LOCUS       NM_011425               2733 bp    mRNA    linear   ROD 03-MAY-2024
DEFINITION  Mus musculus somatostatin receptor 5 (Sstr5), transcript variant 1,
            mRNA.
ACCESSION   NM_011425 XM_139909
VERSION     NM_011425.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2733)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2733)
  AUTHORS   Liu,J., Huang,S., Yu,R., Chen,X., Li,F., Sun,X., Xu,P., Huang,Y.,
            Xue,Y., Fu,T. and Li,Z.
  TITLE     TRPV1+ sensory nerves modulate corneal inflammation after
            epithelial abrasion via RAMP1 and SSTR5 signaling
  JOURNAL   Mucosal Immunol 15 (5), 867-881 (2022)
   PUBMED   35680973
  REMARK    GeneRIF: TRPV1(+) sensory nerves modulate corneal inflammation
            after epithelial abrasion via RAMP1 and SSTR5 signaling.
REFERENCE   3  (bases 1 to 2733)
  AUTHORS   Li,Y., Li,X., Geng,C., Guo,Y. and Wang,C.
  TITLE     Somatostatin receptor 5 is critical for protecting intestinal
            barrier function in vivo and in vitro
  JOURNAL   Mol Cell Endocrinol 535, 111390 (2021)
   PUBMED   34224803
  REMARK    GeneRIF: Somatostatin receptor 5 is critical for protecting
            intestinal barrier function in vivo and in vitro.
REFERENCE   4  (bases 1 to 2733)
  AUTHORS   Treppiedi,D., Di Muro,G., Mangili,F., Catalano,R., Giardino,E.,
            Barbieri,A.M., Locatelli,M., Arosio,M., Spada,A., Peverelli,E. and
            Mantovani,G.
  TITLE     Filamin A is required for somatostatin receptor type 5 expression
            and pasireotide-mediated signaling in pituitary corticotroph tumor
            cells
  JOURNAL   Mol Cell Endocrinol 524, 111159 (2021)
   PUBMED   33428965
  REMARK    GeneRIF: Filamin A is required for somatostatin receptor type 5
            expression and pasireotide-mediated signaling in pituitary
            corticotroph tumor cells.
REFERENCE   5  (bases 1 to 2733)
  AUTHORS   Jepsen,S.L., Albrechtsen,N.J.W., Windelov,J.A., Galsgaard,K.D.,
            Hunt,J.E., Farb,T.B., Kissow,H., Pedersen,J., Deacon,C.F.,
            Martin,R.E. and Holst,J.J.
  TITLE     Antagonizing somatostatin receptor subtype 2 and 5 reduces blood
            glucose in a gut- and GLP-1R-dependent manner
  JOURNAL   JCI Insight 6 (4), 143228 (2021)
   PUBMED   33434183
  REMARK    GeneRIF: Antagonizing somatostatin receptor subtype 2 and 5 reduces
            blood glucose in a gut- and GLP-1R-dependent manner.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2733)
  AUTHORS   Gordon,D.F., Woodmansee,W.W., Lewis,S.R., James,R.A., Wood,W.M. and
            Ridgway,E.C.
  TITLE     Cloning of the mouse somatostatin receptor subtype 5 gene: promoter
            structure and function
  JOURNAL   Endocrinology 140 (12), 5598-5608 (1999)
   PUBMED   10579323
REFERENCE   7  (bases 1 to 2733)
  AUTHORS   Moldovan,S., DeMayo,F. and Brunicardi,F.C.
  TITLE     Cloning of the mouse SSTR5 gene
  JOURNAL   J Surg Res 76 (1), 57-60 (1998)
   PUBMED   9695740
REFERENCE   8  (bases 1 to 2733)
  AUTHORS   Baumeister,H., Kreuzer,O.J., Roosterman,D., Schafer,J. and
            Meyerhof,W.
  TITLE     Cloning, expression, pharmacology and tissue distribution of the
            mouse somatostatin receptor subtype 5
  JOURNAL   J Neuroendocrinol 10 (4), 283-290 (1998)
   PUBMED   9630398
REFERENCE   9  (bases 1 to 2733)
  AUTHORS   Lublin,A.L., Diehl,N.L. and Hochgeschwender,U.
