LOCUS       NM_001355661            3597 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus SSX family member 2 interacting protein (Ssx2ip),
            transcript variant 5, mRNA.
ACCESSION   NM_001355661 XM_006502404
VERSION     NM_001355661.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3597)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3597)
  AUTHORS   Wang,B., He,W., Prosseda,P.P., Li,L., Kowal,T.J., Alvarado,J.A.,
            Wang,Q., Hu,Y. and Sun,Y.
  TITLE     OCRL regulates lysosome positioning and mTORC1 activity through
            SSX2IP-mediated microtubule anchoring
  JOURNAL   EMBO Rep 22 (7), e52173 (2021)
   PUBMED   33987909
  REMARK    GeneRIF: OCRL regulates lysosome positioning and mTORC1 activity
            through SSX2IP-mediated microtubule anchoring.
REFERENCE   3  (bases 1 to 3597)
  AUTHORS   Kurtulmus,B., Wang,W., Ruppert,T., Neuner,A., Cerikan,B., Viol,L.,
            Duenas-Sanchez,R., Gruss,O.J. and Pereira,G.
  TITLE     WDR8 is a centriolar satellite and centriole-associated protein
            that promotes ciliary vesicle docking during ciliogenesis
  JOURNAL   J Cell Sci 129 (3), 621-636 (2016)
   PUBMED   26675238
REFERENCE   4  (bases 1 to 3597)
  AUTHORS   Klinger,M., Wang,W., Kuhns,S., Barenz,F., Drager-Meurer,S.,
            Pereira,G. and Gruss,O.J.
  TITLE     The novel centriolar satellite protein SSX2IP targets Cep290 to the
            ciliary transition zone
  JOURNAL   Mol Biol Cell 25 (4), 495-507 (2014)
   PUBMED   24356449
  REMARK    GeneRIF: The novel centriolar satellite protein SSX2IP targets
            Cep290 to the ciliary transition zone.
REFERENCE   5  (bases 1 to 3597)
  AUTHORS   Fukumoto,Y., Kurita,S., Takai,Y. and Ogita,H.
  TITLE     Role of scaffold protein afadin dilute domain-interacting protein
            (ADIP) in platelet-derived growth factor-induced cell movement by
            activating Rac protein through Vav2 protein
  JOURNAL   J Biol Chem 286 (50), 43537-43548 (2011)
   PUBMED   22027834
  REMARK    GeneRIF: The results indicate that ADIP plays an essential role in
            PDGF-induced cell movement by interacting with afadin and Vav2 and
            regulating the activation of Rac.
REFERENCE   6  (bases 1 to 3597)
  AUTHORS   Asada,M., Irie,K., Yamada,A. and Takai,Y.
  TITLE     Afadin- and alpha-actinin-binding protein ADIP directly binds
            beta'-COP, a subunit of the coatomer complex
  JOURNAL   Biochem Biophys Res Commun 321 (2), 350-354 (2004)
   PUBMED   15358183
REFERENCE   7  (bases 1 to 3597)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   8  (bases 1 to 3597)
  AUTHORS   Asada,M., Irie,K., Morimoto,K., Yamada,A., Ikeda,W., Takeuchi,M.
            and Takai,Y.
  TITLE     ADIP, a novel Afadin- and alpha-actinin-binding protein localized
            at cell-cell adherens junctions
  JOURNAL   J Biol Chem 278 (6), 4103-4111 (2003)
   PUBMED   12446711
  REMARK    GeneRIF: localization at cell-cell adherens junctions
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124987.9.
