LOCUS       NM_198113               2789 bp    mRNA    linear   ROD 18-JUN-2024
DEFINITION  Mus musculus slingshot protein phosphatase 3 (Ssh3), transcript
            variant 1, mRNA.
ACCESSION   NM_198113
VERSION     NM_198113.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2789)
  AUTHORS   Morita,R., Kihira,M., Nakatsu,Y., Nomoto,Y., Ogawa,M., Ohashi,K.,
            Mizuno,K., Tachikawa,T., Ishimoto,Y., Morishita,Y. and Tsuji,T.
  TITLE     Coordination of Cellular Dynamics Contributes to Tooth Epithelium
            Deformations
  JOURNAL   PLoS One 11 (9), e0161336 (2016)
   PUBMED   27588418
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2789)
  AUTHORS   Scekic-Zahirovic,J., Sendscheid,O., El Oussini,H., Jambeau,M.,
            Sun,Y., Mersmann,S., Wagner,M., Dieterle,S., Sinniger,J.,
            Dirrig-Grosch,S., Drenner,K., Birling,M.C., Qiu,J., Zhou,Y., Li,H.,
            Fu,X.D., Rouaux,C., Shelkovnikova,T., Witting,A., Ludolph,A.C.,
            Kiefer,F., Storkebaum,E., Lagier-Tourenne,C. and Dupuis,L.
  TITLE     Toxic gain of function from mutant FUS protein is crucial to
            trigger cell autonomous motor neuron loss
  JOURNAL   EMBO J 35 (10), 1077-1097 (2016)
   PUBMED   26951610
REFERENCE   3  (bases 1 to 2789)
  AUTHORS   Kousaka,K., Kiyonari,H., Oshima,N., Nagafuchi,A., Shima,Y.,
            Chisaka,O. and Uemura,T.
  TITLE     Slingshot-3 dephosphorylates ADF/cofilin but is dispensable for
            mouse development
  JOURNAL   Genesis 46 (5), 246-255 (2008)
   PUBMED   18442045
  REMARK    GeneRIF: Dephosphorylates actin-depolymerizing factor/cofilin, but
            is not essential for viability, fertility, or development of
            epithelial tissues.
REFERENCE   4  (bases 1 to 2789)
  AUTHORS   Ohta,Y., Kousaka,K., Nagata-Ohashi,K., Ohashi,K., Muramoto,A.,
            Shima,Y., Niwa,R., Uemura,T. and Mizuno,K.
  TITLE     Differential activities, subcellular distribution and tissue
            expression patterns of three members of Slingshot family
            phosphatases that dephosphorylate cofilin
  JOURNAL   Genes Cells 8 (10), 811-824 (2003)
   PUBMED   14531860
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC140073.4, AK148293.1, AK164662.1, BE864347.1 and AW060821.1.
            
            On Oct 12, 2017 this sequence version replaced NM_198113.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC028922.1, AB099289.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-71                AC140073.4         154177-154247
            72-147              AK148293.1         4-79
            148-521             AK148293.1         81-454
            522-522             AC140073.4         156802-156802
            523-1397            AK148293.1         455-1329
            1398-1398           AC140073.4         159347-159347
            1399-2092           AK148293.1         1331-2024
            2093-2355           AK164662.1         1731-1993
            2356-2524           BE864347.1         213-381
            2525-2789           AW060821.1         15-279              c
FEATURES             Location/Qualifiers
     source          1..2789
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 3.96 cM"
     gene            1..2789
                     /gene="Ssh3"
                     /gene_synonym="SSH-3; SSH-3L"
                     /note="slingshot protein phosphatase 3"
                     /db_xref="GeneID:245857"
                     /db_xref="MGI:MGI:2683546"
     exon            1..219
                     /gene="Ssh3"
                     /gene_synonym="SSH-3; SSH-3L"
                     /inference="alignment:Splign:2.1.0"
     CDS             154..2103
                     /gene="Ssh3"
                     /gene_synonym="SSH-3; SSH-3L"
                     /EC_number="3.1.3.16"
                     /EC_number="3.1.3.48"
                     /note="isoform 1 is encoded by transcript variant 1;
