LOCUS       NM_001042606            2158 bp    mRNA    linear   ROD 12-FEB-2025
DEFINITION  Mus musculus somatostatin receptor 2 (Sstr2), transcript variant 1,
            mRNA.
ACCESSION   NM_001042606
VERSION     NM_001042606.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2158)
  AUTHORS   Qi,L., Iskols,M., Shi,D., Reddy,P., Walker,C., Lezgiyeva,K.,
            Voisin,T., Pawlak,M., Kuchroo,V.K., Chiu,I.M., Ginty,D.D. and
            Sharma,N.
  TITLE     A mouse DRG genetic toolkit reveals morphological and physiological
            diversity of somatosensory neuron subtypes
  JOURNAL   Cell 187 (6), 1508-1526 (2024)
   PUBMED   38442711
REFERENCE   2  (bases 1 to 2158)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2158)
  AUTHORS   Bai,Y., He,H., Ren,B., Ren,J., Zou,T., Chen,X. and Liu,Y.
  TITLE     Sstr2 Defines the Cone Differentiation-Competent Late-Stage Retinal
            Progenitor Cells in the Developing Mouse Retina
  JOURNAL   Stem Cells Transl Med 13 (1), 83-99 (2024)
   PUBMED   37935630
  REMARK    GeneRIF: Sstr2 Defines the Cone Differentiation-Competent
            Late-Stage Retinal Progenitor Cells in the Developing Mouse Retina.
            Erratum:[Stem Cells Transl Med. 2024 Feb 14;13(2):191. doi:
            10.1093/stcltm/szad083.. PMID: 38006353]
REFERENCE   4  (bases 1 to 2158)
  AUTHORS   Wolfson,R.L., Abdelaziz,A., Rankin,G., Kushner,S., Qi,L., Mazor,O.,
            Choi,S., Sharma,N. and Ginty,D.D.
  TITLE     DRG afferents that mediate physiologic and pathologic
            mechanosensation from the distal colon
  JOURNAL   Cell 186 (16), 3368-3385 (2023)
   PUBMED   37541195
REFERENCE   5  (bases 1 to 2158)
  AUTHORS   Tan,J., Wei,J. and Lu,H.
  TITLE     sST2: A Bridge Between Sirt1/p53/p21 Signal-Induced Senescence and
            TGF-beta1/Smad2/3 Regulation of Cardiac Fibrosis in Mouse Viral
            Myocarditis
  JOURNAL   Inflammation 46 (4), 1305-1317 (2023)
   PUBMED   37036563
  REMARK    GeneRIF: sST2: A Bridge Between Sirt1/p53/p21 Signal-Induced
            Senescence and TGF-beta1/Smad2/3 Regulation of Cardiac Fibrosis in
            Mouse Viral Myocarditis.
REFERENCE   6  (bases 1 to 2158)
  AUTHORS   Vanetti,M., Ziolkowska,B., Wang,X., Horn,G. and Hollt,V.
  TITLE     mRNA distribution of two isoforms of somatostatin receptor 2
            (mSSTR2A and mSSTR2B) in mouse brain
  JOURNAL   Brain Res Mol Brain Res 27 (1), 45-50 (1994)
   PUBMED   7877453
REFERENCE   7  (bases 1 to 2158)
  AUTHORS   Fitzpatrick,V.D. and Vandlen,R.L.
  TITLE     6agonist selectivity determinants in somatostatin receptor subtypes
            I and II
  JOURNAL   J Biol Chem 269 (40), 24621-24626 (1994)
   PUBMED   7929134
REFERENCE   8  (bases 1 to 2158)
  AUTHORS   Elliott,D.E., Metwali,A., Blum,A.M., Sandor,M., Lynch,R. and
            Weinstock,J.V.
