LOCUS       NM_177710               9040 bp    mRNA    linear   ROD 18-JUN-2024
DEFINITION  Mus musculus slingshot protein phosphatase 2 (Ssh2), transcript
            variant 1, mRNA.
ACCESSION   NM_177710
VERSION     NM_177710.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 9040)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 9040)
  AUTHORS   Morita,R., Kihira,M., Nakatsu,Y., Nomoto,Y., Ogawa,M., Ohashi,K.,
            Mizuno,K., Tachikawa,T., Ishimoto,Y., Morishita,Y. and Tsuji,T.
  TITLE     Coordination of Cellular Dynamics Contributes to Tooth Epithelium
            Deformations
  JOURNAL   PLoS One 11 (9), e0161336 (2016)
   PUBMED   27588418
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 9040)
  AUTHORS   Tang,W., Zhang,Y., Xu,W., Harden,T.K., Sondek,J., Sun,L., Li,L. and
            Wu,D.
  TITLE     A PLCbeta/PI3Kgamma-GSK3 signaling pathway regulates cofilin
            phosphatase slingshot2 and neutrophil polarization and chemotaxis
  JOURNAL   Dev Cell 21 (6), 1038-1050 (2011)
   PUBMED   22172670
  REMARK    GeneRIF: A PLCbeta/PI3Kgamma-GSK3 signaling pathway regulates
            cofilin phosphatase slingshot2 and neutrophil polarization and
            chemotaxis.
REFERENCE   4  (bases 1 to 9040)
  AUTHORS   Kousaka,K., Kiyonari,H., Oshima,N., Nagafuchi,A., Shima,Y.,
            Chisaka,O. and Uemura,T.
  TITLE     Slingshot-3 dephosphorylates ADF/cofilin but is dispensable for
            mouse development
  JOURNAL   Genesis 46 (5), 246-255 (2008)
   PUBMED   18442045
REFERENCE   5  (bases 1 to 9040)
  AUTHORS   Ballif,B.A., Villen,J., Beausoleil,S.A., Schwartz,D. and Gygi,S.P.
  TITLE     Phosphoproteomic analysis of the developing mouse brain
  JOURNAL   Mol Cell Proteomics 3 (11), 1093-1101 (2004)
   PUBMED   15345747
REFERENCE   6  (bases 1 to 9040)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   7  (bases 1 to 9040)
  AUTHORS   Ohta,Y., Kousaka,K., Nagata-Ohashi,K., Ohashi,K., Muramoto,A.,
            Shima,Y., Niwa,R., Uemura,T. and Mizuno,K.
  TITLE     Differential activities, subcellular distribution and tissue
            expression patterns of three members of Slingshot family
            phosphatases that dephosphorylate cofilin
  JOURNAL   Genes Cells 8 (10), 811-824 (2003)
   PUBMED   14531860
REFERENCE   8  (bases 1 to 9040)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB099288.1, BC141393.1 and AL607072.15.
            
            On Aug 4, 2011 this sequence version replaced NM_177710.3.
