LOCUS       NM_011176               4017 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus suppression of tumorigenicity 14 (colon carcinoma)
            (St14), mRNA.
ACCESSION   NM_011176
VERSION     NM_011176.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4017)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4017)
  AUTHORS   Ehret,E., Stroh,S., Auberson,M., Ino,F., Jager,Y., Maillard,M.,
            Szabo,R., Bugge,T.H., Frateschi,S. and Hummler,E.
  TITLE     Kidney-Specific Membrane-Bound Serine Proteases CAP1/Prss8 and
            CAP3/St14 Affect ENaC Subunit Abundances but Not Its Activity
  JOURNAL   Cells 12 (19), 2342 (2023)
   PUBMED   37830556
  REMARK    GeneRIF: Kidney-Specific Membrane-Bound Serine Proteases CAP1/Prss8
            and CAP3/St14 Affect ENaC Subunit Abundances but Not Its Activity.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4017)
  AUTHORS   Szabo,R., Kawaguchi,M., Kataoka,H. and Bugge,T.H.
  TITLE     Early-onset tufting enteropathy in HAI-2-deficient mice is
            independent of matriptase-mediated cleavage of EpCAM
  JOURNAL   Development 150 (17) (2023)
   PUBMED   37539662
  REMARK    GeneRIF: Early-onset tufting enteropathy in HAI-2-deficient mice is
            independent of matriptase-mediated cleavage of EpCAM.
REFERENCE   4  (bases 1 to 4017)
  AUTHORS   Ozawa,S., Matsubayashi,M., Nanaura,H., Yanagita,M., Mori,K.,
            Asanuma,K., Kajiwara,N., Hayashi,K., Ohashi,H., Kasahara,M.,
            Yokoi,H., Kataoka,H., Mori,E. and Nakagawa,T.
  TITLE     Proteolytic cleavage of Podocin by Matriptase exacerbates podocyte
            injury
  JOURNAL   J Biol Chem 295 (47), 16002-16012 (2020)
   PUBMED   32907879
  REMARK    GeneRIF: Proteolytic cleavage of Podocin by Matriptase exacerbates
            podocyte injury.
REFERENCE   5  (bases 1 to 4017)
  AUTHORS   Szabo,R., Callies,L.K. and Bugge,T.H.
  TITLE     Matriptase drives early-onset intestinal failure in a mouse model
            of congenital tufting enteropathy
  JOURNAL   Development 146 (22) (2019)
   PUBMED   31628112
  REMARK    GeneRIF: matriptase is a causative agent in the development of
            congenital tufting enteropathy (CTE) and may provide a new target
            for the treatment of CTE in individuals carrying SPINT2 mutation
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4017)
  AUTHORS   List,K., Szabo,R., Wertz,P.W., Segre,J., Haudenschild,C.C.,
            Kim,S.Y. and Bugge,T.H.
  TITLE     Loss of proteolytically processed filaggrin caused by epidermal
            deletion of Matriptase/MT-SP1
  JOURNAL   J Cell Biol 163 (4), 901-910 (2003)
   PUBMED   14638864
REFERENCE   7  (bases 1 to 4017)
  AUTHORS   Vuagniaux,G., Vallet,V., Jaeger,N.F., Hummler,E. and Rossier,B.C.
  TITLE     Synergistic activation of ENaC by three membrane-bound
            channel-activating serine proteases (mCAP1, mCAP2, and mCAP3) and
            serum- and glucocorticoid-regulated kinase (Sgk1) in Xenopus
            Oocytes
  JOURNAL   J Gen Physiol 120 (2), 191-201 (2002)
   PUBMED   12149280
REFERENCE   8  (bases 1 to 4017)
  AUTHORS   List,K., Haudenschild,C.C., Szabo,R., Chen,W., Wahl,S.M., Swaim,W.,
            Engelholm,L.H., Behrendt,N. and Bugge,T.H.
  TITLE     Matriptase/MT-SP1 is required for postnatal survival, epidermal
            barrier function, hair follicle development, and thymic homeostasis
  JOURNAL   Oncogene 21 (23), 3765-3779 (2002)
   PUBMED   12032844
  REMARK    GeneRIF: Matriptase/MT-SP1 is required for postnatal survival,
            epidermal barrier function, hair follicle development, and thymic
            homeostasis. (Matriptase/MTSP1)
REFERENCE   9  (bases 1 to 4017)
  AUTHORS   Cho,E.G., Kim,M.G., Kim,C., Kim,S.R., Seong,I.S., Chung,C.,
            Schwartz,R.H. and Park,D.