  TITLE     T lymphocytes isolated from the hepatic granulomas of
            schistosome-infected mice express somatostatin receptor subtype II
            (SSTR2) messenger RNA
  JOURNAL   J Immunol 153 (3), 1180-1186 (1994)
   PUBMED   7913111
REFERENCE   9  (bases 1 to 2158)
  AUTHORS   Vanetti,M., Kouba,M., Wang,X., Vogt,G. and Hollt,V.
  TITLE     Cloning and expression of a novel mouse somatostatin receptor
            (SSTR2B)
  JOURNAL   FEBS Lett 311 (3), 290-294 (1992)
   PUBMED   1397330
REFERENCE   10 (bases 1 to 2158)
  AUTHORS   Yamada,Y., Post,S.R., Wang,K., Tager,H.S., Bell,G.I. and Seino,S.
  TITLE     Cloning and functional characterization of a family of human and
            mouse somatostatin receptors expressed in brain, gastrointestinal
            tract, and kidney
  JOURNAL   Proc Natl Acad Sci U S A 89 (1), 251-255 (1992)
   PUBMED   1346068
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL603705.16.
            
            On Jun 19, 2019 this sequence version replaced NM_001042606.2.
            
            Summary: The protein encoded by this gene is a receptor for
            somatostatin, which acts at many sites to inhibit the release of
            several hormones and other secretory proteins. The encoded protein
            is a member of the superfamily of receptors having seven
            transmembrane segments and is involved in many processes, including
            adenylyl cyclase inhibition, phosphotyrosine phosphatase
            stimulation, and inhibition of calcium entry and cell growth. Two
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, Sep 2015].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR2680377.1041272.1,
                                           SRR7652917.846762.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-296               AL603705.16        8861-9156           c
            297-2158            AL603705.16        2455-4316           c
FEATURES             Location/Qualifiers
     source          1..2158
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 79.05 cM"
     gene            1..2158
                     /gene="Sstr2"
                     /gene_synonym="Smstr-2; Smstr2; SRIF-1; SS2R; sst2;
                     SSTR-2"
                     /note="somatostatin receptor 2"
                     /db_xref="GeneID:20606"
                     /db_xref="MGI:MGI:98328"
     exon            1..296
                     /gene="Sstr2"
                     /gene_synonym="Smstr-2; Smstr2; SRIF-1; SS2R; sst2;
                     SSTR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            297..2158
                     /gene="Sstr2"
                     /gene_synonym="Smstr-2; Smstr2; SRIF-1; SS2R; sst2;
                     SSTR-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             387..1496
                     /gene="Sstr2"
                     /gene_synonym="Smstr-2; Smstr2; SRIF-1; SS2R; sst2;
                     SSTR-2"
                     /note="isoform A is encoded by transcript variant 1;
                     somatostatin receptor type 2"
                     /codon_start=1
                     /product="somatostatin receptor type 2 isoform A"
                     /protein_id="NP_001036071.1"
                     /db_xref="CCDS:CCDS59571.1"
                     /db_xref="GeneID:20606"
