LOCUS       NM_009216               3869 bp    mRNA    linear   ROD 28-MAY-2024
DEFINITION  Mus musculus somatostatin receptor 1 (Sstr1), transcript variant 1,
            mRNA.
ACCESSION   NM_009216 XM_984503
VERSION     NM_009216.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3869)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3869)
  AUTHORS   Yamaguchi,Y., Maekawa,Y., Kabashima,K., Mizuno,T., Tainaka,M.,
            Suzuki,T., Dojo,K., Tominaga,T., Kuroiwa,S., Masubuchi,S., Doi,M.,
            Tominaga,K., Kobayashi,K., Yamagata,S., Itoi,K., Abe,M.,
            Schwartz,W.J., Sakimura,K. and Okamura,H.
  TITLE     An intact pituitary vasopressin system is critical for building a
            robust circadian clock in the suprachiasmatic nucleus
  JOURNAL   Proc Natl Acad Sci U S A 120 (43), e2308489120 (2023)
   PUBMED   37844254
REFERENCE   3  (bases 1 to 3869)
  AUTHORS   Kaiser,M., Wojahn,I., Rudat,C., Ludtke,T.H., Christoffels,V.M.,
            Moon,A., Kispert,A. and Trowe,M.O.
  TITLE     Regulation of otocyst patterning by Tbx2 and Tbx3 is required for
            inner ear morphogenesis in the mouse
  JOURNAL   Development 148 (8) (2021)
   PUBMED   33795231
REFERENCE   4  (bases 1 to 3869)
  AUTHORS   Zou,S. and Kumar,U.
  TITLE     Somatostatin and cannabinoid receptors crosstalk in protection of
            huntingtin knock-in striatal neuronal cells in response to
            quinolinic acid
  JOURNAL   Neurochem Int 129, 104518 (2019)
   PUBMED   31381945
  REMARK    GeneRIF: SSTR5 is primarily expressed and colocalized
            intracellularly. Activation of SSTR2, 5 and CB1R protected
            huntingtin-mutant knock-in striatal neurons from
            quinolinic-acid-induced toxicity. Co-activation of SSTRs and CB1R
            resulted in loss of protective effects, delayed ERK1/2
            phosphorylation and altered receptor complex composition.
REFERENCE   5  (bases 1 to 3869)
  AUTHORS   Husain,B.F., Nanavaty,I.N., Marathe,S.V., Rajendran,R. and
            Vaidya,V.A.
  TITLE     Hippocampal transcriptional and neurogenic changes evoked by
            combination yohimbine and imipramine treatment
  JOURNAL   Prog Neuropsychopharmacol Biol Psychiatry 61, 1-9 (2015)
   PUBMED   25784603
  REMARK    GeneRIF: This study showed that reduced expression of the Sstr1
            which modulate antidepressant action in hippocampus.
REFERENCE   6  (bases 1 to 3869)
  AUTHORS   Kreienkamp,H.J., Akgun,E., Baumeister,H., Meyerhof,W. and
            Richter,D.
  TITLE     Somatostatin receptor subtype 1 modulates basal inhibition of
            growth hormone release in somatotrophs
  JOURNAL   FEBS Lett 462 (3), 464-466 (1999)
   PUBMED   10622746
REFERENCE   7  (bases 1 to 3869)
  AUTHORS   Brinkmeier,M.L. and Camper,S.A.
  TITLE     Localization of somatostatin receptor genes on mouse chromosomes 2,
            11, 12, 15, and 17: correlation with growth QTLs
  JOURNAL   Genomics 43 (1), 9-14 (1997)
   PUBMED   9226367
REFERENCE   8  (bases 1 to 3869)
  AUTHORS   Viollet,C., Lanneau,C., Faivre-Bauman,A., Zhang,J.,
            Djordjijevic,D., Loudes,C., Gardette,R., Kordon,C. and Epelbaum,J.
