LOCUS       NM_001417475             913 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Mus musculus somatostatin (Sst), transcript variant 2, mRNA.
ACCESSION   NM_001417475 XM_030249009
VERSION     NM_001417475.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 913)
  AUTHORS   Maltese,F., Pacinelli,G., Monai,A., Bernardi,F., Capaz,A.M.,
            Niello,M., Walle,R., de Leon,N., Manago,F., Leroy,F. and Papaleo,F.
  TITLE     Self-experience of a negative event alters responses to others in
            similar states through prefrontal cortex CRF mechanisms
  JOURNAL   Nat Neurosci 28 (1), 122-136 (2025)
   PUBMED   39627538
REFERENCE   2  (bases 1 to 913)
  AUTHORS   Garbett,K., Tosun,B., Lopez,J.M., Smith,C.M., Honkanen,K. and
            Sando,R.C.
  TITLE     Synaptic Galpha12/13 signaling establishes hippocampal PV
            inhibitory circuits
  JOURNAL   Proc Natl Acad Sci U S A 121 (52), e2407828121 (2024)
   PUBMED   39693341
REFERENCE   3  (bases 1 to 913)
  AUTHORS   Sung,K., Jeong,M.J., Yoo,T., Jung,J.H., Kang,S., Yoo,J.Y.,
            Kim,H.J., Park,K., Pyo,J.H., Lee,H.Y., Koo,N., Choi,S.H. and
            Kim,J.H.
  TITLE     ErbB4 precludes the occurrence of PTSD-like fear responses by
            supporting the bimodal activity of the central amygdala
  JOURNAL   Exp Mol Med 56 (12), 2703-2713 (2024)
   PUBMED   39623093
REFERENCE   4  (bases 1 to 913)
  AUTHORS   Manas-Ojeda,A., Hidalgo-Cortes,J., Garcia-Mompo,C., Zahran,M.A.,
            Gil-Miravet,I., Olucha-Bordonau,F.E., Guirado,R. and
            Castillo-Gomez,E.
  TITLE     Activation of somatostatin neurons in the medial amygdala reverses
            long-term aggression and social deficits associated to early-life
            stress in male mice
  JOURNAL   Mol Psychiatry (2024) In press
   PUBMED   39580603
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   5  (bases 1 to 913)
  AUTHORS   Jiang,T., Feng,M., Hutsell,A. and Luscher,B.
  TITLE     Sex-specific GABAergic microcircuits that switch vulnerability into
            resilience to stress and reverse the effects of chronic stress
            exposure
  JOURNAL   Mol Psychiatry (2024) In press
   PUBMED   39550416
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   6  (bases 1 to 913)
  AUTHORS   Shimamura,K., Takahashi,T. and Takeichi,M.
  TITLE     E-cadherin expression in a particular subset of sensory neurons
  JOURNAL   Dev Biol 152 (2), 242-254 (1992)
   PUBMED   1644219
REFERENCE   7  (bases 1 to 913)
  AUTHORS   Serikawa,T., Kuramoto,T., Hilbert,P., Mori,M., Yamada,J.,
            Dubay,C.J., Lindpainter,K., Ganten,D., Guenet,J.L., Lathrop,G.M. et
            al.
  TITLE     Rat gene mapping using PCR-analyzed microsatellites
  JOURNAL   Genetics 131 (3), 701-721 (1992)
   PUBMED   1628813
REFERENCE   8  (bases 1 to 913)
  AUTHORS   Yasue,M., Serikawa,T., Kuramoto,T., Mori,M., Higashiguchi,T.,
            Ishizaki,K. and Yamada,J.
  TITLE     Chromosomal assignments of 17 structural genes and 11 related DNA
            fragments in rats (Rattus norvegicus) by Southern blot analysis of
            rat x mouse somatic cell hybrid clones
  JOURNAL   Genomics 12 (4), 659-664 (1992)
   PUBMED   1572638
REFERENCE   9  (bases 1 to 913)
  AUTHORS   Gittes,G.K. and Rutter,W.J.
  TITLE     Onset of cell-specific gene expression in the developing mouse
            pancreas
  JOURNAL   Proc Natl Acad Sci U S A 89 (3), 1128-1132 (1992)
   PUBMED   1371010
REFERENCE   10 (bases 1 to 913)
  AUTHORS   Iwasaki,Y., Ohkubo,A., Kamei,S. and Kosaka,K.
