LOCUS       NM_001356317            1060 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus signal sequence receptor, beta (Ssr2), transcript
            variant 2, mRNA.
ACCESSION   NM_001356317 XM_006501878
VERSION     NM_001356317.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1060)
  AUTHORS   Martinez-Mayer,J., Brinkmeier,M.L., O'Connell,S.P., Ukagwu,A.,
            Marti,M.A., Miras,M., Forclaz,M.V., Benzrihen,M.G., Cheung,L.Y.M.,
            Camper,S.A., Ellsworth,B.S., Raetzman,L.T., Perez-Millan,M.I. and
            Davis,S.W.
  TITLE     Knockout mice with pituitary malformations help identify human
            cases of hypopituitarism
  JOURNAL   Genome Med 16 (1), 75 (2024)
   PUBMED   38822427
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1060)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1060)
  AUTHORS   Radford,B.N., Zhao,X., Glazer,T., Eaton,M., Blackwell,D.,
            Mohammad,S., Lo Vercio,L.D., Devine,J., Shalom-Barak,T.,
            Hallgrimsson,B., Cross,J.C., Sucov,H.M., Barak,Y., Dean,W. and
            Hemberger,M.
  TITLE     Defects in placental syncytiotrophoblast cells are a common cause
            of developmental heart disease
  JOURNAL   Nat Commun 14 (1), 1174 (2023)
   PUBMED   36859534
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1060)
  AUTHORS   Ansarullah, Jain,C., Far,F.F., Homberg,S., Wissmiller,K., von
            Hahn,F.G., Raducanu,A., Schirge,S., Sterr,M., Bilekova,S.,
            Siehler,J., Wiener,J., Oppenlander,L., Morshedi,A.,
            Bastidas-Ponce,A., Collden,G., Irmler,M., Beckers,J.,
            Feuchtinger,A., Grzybek,M., Ahlbrecht,C., Feederle,R.,
            Plettenburg,O., Muller,T.D., Meier,M., Tschop,M.H., Coskun,U. and
            Lickert,H.
  TITLE     Inceptor counteracts insulin signalling in beta-cells to control
            glycaemia
  JOURNAL   Nature 590 (7845), 326-331 (2021)
   PUBMED   33505018
  REMARK    Erratum:[Nature. 2021 Apr;592(7852):E1. doi:
            10.1038/s41586-021-03347-z.. PMID: 33712809]
REFERENCE   5  (bases 1 to 1060)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1060)
  AUTHORS   Geyer,S.H., Reissig,L., Rose,J., Wilson,R., Prin,F., Szumska,D.,
            Ramirez-Solis,R., Tudor,C., White,J., Mohun,T.J. and Weninger,W.J.
  TITLE     A staging system for correct phenotype interpretation of mouse
            embryos harvested on embryonic day 14 (E14.5)
  JOURNAL   J Anat 230 (5), 710-719 (2017)
   PUBMED   28185240
REFERENCE   7  (bases 1 to 1060)
  AUTHORS   Wilson,R., Geyer,S.H., Reissig,L., Rose,J., Szumska,D., Hardman,E.,
            Prin,F., McGuire,C., Ramirez-Solis,R., White,J., Galli,A.,
            Tudor,C., Tuck,E., Mazzeo,C.I., Smith,J.C., Robertson,E.,
            Adams,D.J., Mohun,T. and Weninger,W.J.
  TITLE     Highly variable penetrance of abnormal phenotypes in embryonic
            lethal knockout mice
  JOURNAL   Wellcome Open Res 1, 1 (2017)
   PUBMED   27996060
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1060)
  AUTHORS   Hegde,R.S. and Kang,S.W.
  TITLE     The concept of translocational regulation
  JOURNAL   J Cell Biol 182 (2), 225-232 (2008)
   PUBMED   18644895
  REMARK    Review article
REFERENCE   9  (bases 1 to 1060)
  AUTHORS   Uematsu,R., Furukawa,J., Nakagawa,H., Shinohara,Y., Deguchi,K.,
            Monde,K. and Nishimura,S.
  TITLE     High throughput quantitative glycomics and glycoform-focused
            proteomics of murine dermis and epidermis
  JOURNAL   Mol Cell Proteomics 4 (12), 1977-1989 (2005)
   PUBMED   16170054
REFERENCE   10 (bases 1 to 1060)
  AUTHORS   McClive,P.J., Hurley,T.M., Sarraj,M.A., van den Bergen,J.A. and
            Sinclair,A.H.
  TITLE     Subtractive hybridisation screen identifies sexually dimorphic gene
            expression in the embryonic mouse gonad
  JOURNAL   Genesis 37 (2), 84-90 (2003)
   PUBMED   14595844
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK005340.1 and AC145168.5.