                     slingshot-like 3; slingshot-3L; protein phosphatase
                     Slingshot homolog 3; SSH-like protein 3; slingshot homolog
                     3"
                     /codon_start=1
                     /product="protein phosphatase Slingshot homolog 3 isoform
                     1"
                     /protein_id="NP_932781.1"
                     /db_xref="CCDS:CCDS29425.1"
                     /db_xref="GeneID:245857"
                     /db_xref="MGI:MGI:2683546"
                     /translation="MALVTVSRSPPASGHSTPVGPTQDRVVRRRGRLQRRQSFAVLRG
                     AVLGLQDGGDSNVASEADSEPMEEPSGEEQPTEDQTDKGQGLQSPWKQVQKRHLHLMV
                     ELLRPQDDIRLAAQLEAARPPRLRYLLVVSTGEELSEEAILLGVDFPDSSSHSCTLGL
                     VLPLWSDTQVYLDGDGGFSVTSGGQSRIFKPVSIQTMWATLQVLHQACEVALGSGLVP
                     GGSALAWATYYQEKLNSDQGCLNEWMAMSDLESFRPPNAEPGQASEQEKMEQAILAEL
                     WQVLDTSDLDSVTSKEIRQALELRLGCPLQQYRDFIDNQMLLLMAQQDRASRIFPHLY
                     LGSEWNAANLEELQKNRVSHILNMAREIDNFFPERFTYYNVRVWDEESAQLLPHWKET
                     HRFIEDARAQGTRVLVHCKMGVSRSAATVLAYAMKQYGWDLEQALIHVQELRPIVRPN
                     HGFLRQLRTYQGILTASRQSHVWEQKVGVVSPEEPLAPEVSTPLPPLPPEPGGSGEVM
                     VMGLEGSQETPKEELGLRPRINLRGVMRSISLLEPSESESTPEAGGLPEVFSSDEEPL
                     HPFSQLSRAKGGQRVRKGPWPALKSRQSVVALHSAALVASRTRAFQEQGQGQEQSEPG
                     MSSTPRLRKVMRQASVDDSREEDKA"
     exon            220..260
                     /gene="Ssh3"
                     /gene_synonym="SSH-3; SSH-3L"
                     /inference="alignment:Splign:2.1.0"
     exon            261..492
                     /gene="Ssh3"
                     /gene_synonym="SSH-3; SSH-3L"
                     /inference="alignment:Splign:2.1.0"
     exon            493..608
                     /gene="Ssh3"
                     /gene_synonym="SSH-3; SSH-3L"
                     /inference="alignment:Splign:2.1.0"
     exon            609..680
                     /gene="Ssh3"
                     /gene_synonym="SSH-3; SSH-3L"
                     /inference="alignment:Splign:2.1.0"
     exon            681..746
                     /gene="Ssh3"
                     /gene_synonym="SSH-3; SSH-3L"
                     /inference="alignment:Splign:2.1.0"
     exon            747..935
                     /gene="Ssh3"
                     /gene_synonym="SSH-3; SSH-3L"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1029
                     /gene="Ssh3"
                     /gene_synonym="SSH-3; SSH-3L"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1158
                     /gene="Ssh3"
                     /gene_synonym="SSH-3; SSH-3L"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..1205
                     /gene="Ssh3"
                     /gene_synonym="SSH-3; SSH-3L"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1352
                     /gene="Ssh3"
                     /gene_synonym="SSH-3; SSH-3L"
                     /inference="alignment:Splign:2.1.0"
     exon            1353..1553
                     /gene="Ssh3"
                     /gene_synonym="SSH-3; SSH-3L"
                     /inference="alignment:Splign:2.1.0"
     exon            1554..1824
                     /gene="Ssh3"
                     /gene_synonym="SSH-3; SSH-3L"
                     /inference="alignment:Splign:2.1.0"
     exon            1825..2789
                     /gene="Ssh3"
                     /gene_synonym="SSH-3; SSH-3L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2743..2748
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ssh3"
                     /gene_synonym="SSH-3; SSH-3L"
                     /note="hexamer: AATAAA"
     regulatory      2761..2766
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ssh3"
                     /gene_synonym="SSH-3; SSH-3L"
