LOCUS       NM_009218               3928 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus somatostatin receptor 3 (Sstr3), transcript variant 1,
            mRNA.
ACCESSION   NM_009218
VERSION     NM_009218.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3928)
  AUTHORS   Adamson,S.E., Li,Z.A. and Hughes,J.W.
  TITLE     Beta cell primary cilia mediate somatostatin responsiveness via
            SSTR3
  JOURNAL   Islets 15 (1), 2252855 (2023)
   PUBMED   37660302
  REMARK    GeneRIF: Beta cell primary cilia mediate somatostatin
            responsiveness via SSTR3.
REFERENCE   2  (bases 1 to 3928)
  AUTHORS   Barbeito,P., Tachibana,Y., Martin-Morales,R., Moreno,P.,
            Mykytyn,K., Kobayashi,T. and Garcia-Gonzalo,F.R.
  TITLE     HTR6 and SSTR3 ciliary targeting relies on both IC3 loops and
            C-terminal tails
  JOURNAL   Life Sci Alliance 4 (3), e202000746 (2020)
   PUBMED   33372037
  REMARK    GeneRIF: HTR6 and SSTR3 ciliary targeting relies on both IC3 loops
            and C-terminal tails.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3928)
  AUTHORS   Shinde,S.R., Nager,A.R. and Nachury,M.V.
  TITLE     Ubiquitin chains earmark GPCRs for BBSome-mediated removal from
            cilia
  JOURNAL   J Cell Biol 219 (12) (2020)
   PUBMED   33185668
  REMARK    GeneRIF: Ubiquitin chains earmark GPCRs for BBSome-mediated removal
            from cilia.
REFERENCE   4  (bases 1 to 3928)
  AUTHORS   Badgandi,H.B., Hwang,S.H., Shimada,I.S., Loriot,E. and
            Mukhopadhyay,S.
  TITLE     Tubby family proteins are adapters for ciliary trafficking of
            integral membrane proteins
  JOURNAL   J Cell Biol 216 (3), 743-760 (2017)
   PUBMED   28154160
REFERENCE   5  (bases 1 to 3928)
  AUTHORS   Green,J.A., Schmid,C.L., Bley,E., Monsma,P.C., Brown,A., Bohn,L.M.
            and Mykytyn,K.
  TITLE     Recruitment of beta-Arrestin into Neuronal Cilia Modulates
            Somatostatin Receptor Subtype 3 Ciliary Localization
  JOURNAL   Mol Cell Biol 36 (1), 223-235 (2015)
   PUBMED   26503786
  REMARK    GeneRIF: results implicate beta-arrestin in the modulation of Sstr3
            ciliary localization and further suggest a role for beta-arrestin
            in the mediation of Sstr3 ciliary signaling.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3928)
  AUTHORS   Herbarth,B., Pingault,V., Bondurand,N., Kuhlbrodt,K.,
            Hermans-Borgmeyer,I., Puliti,A., Lemort,N., Goossens,M. and
            Wegner,M.
  TITLE     Mutation of the Sry-related Sox10 gene in Dominant megacolon, a
            mouse model for human Hirschsprung disease
  JOURNAL   Proc Natl Acad Sci U S A 95 (9), 5161-5165 (1998)
   PUBMED   9560246
REFERENCE   7  (bases 1 to 3928)
  AUTHORS   Letts,V.A., Valenzuela,A., Kirley,J.P., Sweet,H.O., Davisson,M.T.
            and Frankel,W.N.
  TITLE     Genetic and physical maps of the stargazer locus on mouse
            chromosome 15
  JOURNAL   Genomics 43 (1), 62-68 (1997)
   PUBMED   9226373
REFERENCE   8  (bases 1 to 3928)
  AUTHORS   Brinkmeier,M.L. and Camper,S.A.
  TITLE     Localization of somatostatin receptor genes on mouse chromosomes 2,
            11, 12, 15, and 17: correlation with growth QTLs
  JOURNAL   Genomics 43 (1), 9-14 (1997)
   PUBMED   9226367
REFERENCE   9  (bases 1 to 3928)
  AUTHORS   Pingault,V., Puliti,A., Prehu,M.O., Samadi,A., Bondurand,N. and
            Goossens,M.
  TITLE     Human homology and candidate genes for the Dominant megacolon
            locus, a mouse model of Hirschsprung disease
  JOURNAL   Genomics 39 (1), 86-89 (1997)
   PUBMED   9027489
REFERENCE   10 (bases 1 to 3928)
  AUTHORS   Yasuda,K., Rens-Domiano,S., Breder,C.D., Law,S.F., Saper,C.B.,
            Reisine,T. and Bell,G.I.
  TITLE     Cloning of a novel somatostatin receptor, SSTR3, coupled to
            adenylylcyclase
  JOURNAL   J Biol Chem 267 (28), 20422-20428 (1992)
   PUBMED   1328199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL590144.10.