                     /db_xref="MGI:MGI:98328"
                     /translation="MEMSSEQLNGSQVWVSSPFDLNGSLGPSNGSNQTEPYYDMTSNA
                     VLTFIYFVVCVVGLCGNTLVIYVILRYAKMKTITNIYILNLAIADELFMLGLPFLAMQ
                     VALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAK
                     MINVAVWCVSLLVILPIMIYAGLRSNQWGRSSCTINWPGESGAWYTGFIIYAFILGFL
                     VPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVTRMVSIVVAVFIFCWLPFYIFN
                     VSSVSVAISPTPALKGMFDFVVILTYANSCANPILYAFLSDNFKKSFQNVLCLVKVSG
                     TEDGERSDSKQDKSRLNETTETQRTLLNGDLQTSI"
ORIGIN      
        1 actgctagcg gcgcagccac cggcgcgctc gcgaggccac cggcgcctgg agcaccagtc
       61 cgcggctggg cgtcaatgat ctacaggcca agctagctct ctcggggccc gggcaagctc
      121 tctcagacgc cagaagggcc agcacgagcc agccaaggaa gctgggagcc ccgggagcca
      181 ctgctgagcg ccaaacaccc gctaagcctg ctgtgctcct ggacgcccag ctgggtaaaa
      241 gaacagcttc tgggtgctag agaacacagg gaagcgagtg ctcgaggaaa accaagatgt
      301 cacagtagaa tcttggcccc cagagtcctg tgaggcgaga ggaagatctc taggcagctt
      361 ggttctagac ggagtggaaa gcagccatgg agatgagctc tgagcagttg aatgggagcc
      421 aagtgtgggt gtcctctcca tttgacctca acggctcact ggggccaagc aatggctcca
      481 accagaccga gccatactac gacatgacaa gcaacgccgt cctcacgttc atctacttcg
      541 tggtgtgtgt tgtcgggctg tgcggcaaca cgctggtcat ttatgtcatc ctccgctatg
      601 ccaagatgaa gaccatcacc aacatctaca tccttaacct ggccattgca gatgaactct
      661 tcatgctagg gctgcccttc ttggccatgc aggtggcgct agtccactgg ccttttggca
      721 aggccatctg ccgggtggtc atgactgtag atggcatcaa tcagttcacc agtatcttct
      781 gcttgacggt catgagcatc gaccgctacc tggccgtggt gcaccccatt aagtcagcca
      841 aatggaggcg accccggaca gccaagatga tcaatgtagc tgtgtggtgt gtgtctctgc
      901 tcgtcatttt gcccatcatg atatacgccg gcctccggag caaccagtgg ggcaggagca
      961 gctgtaccat caactggcca ggcgaatccg gggcgtggta cacaggtttc attatctacg
     1021 ccttcatcct ggggttcctg gtacccctta ccatcatttg tctctgctac ctgttcatca
     1081 tcatcaaggt gaagtcctct ggaatccgag tgggatcatc caagaggaaa aagtcagaga
     1141 aaaaggtgac ccgcatggtg tccatcgtag tggctgtctt catcttctgc tggctcccct
     1201 tctacatctt caacgtctct tccgtgtctg tggccatcag tcccacccca gccctgaaag
     1261 gcatgtttga ctttgtggtg atcctcacct atgccaacag ctgcgccaac cccatcctgt
     1321 acgccttctt gtctgacaac ttcaagaaga gcttccagaa tgttctttgc ttggtcaagg
     1381 tgagtggtac ggaggatggg gagaggagcg acagtaagca ggacaaatcc cggctgaatg
     1441 agaccacgga gacccagagg accctcctca atggagacct ccaaaccagt atctgaacaa
     1501 cccaggaacg caacatgcac acacactagc caagccctga ctcctgtcag tgtgtctccc
     1561 attccctggc ttcccgcctc ccctatccat cacacccggc ttctagaaca gagctgtgtt
     1621 ctacacgcac cccgttcaga gaacaggatt tgagtctggc ttgtccgaaa gtatacccct
     1681 ctggtcacgt ctcccctaaa gtgaacgttt tcgtgcaggc agacaattca caatccggag
     1741 cggaagacat cattgcctgg gtgtgacctg gtggaaaaca gctgcccggc agaaaccgga
     1801 aaaaccaaaa ctaaatcaaa gtcctgtgtg tatgtgtgct aacacgttac gtaaatcttg
     1861 tgatctgata tttacatttg tatattctcc cctccccggt cacacaaaca tgtcccgtgt
     1921 ttgtaagccc aagtagctag ttcgtgtgcg tctagtatag gtggacagtt accacaacgc
     1981 tgaacctgaa gaaaaggact cgccacgtca cagtcagtcc aatctaagct tccagcatct
     2041 gtcttgcatg ggccatcccc agacactgga ggagcatgag cagtatgtat gttcatagga
     2101 taatataata atatgttcat agaataatat aataatacgt ttttgtaaaa aaaaaaaa
//