  TITLE     N-terminal processing is essential for release of epithin, a mouse
            type II membrane serine protease
  JOURNAL   J Biol Chem 276 (48), 44581-44589 (2001)
   PUBMED   11567025
REFERENCE   10 (bases 1 to 4017)
  AUTHORS   Kim,M.G., Chen,C., Lyu,M.S., Cho,E.G., Park,D., Kozak,C. and
            Schwartz,R.H.
  TITLE     Cloning and chromosomal mapping of a gene isolated from thymic
            stromal cells encoding a new mouse type II membrane serine
            protease, epithin, containing four LDL receptor modules and two CUB
            domains
  JOURNAL   Immunogenetics 49 (5), 420-428 (1999)
   PUBMED   10199918
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC114542.9 and CT025653.7.
            
            On Nov 17, 2006 this sequence version replaced NM_011176.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK052738.1, BC008514.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-254               AC114542.9         200261-200514       c
            255-414             CT025653.7         246151-246310       c
            415-542             CT025653.7         245735-245862       c
            543-613             CT025653.7         245484-245554       c
            614-771             CT025653.7         244297-244454       c
            772-807             CT025653.7         244069-244104       c
            808-1048            CT025653.7         243594-243834       c
            1049-1188           CT025653.7         241266-241405       c
            1189-1286           CT025653.7         240456-240553       c
            1287-1396           CT025653.7         237966-238075       c
            1397-1527           CT025653.7         237720-237850       c
            1528-1632           CT025653.7         235137-235241       c
            1633-1743           CT025653.7         234653-234763       c
            1744-1857           CT025653.7         234434-234547       c
            1858-1980           CT025653.7         234055-234177       c
            1981-2167           CT025653.7         233115-233301       c
            2168-2442           CT025653.7         228917-229191       c
            2443-2579           CT025653.7         227982-228118       c
            2580-4017           CT025653.7         226170-227607       c
FEATURES             Location/Qualifiers
     source          1..4017
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 16.61 cM"
     gene            1..4017
                     /gene="St14"
                     /gene_synonym="Epithin; matriptase; mCAP3; MT-SP1; Prss14;
                     Tmprss14"
                     /note="suppression of tumorigenicity 14 (colon carcinoma)"
                     /db_xref="GeneID:19143"
                     /db_xref="MGI:MGI:1338881"
     exon            1..254
                     /gene="St14"
                     /gene_synonym="Epithin; matriptase; mCAP3; MT-SP1; Prss14;
                     Tmprss14"
                     /inference="alignment:Splign:2.1.0"
     CDS             174..2741
                     /gene="St14"
                     /gene_synonym="Epithin; matriptase; mCAP3; MT-SP1; Prss14;
                     Tmprss14"
                     /EC_number="3.4.21.109"
                     /note="matriptase/MT-SP1; protease, serine, 14 (epithin)"
                     /codon_start=1
                     /product="suppressor of tumorigenicity 14 protein homolog"
                     /protein_id="NP_035306.2"
                     /db_xref="CCDS:CCDS22948.1"
                     /db_xref="GeneID:19143"
                     /db_xref="MGI:MGI:1338881"