            
            Transcript Variant: This variant (1) represents the shorter
            transcript and encodes the shorter isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB099288.1, BC141393.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 AB099288.1         1-6
            7-4321              BC141393.1         1-4315
            4322-9040           AL607072.15        37119-41837
FEATURES             Location/Qualifiers
     source          1..9040
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 46.36 cM"
     gene            1..9040
                     /gene="Ssh2"
                     /gene_synonym="mSSH-2L; SSH-2; SSH-2L"
                     /note="slingshot protein phosphatase 2"
                     /db_xref="GeneID:237860"
                     /db_xref="MGI:MGI:2679255"
     exon            1..91
                     /gene="Ssh2"
                     /gene_synonym="mSSH-2L; SSH-2; SSH-2L"
                     /inference="alignment:Splign:2.1.0"
     CDS             29..4300
                     /gene="Ssh2"
                     /gene_synonym="mSSH-2L; SSH-2; SSH-2L"
                     /EC_number="3.1.3.16"
                     /EC_number="3.1.3.48"
                     /note="isoform 1 is encoded by transcript variant 1;
                     slingshot-like 2; slingshot 2L; protein phosphatase
                     Slingshot homolog 2; SSH-like protein 2; slingshot homolog
                     2"
                     /codon_start=1
                     /product="protein phosphatase Slingshot homolog 2 isoform
                     1"
                     /protein_id="NP_808378.2"
                     /db_xref="CCDS:CCDS25076.1"
                     /db_xref="GeneID:237860"
                     /db_xref="MGI:MGI:2679255"
                     /translation="MALVTVQRSPTPSTTSSPCASEADSGEEECRSQPRSISESFLTV
                     KGAALFLPRGNGSSTPRVSHRRNKHAGDLQQHLQAMFILLRPEDNIRLAVRLESTYQN
                     RTRYMVVVSTNGRQDTEESIVLGMDFSSNDSSTCTMGLVLPLWSDTLIHLDGDGGFSV
                     STDNRVHIFKPVSVQAMWSALQSLHKACEVARMHNYYPGSLFLTWVSYYESHINSDQS
                     SVNEWNAMQDVQSHRPDSPALFTDIPTERERTERLIKTKLREIMMQKDLENITSKEIR
                     TELEMQMVCNLREFKEFIDNEMIVILGQMDSPTQIFEHVFLGSEWNASNLEDLQNRGV
                     RYILNVTREIDNFFPGVFEYHNIRVYDEEATDLLAYWNDTYKFISKAKKHGSKCLVHC
                     KMGVSRSASTVIAYAMKEYGWNLDRAYDYVKERRTVTKPNPSFMRQLEEYQGILLASK
                     QRHNKLWRSHSDSDLSDHHEPICKPGLELNKKEMTTSADQIAEVKTVENLAAMPTVFM
                     EHVVPQDANQKGLHTKERVICLEFSSQEFRAGQIEDELNLNDINGCSSGCCLSESKLP
                     LDNCHASKALLQPGQAPDIANKFPDLAVEDLETDALKADMNVHLLPMEELTSRLKDLP
                     MSPDLESPSPQASCQAAISDFSTDRIDFFSALEKFVELSQETRSRSFSHSRIEELGGG
                     RSEGCRLSVIEVAASEMAADDQRSSSLSNTPHASEESSVDEDQSKAITELVSPDIIMQ
                     SHSENAISVKEIVTEIESISQGVGQVQLKGDILSNPCHTPKKSTIHELPLERVPAPES
                     KPGHWEQDESFCSVQPELARDSGKCAPEEGCLTTHSSTADLEEEEPVEGEHDWGPGMH