            
            On Sep 22, 2017 this sequence version replaced XM_006502404.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7974084.29219.1,
                                           SRR7652917.576055.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-294               AC124987.9         98839-99132
            295-478             AC124987.9         111804-111987
            479-648             AC124987.9         112472-112641
            649-861             AC124987.9         113332-113544
            862-972             AC124987.9         117093-117203
            973-1108            AC124987.9         120520-120655
            1109-1184           AC124987.9         122022-122097
            1185-1365           AC124987.9         122184-122364
            1366-1516           AC124987.9         125126-125276
            1517-1653           AC124987.9         126678-126814
            1654-1827           AC124987.9         127170-127343
            1828-1942           AC124987.9         130740-130854
            1943-2108           AC124987.9         131373-131538
            2109-3597           AC124987.9         132853-134341
FEATURES             Location/Qualifiers
     source          1..3597
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 71.03 cM"
     gene            1..3597
                     /gene="Ssx2ip"
                     /gene_synonym="Adip"
                     /note="SSX family member 2 interacting protein"
                     /db_xref="GeneID:99167"
                     /db_xref="MGI:MGI:2139150"
     exon            1..294
                     /gene="Ssx2ip"
                     /gene_synonym="Adip"
                     /inference="alignment:Splign:2.1.0"
     exon            295..478
                     /gene="Ssx2ip"
                     /gene_synonym="Adip"
                     /inference="alignment:Splign:2.1.0"
     CDS             436..2283
                     /gene="Ssx2ip"
                     /gene_synonym="Adip"
                     /note="isoform a is encoded by transcript variant 5;
                     afadin DIL domain-interacting protein; afadin- and
                     alpha-actinin-binding protein; synovial sarcoma, X
                     breakpoint 2 interacting protein; synovial sarcoma, X 2
                     interacting protein; SSX 2 interacting protein"
                     /codon_start=1
                     /product="afadin- and alpha-actinin-binding protein
                     isoform a"
                     /protein_id="NP_001342590.1"
                     /db_xref="CCDS:CCDS38665.1"
                     /db_xref="GeneID:99167"
                     /db_xref="MGI:MGI:2139150"
                     /translation="MGDWMTVTDPVLCTENKNLSQYTSETKMSPSSLYSQQVLCSSVP
                     LSKNVHGVFGVFCTGENIEQSISYLDQELTTFGFPSLYEESKSKEAKRELNIVAVLNC
                     MNELLVLQRKNLLAQESVETQNLKLGSDMDHLQSCYAKLKEQLETSRREMIGLQERDR
                     QLQCKNRSLHQLLKNEKDEVQKLQNIIASRATQYNHDVKRKEREYNKLKERLHQLVMN
                     KKDKNIAMDVLNYVGRADGKRGSWRTDKTEARNEDEMYKILLNDYEYRQKQILMENAE
                     LKKVLQQMKKEMISLLSPQKKKPRERAEDGTGTVAISDIEDDSGELSRDSVWGLSCDT
                     VREQLTNSIRKQWRILKSHVEKLDNQASKVHSEGLNEEDVISRQDHEQETEKLELEIE
                     RCKEMIKAQQQLLQQQLATTCDDDTTSLLRDCYLLEEKERLKEEWTLFKEQKKNFERE
                     RRSFTEAAIRLGLERKAFEEERASWVKQQFLNMTNFDHQNSENVKLFSAFSGSSDPDN
                     LIVHSRPRQKKLHSVANGVPACTSKLTKSLPASPSTSDFRQTHSCVSEHSSISVLNIT
                     PEESKPSEVARESTDQKWSVQSRPSSREGCYSGCSSAFRSAHGDRDDLP"