                     /translation="MGSNRGRKAGGGSQDFGAGLKYNSRLENMNGFEEGVEFLPANNA
                     KKVEKRGPRRWVVLVAVLFSFLLLSLMAGLLVWHFHYRNVRVQKVFNGHLRITNEIFL
                     DAYENSTSTEFISLASQVKEALKLLYNEVPVLGPYHKKSAVTAFSEGSVIAYYWSEFS
                     IPPHLAEEVDRAMAVERVVTLPPRARALKSFVLTSVVAFPIDPRMLQRTQDNSCSFAL
                     HAHGAAVTRFTTPGFPNSPYPAHARCQWVLRGDADSVLSLTFRSFDVAPCDEHGSDLV
                     TVYDSLSPMEPHAVVRLCGTFSPSYNLTFLSSQNVFLVTLITNTDRRHPGFEATFFQL
                     PKMSSCGGFLSDTQGTFSSPYYPGHYPPNINCTWNIKVPNNRNVKVRFKLFYLVDPNV
                     PVGSCTKDYVEINGEKYCGERSQFVVSSNSSKITVHFHSDHSYTDTGFLAEYLSYDSN
                     DPCPGMFMCKTGRCIRKELRCDGWADCPDYSDERYCRCNATHQFTCKNQFCKPLFWVC
                     DSVNDCGDGSDEEGCSCPAGSFKCSNGKCLPQSQKCNGKDNCGDGSDEASCDSVNVVS
                     CTKYTYRCQNGLCLSKGNPECDGKTDCSDGSDEKNCDCGLRSFTKQARVVGGTNADEG
                     EWPWQVSLHALGQGHLCGASLISPDWLVSAAHCFQDDKNFKYSDYTMWTAFLGLLDQS
                     KRSASGVQELKLKRIITHPSFNDFTFDYDIALLELEKSVEYSTVVRPICLPDATHVFP
                     AGKAIWVTGWGHTKEGGTGALILQKGEIRVINQTTCEDLMPQQITPRMMCVGFLSGGV
                     DSCQGDSGGPLSSAEKDGRMFQAGVVSWGEGCAQRNKPGVYTRLPVVRDWIKEHTGV"
     exon            255..414
                     /gene="St14"
                     /gene_synonym="Epithin; matriptase; mCAP3; MT-SP1; Prss14;
                     Tmprss14"
                     /inference="alignment:Splign:2.1.0"
     exon            415..542
                     /gene="St14"
                     /gene_synonym="Epithin; matriptase; mCAP3; MT-SP1; Prss14;
                     Tmprss14"
                     /inference="alignment:Splign:2.1.0"
     exon            543..613
                     /gene="St14"
                     /gene_synonym="Epithin; matriptase; mCAP3; MT-SP1; Prss14;
                     Tmprss14"
                     /inference="alignment:Splign:2.1.0"
     exon            614..771
                     /gene="St14"
                     /gene_synonym="Epithin; matriptase; mCAP3; MT-SP1; Prss14;
                     Tmprss14"
                     /inference="alignment:Splign:2.1.0"
     exon            772..807
                     /gene="St14"
                     /gene_synonym="Epithin; matriptase; mCAP3; MT-SP1; Prss14;
                     Tmprss14"
                     /inference="alignment:Splign:2.1.0"
     exon            808..1048
                     /gene="St14"
                     /gene_synonym="Epithin; matriptase; mCAP3; MT-SP1; Prss14;
                     Tmprss14"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1188
                     /gene="St14"
                     /gene_synonym="Epithin; matriptase; mCAP3; MT-SP1; Prss14;
                     Tmprss14"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..1286
                     /gene="St14"
                     /gene_synonym="Epithin; matriptase; mCAP3; MT-SP1; Prss14;
                     Tmprss14"
                     /inference="alignment:Splign:2.1.0"
     exon            1287..1396
                     /gene="St14"
                     /gene_synonym="Epithin; matriptase; mCAP3; MT-SP1; Prss14;
                     Tmprss14"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..1527
                     /gene="St14"
                     /gene_synonym="Epithin; matriptase; mCAP3; MT-SP1; Prss14;
                     Tmprss14"
                     /inference="alignment:Splign:2.1.0"
     exon            1528..1632
                     /gene="St14"
                     /gene_synonym="Epithin; matriptase; mCAP3; MT-SP1; Prss14;
                     Tmprss14"
