LOCUS       NM_026899               1478 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus Ssu72 RNA polymerase II CTD phosphatase homolog
            (yeast) (Ssu72), mRNA.
ACCESSION   NM_026899
VERSION     NM_026899.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1478)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1478)
  AUTHORS   Park,E.J., Kim,H.S., Lee,D.H., Kim,S.M., Yoon,J.S., Lee,J.M.,
            Im,S.J., Lee,H., Lee,M.W. and Lee,C.W.
  TITLE     Ssu72 phosphatase is essential for thermogenic adaptation by
            regulating cytosolic translation
  JOURNAL   Nat Commun 14 (1), 1097 (2023)
   PUBMED   36841836
  REMARK    GeneRIF: Ssu72 phosphatase is essential for thermogenic adaptation
            by regulating cytosolic translation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1478)
  AUTHORS   Ko,J.S., Jeong,D., Koh,J., Jung,H., Jung,K.C., Jeon,Y.K., Kim,H.Y.,
            Yi,E.C., Lee,H., Lee,C.W. and Chung,D.H.
  TITLE     Ssu72 phosphatase directly binds to ZAP-70, thereby providing
            fine-tuning of TCR signaling and preventing spontaneous
            inflammation
  JOURNAL   Proc Natl Acad Sci U S A 118 (35) (2021)
   PUBMED   34452999
  REMARK    GeneRIF: Ssu72 phosphatase directly binds to ZAP-70, thereby
            providing fine-tuning of TCR signaling and preventing spontaneous
            inflammation.
REFERENCE   4  (bases 1 to 1478)
  AUTHORS   Lee,J.K., Koo,S.Y., Nam,H.M., Lee,J.B., Ko,J., Kim,K.M., Park,E.J.,
            Kim,T.J., Lee,H., Go,H. and Lee,C.W.
  TITLE     Ssu72 is a T-cell receptor-responsive modifier that is
            indispensable for regulatory T cells
  JOURNAL   Cell Mol Immunol 18 (6), 1395-1411 (2021)
   PUBMED   33850312
  REMARK    GeneRIF: Ssu72 is a T-cell receptor-responsive modifier that is
            indispensable for regulatory T cells.
REFERENCE   5  (bases 1 to 1478)
  AUTHORS   Woo,Y.D., Koh,J., Ko,J.S., Kim,S., Jung,K.C., Jeon,Y.K., Kim,H.Y.,
            Lee,H., Lee,C.W. and Chung,D.H.
  TITLE     Ssu72 regulates alveolar macrophage development and allergic airway
            inflammation by fine-tuning of GM-CSF receptor signaling
  JOURNAL   J Allergy Clin Immunol 147 (4), 1242-1260 (2021)
   PUBMED   32910932
  REMARK    GeneRIF: Ssu72 regulates alveolar macrophage development and
            allergic airway inflammation by fine-tuning of GM-CSF receptor
            signaling.
REFERENCE   6  (bases 1 to 1478)
  AUTHORS   Kim,S.H., Jeon,Y., Kim,H.S., Lee,J.K., Lim,H.J., Kang,D., Cho,H.,
            Park,C.K., Lee,H. and Lee,C.W.
  TITLE     Hepatocyte homeostasis for chromosome ploidization and liver
            function is regulated by Ssu72 protein phosphatase
  JOURNAL   Hepatology 63 (1), 247-259 (2016)
   PUBMED   26458163
REFERENCE   7  (bases 1 to 1478)
  AUTHORS   Ghazy,M.A., He,X., Singh,B.N., Hampsey,M. and Moore,C.
  TITLE     The essential N terminus of the Pta1 scaffold protein is required
            for snoRNA transcription termination and Ssu72 function but is
            dispensable for pre-mRNA 3'-end processing
  JOURNAL   Mol Cell Biol 29 (8), 2296-2307 (2009)
   PUBMED   19188448
  REMARK    GeneRIF: the amino terminus of Pta1 has an inhibitory effect and
            that this effect can be neutralized through the interaction with
            Ssu72.
REFERENCE   8  (bases 1 to 1478)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY237911.1, BB867926.1, AK019168.1 and BU842478.1.