                     SGAKWCPGSVRRATLEFEERLRQEQENHGTASAGPTLSNRKNSKNDSSVADLMPKWKS
                     DETTPEHSFFLKEAEPSKGKGKCSGSEAGSLSHCERNPTMPDCELLEHHSLPAPQDCL
                     GSDSRSKKQEGDLKKQRAVVPNQECDTQAILLPLPKKIEIIEYTPTVTSLGHTEPGGE
                     ATPSKEGEKQGLRKVKMEQSITMFCALDENLNRTLEPSQVSLHPQVLPLPHSSSECDR
                     PADPNPMLSSPQDKGDCPSTPFKTAAPFVSCSTQGASFSLDYLLPHSVVHLEGCTEQS
                     SATDNELSPEQASWEDSRGHFLSSGSGMAHTSSPLTNEDLSLINKLGDSVGVLQKKLD
                     PSPEACRIPHSSSSENIRDLSHSRGVVKEHAKEIESRVIFQAGFSKTSQMKRSASLAK
                     LGYLDLCKDYLPDRELVSSESPHLKLLQPFLRTDSGMHALMAHEPSESAGAQQNPQPT
                     KYSVEQLKTSECIVQSKPVERPSVQYAKEFGYSQQCLLPKARPELTSSEGGLPLLQTQ
                     GLQYTGPSPGLAVAPRQQHGRTHPLRRLKRANDKKRTTNPFYNTM"
     exon            92..135
                     /gene="Ssh2"
                     /gene_synonym="mSSH-2L; SSH-2; SSH-2L"
                     /inference="alignment:Splign:2.1.0"
     exon            136..239
                     /gene="Ssh2"
                     /gene_synonym="mSSH-2L; SSH-2; SSH-2L"
                     /inference="alignment:Splign:2.1.0"
     exon            240..304
                     /gene="Ssh2"
                     /gene_synonym="mSSH-2L; SSH-2; SSH-2L"
                     /inference="alignment:Splign:2.1.0"
     exon            305..426
                     /gene="Ssh2"
                     /gene_synonym="mSSH-2L; SSH-2; SSH-2L"
                     /inference="alignment:Splign:2.1.0"
     exon            427..495
                     /gene="Ssh2"
                     /gene_synonym="mSSH-2L; SSH-2; SSH-2L"
                     /inference="alignment:Splign:2.1.0"
     exon            496..561
                     /gene="Ssh2"
                     /gene_synonym="mSSH-2L; SSH-2; SSH-2L"
                     /inference="alignment:Splign:2.1.0"
     exon            562..756
                     /gene="Ssh2"
                     /gene_synonym="mSSH-2L; SSH-2; SSH-2L"
                     /inference="alignment:Splign:2.1.0"
     exon            757..850
                     /gene="Ssh2"
                     /gene_synonym="mSSH-2L; SSH-2; SSH-2L"
                     /inference="alignment:Splign:2.1.0"
     exon            851..979
                     /gene="Ssh2"
                     /gene_synonym="mSSH-2L; SSH-2; SSH-2L"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1026
                     /gene="Ssh2"
                     /gene_synonym="mSSH-2L; SSH-2; SSH-2L"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1173
                     /gene="Ssh2"
                     /gene_synonym="mSSH-2L; SSH-2; SSH-2L"
                     /inference="alignment:Splign:2.1.0"
     exon            1174..1374
                     /gene="Ssh2"
                     /gene_synonym="mSSH-2L; SSH-2; SSH-2L"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..2209
                     /gene="Ssh2"
                     /gene_synonym="mSSH-2L; SSH-2; SSH-2L"
