctgcga cccattaagg
     1981 atggacacaa cacatcacac ctctcaattt gcagccccaa catctcccag gagccagtgt
     2041 gttccagacg cttccggggc tgaactcggg gtgttcccag gctttctggc agccccttgc
     2101 accctcatgt tgttatcatc tacttagcaa agttgtccaa ctctcccagg atacagagcc
     2161 agtctcgggc ctgtctacag tgggagcact ttcccaccgc tgtcccctag ctggggaaaa
     2221 gcgagccaat accaggaaag gtctagcctc caaacaagtt attttgtctt ctgagttgga
     2281 ttggagggag gggatgggag aaaataaatc ctgaagattc ttatgttcaa aagagtgaac
     2341 atttcccgga agtcatttag aggctgccac tgaactgtgg gcctcatgct caactcagac
     2401 tctggctggg aatgtttggg ccagtcatct gcagagccac actgggctac accagcagag
     2461 gggcaagata ccgttctcct ttgcatgaag cctagcctgt tatttgagat gacatcccca
     2521 ttgtcccttt cttcaataag gtcaccggtg atggctaggc aaaacttcta actccagagg
     2581 tcttccaggg aagcctggcc atgtgtggct gacaggagtg aaaccctggt cacagttctg
     2641 cgtgattttc cctccgtagt gatgctgatg gccagagcag gtctgactac ttccacgtgc
     2701 ctttgaactt gagaaagaag tgcatgcatt ggctgatagg aagcaaaacc cccaattgga
     2761 gaaaggggac ctccaccagc acctcgcttt gctgcatagc tcaaaatctc ttttcaaatg
     2821 ctattccgca cctccaccca gaatatacca ggcatgggat gggtcctcac ttctatttcc
     2881 tcagactgct gggttcagga ccactaacaa ccagcatcct cccatgggtc ctgaacactg
     2941 agccaagtcc ccagcagcca ccttcctgga ctcgtttggg gccgcactgg ggacactcta
     3001 gaaccacaac tgaaatgcat gtacctcttc ttcttggttc tgtctgctct cccctccttc
     3061 ctctatggaa atcctgatta tttattgatt tgttaattca gctgaccctg tgcacactct
     3121 tccccatggc tgatcacaat gtgttttgtt gctttgcctg gcaagtggga gcaggaacag
     3181 aagggagagc atcctggatg tatgtgttga gacatcagga cttggggctt gctggcgggc
     3241 agatcctgtg gcgccgacaa tcctttgtag aatccatgtc acctcccttt ctagtacaag
     3301 tgacttgccc tcttcctcac tgcagcaggg aggagagcgg gcacttggag gtaactgtca
     3361 cctccttaca gatgttcaat aagagaaacc tctgtttctg ttgaaaaaat agtccctaaa
     3421 gaccaccaca acttcatcaa ggcagattat gagagaggga tcttgagggt tgggccatct
     3481 ccctctactc agattcccct ctgcaagtaa gagctcggga gcccctctca actttgggct
     3541 gttcacagac atcaccaaag agcagacact aagactgtca tttcctagga gtctgtcctg
     3601 ggagctttgg gattgctttt gtttaatttt cgatggctca gaattcgggc ttttaatgag
     3661 ggaacgatag gtttcacctt ttttttttcc attttttatt aggtatttag ctcatttaca
     3721 tttccaatgc tataccaaaa gtcccccata cccacccacc cccactcccc taccctccca
     3781 ctcccccttt ttggccctgc cgttcccctg tactggggca tataaagttt gcgtgtccaa
     3841 tgggaaaatc ttcctgccat aaaacccttg gctgaaaagg ctagactcct gtgaggtcct
     3901 tgctgtggag ggccctcctc aagggtccca gtttgaggaa ctcagcagat gtttgtgggt
     3961 cagcccgtca atccctacat caaatcaaaa atagtggacg ttggcttagg ggtgagagtt
     4021 caggtgtagc tgggttctga tgcatgagag caagtacctg cagtgaaggt gtagccattt
     4081 ccagctgctc aagaagttct tctgctctcc attggcccct cccactccct ctgcccccac
     4141 ctgccttcct gccccctctc cctccctccc tcactccctc cctccctccc tccctccctc
     4201 cctccctccc tccctccctc cctccctctt ccggccaagg agccaatgga tctctttcct
     4261 ataaccctca tccctcccct gtgtttcact ggcttaacgg tgggctctta actgaataga
     4321 atacagttgg ttgtggccag aattaagtgc accaattagt ttaaggtaac tggagctttc
     4381 cctgggtgtg agtgactgag aacaggaaag gccttccccg aagagactgg gcagactgct
     4441 gacagaaaag ctagtcctgg gttccaggca gagagcaaag ggctggcttc cagtacagat
     4501 tcttagtaga agaatctact aagtccaagg gaattggagg tgggggttct catcatcacc
     4561 ccagatgact aaccaggagg ctggtgtttc ttccactccc ctcagcctct gttaggagag
     4621 agagaagccg atctgtagcc tttggttcct gggcatcaga catcattcaa taagccatgt
     4681 gggcagggtt agtggaacag acccccaaaa cagtgataga accagcaacc gtctaggtct
     4741 gtgacagtct aaaggtctgg agaccataga aggatagata cacagtggat attgagaacc
     4801 tagagggtgg cttcacctgt gcccgtcaaa gaagcccctg acatgcagtg tgggggaggc
     4861 cctagataac cctgcacaga ggacagaggg acagctgtat gccctcagga actggcagtt
     4921 ggaaccacag gttctatcat agccaggtgg ctatgaggtg ggaaagattg gatctaggca
     4981 gctcagccac aaaggcctgg ctagccaatt ttcagatagc atcagctctc ctctttgtca
     5041 tcctctcctg tgccgcaggt gttacctaag acctctaaaa agcaccagag ggtgaagaaa
     5101 gaaagcaggg accagcagag tagtgccccg agctttcagc ctcaaagtta gtaaatgcgt
     5161 catcagccaa gcccggcctg gaacctgctt ccgcctgctg aaccccatct tgaccttcct
     5221 aacctctctg ctcatttagc ttttaccctg gctccgcctg cccagggtct gccccatggc
     5281 aaccgcttta accctttctc cagagcctaa tccggatctt gcacacccta ccagatgaac
     5341 atgggtaact cctgctgccc cccacctcct tgcacaatca ctttaaccat ttcccaagag
     5401 cctgatctgg actttgctca acccacccta gtaggtagac atgggttcct cctgcacctc
     5461 taggcacaat cactttagcc ctttcccaag tctgcttccg agccaaagtt ttccaagcac
     5521 tttctgcccg aaagctcttc cttccttgcc tcctgtgacc cagcattgcc tgtttaaact
     5581 ttgctttctc ctgcccacgt cttgtaatcc tcctgattgg tctgaatgca tttccaatga
     5641 tgtcagggag tctgccttcc tcagcctcgg ctccatttta tttattgttg aatatttcca
     5701 attattcaaa tcaaagtgaa taaaaaaaga gctattttat tgtt
//