            
            On Apr 5, 2008 this sequence version replaced NM_026899.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK005220.1, BY705398.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-285               BY237911.1         3-287
            286-545             BB867926.1         2-261
            546-1329            AK019168.1         2-785
            1330-1478           BU842478.1         262-410
FEATURES             Location/Qualifiers
     source          1..1478
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 87.07 cM"
     gene            1..1478
                     /gene="Ssu72"
                     /gene_synonym="1190002E22Rik; 1500011L16Rik;
                     2610101M12Rik"
                     /note="Ssu72 RNA polymerase II CTD phosphatase homolog
                     (yeast)"
                     /db_xref="GeneID:68991"
                     /db_xref="MGI:MGI:1916241"
     exon            1..647
                     /gene="Ssu72"
                     /gene_synonym="1190002E22Rik; 1500011L16Rik;
                     2610101M12Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             568..1152
                     /gene="Ssu72"
                     /gene_synonym="1190002E22Rik; 1500011L16Rik;
                     2610101M12Rik"
                     /EC_number="3.1.3.16"
                     /note="CTD phosphatase SSU72"
                     /codon_start=1
                     /product="RNA polymerase II subunit A C-terminal domain
                     phosphatase SSU72"
                     /protein_id="NP_081175.2"
                     /db_xref="CCDS:CCDS19036.1"
                     /db_xref="GeneID:68991"
                     /db_xref="MGI:MGI:1916241"
                     /translation="MPSSPLRVAVVCSSNQNRSMEAHNILSKRGFSVRSFGTGTHVKL
                     PGPAPDKPNVYDFKTTYDQMYNDLLRKDKELYTQNGILHMLDRNKRIKPRPERFQNCT
                     DLFDLILTCEERVYDQVVEDLNSREQETCQPVHVVNVDIQDNHEEATLGAFLICELCQ
                     CIQHTEDMENEIDELLQEFEEKSGRAFLHTVCFY"
     exon            648..791
                     /gene="Ssu72"
                     /gene_synonym="1190002E22Rik; 1500011L16Rik;
                     2610101M12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            792..931
                     /gene="Ssu72"
                     /gene_synonym="1190002E22Rik; 1500011L16Rik;
                     2610101M12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1050
                     /gene="Ssu72"
                     /gene_synonym="1190002E22Rik; 1500011L16Rik;
                     2610101M12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1457
                     /gene="Ssu72"
                     /gene_synonym="1190002E22Rik; 1500011L16Rik;
                     2610101M12Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1336..1341
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ssu72"
                     /gene_synonym="1190002E22Rik; 1500011L16Rik;
                     2610101M12Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1362
                     /gene="Ssu72"
                     /gene_synonym="1190002E22Rik; 1500011L16Rik;
                     2610101M12Rik"
                     /note="major polyA site"
ORIGIN      
        1 ctagaagtcc agtgactctg aggaaggtac tcgtgataga gatagggcac aaaccaagtg
       61 ctggagccca gtgcatctat gaaattggca gagtgaccac ctggaggaaa ccggaatgaa
      121 aaacgtccca accacaccaa gagaagccgc ggaaaggact tgagactccc cggacccgcc
      181 ccaacgcccg tcccactgaa gttttcagta ttgcgcaagc gccgcgccta gcgcgtcatc
      241 cgaggcgacg gtacattagg acgcaggcgc ggctcacacc gctccagttg ccggcgcagg
      301 tcctgtgacg tcacgcgccg gcgaaggtgg tccacgaccg ccggcctcgg ctgctctcag
      361 gctgattcgg cgtcggccgg tcgccctccc gcgccggctg cagtacgagc ccaggagagc
      421 accgtcggcc tccccacgcg ttgcgttgcg ttgcgttgcg ttcacttccg tgtcgcagat
      481 ttccggttac cgccatcttc ctcgcgcgga agccggcttc taggtgggag ctccgtagcg
      541 agagcagtgg gtagttcggt cggtgccatg ccgtcatcgc cgctgcgggt ggcggtggtg
      601 tgctcgagta accagaatcg gagcatggaa gcacacaaca tcctcagcaa gcgaggtttc
      661 agtgtccgct cctttggaac aggaactcat gtgaagctcc caggaccagc acctgacaag
      721 cccaatgttt atgacttcaa aaccacatat gaccagatgt acaatgacct cctcaggaaa
      781 gacaaagaac tctatacaca aaatggaatt ttacatatgt tggacagaaa taaaaggatc
      841 aagccccgtc cagaaaggtt ccagaactgc acggacctgt ttgacttgat cctcacttgt
      901 gaagagagag tctatgacca ggttgtagaa gatctgaact ccagagaaca ggagacctgc
      961 cagccagtgc atgtggtcaa tgtggacatc caggacaacc atgaagaggc cactctggga
     1021 gcattcctta tctgcgagct ctgccagtgt atccagcaca ctgaggacat ggagaatgaa
     1081 atcgacgagc tgctgcagga gttcgaggag aagagtggcc gggcctttct gcatactgtc
     1141 tgcttctact gagcctcctg tgctcggtgc atggcctgcc ctgcacagcc acctttgttg
     1201 aagccacttt ttcagtgtgt tttcctttca gatatttgtt tttactgcta ggtgtacatc
     1261 atcaatgtac tgtacatatg gaatgagacg tacgcagaaa tgccagattc aaatccattg
     1321 tttttaacca aaagaaataa agatggttta ctctacagcc tacagcaagt gtctgttgtt
     1381 ggcccttttc tctccactgc tgaattgtac agaaacctaa ataaagcaac aggctgtctt
     1441 attaagggga aaaaaaaaaa aaaaaaaaaa aaaaaaaa
//