                     /inference="alignment:Splign:2.1.0"
     exon            2210..9040
                     /gene="Ssh2"
                     /gene_synonym="mSSH-2L; SSH-2; SSH-2L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9016..9021
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ssh2"
                     /gene_synonym="mSSH-2L; SSH-2; SSH-2L"
                     /note="hexamer: AATAAA"
     polyA_site      9040
                     /gene="Ssh2"
                     /gene_synonym="mSSH-2L; SSH-2; SSH-2L"
                     /note="major polyA site"
ORIGIN      
        1 ctgcccggaa caacccagca gcacctagat ggctttggtc acggtccagc ggtcgcctac
       61 ccccagcacc acctccagcc cttgcgcctc ggaggccgac agtggggagg aggaatgccg
      121 gtcacagccc agaagcatca gcgagagctt cttaactgtc aaaggtgctg ccctttttct
      181 accacgaggg aatggctcgt ctacaccaag agtcagccac agacgcaaca agcatgcagg
      241 tgatctccaa cagcatcttc aagcaatgtt catattactc cgcccagaag acaacataag
      301 gctggctgta agactggaaa gtacttacca aaaccgaaca cgctatatgg tcgtggtttc
      361 aactaatggt agacaagaca ctgaagaaag cattgtcctg ggaatggatt tttcttctaa
      421 tgacagtagc acttgtacca tgggcttggt cttgcctctc tggagtgaca ccctaattca
      481 tttggatggt gatggtgggt tcagcgtatc aacagataac agagttcaca tattcaaacc
      541 tgtatctgtg caagcaatgt ggtctgcact acagagtttg cacaaggctt gtgaagtggc
      601 cagaatgcat aactactatc caggcagcct ttttctcact tgggtgagtt attacgagag
      661 ccatatcaac tcagatcagt cctcagtcaa tgagtggaat gctatgcagg atgtgcagtc
      721 tcatcggcct gactctccag ccctcttcac agacatacca actgaacgtg agcgaacaga
      781 aaggcttatt aagactaaat taagggagat catgatgcaa aaggatttgg agaatatcac
      841 ctccaaagag atacgcacgg agctggagat gcagatggtg tgcaacttgc gagaatttaa
      901 ggaattcata gataatgaaa tgatcgtgat ccttggtcag atggacagtc ccacacagat
      961 atttgagcat gtattcctgg gctcagaatg gaatgcctcg aacttagagg acttgcagaa
     1021 ccgaggggta cggtatatct tgaatgttac tcgagagata gataacttct tccctggagt
     1081 ctttgagtat cataacattc gagtatatga tgaagaagca acagatctcc tggcttactg
     1141 gaatgacact tacaaattca tctctaaagc aaagaaacat ggatctaaat gtcttgtgca
     1201 ctgcaaaatg ggggtgagtc gctcagcctc cactgtgatt gcctatgcaa tgaaggagta
     1261 tggatggaat ctggatcgag cctatgacta tgtgaaggaa agacgaacgg tgaccaagcc
     1321 taaccccagc ttcatgagac aactggaaga ataccaaggg atcttgctgg ccagcaaaca
     1381 gcggcataac aaactctgga gatctcattc agatagtgac ctttcagacc accacgaacc
     1441 catctgtaaa cctgggctcg agctcaacaa gaaggagatg accacgtcag cagaccagat
     1501 cgctgaggtg aagactgtgg agaaccttgc tgccatgcct accgtcttta tggaacatgt
     1561 ggtcccacaa gatgcaaatc agaaaggact acacaccaaa gaaagagtca tctgcttgga
     1621 gttttcttca caagagtttc gtgccggaca gattgaagat gaattaaatt taaatgacat
     1681 caatggatgc tcatcagggt gttgtctcag tgaatcaaaa ctccctcttg acaactgcca
     1741 tgcgtctaaa gccttactcc aacctggaca ggccccagac attgccaaca agttcccaga
     1801 cttagctgtg gaagatctgg agacagacgc actgaaagca gacatgaatg tccacctact
     1861 gccaatggaa gagttgacat ctcgactgaa agacctcccc atgtcacctg atctggagtc