  TITLE     Distinct patterns of expression and physiological effects of sst1
            and sst2 receptor subtypes in mouse hypothalamic neurons and
            astrocytes in culture
  JOURNAL   J Neurochem 68 (6), 2273-2280 (1997)
   PUBMED   9166719
REFERENCE   9  (bases 1 to 3869)
  AUTHORS   Fitzpatrick,V.D. and Vandlen,R.L.
  TITLE     6agonist selectivity determinants in somatostatin receptor subtypes
            I and II
  JOURNAL   J Biol Chem 269 (40), 24621-24626 (1994)
   PUBMED   7929134
REFERENCE   10 (bases 1 to 3869)
  AUTHORS   Yamada,Y., Post,S.R., Wang,K., Tager,H.S., Bell,G.I. and Seino,S.
  TITLE     Cloning and functional characterization of a family of human and
            mouse somatostatin receptors expressed in brain, gastrointestinal
            tract, and kidney
  JOURNAL   Proc Natl Acad Sci U S A 89 (1), 251-255 (1992)
   PUBMED   1346068
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK046464.1 and AC123932.4.
            
            On Mar 9, 2007 this sequence version replaced NM_009216.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK046464.1, BY236756.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-340               AK046464.1         1-340
            341-3869            AC123932.4         73220-76748         c
FEATURES             Location/Qualifiers
     source          1..3869
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 25.61 cM"
     gene            1..3869
                     /gene="Sstr1"
                     /gene_synonym="Smstr-1; Smstr1; SRIF-2; SS-1-R; SS1-R;
                     SS1R; sst1"
                     /note="somatostatin receptor 1"
                     /db_xref="GeneID:20605"
                     /db_xref="MGI:MGI:98327"
     exon            1..78
                     /gene="Sstr1"
                     /gene_synonym="Smstr-1; Smstr1; SRIF-2; SS-1-R; SS1-R;
                     SS1R; sst1"
                     /inference="alignment:Splign:2.1.0"
     exon            79..3869
                     /gene="Sstr1"
                     /gene_synonym="Smstr-1; Smstr1; SRIF-2; SS-1-R; SS1-R;
                     SS1R; sst1"
                     /inference="alignment:Splign:2.1.0"
     CDS             426..1601
                     /gene="Sstr1"
                     /gene_synonym="Smstr-1; Smstr1; SRIF-2; SS-1-R; SS1-R;
                     SS1R; sst1"
                     /codon_start=1
                     /product="somatostatin receptor type 1"
                     /protein_id="NP_033242.1"
                     /db_xref="CCDS:CCDS36456.1"
                     /db_xref="GeneID:20605"
                     /db_xref="MGI:MGI:98327"
                     /translation="MFPNGTASSPSSSPSPSPGSCGEGACSRGPGSGAADGMEEPGRN
                     ASQNGTLSEGQGSAILISFIYSVVCLVGLCGNSMVIYVILRYAKMKTATNIYILNLAI
                     ADELLMLSVPFLVTSTLLRHWPFGALLCRLVLSVDAVNMFTSIYCLTVLSVDRYVAVV