  TITLE     [Serial determination of serum GOT isozyme activities for the
            evaluation of acute hepatic damage (author's transl)]
  JOURNAL   Nihon Shokakibyo Gakkai Zasshi 75 (1), 34-43 (1978)
   PUBMED   642215
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC127241.3.
            
            On Mar 6, 2023 this sequence version replaced XM_030249009.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.1919598.1,
                                           ERR2844019.322371.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849389, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-213               AC127241.3         53155-53367
            214-548             AC127241.3         53505-53839
            549-913             AC127241.3         54505-54869
FEATURES             Location/Qualifiers
     source          1..913
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 15.0 cM"
     gene            1..913
                     /gene="Sst"
                     /gene_synonym="Smst; SOM; SRIF; SS"
                     /note="somatostatin"
                     /db_xref="GeneID:20604"
                     /db_xref="MGI:MGI:98326"
     exon            1..213
                     /gene="Sst"
                     /gene_synonym="Smst; SOM; SRIF; SS"
                     /inference="alignment:Splign:2.1.0"
     exon            214..548
                     /gene="Sst"
                     /gene_synonym="Smst; SOM; SRIF; SS"
                     /inference="alignment:Splign:2.1.0"
     CDS             411..761
                     /gene="Sst"
                     /gene_synonym="Smst; SOM; SRIF; SS"
                     /note="preprosomatostatin"
                     /codon_start=1
                     /product="somatostatin precursor"
                     /protein_id="NP_001404404.1"
                     /db_xref="GeneID:20604"
                     /db_xref="MGI:MGI:98326"
                     /translation="MLSCRLQCALAALCIVLALGGVTGAPSDPRLRQFLQKSLAAATG
                     KQELAKYFLAELLSEPNQTENDALEPEDLPQAAEQDEMRLELQRSANSNPAMAPRERK
                     AGCKNFFWKTFTSC"
     exon            549..913
                     /gene="Sst"
                     /gene_synonym="Smst; SOM; SRIF; SS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      887..892
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sst"
                     /gene_synonym="Smst; SOM; SRIF; SS"
                     /note="hexamer: AATAAA"
     polyA_site      913
                     /gene="Sst"
                     /gene_synonym="Smst; SOM; SRIF; SS"
                     /note="major polyA site"
ORIGIN      
        1 attctgagat tgtttcctag acagatcgct ctaagtctca ctcgccatac aaaaagttaa
       61 aggtgaatgc aagtccagta atctgggtac attgacaggt acccaactga gtgtgatgat
      121 gtattgctaa ccaaggactg agtgatctct gtgtaattaa gtgtgctcct atgtggctga
      181 aatatgggag cggcatgtca gcactgagtg aaggctaatg gtgcgtaaaa gcactggtga
      241 gatctggggg cgcctccttg gctgacgtca gagagagagt ttaaaaaggg gagaccgtgg
      301 agagctccat agcggctgaa ggagacgcta ccgaagccgt cgctgctgcc tgaggacctg
      361 cgactagact gacccaccgc gctccagctt ggctgcctga ggcaaggaag atgctgtcct
      421 gccgtctcca gtgcgccctg gctgcgctct gcatcgtcct ggctttgggc ggtgtcaccg
      481 gcgcgccctc ggaccccaga ctccgtcagt ttctgcagaa gtctctggcg gctgccaccg
      541 ggaaacagga actggccaag tacttcttgg cagagctgct gtccgagccc aaccagacag
      601 agaatgatgc cctggagccc gaggatttgc cccaggcagc tgagcaggac gagatgaggc
      661 tggagctgca gaggtctgcc aactcgaacc cagcaatggc accccgggaa cgcaaagctg
      721 gctgcaagaa cttcttctgg aagacattca catcctgtta gctttaatat tgttgtccta
      781 gccagacctc tgatccctct cccccaaacc ccatatctct tccttaactc ctggcccccg
      841 atgctcaact tgaccctgca ttagaaattg aagactgtaa atacaaaata aaattatggt
      901 gagattatga aga
//