     1921 accaagcccc caagccagtt gccaagctgc catctcagat tttagtacag atcgtattga
     1981 cttttttagt gccctggaga aatttgtaga gctttctcaa gaaacccggt ctcggtcttt
     2041 ttctcactca aggatagaag aattaggtgg aggaaggagt gagggctgtc gtttgtcagt
     2101 gatagaagtg gcagcttcag aaatggcagc tgatgaccag agaagcagct ctttgagtaa
     2161 tacgccccac gcctctgaag agtcttctgt ggatgaggac cagtcgaagg caatcaccga
     2221 acttgtcagc ccagacatca tcatgcaatc tcactcagaa aatgcaattt cagtcaaaga
     2281 aattgtgact gaaattgagt ccattagtca aggagttggg caggttcagt taaaaggaga
     2341 catcctctct aacccatgcc acacaccaaa gaagagcacc attcatgagc tgcccctgga
     2401 gagggtgcca gcccctgaga gcaaacctgg acattgggag caggatgaga gtttctgtag
     2461 tgtccagcca gaactagcta gagactcagg gaagtgtgcc ccggaggaag gctgtctgac
     2521 cacacactca tccacagcag acttggaaga agaagaacca gttgaggggg aacatgactg
     2581 gggcccaggg atgcactctg gtgctaagtg gtgccctggg tctgtgaggc gagccaccct
     2641 ggagtttgaa gagcgcttgc gacaagagca agagaaccat ggtacagcct ctgcaggccc
     2701 cacattatcc aatcgcaaaa actctaagaa tgattcttct gtggcagact taatgccaaa
     2761 atggaaaagt gatgaaacta ccccagaaca ttcatttttc ctcaaagaag ccgagccgag
     2821 caagggtaaa gggaaatgca gtggttctga agccggatca ctatcccact gtgagcgtaa
     2881 tcccaccatg ccagactgtg agctgctgga gcatcattcc ttgccggctc ctcaggactg
     2941 cctagggtca gatagtagaa gtaagaagca ggaaggagac ctaaagaagc agagggctgt
     3001 ggttccaaac caggaatgtg acacacaggc catccttctc ccccttccca agaaaataga
     3061 aatcattgag tatacgccga cagttacatc actgggtcac accgagccag gaggtgaggc
     3121 gacacccagc aaagagggtg agaaacaagg actgaggaaa gtgaagatgg agcagtctat
     3181 cactatgttt tgtgcgctgg atgaaaatct gaacaggact ctggagccca gtcaagtttc
     3241 tctgcatccc caagtgctac ctctgcctca ttcttcctca gagtgtgaca ggcccgctga
     3301 cccaaaccct atgttaagta gcccgcaaga caaaggggac tgcccatcca cacccttcaa
     3361 gacagcagca ccttttgtca gctgcagtac ccagggagca tctttcagct tggattattt
     3421 gcttccccac tctgtggttc acctggaagg ctgcacagag caaagcagtg ccactgacaa
     3481 tgaactgtct ccagagcagg ctagctggga ggacagccgg gggcatttcc tctccagtgg
     3541 tagtggaatg gcacacacat cctccccatt aactaacgaa gacctaagtt taattaacaa
     3601 acttggtgac agtgttggtg tgttacagaa aaaactggac ccgtcacctg aagcctgtag
     3661 aatcccacat agctctagta gtgaaaatat aagagatctc agccacagcc gtggtgtggt
     3721 gaaggagcat gctaaagaaa ttgagtctcg agtgatcttc caggcagggt tttccaaaac
     3781 atcccaaatg aagcgctcag cttcccttgc caagttgggt tacctggacc tttgtaaaga
     3841 ctacttacca gatagagagc ttgtctcctc agaatcccct catctcaaat tgcttcagcc
     3901 cttcctcaga acagactcag gcatgcatgc cttgatggcc catgagccct cagaaagcgc
     3961 aggtgcccag cagaacccac agcccaccaa gtattctgta gagcaactca aaacatcaga
     4021 gtgtattgtg cagagcaaac cagtggagag gcccagtgtg cagtatgcca aagagtttgg
     4081 ttacagtcag cagtgtttgc tccccaaggc aagaccagaa ttgactagtt ctgaaggagg
     4141 ccttcctttg ctacagacac agggtctgca gtacacaggc ccctctccag ggctggctgt
     4201 ggcgccccgt cagcaacatg gcagaactca cccccttaga agactgaaaa gagcaaatga
     4261 taaaaaacgg acaaccaacc ccttctataa caccatgtga tcctgagccc acacacgtga