                     HPIKAARYRRPTVAKVVNLGVWVLSLLVILPIVVFSRTAANSDGTVACNMLMPEPAQR
                     WLVGFVLYTFLMGFLLPVGAICLCYVLIIAKMRMVALKAGWQQRKRSERKITLMVMMV
                     VMVFVICWMPFYVVQLVNVFAEQDDATVSQLSVILGYANSCANPILYGFLSDNFKRSF
                     QRILCLSWMDNAAEEPVDYYATALKSRAYSVEDFQPENLESGGVFRNGTCASRISTL"
     regulatory      3846..3851
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sstr1"
                     /gene_synonym="Smstr-1; Smstr1; SRIF-2; SS-1-R; SS1-R;
                     SS1R; sst1"
                     /note="hexamer: AATAAA"
     polyA_site      3869
                     /gene="Sstr1"
                     /gene_synonym="Smstr-1; Smstr1; SRIF-2; SS-1-R; SS1-R;
                     SS1R; sst1"
                     /note="major polyA site"
ORIGIN      
        1 gagacatcat tgacttgggg atctgaaggc ctgaaatctc caggtacagg tttaaagaac
       61 tggcaagcag gaaaggagct gctgacgcga tggtgccgct tattaatcat tcatcagtcc
      121 agagcctttc cacttaatgg atgtgccgcg ctgggctcta gcctcttggc ctctcctctc
      181 cactctccag tgtgcccagg acccccggag ctgcaagaga gacagcgctc aagcaagctg
      241 ccgctgggtg atgctcccgg cggcctcagt cggagccgcg ctcgccacag ctgctgcgct
      301 ctgccgggtg gcgccaggcg gcggtgagct gtgagcttgg agccttgagc ctagggaggg
      361 cgcagacagc aagggcgcaa ggtgagcgcc ccagccggca gccgcaccgg cccacttcag
      421 ctgggatgtt ccccaatggc accgcctcct ctccctcctc ttctccaagc cccagcccag
      481 gcagctgcgg ggaaggagcc tgcagcaggg gtccggggtc cggcgctgcg gacggcatgg
      541 aagagcctgg acgaaacgct tcccagaatg ggaccttaag cgagggacag ggtagcgcca
      601 ttctcatctc tttcatctac tccgtggtat gcttggtggg actgtgtggg aactctatgg
      661 tcatctatgt gatcctgcgc tacgccaaga tgaagaccgc taccaacatc tacattctaa
      721 acctggctat tgctgatgag ctgctcatgc tcagcgtgcc ctttctggtc acttccacgc
      781 tgttgcgcca ctggcccttc ggcgcgctac tttgccgcct ggtgctcagc gtggatgcgg
      841 tcaacatgtt caccagcatc tactgtctga ctgtgcttag tgtggaccgc tatgtggctg
      901 tggtgcaccc gatcaaggca gcgcgctacc gtcggcccac tgtggccaaa gtagtgaacc
      961 tgggcgtgtg ggtcctgtca ttactggtta tcttgcccat cgtggtcttc tcacgcaccg
     1021 cagccaacag cgatggcacg gtagcctgca acatgctcat gcccgagccc gcccagcgct
     1081 ggttggtggg cttcgtctta tacacatttc tcatgggctt cctgctgcct gtcggggcca
     1141 tttgcctgtg ttatgtgctc atcattgcca agatgcgcat ggtggccctc aaggctggct
     1201 ggcagcagcg caagcgctca gagcgcaaga tcactctaat ggtgatgatg gtggtgatgg
     1261 tttttgtcat ctgctggatg cctttctacg tggtacagct ggtcaacgtg ttcgccgagc
     1321 aagacgacgc caccgtgagc cagttgtctg tcatcctggg ctatgccaac agctgtgcca
     1381 accccatcct ctacggcttc ctgtcggaca acttcaagcg ctctttccag cgcatcctgt
     1441 gcctcagctg gatggataac gctgcggagg aaccagtcga ctactatgcc actgccctga
     1501 agagtcgagc ctacagcgtg gaggacttcc agcccgagaa tctggagtct ggaggcgttt
     1561 tccgtaatgg cacctgcgct tccaggatca gcacgctttg aggccgggca ctgccgggag