            
            On Sep 29, 2017 this sequence version replaced XM_006501878.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK005340.1, BY705504.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-988               AK005340.1         2-989
            989-1060            AC145168.5         154436-154507
FEATURES             Location/Qualifiers
     source          1..1060
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 38.88 cM"
     gene            1..1060
                     /gene="Ssr2"
                     /gene_synonym="1500032E05Rik; SSR-beta; TLAP; TRAPB;
                     TRAPbeta"
                     /note="signal sequence receptor, beta"
                     /db_xref="GeneID:66256"
                     /db_xref="MGI:MGI:1913506"
     exon            1..79
                     /gene="Ssr2"
                     /gene_synonym="1500032E05Rik; SSR-beta; TLAP; TRAPB;
                     TRAPbeta"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..631
                     /gene="Ssr2"
                     /gene_synonym="1500032E05Rik; SSR-beta; TLAP; TRAPB;
                     TRAPbeta"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; translocon-associated protein subunit beta;
                     signal sequence receptor subunit beta"
                     /codon_start=1
                     /product="translocon-associated protein subunit beta
                     isoform 2 precursor"
                     /protein_id="NP_001343246.1"
                     /db_xref="CCDS:CCDS17480.1"
                     /db_xref="GeneID:66256"
                     /db_xref="MGI:MGI:1913506"
                     /translation="MRLLAVVVLALLAVSQAEEGARLLASKSLLNRYAVEGRDLTLQY
                     NIYNVGSSAALDVELSDDSFPPEDFGIVSGMLNVKWDRIAPASNVSHTVVLRPLKAGY
                     FNFTSATITYLAQEDGPVVIGSTSAPGQGGILAQREFDRRFSPHFLDWAAFGVMTLPS
                     IGIPLLLWYSSKRKYDTPKPKKN"
     exon            80..234
                     /gene="Ssr2"
                     /gene_synonym="1500032E05Rik; SSR-beta; TLAP; TRAPB;
                     TRAPbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            235..333
                     /gene="Ssr2"
                     /gene_synonym="1500032E05Rik; SSR-beta; TLAP; TRAPB;
                     TRAPbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            334..442
                     /gene="Ssr2"
                     /gene_synonym="1500032E05Rik; SSR-beta; TLAP; TRAPB;
                     TRAPbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            443..520
                     /gene="Ssr2"
                     /gene_synonym="1500032E05Rik; SSR-beta; TLAP; TRAPB;
                     TRAPbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            521..1060
                     /gene="Ssr2"
                     /gene_synonym="1500032E05Rik; SSR-beta; TLAP; TRAPB;
                     TRAPbeta"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1038..1043
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ssr2"
                     /gene_synonym="1500032E05Rik; SSR-beta; TLAP; TRAPB;
                     TRAPbeta"
                     /note="hexamer: AATAAA"
     polyA_site      1060
                     /gene="Ssr2"
                     /gene_synonym="1500032E05Rik; SSR-beta; TLAP; TRAPB;
                     TRAPbeta"
                     /note="major polyA site"
ORIGIN      
        1 agatccgttt ccggtctttc ggaggctgac gttgttttcc ggttgtctgt ggcccaggga
       61 ggcgtttggg gtgctcacga tgaggctgct ggcggttgtg gtgttggctc tgttagccgt
      121 cagtcaagca gaagaaggag ccaggctttt ggcctccaaa tcattgctca acagatacgc
      181 tgtggaaggg agggacctga ccctgcagta taacatctac aacgtcggct ccagcgctgc
      241 attagatgtg gaattatctg acgattcctt ccctccagaa gacttcggca ttgtctccgg
      301 tatgctcaat gtcaaatggg accggattgc ccccgctagc aatgtctccc acacagttgt
      361 cctgcgtcct ctcaaagctg gctacttcaa cttcacttct gccacgatta cttacctggc
      421 ccaggaggat ggacctgttg tgattggctc caccagcgcc cctggacagg gaggaatcct
      481 cgctcagcgg gagtttgaca ggagattctc cccccatttt ctggactggg cagcctttgg
      541 ggtcatgacc ttgccctcca taggcatccc cctgctcctg tggtattcca gcaagaggaa
      601 gtacgatact cccaaaccca agaagaactg aatgcagttt cctcggccct tctctcccaa
      661 gaaaccaggt tttttctaga ctccagaggg tgtcaaaagt gttctcttgg cccttggccc
      721 gtggctattt tgtcctgaat cttaccccga actcaaccag aatgcgaggg gcaggcctgg
      781 aagttggaga gggcctcccc gttgtcactg aagccatata gacaggacag cccttagcca
      841 cagcttcagg gcttgagggt cccaccaagg tgctgttggt atattattag caatgtgaac
      901 tctttggggt ccaggagggg ccctttggat actgtctgac acccccatcc cctggcagct
      961 cctctcaaga gggtagagga ttatgggggc tacacaggcc ctgcctggat taggggcact
     1021 taccaaatga attttctaat aaaaacaaat gccataccga
//