     4321 ttttctaaga aaatgtttgt taaaaaggtg gtgtaatatg taaggaacat gcactttatt
     4381 ggttaatttt ataatatttt tggtcatttt actgttcctg gctcatgcag ggtttgggtt
     4441 tttccatgtg tgtacgtgca tgtatgtatg tgtgtgtgta tgtgtgtgtg tgtgtgtgtg
     4501 tgcgcgcgca cgcacatgca cgcatgctgt atgtatgtat gtatgtgtac tgatttggat
     4561 ggcaagatca ttttattatt tttatttttt taaaaattca aacctcaaaa aaattttttt
     4621 taaaagagca cctttatcaa aggcaaattg ctgtttttca atcaactgcc acctgtctct
     4681 tctcattttg ccctctgaga aaagacatgc ctgcttcgtt gagggaaaga aacagatggg
     4741 gtaggtggca ctgaagctgg gaactggaga tgctcaccca ggcctgaggc gacctatctg
     4801 ctgaagggca gagggaagtc actgctctca gccttctcca agctctcttt tggagtctgt
     4861 gaagttgtag gctctgcttt gctttaccag gcagttgaga ctcccatttc ttctgatatt
     4921 ccaaaaggca tcgatcatta cagaaaaaaa ggagtggtaa ttggcctatt gtgaagcaaa
     4981 taattttccc caagaaaaca atctgaaaag ggaaccctaa tcgaaattca aggtcatctg
     5041 tagagaaatg cattaagaga gaaggtggaa atgcagcccc tgcgttgctg tgggggccag
     5101 tggactccac ccaggtgaat cctggcactg cctgccggat ccccgtctgc cggatgacat
     5161 gctctgccac agcctcccaa ctaaagacct ggaaacaggc ttgaaaaaca gcaaagtcag
     5221 tgtgttcttg taaaatgaat acatactgtg gggttttaac cctgttactt gaatactctg
     5281 tgggccttct gagtttaatg gccgtggttt tccaattgat ttcttctctc ttgctgtttt
     5341 cccatccttc ccttttctta atttcacaaa ttatattttg ttacattaca tacatagaac
     5401 ctattaacac ttgacacaag ttttttcccc taatttttcc taggtttgtc gtttctctac
     5461 agttcataca cagtatttat gtacataatg tcacttttta aatgtttcat ggttgatatt
     5521 gtgggtcttt tgatttattc ttgttaagga gtagagttgc aactggaaaa gaaagagaca
     5581 ccagaaataa actggtagtt tctggtagaa atctttattt gttttaaatg aaaacttgtc
     5641 attgccagct cctgccaaat taagtacttc ctcttaagaa acccctgcag gctcccacta
     5701 gatcacactg aacgctggct tctgtttgag gctgaagtcc cagatcactg tttgccagta
     5761 attgaagcgc agccagatat gtgtcttcgc tgcccaaact agtagactcc ccgtgtgcgg
     5821 ctgagaggct ggggcagctc agccaagagc acagatccca cttaggatac cattgctttg
     5881 ttgctggcct gctgctctta aacactggcc tatctactgc aaatatgcct ctgagaatag
     5941 tacagaaaac atctggagat aaccaacaca gctcagcaaa actgaagagg tctacaaatt
     6001 tgcttcctgc ttgcttttgt tgatgtcgga attgctgagg attgtctgag taggagccag
     6061 ggacttaggt ttttgattca tcatagccct agttagaaat aaacagacac acagattaat
     6121 tatcattaga ggcagacttt ggagggagca ggtagtagga tacaggagaa gtagactgca
     6181 gccattttca agtgctccag agctgggagt ccacttgcca ttaaaaaaaa aaaaaaaaaa
     6241 aaaaaaagtg gttggttctg acattactgc caggaagcag ttagcgacca cctgcggaaa
     6301 tatgtggtat agaagttata tatacctgtg ctgtctttcg gtagtttctt taaatgttac
     6361 atctttgtgc atcttggata tttgtgtgtt gtctcgttag gtggtatgtt tcattgtgag
     6421 gaaggcttgg gaggcaagat ggtggattcc aggacccatc tgctaaagaa tcctgtctac
     6481 cagtgtgacg gaaggacgag aagttatgat agggtgagga gtgtttacat caaggttgag
     6541 agagtgcatc accaaaaata ataataaaag ctgggtgtag tggctcacat ctgtagtccc
     6601 agcacttggg aggctgaggc aggaggatca ctatgagctg gacgctaact tcggctaaag