                     /inference="alignment:Splign:2.1.0"
     exon            1633..1743
                     /gene="St14"
                     /gene_synonym="Epithin; matriptase; mCAP3; MT-SP1; Prss14;
                     Tmprss14"
                     /inference="alignment:Splign:2.1.0"
     exon            1744..1857
                     /gene="St14"
                     /gene_synonym="Epithin; matriptase; mCAP3; MT-SP1; Prss14;
                     Tmprss14"
                     /inference="alignment:Splign:2.1.0"
     exon            1858..1980
                     /gene="St14"
                     /gene_synonym="Epithin; matriptase; mCAP3; MT-SP1; Prss14;
                     Tmprss14"
                     /inference="alignment:Splign:2.1.0"
     exon            1981..2167
                     /gene="St14"
                     /gene_synonym="Epithin; matriptase; mCAP3; MT-SP1; Prss14;
                     Tmprss14"
                     /inference="alignment:Splign:2.1.0"
     exon            2168..2442
                     /gene="St14"
                     /gene_synonym="Epithin; matriptase; mCAP3; MT-SP1; Prss14;
                     Tmprss14"
                     /inference="alignment:Splign:2.1.0"
     exon            2443..2579
                     /gene="St14"
                     /gene_synonym="Epithin; matriptase; mCAP3; MT-SP1; Prss14;
                     Tmprss14"
                     /inference="alignment:Splign:2.1.0"
     exon            2580..4017
                     /gene="St14"
                     /gene_synonym="Epithin; matriptase; mCAP3; MT-SP1; Prss14;
                     Tmprss14"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3177..3182
                     /regulatory_class="polyA_signal_sequence"
                     /gene="St14"
                     /gene_synonym="Epithin; matriptase; mCAP3; MT-SP1; Prss14;
                     Tmprss14"
                     /note="hexamer: AGTAAA"
     polyA_site      3200
                     /gene="St14"
                     /gene_synonym="Epithin; matriptase; mCAP3; MT-SP1; Prss14;
                     Tmprss14"
                     /note="major polyA site"
ORIGIN      
        1 gatgagaact ggagcctccg ccgcgggccg ggcgcgctgg gcctgccccg gaacttggcc
       61 cgtgcctcac ctcgtccccc tcgtccctcg tgtccccaac accccgcggg ccatggtaga
      121 cggctgcccg gagggaccac gcgtctgaga ccggcgatcg gaccgccaaa accatgggta
      181 gcaatcgggg ccgcaaggcc ggagggggct ctcaggactt cggcgcggga ctcaagtaca
      241 actcccggct agagaacatg aatggctttg aggagggtgt ggagttcctg cctgcgaaca
      301 atgccaagaa agtggagaag cgaggcccca ggcgctgggt ggtgctggtg gcagtgctgt
      361 tcagcttcct cttgctctcc ctcatggctg gcttgctggt gtggcacttc cattatcgga
      421 atgtgcgggt tcaaaaagtc ttcaatggcc atctgaggat cacaaatgag atctttctgg
      481 atgcgtatga gaactccacc tccacagagt ttatcagcct ggccagccag gtgaaggagg
      541 cgctgaagct gctgtacaat gaagtccctg tcctgggtcc ctaccacaag aagtcggctg
      601 taactgcctt cagtgagggc agtgtcatcg cctactactg gtcagagttc agcatccccc
      661 cacacctggc agaagaggtt gatcgcgcca tggctgtgga gcgagttgta acattgccac
      721 cccgagcacg ggcactgaaa tccttcgtgc taacatctgt ggtggccttc cccattgacc
      781 ccagaatgct gcagaggact caggacaaca gctgcagttt tgccctgcat gcccatggtg
      841 cagcagtgac acgcttcact acccctggct tccccaacag tccctacccg gcgcatgccc
      901 gctgccagtg ggtcctgcgg ggggacgccg actctgtgct gagcctcacc ttccgaagct
      961 ttgatgtcgc tccctgtgat gagcatggca gtgacctggt caccgtgtat gatagcctga
     1021 gccccatgga accccacgct gtggtgcggc tgtgtggcac cttctcaccc tcctacaacc
     1081 tgactttcct ctcctcccag aacgtcttcc ttgtcacgct gataaccaat actgaccggc
