LOCUS       NM_009219               1388 bp    mRNA    linear   ROD 27-MAY-2024
DEFINITION  Mus musculus somatostatin receptor 4 (Sstr4), mRNA.
ACCESSION   NM_009219
VERSION     NM_009219.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1388)
  AUTHORS   Abe,Y., Murase,T., Mitsuma,M., Shinba,Y., Yamashita,H. and
            Ikematsu,K.
  TITLE     Dynamics of somatostatin 4 receptor expression during
            chronic-stress loading and its potential as a chronic-stress marker
  JOURNAL   Sci Rep 14 (1), 10045 (2024)
   PUBMED   38698013
  REMARK    GeneRIF: Dynamics of somatostatin 4 receptor expression during
            chronic-stress loading and its potential as a chronic-stress
            marker.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1388)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1388)
  AUTHORS   Lupp,A., Ehms,B., Stumm,R., Gockeritz,J., Mawrin,C. and Schulz,S.
  TITLE     Reassessment of SST4 Somatostatin Receptor Expression Using
            SST4-eGFP Knockin Mice and the Novel Rabbit Monoclonal Anti-Human
            SST4 Antibody 7H49L61
  JOURNAL   Int J Mol Sci 22 (23), 12981 (2021)
   PUBMED   34884783
  REMARK    GeneRIF: Reassessment of SST4 Somatostatin Receptor Expression
            Using SST4-eGFP Knockin Mice and the Novel Rabbit Monoclonal
            Anti-Human SST4 Antibody 7H49L61.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1388)
  AUTHORS   Nemes,B., Bolcskei,K., Kecskes,A., Kormos,V., Gaszner,B., Aczel,T.,
            Hegedus,D., Pinter,E., Helyes,Z. and Sandor,Z.
  TITLE     Human Somatostatin SST4 Receptor Transgenic Mice: Construction and
            Brain Expression Pattern Characterization
  JOURNAL   Int J Mol Sci 22 (7), 3758 (2021)
   PUBMED   33916620
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1388)
  AUTHORS   Dombi,A., Santa,C., Batai,I.Z., Kormos,V., Kecskes,A., Tekus,V.,
            Pohoczky,K., Bolcskei,K., Pinter,E. and Pozsgai,G.
  TITLE     Dimethyl Trisulfide Diminishes Traumatic Neuropathic Pain Acting on
            TRPA1 Receptors in Mice
  JOURNAL   Int J Mol Sci 22 (7), 3363 (2021)
   PUBMED   33806000
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1388)
  AUTHORS   Ramirez,J.L., Mouchantaf,R., Kumar,U., Otero Corchon,V.,
            Rubinstein,M., Low,M.J. and Patel,Y.C.
  TITLE     Brain somatostatin receptors are up-regulated in
            somatostatin-deficient mice
  JOURNAL   Mol Endocrinol 16 (8), 1951-1963 (2002)
   PUBMED   12145348
  REMARK    GeneRIF: Brain somatostatin receptors 1,2,4 and 5 are up-regulated
            in somatostatin-deficient mice, and SSTR3 is down-regulated.
REFERENCE   7  (bases 1 to 1388)
  AUTHORS   Hannon,J.P., Petrucci,C., Fehlmann,D., Viollet,C., Epelbaum,J. and
            Hoyer,D.
  TITLE     Somatostatin sst2 receptor knock-out mice: localisation of sst1-5
            receptor mRNA and binding in mouse brain by semi-quantitative
            RT-PCR, in situ hybridisation histochemistry and receptor
            autoradiography
  JOURNAL   Neuropharmacology 42 (3), 396-413 (2002)
   PUBMED   11897118
  REMARK    GeneRIF: The effect of sst2 receptor knockout on sst4 receptor mRNA
            localization and binding sites throughout the brain has been
            determined.
REFERENCE   8  (bases 1 to 1388)
  AUTHORS   Lin,X., Janovick,J.A., Cardenas,R., Conn,P.M. and Peter,R.E.
  TITLE     Molecular cloning and expression of a type-two somatostatin
            receptor in goldfish brain and pituitary
  JOURNAL   Mol Cell Endocrinol 166 (2), 75-87 (2000)
   PUBMED   10996426
REFERENCE   9  (bases 1 to 1388)
  AUTHORS   Brinkmeier,M.L. and Camper,S.A.
  TITLE     Localization of somatostatin receptor genes on mouse chromosomes 2,
            11, 12, 15, and 17: correlation with growth QTLs
  JOURNAL   Genomics 43 (1), 9-14 (1997)
   PUBMED   9226367
REFERENCE   10 (bases 1 to 1388)
  AUTHORS   Schwabe,W., Brennan,M.B. and Hochgeschwender,U.