     6661 agtgagaccc tgtctcaaaa aaagtagcat ccatatgcca cacattatca ccaatggaca
     6721 ctgctctctc atctcccggt gtagaatatc ctcactgcat ctctcttagc agagactgag
     6781 aaaatgccca atgagggcac tggggagcgg acggacaaat gacaacacct gattttgttt
     6841 tcaagattta aagaatggaa gaaaccatct tctgctgtct tccttcttaa ttgtatttcc
     6901 tatcatttaa ctcacctgcc taggtatctt ccacacaggg tctataattc agctatgcca
     6961 aagggtcttg ccagccctcc aaaccccaac acttgggttg ttcctaagtc atgcttatgg
     7021 ctaaggcagg tgcataataa gctgttgaag actttttact ttagcatttg ataatttcag
     7081 attgtctgtc tgtttttttt tctgttcatg gaaagcctgg acctaactct gacgaactgt
     7141 taagcaggaa aaatcttgac ctcctgacta gtgcttaacc tcttgctcaa tgcctctgtc
     7201 tctctttact gtttttaaga ccacagtagt cctgtcagta ggtctggaaa agtgtataag
     7261 catacatgtg ggcacttaga cagaggagct gacatttcag tgcctgggct aacagcccca
     7321 ggagcaggca ggattggagc tacagcctga ctacattgag ctatacctga ctatagggag
     7381 aggaccctag ccctttgttg tttttggaaa cagcagcagt gggtggtgtg ggcacagtat
     7441 agtagggagc acttcatctc agtttagttg cctcttgttc ttcttaacat attcgttcct
     7501 gttcctgcat ccccacctct tcagcatctt agtgttttcc tgctctgtac ctttgtctct
     7561 actgctattt ccttctttct cattctgaga actaccaaga gctccaggga cagcctgggg
     7621 acacatccca ggttccaagg tctcctgctc ctgagcccag atgtttcctc tgaaggcctc
     7681 tgacagtggc tcacaggatt ctgcacctga ggttctcttt cagtaaagat gttctgtggg
     7741 agttgggttt tttggggttt tttgtttttg tttttttcta agcattatgc aaaaagtttt
     7801 aagggcattt taaagaaaag ccagtttttc ttggcttttc caaacaacta tctgtggata
     7861 ctttgtttac tttgtgagta ttaaaatatg catcatcgct gtggcctcag gctctgaagc
     7921 catggttgtc ctatgagtcc tcccccagag aaaatgccat attattgtca gcccttgtgg
     7981 ataagtgggt cagctgtgga gccgatctcc ttctgtgtcc tgcactcgca tccagcagtc
     8041 ctttcttagt gctgatgtgt ctccatagtg atggtcgtga tggtgaatgg atagtatgat
     8101 tgtttggttt ttgattttta acggtagaca aggtgacatt ccgttgtttc agcaccaatc
     8161 caacttaaaa gatcatagac ttcgttatcc cttccaaact aaaagatcaa gcatgtattg
     8221 gacataagtg tatgcgttgc ctcgactcat ctggcaccca tattaggaaa aggcctgcca
     8281 ccaaagcagg aagctgcacg ctgctctccc cagggctttg ggacctcttg atgccatgaa
     8341 gagctattgc aaggtgcttc tgtactgctc cagcctgaag cagaggtgac taggcctgct
     8401 tctgctagga agagaaccag cctcatctca gtgccccaga gatctaggac aggatttcta
     8461 aactggaatc acctcttacc aacttgaaga gccccacccc accccaggta tagggctggt
     8521 gctgccatcg gccttcacag cgaagctggt ggcagcatcc tgtctacaga gagcaaatac
     8581 cccaaatgga aagctgagaa actgacatgt gtcctagtca gtaagcccac tgggaaatga
     8641 tgggttttgt tttatttgat tgatttgctt ggcgtagcaa aggtgccttt cccaccctcc
     8701 tccctttaaa ctttgttttg taagacttgt ttgaaaccca aacaagtcca aaagactcgc
     8761 actgactgtt acctttgtcc aggctatccc aaacttctct atgctctcat tttattaaaa
     8821 gcaggtgctc cctggaatct ctgggacctt tctgaggcat tcaaagcaga atataaagag
     8881 tggtctcatc tccttcctta atcctggtgg ttgggatgtc ccacttgtat catagttgtt
     8941 tttattatta ctgatgtgct ccgctgtttt taaatgtgaa cttgtgcgca gattcaatgt
     9001 tcttgttaca gattgaataa atttttattt tgaagacaaa
//