  TITLE     Isolation and characterization of the gene encoding the type 5
            mouse (Mus musculus) somatostatin receptor (msst5)
  JOURNAL   Gene 195 (1), 63-66 (1997)
   PUBMED   9300821
REFERENCE   10 (bases 1 to 2733)
  AUTHORS   Brinkmeier,M.L. and Camper,S.A.
  TITLE     Localization of somatostatin receptor genes on mouse chromosomes 2,
            11, 12, 15, and 17: correlation with growth QTLs
  JOURNAL   Genomics 43 (1), 9-14 (1997)
   PUBMED   9226367
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC131323.10 and AK133609.1.
            
            On Jul 9, 2010 this sequence version replaced NM_011425.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK133609.1, BC145943.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-118               AC131323.10        171170-171287       c
            119-1689            AK133609.1         85-1655
            1690-2733           AC131323.10        163874-164917       c
FEATURES             Location/Qualifiers
     source          1..2733
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 12.62 cM"
     gene            1..2733
                     /gene="Sstr5"
                     /gene_synonym="Smstr5; sst5"
                     /note="somatostatin receptor 5"
                     /db_xref="GeneID:20609"
                     /db_xref="MGI:MGI:894282"
     exon            1..167
                     /gene="Sstr5"
                     /gene_synonym="Smstr5; sst5"
                     /inference="alignment:Splign:2.1.0"
     exon            168..319
                     /gene="Sstr5"
                     /gene_synonym="Smstr5; sst5"
                     /inference="alignment:Splign:2.1.0"
     exon            320..2733
                     /gene="Sstr5"
                     /gene_synonym="Smstr5; sst5"
                     /inference="alignment:Splign:2.1.0"
     CDS             355..1443
                     /gene="Sstr5"
                     /gene_synonym="Smstr5; sst5"
                     /note="SS5R; SS5-R; SS-5-R"
                     /codon_start=1
                     /product="somatostatin receptor type 5"
                     /protein_id="NP_035555.1"
                     /db_xref="CCDS:CCDS28520.1"
                     /db_xref="GeneID:20609"
                     /db_xref="MGI:MGI:894282"
                     /translation="MEPLSLTSTPSWNASAASSSSHNWSLVDPVSPMGARAVLVPVLY
                     LLVCTVGLGGNTLVIYVVLRYAKMKTVTNVYILNLAVADVLFMLGLPFLATQNAVSYW
                     PFGSFLCRLVMTLDGINQFTSIFCLMVMSVDRYLAVVHPLRSARWRRPRVAKLASAAV
                     WVFSLLMSLPLLVFADVQEGWGTCNLSWPEPVGLWGAAFITYTSVLGFFGPLLVICLC
                     YLLIVVKVKAAGMRVGSSRRRRSERKVTRMVVVVVLVFVGCWLPFFIVNIVNLAFTLP
                     EEPTSAGLYFFVVVLSYANSCANPLLYGFLSDNFRQSFRKALCLRRGYGVEDADAIEP
                     RPDKSGRPQTTLPTRSCEANGLMQTSRL"
ORIGIN      
        1 acgccccctc tatctcctcc accctctccc tccccctagc ctgagggcgg gcgccgactt
       61 cgtacagcaa tccagtgagc gctctgctct ttgagctcga gggcgctgcc tgaccgcgaa
      121 gtaccgccgc ctcgtccgcc ccggcgtggg catcctgtcc tgcacaggag aggtctccac
      181 ggctgtccac gggacatgtg aggataactt ttaaagtgcc ataaagatac ttcctgagac