  TITLE     Isolation and characterization of the mouse (Mus musculus)
            somatostatin receptor type-4-encoding gene (mSSTR4)
  JOURNAL   Gene 168 (2), 233-235 (1996)
   PUBMED   8654950
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK051189.1 and
            CB522494.1.
            
            On Mar 23, 2007 this sequence version replaced NM_009219.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1300              AK051189.1         36-1335
            1301-1388           CB522494.1         382-469
FEATURES             Location/Qualifiers
     source          1..1388
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 73.44 cM"
     gene            1..1388
                     /gene="Sstr4"
                     /gene_synonym="Smstr4; sst4"
                     /note="somatostatin receptor 4"
                     /db_xref="GeneID:20608"
                     /db_xref="MGI:MGI:105372"
     exon            1..1388
                     /gene="Sstr4"
                     /gene_synonym="Smstr4; sst4"
                     /inference="alignment:Splign:2.1.0"
     CDS             95..1252
                     /gene="Sstr4"
                     /gene_synonym="Smstr4; sst4"
                     /note="SS4R; SS4-R; SS-4-R"
                     /codon_start=1
                     /product="somatostatin receptor type 4"
                     /protein_id="NP_033245.2"
                     /db_xref="CCDS:CCDS38260.1"
                     /db_xref="GeneID:20608"
                     /db_xref="MGI:MGI:105372"
                     /translation="MNAPATLPPGVEDTTWTPGINASWAPDEEEEDAMGSDGTGTAGM
                     VTIQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVAS
                     AAALRHWPFGAVLCRAVLSVDGLNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVA
                     KLINLGVWLASLLVTLPIAVFADTRPARGGEAVACNLHWPHPAWSAVFVIYTFLLGFL
                     LPVLAIGLCYLLIVGKMRAVALRAGWQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQ
                     LLNLFVTSLDATVNHVSLILSYANSCANPILYGFLSDNFRRSFQRVLCLRCCLLETTG
                     GAEEEPLDYYATALKSRGGAGCICPPLPCQQEPVQAEPGCKQVPFTKTTTF"
ORIGIN      
        1 gtgcgcgcgc gaccccagcc cgcctcttgg tccttggctc agcgctccgc tgctctccac
       61 cgcattccgc tgcccggggt gggcaccccg agacatgaac gcgccagcaa ctctgcctcc
      121 gggggtcgag gacaccacct ggacccctgg gatcaacgcc agctgggctc cggacgagga
      181 ggaggaggat gcgatggggt ccgacggcac agggacagcg ggcatggtca ctatccagtg
      241 catctatgcg ctcgtgtgtc tggtgggcct ggtgggaaac gccctggtca tcttcgtgat
      301 cctacgctat gccaagatga agacagccac caacatctac ctactcaacc tggccgtcgc
      361 cgatgagctc ttcatgctca gcgtgccatt cgtggcctcg gcggctgccc tgcgccactg
      421 gccgttcggg gcggtgctgt gtcgcgcagt gcttagcgtg gacggcctga acatgttcac
      481 tagtgtcttc tgcctcaccg tgctcagcgt ggaccgctat gtggctgttg tgcaccctct
      541 gcgcgccgcc acctaccggc ggcccagcgt ggccaagcta atcaacctgg gagtgtggct
      601 agcatccttg ctggtcaccc tgcccatcgc agtcttcgct gacaccaggc cagctcgtgg
      661 gggcgaggcc gtggcttgca acctgcactg gcctcacccg gcctggtctg cggtctttgt
      721 gatctatact tttttgttgg gcttcctact cccggttctg gccatcggat tatgctacct
      781 gcttattgtg ggcaagatgc gcgctgtggc cctgcgggct ggctggcaac aacggaggcg
      841 ctcagagaag aagatcacta ggctcgtgct aatggtggtg accgtctttg tgctatgctg
      901 gatgcctttc tatgtggtgc agcttctgaa cctgtttgtc accagcctcg atgccactgt
      961 caaccatgtg tccctcatcc tgagctatgc caacagctgt gccaatccca ttctctatgg
     1021 cttcctctct gacaacttcc ggcgctcttt ccagcgggtt ctgtgcctgc gctgctgtct
     1081 cctggaaaca actggaggtg ctgaggaaga gcccctggac tactatgcca ctgctctcaa
     1141 aagcagaggg ggtgcaggat gcatatgccc tcctctgccc tgccagcagg agcccgtgca
     1201 agcagaacct ggctgcaagc aagtcccttt caccaagacc actactttct gaaaaccatt
     1261 ttaccctccc tcacctcgcc tgcaaacggg tctgcgccac tctctcaagc cagcaacttc
     1321 aagaacaact cctgttttca ctaagccagg ccctttcagc agcctgtgtg ctgtccccag
     1381 gagcctca
//
