LOCUS       NP_932781                649 aa            linear   ROD 27-APR-2025
DEFINITION  protein phosphatase Slingshot homolog 3 isoform 1 [Mus musculus].
ACCESSION   NP_932781
VERSION     NP_932781.1
DBSOURCE    REFSEQ: accession NM_198113.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 649)
  AUTHORS   Morita,R., Kihira,M., Nakatsu,Y., Nomoto,Y., Ogawa,M., Ohashi,K.,
            Mizuno,K., Tachikawa,T., Ishimoto,Y., Morishita,Y. and Tsuji,T.
  TITLE     Coordination of Cellular Dynamics Contributes to Tooth Epithelium
            Deformations
  JOURNAL   PLoS One 11 (9), e0161336 (2016)
   PUBMED   27588418
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 649)
  AUTHORS   Scekic-Zahirovic,J., Sendscheid,O., El Oussini,H., Jambeau,M.,
            Sun,Y., Mersmann,S., Wagner,M., Dieterle,S., Sinniger,J.,
            Dirrig-Grosch,S., Drenner,K., Birling,M.C., Qiu,J., Zhou,Y., Li,H.,
            Fu,X.D., Rouaux,C., Shelkovnikova,T., Witting,A., Ludolph,A.C.,
            Kiefer,F., Storkebaum,E., Lagier-Tourenne,C. and Dupuis,L.
  TITLE     Toxic gain of function from mutant FUS protein is crucial to
            trigger cell autonomous motor neuron loss
  JOURNAL   EMBO J 35 (10), 1077-1097 (2016)
   PUBMED   26951610
REFERENCE   3  (residues 1 to 649)
  AUTHORS   Kousaka,K., Kiyonari,H., Oshima,N., Nagafuchi,A., Shima,Y.,
            Chisaka,O. and Uemura,T.
  TITLE     Slingshot-3 dephosphorylates ADF/cofilin but is dispensable for
            mouse development
  JOURNAL   Genesis 46 (5), 246-255 (2008)
   PUBMED   18442045
  REMARK    GeneRIF: Dephosphorylates actin-depolymerizing factor/cofilin, but
            is not essential for viability, fertility, or development of
            epithelial tissues.
REFERENCE   4  (residues 1 to 649)
  AUTHORS   Ohta,Y., Kousaka,K., Nagata-Ohashi,K., Ohashi,K., Muramoto,A.,
            Shima,Y., Niwa,R., Uemura,T. and Mizuno,K.
  TITLE     Differential activities, subcellular distribution and tissue
            expression patterns of three members of Slingshot family
            phosphatases that dephosphorylate cofilin
  JOURNAL   Genes Cells 8 (10), 811-824 (2003)
   PUBMED   14531860
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC140073.4, AK148293.1, AK164662.1, BE864347.1 and AW060821.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC028922.1, AB099289.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..649
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 3.96 cM"
     Protein         1..649
                     /product="protein phosphatase Slingshot homolog 3 isoform
                     1"
                     /EC_number="3.1.3.16"
                     /EC_number="3.1.3.48"
                     /note="slingshot-like 3; slingshot-3L; protein phosphatase
                     Slingshot homolog 3; SSH-like protein 3; slingshot homolog
                     3"
                     /calculated_mol_wt=72097
     Region          1..32
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K330.1)"
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylalanine.
                     /evidence=ECO:0007744|PubMed:17242355; propagated from
                     UniProtKB/Swiss-Prot (Q8K330.1)"
     Region          3..256
                     /region_name="SSH-N"
                     /note="N-terminal domain conserved in slingshot (SSH)
                     phosphatases; cd11652"
                     /db_xref="CDD:212166"
     Site            9
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q8K330.1)"
     Site            38
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q8K330.1)"
     Region          49..90
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K330.1)"
     Site            88
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8TE77; propagated from
                     UniProtKB/Swiss-Prot (Q8K330.1)"
     Region          269..320
                     /region_name="DEK_C"
                     /note="DEK C terminal domain; pfam08766"
                     /db_xref="CDD:462592"
     Region          323..466
                     /region_name="DSP_slingshot_3"
                     /note="dual specificity phosphatase domain of slingshot
                     homolog 3; cd14571"
                     /db_xref="CDD:350419"
     Region          541..586
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K330.1)"
     Region          608..649
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K330.1)"
     CDS             1..649
                     /gene="Ssh3"
                     /gene_synonym="SSH-3; SSH-3L"
                     /coded_by="NM_198113.3:154..2103"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS29425.1"
                     /db_xref="GeneID:245857"
                     /db_xref="MGI:MGI:2683546"
ORIGIN      
        1 malvtvsrsp pasghstpvg ptqdrvvrrr grlqrrqsfa vlrgavlglq dggdsnvase
       61 adsepmeeps geeqptedqt dkgqglqspw kqvqkrhlhl mvellrpqdd irlaaqleaa
      121 rpprlryllv vstgeelsee aillgvdfpd ssshsctlgl vlplwsdtqv yldgdggfsv
      181 tsggqsrifk pvsiqtmwat lqvlhqacev algsglvpgg salawatyyq eklnsdqgcl
      241 newmamsdle sfrppnaepg qaseqekmeq ailaelwqvl dtsdldsvts keirqalelr
      301 lgcplqqyrd fidnqmlllm aqqdrasrif phlylgsewn aanleelqkn rvshilnmar
      361 eidnffperf tyynvrvwde esaqllphwk ethrfiedar aqgtrvlvhc kmgvsrsaat
      421 vlayamkqyg wdleqalihv qelrpivrpn hgflrqlrty qgiltasrqs hvweqkvgvv
      481 speeplapev stplpplppe pggsgevmvm glegsqetpk eelglrprin lrgvmrsisl
      541 lepsesestp eagglpevfs sdeeplhpfs qlsrakggqr vrkgpwpalk srqsvvalhs
      601 aalvasrtra fqeqgqgqeq sepgmsstpr lrkvmrqasv ddsreedka
//