            
            On Mar 20, 2007 this sequence version replaced NM_009218.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK136904.1, SRR1660817.72456.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-210               AL590144.10        33764-33973
            211-357             AL590144.10        34160-34306
            358-3928            AL590144.10        37524-41094
FEATURES             Location/Qualifiers
     source          1..3928
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 37.55 cM"
     gene            1..3928
                     /gene="Sstr3"
                     /gene_synonym="Smstr-3; Smstr3; sst3"
                     /note="somatostatin receptor 3"
                     /db_xref="GeneID:20607"
                     /db_xref="MGI:MGI:98329"
     exon            1..210
                     /gene="Sstr3"
                     /gene_synonym="Smstr-3; Smstr3; sst3"
                     /inference="alignment:Splign:2.1.0"
     exon            211..357
                     /gene="Sstr3"
                     /gene_synonym="Smstr-3; Smstr3; sst3"
                     /inference="alignment:Splign:2.1.0"
     exon            358..3928
                     /gene="Sstr3"
                     /gene_synonym="Smstr-3; Smstr3; sst3"
                     /inference="alignment:Splign:2.1.0"
     CDS             398..1684
                     /gene="Sstr3"
                     /gene_synonym="Smstr-3; Smstr3; sst3"
                     /note="SS3R; SS3-R; SS-3-R; SSR-28"
                     /codon_start=1
                     /product="somatostatin receptor type 3"
                     /protein_id="NP_033244.2"
                     /db_xref="CCDS:CCDS27617.1"
                     /db_xref="GeneID:20607"
                     /db_xref="MGI:MGI:98329"
                     /translation="MATVTYPSSEPTTLDPGNASSTWPLDTTLGNTSAGASLTGLAVS
                     GILISLVYLVVCVVGLLGNSLVIYVVLRHTSSPSVTSVYILNLALADELFMLGLPFLA
                     AQNALSYWPFGSLMCRLVMAVDGINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPV
                     ARTVSAAVWVASAVVVLPVVVFSGVPRGMSTCHMQWPEPAAAWRTAFIIYTAALGFFG
                     PLLVICLCYLLIVVKVRSTTRRVRAPSCQWVQAPACQRRRRSERRVTRMVVAVVALFV
                     LCWMPFYLLNIVNVVCPLPEEPAFFGLYFLVVALPYANSCANPILYGFLSYRFKQGFR
                     RILLRPSRRIRSQEPGSGPPEKTEEEEDEEEEERREEEERRMQRGQEMNGRLSQIAQA
                     GTSGQQPRPCTGTAKEQQLLPQEATAGDKASTLSHL"
ORIGIN      
        1 aggtgcgggt gacaagtcag ggccgaggac cagatgggag aggcgacgtg ggctgacgtg
       61 gcccccaagg acctaggaag ggtccacgcc cacgaacgct ggacgagtgt gcaccgtgtg
      121 gcaccccagc tggctgtgct ctggtggtac ctggctgcag aatgctaacc agcctggcaa
      181 ctacaaaggg agttcttgcc cagtgggcag agtcttggag cctctgtgca gcagcatgtc
      241 agaactggac caaaccagac gcaagctacc atctggcctc ccgggcctcg agcatccctt
      301 gaagctggca gtggtgcctc tgaagagccc cctccacctc tgcagcaacc ctgtaaggtt
      361 agggctggtt ggctgctgac tgatcctcat ctcagccatg gccactgtta cctatccttc
      421 atctgagcct acgaccttgg accctgggaa cgcatcctcg acctggcccc tggataccac
      481 cctggggaac acatccgctg gcgctagcct gacaggcctg gctgtcagtg gcatcttgat
      541 ctctctggtg tacctggtgg tgtgcgtggt gggtttgctg ggcaactcgc tggtgatcta
      601 cgtggtcctg cggcacacgt ccagcccatc agtgaccagt gtctatatcc tcaacctggc
      661 tctggctgat gagctcttca tgctagggct acccttcctg gctgctcaga acgccctgtc
      721 ctactggccc ttcggatctc tcatgtgccg tctggtcatg gccgtggatg gcatcaacca
      781 gttcaccagc atcttctgcc tcaccgtcat gagtgtggac cgctatctgg ctgtggtgca
      841 ccccacacgc tcagcccgct ggcgcacggc accagtggct cgcacggtca gtgcagctgt
      901 ctgggtggcc tcggctgtgg tggtgctgcc tgtggttgtg ttctcaggag tgccccgggg
      961 catgagcacg tgccacatgc agtggccaga gccagcggct gcctggcgaa cagccttcat