     exon            479..648
                     /gene="Ssx2ip"
                     /gene_synonym="Adip"
                     /inference="alignment:Splign:2.1.0"
     exon            649..861
                     /gene="Ssx2ip"
                     /gene_synonym="Adip"
                     /inference="alignment:Splign:2.1.0"
     exon            862..972
                     /gene="Ssx2ip"
                     /gene_synonym="Adip"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1108
                     /gene="Ssx2ip"
                     /gene_synonym="Adip"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1184
                     /gene="Ssx2ip"
                     /gene_synonym="Adip"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1365
                     /gene="Ssx2ip"
                     /gene_synonym="Adip"
                     /inference="alignment:Splign:2.1.0"
     exon            1366..1516
                     /gene="Ssx2ip"
                     /gene_synonym="Adip"
                     /inference="alignment:Splign:2.1.0"
     exon            1517..1653
                     /gene="Ssx2ip"
                     /gene_synonym="Adip"
                     /inference="alignment:Splign:2.1.0"
     exon            1654..1827
                     /gene="Ssx2ip"
                     /gene_synonym="Adip"
                     /inference="alignment:Splign:2.1.0"
     exon            1828..1942
                     /gene="Ssx2ip"
                     /gene_synonym="Adip"
                     /inference="alignment:Splign:2.1.0"
     exon            1943..2108
                     /gene="Ssx2ip"
                     /gene_synonym="Adip"
                     /inference="alignment:Splign:2.1.0"
     exon            2109..3597
                     /gene="Ssx2ip"
                     /gene_synonym="Adip"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2343..2348
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ssx2ip"
                     /gene_synonym="Adip"
                     /note="hexamer: CATAAA"
     polyA_site      2366
                     /gene="Ssx2ip"
                     /gene_synonym="Adip"
     regulatory      3569..3574
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ssx2ip"
                     /gene_synonym="Adip"
                     /note="hexamer: ATTAAA"
     polyA_site      3592
                     /gene="Ssx2ip"
                     /gene_synonym="Adip"
                     /note="major polyA site"
ORIGIN      
        1 gggatgggcg cccgccgagg aaagcggcga gaggcgggcc gggcggaccg ggcgggctgg
       61 aggctgcgcg gagccgctgc gtgccgccgc gggtgcgggc ccgcgggctg cgggaggcgt
      121 gagccgctcc cggagccgtg acggtgagcg gcgggattgt gacgcgcagg cggggaggag
      181 ggcaccgggc tggacgtgga cgcaggcacc ggggccgact ctgggcgggc tcgtcgcggc
      241 cgttgcagcg gttggagagc gttgctgccc gccgcctgca gcggaaagtg cgaggagatg
      301 ctcacgtagg agagtggcag gagctgtcat aagcatcgca gcactgagcc gcctcacgta
      361 ggagagtgac aggagctgtt gtaagcgtcg cagcactgag ccgcctcctc aggtatcctg
      421 gctctggaac ttgctatggg agattggatg actgtgacag atccagttct gtgtacagaa
      481 aacaaaaatc tctctcaata tacctcagaa acaaagatgt ctccgtccag tttgtactcc
      541 cagcaagttc tgtgctcttc agtaccttta tccaaaaacg tgcatggtgt tttcggtgtc
      601 ttctgcacag gagagaacat tgaacaaagt atttcctatc ttgatcagga gctgaccacc
      661 ttcgggtttc cttccttgta tgaagaatcc aaaagtaaag aggcaaagag agaattaaat
      721 atagtcgctg ttctgaactg tatgaacgag ctgctcgtgc ttcagcggaa gaacctgctg