      241 cagcccctgt gagccaacct ctgtgagcag ttccacctac tgagctccaa ggaggctcct
      301 ctaacattgt ctttttaaga gatacatgtg ctctggcatc ctgaacctga cagcatggag
      361 cccctctctt tgacttccac acctagctgg aatgcctcag ctgcttccag cagtagccat
      421 aactggtcac tagtggaccc ggtgtcaccc atgggagccc gggcggtatt agtgcctgtg
      481 ctctacttgt tggtatgcac cgtgggactg ggtggaaaca cactggtcat ctatgtggtg
      541 ttgcggtacg ccaagatgaa gacagttact aacgtgtata tcctgaacct ggccgtggct
      601 gacgtgttgt ttatgttggg gcttcctttc ctggcaacgc agaatgctgt ctcctactgg
      661 ccctttggct ccttcttgtg ccgcctggtc atgacgctgg acggcatcaa ccagttcacc
      721 agtatcttct gcctgatggt catgagtgtc gaccgctacc tggccgtggt ccaccctctc
      781 cgctcagccc ggtggcgtcg cccacgggta gccaagctgg ctagtgctgc cgtctgggtc
      841 ttctcgctgc tcatgtctct gccgctcttg gtctttgcgg atgtccagga gggctggggc
      901 acctgcaacc tgagctggcc agagcctgtg ggactgtggg gtgcagcctt catcacttac
      961 acgtctgtgc tgggcttctt tgggcccctg ctggtcatct gcttgtgcta tttgctcatc
     1021 gtagtgaagg tgaaggctgc aggtatgcgt gtgggctcct cacggcggag gcgctcagaa
     1081 cgcaaggtga ctcgcatggt ggtggtagtg gtgctggtgt tcgtgggctg ctggctgcct
     1141 ttcttcatcg tcaacatcgt caacctggcc ttcacgctac ccgaggagcc cacctctgcc
     1201 ggcctctact tctttgtggt ggtcctgtct tatgccaata gctgtgccaa ccccctgctc
     1261 tatggctttc tctctgataa cttccgccag agtttccgga aggctctgtg cctacgtaga
     1321 ggatacggtg tggaggatgc agatgccata gagccacggc cagacaagag tgggcggcca
     1381 cagaccacac tgcccacacg cagctgtgag gccaacgggc tcatgcagac cagcaggctt
     1441 tgagtgtccc agtaacacct ggggggtcct gcggggcctc tgtggtgttg tcttctggga
     1501 tatgagagtt tgctgagatg cactcgcccc caggcctata agttggactc ctcttggtgg
     1561 cagtgtgaag acagctgtct gcggctaagc catgggtgac tgatcatctc tctcaccaaa
     1621 acgttctgct agaccagggt ctgagagttt ggagaccatg tgataggctt ggcagggaga
     1681 aagggctgga ttttgcccct ggtaatattc aggcaccttc acccgtactg tggcatcatt
     1741 tttgtcagtc tctcaggcca agaagcaatt tttcagaaga gagccaagaa atgattctct
     1801 tgtagactat tggtgtgtgc tggcgattac ccaccctgaa gctgtgctgg cctgctggcc
     1861 cctcagccac tgttccttgt tctggtcagc gtgggagaca aatgaaaggt atccatgtgt
     1921 gttcagcccc agcctctgcg aacctgcagc tacatgtact tcgaggcgac agttttaaca
     1981 aagatgcact ggccctgggg cagcagagat gaaaccttgg gccctattct ggctgcttcc
     2041 catctttctc cagcacaagg aaaagcaagg tcttggcctt tatgatggga gcaggtaggc
     2101 ggggcagacg catggtgaag actggaaaga gaatggacac accacgatct ggtctctgca
     2161 gagtggccca gtgaagaagg ttctattgag gcttccctgg gactgagaga cgacgaggac
     2221 acacagggga cttaacagcc ttccatctct ttaaggcagg ttgctggggc tctgtccctg
     2281 gagaaggagc agggtgggca ggtagcaggc aggaacaaac agcagagcct ggaaagacct
     2341 accattcgag agagtgcaaa tgccagccag tgccagggag ggccaagtcc ctggggaatc
     2401 tgtgatcccg cctcagcagc ttctctacgc cagacccaga atgtgctcaa agcccccatg
     2461 tccacatttt gccatggtgt ccccggggct ggagaaaagt taatcctact atttattctt
     2521 ctgctctggg ctgccctgcc tggcatgcct ggctccctgg gagggtgcag agaccaggac
     2581 agcaggatct ggcagaggga aggctgtggg ggttgctctg tctcaaatgt gaccccctcc
     2641 cccggcaaat gctagccctg taagctcatt cctcataatg agggcacttg tgctccacaa
     2701 cctgcctctg aataaattag aaaataagct gtt
//