     1141 gacatcctgg ctttgaggcc actttcttcc agctgcccaa gatgagcagc tgtggcggct
     1201 ttttgagtga cacccaaggg acatttagca gcccctacta tccaggccac tacccgccca
     1261 acatcaactg cacatggaat atcaaggtgc ccaacaaccg gaacgtgaag gtgcgcttca
     1321 aactcttcta tctggtggac cccaacgtac cagtgggctc ctgcaccaag gactatgtgg
     1381 agatcaacgg ggagaagtac tgcggtgaga ggtcccagtt tgtggtgagc agcaacagca
     1441 gcaagattac agtccacttc cattctgatc actcgtacac ggacaccggg ttcctagctg
     1501 agtacctctc ctacgactcc aacgacccgt gcccagggat gttcatgtgc aagactggac
     1561 ggtgcatccg aaaggaactg cgctgcgacg gctgggcaga ctgcccggat tatagtgatg
     1621 agcgttactg ccgatgcaat gccacccacc agttcacgtg caaaaaccag ttctgcaagc
     1681 ccctcttctg ggtctgtgac agtgtcaacg actgtgggga cggaagtgac gaggagggct
     1741 gcagctgtcc tgctgggagt ttcaagtgtt ccaatgggaa gtgtctccct cagagccaga
     1801 agtgtaatgg gaaggacaac tgtggagatg ggtctgacga ggcttcatgt gacagcgtga
     1861 atgtcgtctc ttgcaccaaa tatacctacc gctgccaaaa tggcctctgt ctgagcaagg
     1921 gcaaccctga gtgtgatggg aagacggact gtagcgatgg ctccgatgag aaaaactgtg
     1981 actgtgggct gcgatccttt accaaacagg ctcgcgtggt tggtggcacg aatgcggacg
     2041 agggcgagtg gccctggcag gtgagcctcc acgccctggg ccagggccac ttgtgtgggg
     2101 cctcgctcat ctctcctgac tggctggtct ctgcagctca ttgctttcag gatgacaaaa
     2161 atttcaagta ctcagactac acgatgtgga cggccttcct gggtctgctg gaccagagca
     2221 agcgcagtgc ctctggggtg caggagctga agctcaaacg tatcatcacc cacccttcct
     2281 tcaatgattt caccttcgac tatgacatcg ccttgctgga gctggagaag tcggtggagt
     2341 acagcaccgt cgtgcgcccc atctgcctgc ctgatgctac ccatgtcttc cctgctggca
     2401 aggccatctg ggtcacaggc tgggggcaca caaaagaggg aggtaccgga gcgctgatcc
     2461 tgcagaaggg tgagatccgt gtcatcaacc agaccacctg tgaggacctc atgccgcagc
     2521 agatcacccc acgaatgatg tgtgtgggtt tcctcagtgg gggtgtggac tcctgccagg
     2581 gtgactctgg tggccccttg tcaagcgcgg agaaagatgg gcgaatgttc caggctggtg
     2641 tggtgagctg gggtgaaggc tgcgctcaga ggaacaagcc aggcgtgtac acaaggctcc
     2701 ctgtagttcg ggactggatc aaagagcaca ctggggtata gcagcatgga cagacagccg
     2761 accacaaaca cccacaggga tgcccgacat gcacacctgg atacaggaga ggaacactga
     2821 cgacatttat gctgtggcct ccccccccca acacaaccca gactgtgaac tgcatcctta
     2881 ggactcagag ttcttccaaa gtgggacccc ctcaagagtt ggagagagaa cttgcgtgct
     2941 agcggcccag cctgggggca agggtttgat ggcagccttc cccctctagc cctgagctgg
     3001 gtgaagatga tgctgtcccg gagagctgct tccaactgtc attgagctcc cgggagccct
     3061 atgggaggag gggctcaggg tcactctttt caggaagcgc cagccctagg aaccccagaa
     3121 aagagtggta cctaaggctg aaattgtttt gctgttgcca ggggtgggta tttgagagta
     3181 aaacatttta tttcttttta ggtaatttgt ttttcttgct atactactac acctccctcc
     3241 cccatcccct ctatgaatag ttttctttgc actaaactag aactaaattt cccctagtac
     3301 agaccctgtg cagaccacag cgtcttgtct tccctaggcc aagggctgtc tgtccttggt
     3361 tataacaagt gctcacttgt aagccaggcc ctgattgcaa cagaaacttg gtcagaagga
     3421 agtttggggg agatgaatca tgtgactgtc caggactgac cctggccttg ccctaccggg
     3481 ggttgagagg acaggcagta gtagtcatgg tgacatgtca gaggaagagg gagatgccaa
     3541 gtgttgtggg tttgctttcg gtgcacaggt gtcacacatg ttgtgtatac acacatggat
     3601 gcatacacga ggtgcacatg gatgcagggc ccagcatggg atgggtggat gggttgcagt
     3661 tcgggggatg atgctgtgtt agtgatgggt gcttacacct cctatgccat ccctctttct
     3721 actttatcaa gtattctcaa cttagttgga gttgcccagg gaggtggggc tgtagatctg
     3781 aggagaggtt agagatcttt tgaaaggccc ttcgaaggct cctggggcca tgcatgggct
     3841 gaggctgaag aaggagtggc ctctggtaga tgtggaggtg actgtgtcag ggtcatgagg
     3901 gaagccagct ctgcccattg cttttcccca gctcaggcct cccgagctcc tggacgttgc
     3961 tgttgcttac cattggcctt tgttaacaca aagttaagac agttgttctg actgctc
//