     1621 ggggggagtg gtcagaaaga tggagctggg aagcgggtgg gagggaatgg taacccgaca
     1681 ccaggtgctg aagtcatagt gcatgacagc gatgcagcgc gcctggttag ctggaccaaa
     1741 gaaagctgtg tgactaaggt aaaagggaga gatttatgga ttaactgtga ctgctttcgg
     1801 ggcatctggt agtctgagca actctgttct ccaaacccga taatttgcat cctccctccc
     1861 agttctacta gtacaaactg caaacttaat gtcgccaact catttctgct tctttaagct
     1921 gagccaaggt taccatcatg tgtttccttt gggctgagtc cgtccccccc cccccccccc
     1981 cgcccctgcg ctgaaccctg ttccgctgcg caggtcagcg ggccagactc ttttcagagt
     2041 ggctacaaga cagtccctaa tcaccgctct cctttcgcag agccttactg tcaaggaagc
     2101 ccagctcgag gatgtctagg caacttgtct tttctactct cagagaagga aggcacattt
     2161 tcccttgggc ccttcctctg ctccactcca tcccgagcag agctaggcgc ttaagaaaaa
     2221 gttctgtgcc ctgatctcca gtcttggtat agtaccacac atatgcttct ttggagcaaa
     2281 aaaaaaaaaa aaaaggagct aagagggagc agaagggcaa gtttgtaaga ttcctgggtt
     2341 gtgggtgtag ataccataga aaccactctc ccacagagct caggacctga gcactaagct
     2401 caaaagtccc agctagggga gctccccgct ggtgaatagc ttaggcaccc aggtgggtga
     2461 acctgaattg caaagcactt cctcttggag tcctccctag cataacaaaa gattgggttg
     2521 cctgcaccag tacaagttcg gagtccagct cacgctccag tgacaaatcg ccgagcctct
     2581 gccaaagctg ggtgggctgc ttcagcttgt ctgatcccta aagttttctg cctttcaaac
     2641 ggtgcctaat aagttatttc ttgttcgaca tatttattta tttatttgtg gtgttgaaaa
     2701 aaaaaaagtg tacttccact ttctttttct gtatttgcct aacagggctg ctcttgggaa
     2761 tcctgggggc gtggcggtgt gggagggagc tgggagcgaa gaaaagttct ctcctggccc
     2821 caagagcccc tcagaagttt ccctctctta gccttttctc aatccttctt ggttttgctt
     2881 gtgcccagtg aagtttggag attttaaaat aatttttttt aactgtaggt ttttgtctcg
     2941 ttaaaataaa tgaatggcaa tgtgggttaa cttttgtcgg tgcggagtga aaggcctgaa
     3001 agcctggcat cccaggaaac atagaacacg cctcaccatc tgtgatgtgt gtgtgtatgt
     3061 gtgctgctat gcacaagtca catgtacatc ctatataggt atatgtacac acatgtataa
     3121 ggatagattt gttaatcttg acatactgtc actagtccat gaaacagttt taaggacacc
     3181 cacaaagtga caagtgtgac ctgagctgta gtattcaaac tgagaaatgt cagagactcc
     3241 agtcactgct gaagacattg ctgccttttt ctgtccccgg tgacaaaggt gacgcttact
     3301 tatacccagt aagggcagtc acctctgtcg aggaatggaa gtgaaacaat tctgcatttc
     3361 ctgactactg tggatccctg agcagggcga ggacccagct tttctcacct tcacatttgc
     3421 tgtccaattg agtatgctgc tttgtatata ggggtcactg aaaggatatc ttgcttggtt
     3481 gtttaaggaa gccagtgcat atcagtggaa caatgaacct ggggttcgca agttcacact
     3541 gacctgacat acaatgcttg gatgcactat tgaaaaatat gttttctgta tatttgcttc
     3601 aagatttcta aaaacagtaa ctcagagttg aactgtctca tatgttttgt ttaaataaat
     3661 gaacaaatat gcttttgatc ataagtgaaa aagtttagat cttttcctaa gaatagtata
     3721 tatatacttt tctgttaagt agatttttta attgttaaga agagtgaact ttataaactg
     3781 aaatctccat cattatcatc tcaacaggat aaaaatgtag tgttcttaac ctgtaatcgt
     3841 aactgaataa acagatgtgt tacactgtt
//