                     /note="hexamer: ATTAAA"
     polyA_site      2767
                     /gene="Ssh3"
                     /gene_synonym="SSH-3; SSH-3L"
                     /note="major polyA site"
     polyA_site      2789
                     /gene="Ssh3"
                     /gene_synonym="SSH-3; SSH-3L"
                     /note="major polyA site"
ORIGIN      
        1 agtcgggccc tttaagggcc gctcccgagg aggtgccagg ccctggtggc tccaatctct
       61 tcttcctggt tgtgcgaagg cagggactga ccgtaaggct gagggagggg tcgtgccggg
      121 tgttcgccca ggtgttccgg gcctgcctac cttatggcgc tggtcacagt gagtcgctcg
      181 ccgccggcaa gtggccactc cacgcctgtg ggacccacgc aggaccgagt ggtaagacgc
      241 agaggccggc tccagcgcag gcagagtttt gcggtgctcc gaggggctgt cctgggactt
      301 caggatggag gggacagtaa tgttgcatct gaggctgact ctgagccaat ggaggaaccc
      361 tcaggtgagg aacagcccac cgaggaccag actgacaaag ggcaaggact ccagagtccc
      421 tggaaacaag tgcaaaagcg gcacctgcac ctcatggtgg agctgctgag gccgcaggat
      481 gatatccgcc tggcagccca gctggaggca gcccgacccc ccagacttcg ctacctgctg
      541 gtagtatcca cgggagaaga actgagtgag gaggccatcc tgcttggggt ggacttccct
      601 gacagcagtt cccacagctg caccctgggc ctggtcttgc ccctctggag tgatacccag
      661 gtgtacctgg acggcgatgg gggcttcagt gtgacatctg gtggtcaaag ccgaatcttc
      721 aagcctgtct ctatccagac catgtgggcc acactgcagg tattgcacca ggcatgtgag
      781 gtagctctag gcagtggcct tgtgcctggt ggcagtgccc ttgcctgggc tacttactac
      841 caggagaaac tcaactctga ccagggttgc ctcaatgagt ggatggccat gtctgacctg
      901 gagtcctttc gaccacctaa tgctgagcct ggacaggctt cagagcagga aaagatggag
      961 caggcgatcc tggctgaatt gtggcaggtg ttggacacca gtgacctgga cagtgtcact
     1021 tctaaagaga tccgtcaggc cctggagctg cgtctgggat gtcctctcca gcagtaccgt
     1081 gactttattg acaaccagat gttgctgctc atggcccagc aagaccgggc ctctcgcatc
     1141 ttcccccacc tctacttggg ctctgagtgg aatgctgcca acctggagga acttcagaaa
     1201 aacagagtaa gtcacatctt gaacatggcc cgggagattg acaacttctt ccctgagcgc
     1261 ttcacctatt acaatgtacg tgtctgggat gaggaatcgg cacagcttct gccccactgg
     1321 aaggagacac atcgattcat tgaggatgcc agagcacagg gcactcgggt gctagtccac
     1381 tgtaagatgg gtgtcagccg ttctgccgcc acggtactag cctatgccat gaaacagtat
     1441 ggctgggacc tggagcaagc cctgatccac gtgcaggagc tccggcccat tgtacgcccc
     1501 aaccacggct tcctgcgcca gctacggacc taccagggca ttctgactgc cagccggcag
     1561 agccacgtct gggagcagaa agtgggtgtg gtctccccag aggagcccct ggcgcctgaa
     1621 gtttctacac cattgccacc tcttccacca gaaccagggg gcagtgggga ggtgatggta
     1681 atgggcctgg aaggaagcca ggaaacccca aaagaagaac ttggactgcg gccccgcatc
     1741 aaccttcgag gggtcatgcg ctccatcagt ctcctggagc cctcagagtc agagagtacc
     1801 ccagaggcgg gaggcctgcc agaagttttc tcttcagatg aagagcctct tcatccattc
     1861 tctcagcttt caagagccaa aggtggccag cgggtccgca aggggccttg gcctgccctg
     1921 aagtctcgac agtctgtggt tgcccttcat agtgctgccc tggtggccag caggacacgg
     1981 gccttccaag aacaggggca agggcaagag cagagcgagc ctggtatgtc ttctacccct
     2041 aggctccgga aggtgatgag gcaggccagt gtagatgaca gcagggagga ggacaaggcc
     2101 taagccctca tgctgtgtcc gcccccagac actaatcgcg actggtcaca gcgcctcaga
     2161 tgagtggtct ttagacctat gggcctgcac acgccctgca gctccttccc agctgccctc
     2221 agacctttgc cacttcctgc agccttaggt ctcagcccat atctacctgt taagggctca
     2281 atcctttttc tacatagggg ctgggttaga gccgtttaag gtgcctttag ggtaataaca
     2341 ccctagtttc attgtacact cactcactta acattgtgta cagccatgga gttaaaacca
     2401 gaatttttta gggtgggttt tctagttcat gtctcccttg ccctcgactt gtggccattc
     2461 caccctgcgt cttccaccct ctcctactgc agtcctggag acagctaggc caggggacta
     2521 gtggccacaa aggcagatag cactttcagt ccccagtccc acaggctctg agggggctca
     2581 caggtcaccc acccacccac ccaactgacc cgaatctctg ctgctgccct cagttccccc
     2641 atgcccctca ctgggtcaca gcactgagag tcttcttgtt cttgaagatc tctggccagg
     2701 caagtttttc atagttgtat agtatttggc tttgtattga gaaataaaag acattttcat
     2761 attaaaagac attttccatt tgtgacaaa
//