      781 gcccaggaga gcgtggagac acagaacttg aagctgggca gtgacatgga ccacctgcag
      841 agctgctacg ccaaacttaa ggagcagttg gaaacgtcca ggcgggagat gatcgggctt
      901 caagagagag acaggcagct gcagtgcaag aacaggagtt tgcatcagct cctgaagaat
      961 gagaaagatg aggtacaaaa attacaaaat atcatagcca gccgggctac tcagtataat
     1021 catgatgtga agaggaagga gcgtgaatat aataagctaa aggagcgcct gcatcagctc
     1081 gttatgaaca agaaggataa aaacatagcc atggatgttt taaattatgt gggtcgagct
     1141 gatggcaaac gaggctcatg gaggactgac aaaacagaag ccaggaatga agatgagatg
     1201 tacaaaattc tgttgaatga ttatgagtac cgccagaagc agatcctgat ggagaacgcg
     1261 gagctgaaga aggtcctcca gcagatgaag aaggagatga tctctctcct gtctcctcag
     1321 aagaagaagc ccagggaaag agcagaggac ggcacaggca ctgttgctat ctccgatata
     1381 gaagatgact ctggggaact gagcagagac agcgtgtggg gcctttcctg tgacactgtg
     1441 agagagcagc tgacaaacag catcaggaaa cagtggagaa ttttgaaaag tcatgtagaa
     1501 aaactcgata accaagcttc gaaggtacac tcagagggcc ttaatgagga ggacgtcatc
     1561 tcacgacaag accatgagca agagactgag aaactggagc tggagattga gcggtgtaaa
     1621 gagatgatca aggctcagca gcagctctta cagcagcagc tggccaccac gtgtgatgat
     1681 gacaccacct cactgttgcg agactgttac ttgctggaag aaaaggaacg ccttaaagaa
     1741 gagtggaccc tttttaaaga gcaaaaaaag aattttgaga gagaaaggcg aagctttaca
     1801 gaagctgcca ttcgattggg gttggagaga aaggcgtttg aagaagagcg agccagctgg
     1861 gtaaagcagc agtttttaaa catgacgaac tttgaccacc agaactcaga aaatgtgaaa
     1921 cttttcagtg ccttctcagg aagttctgat ccagacaatc ttatagtcca ctcacggcca
     1981 cggcaaaaga agctacacag tgtggctaat ggggtgccag cttgcacatc aaaactgact
     2041 aaatctcttc ctgcctcacc ttctacttca gactttcgcc agacacattc atgtgtgtct
     2101 gaacacagtt ccatcagtgt gctgaatata actcctgaag aaagtaaacc aagtgaggtt
     2161 gcaagagaaa gcacggatca gaagtggagc gtgcagtcga ggcccagctc gcgggagggg
     2221 tgctacagcg gatgctcctc ggccttcagg agcgctcacg gggaccgaga tgacttacct
     2281 taaatgtgcg ggctgcagtg ctgttcccag atgtgcgcta gaggagttga cacagggtgt
     2341 agcataaagt cagtcgtcta acttaagatg ctcagagttg tttgtttgga cttcgctgtc
     2401 ttcccccaaa gagctgaaat gctaagctac ttaaaaggat gcaaagcttt ggttgtgtgt
     2461 tagtaacaga agcccctggc tctgtgactg caggaatgca tggcgtttgg atggaaacag
     2521 aagcgctgga atgattgcct cgccaggtac cgagaagagc acttttaggg actggttcct
     2581 gtaaacatta aatattcgtc ccaagtgtgg ttggcattgg aagtgtagcc tttacttgaa
     2641 tgtatactgt agatttttaa caaagcaggt tctatattta ttatgtttag tgtgattttg
     2701 ggattacctc tttcatatgt tttgtgtctg tacataaata tacatgacta tgttaagagg
     2761 ctttaaggtt taaaaacttc acaccatgct tgagtatagc atttcatgcc aattaaaatg
     2821 ttttcagtgg catggtgttt acagaggtta ggaccactgc cacatgacag ttaagacttt
     2881 atttttaagc catctgggca ataaaaattc aaagcccctt cataagctga gttcagataa
     2941 ctagaactac taacgttaca tttttgagat ttttaaagca ttgtatttta ttttatatat
     3001 gtgaatgtta taatttctaa gaggaatatt gattatggag taatggggga aagacaaacg
     3061 tatctttgaa taataatata agagcattgg gttgagatat ttggatgata aaggatattt
     3121 aagatagctg gatgctcata ttttccttac caaatgggtg ccagtacagt cgtgtctgta
     3181 ccggccaggg ctttatatca ttgccaataa ttttgtaatt aaaaaatttt caactagatc
     3241 cctctactaa agaaataaga caatgtgaag cattgacttt tataaccgag acatggcact
     3301 ctgggcactg tgtcgtctca ttttcagaac aatcttagga tctttctgtt tctgctgcat
     3361 gtttcctcgt aagaagtatg gcactatgat agtaatgaca gtaacataaa cgtagacgta
     3421 ggcccaggct tctcctggat gggttttcat ccagcagctt ttaagtgcct caccctgctt
     3481 gtctctacgc tgccgacaca agccctcgct tgctgaggca ggtagtccat ctgcctttct
     3541 ctttccttgt tcctgctgtg actgttgcat taaattcatc atgctaccaa aagtgaa
//