     1021 catctacacg gccgcactgg gcttctttgg gcccctgctg gtcatctgct tgtgctactt
     1081 gctcattgtg gtaaaggtgc ggtcgaccac ccggcgggtg cgggcgccct cgtgtcagtg
     1141 ggtacaggca cccgcatgcc agcggcgacg ccgctctgag cgcagggtca cacgcatggt
     1201 ggtggccgtg gtggcactct tcgtcctctg ctggatgcct ttctatctgc tcaacatcgt
     1261 caatgtggtg tgcccgctgc cggaggagcc cgccttcttc ggcctctact tcctggtggt
     1321 ggcgctgccc tacgccaaca gctgcgcaaa ccccatcctc tacggcttcc tctcctaccg
     1381 cttcaagcag ggctttcgca ggatcctgct aagaccatca cgtcgcattc ggagccagga
     1441 gccagggtcg ggacctccag agaagactga agaggaggag gatgaagaag aagaagagag
     1501 aagggaagag gaggagcgga ggatgcagag agggcaggag atgaacggga ggctcagtca
     1561 gatcgcacag gctggcacta gtggacaaca gccacggccc tgcacaggga ctgctaagga
     1621 gcagcagctt ctgccccagg aggccacagc tggggacaag gccagcacac tgagccatct
     1681 gtaaggacct tcaaagaacc agcgtggttc agaaaagagc agaagctggg cttgacctcg
     1741 gggctcgaac acccacatgc agtgatctga gcagcagcga gaatgacctt atgtacatgg
     1801 ctgtcctggt cctctctgga ccgctgtggt accagggtcc agtgatggaa tgtttatagg
     1861 cttgaactct gtgccactgt gccaggactt gctgtgtgtc ctttggccgg tcatttaccc
     1921 tttctgggcc ttgttttctt cttttgactc agggatgggt aaactgagcc tggatgggcc
     1981 ctgtcagaag aggggtctgg aatccttacc aggatcactc tcctttcaga tcagggccca
     2041 agttaagaga atttgggcca tctggccaag aaacaagata tcttggtgat cagtctgtgt
     2101 cttggccctc aaggagatat accaggactt gggaaatcag agatgcgggt gagccagggg
     2161 cttacttggc tgaaacctaa aggaagtgtt agttggcgct gtgggatgcc acagcttagg
     2221 acccaggtga gccctcccca tgctgctgtg tggtctcggc caatctgttc atgcccaggc
     2281 ctcctacctc ttctgcagga cagtccagtg tcctacagac cctcacccca gcctctgagc
     2341 actgggcctt ctatgctcct ggacatgagg ggaagaattt tccagaaggc aaatgaaacc
     2401 aagtttcagg ggttcttact gcttgggccc ctctggggcc tacagctgac tcgtcttcta
     2461 attttgtatt ccttctctgg tggtggtgat ggggttgagg ggactgcaca ccacacaggc
     2521 tcaggccacc ggagatctga ctcaccctat taaggctatt caggtcagct acctggtccc
     2581 cagggcagac accatgcagc agcctgaggc aagaagaggg agaaagaagg agagggagat
     2641 gaggtagtag gaagagggtg ggggatggga gaggagggag gagagaacag aacttggtgg
     2701 tgatcctgag ccaacctcct gctcccctta ggctaagctc agttgcagtg ttgatggctt
     2761 caggcagaat ctgaagaaga cacgtggcca ggatcccctg gagggtgcat ggggctggtg
     2821 agaggggcac aggccatgat agagtcctgg gaatgggctt ggctcctcaa gacacttggg
     2881 agggatgata agccctttgg gtgggtcaga cctcccatcc tctgtattcc caaggctcca
     2941 gctgatgtga agactaaagg gctgttgtca gggagtagcc actgttccag ctggttcagg
     3001 acttcatcct ccccttccca gagatggtcc ttctgggtcc agcaaggctg gccctggaga
     3061 ggttggagct tctgcccaaa cccccgccct accctgcaga gaggcagggc tctcagggaa
     3121 cccacaaatc cagacattga gaaagctgga tcttctagtc acctcaagcc acttggccac
     3181 accctctgtc tctgcacctc agtatcctca tcataacgag aatggggttc ctcagttcgc
     3241 cagtctgctg gaatttggga gggaattgag tcttgctggg gaagctactg ctggccacaa
     3301 cagggctgcc tcgggataca aagtggcaag gatacatagt ggcaaggata caaagtggca
     3361 aggttacaaa gtggctagga cacaacatag caagagtaca aagtagcaag gttgcaaatg
     3421 tggcaaggat acaaagtagc aaggttacaa agtagcaagg atgcaaagta gcaaggatgc
     3481 aaagtggcaa ggatgcatca tgtcaaggat acaaagtggc aagggtagca aggatagaaa
     3541 gtagcaagga tgcaaggtgg caaggatgca aagtggcaag gatacaaaga ggaggtgacc
     3601 ctacctcagg ttcagcccat accctgcccc ttcagtgggt ggtttctgtg tcagctactg
     3661 gaggtgaagg tattcatgaa aaatgggggc caagaggtcc gaagccaagg gccagggaga
     3721 atgcaaagca ccccagaagg aggaagtttg caaacgtagg catgtgtggg gcctgaggcc
     3781 agtccagggc ttcctctgag aaggaatggg atcaggaagt gagcaggcca gccttcctgg
     3841 atggggcagg taagggagga ggatggtcag ttgagaaatt cttcgctgct tctgacctga
     3901 gcgcctatca ataaagacag tgactaag
//
