LOCUS       NM_023672               3211 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus single-stranded DNA binding protein 3 (Ssbp3),
            transcript variant 1, mRNA.
ACCESSION   NM_023672 XM_993903
VERSION     NM_023672.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3211)
  AUTHORS   Toren,E., Kepple,J.D., Coutinho,K.V., Poole,S.O., Deeba,I.M.,
            Pierre,T.H., Liu,Y., Bethea,M.M. and Hunter,C.S.
  TITLE     The SSBP3 co-regulator is required for glucose homeostasis,
            pancreatic islet architecture, and beta-cell identity
  JOURNAL   Mol Metab 76, 101785 (2023)
   PUBMED   37536498
  REMARK    GeneRIF: The SSBP3 co-regulator is required for glucose
            homeostasis, pancreatic islet architecture, and beta-cell identity.
REFERENCE   2  (bases 1 to 3211)
  AUTHORS   Wade,A.K., Liu,Y., Bethea,M.M., Toren,E., Tse,H.M. and Hunter,C.S.
  TITLE     LIM-domain transcription complexes interact with ring-finger
            ubiquitin ligases and thereby impact islet beta-cell function
  JOURNAL   J Biol Chem 294 (31), 11728-11740 (2019)
   PUBMED   31186351
REFERENCE   3  (bases 1 to 3211)
  AUTHORS   Liu,J., Luo,X., Xu,Y., Gu,J., Tang,F., Jin,Y. and Li,H.
  TITLE     Single-stranded DNA binding protein Ssbp3 induces differentiation
            of mouse embryonic stem cells into trophoblast-like cells
  JOURNAL   Stem Cell Res Ther 7 (1), 79 (2016)
   PUBMED   27236334
  REMARK    GeneRIF: Ssbp3 induces differentiation of mouse embryonic stem
            cells into trophoblast-like cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3211)
  AUTHORS   Lee,B., Lee,S., Agulnick,A.D., Lee,J.W. and Lee,S.K.
  TITLE     Single-stranded DNA binding proteins are required for LIM complexes
            to induce transcriptionally active chromatin and specify spinal
            neuronal identities
  JOURNAL   Development 143 (10), 1721-1731 (2016)
   PUBMED   26965372
REFERENCE   5  (bases 1 to 3211)
  AUTHORS   Galloway,J.R., Bethea,M., Liu,Y., Underwood,R., Mobley,J.A. and
            Hunter,C.S.
  TITLE     SSBP3 Interacts With Islet-1 and Ldb1 to Impact Pancreatic
            beta-Cell Target Genes
  JOURNAL   Mol Endocrinol 29 (12), 1774-1786 (2015)
   PUBMED   26495868
  REMARK    GeneRIF: SSBP3 Interacts With Islet-1 and Ldb1 to Impact Pancreatic
            beta-Cell Target Genes
REFERENCE   6  (bases 1 to 3211)
  AUTHORS   Nishioka,N., Nagano,S., Nakayama,R., Kiyonari,H., Ijiri,T.,
            Taniguchi,K., Shawlot,W., Hayashizaki,Y., Westphal,H.,
            Behringer,R.R., Matsuda,Y., Sakoda,S., Kondoh,H. and Sasaki,H.
  TITLE     Ssdp1 regulates head morphogenesis of mouse embryos by activating
            the Lim1-Ldb1 complex
  JOURNAL   Development 132 (11), 2535-2546 (2005)
   PUBMED   15857913
  REMARK    GeneRIF: Ssdp1 regulates the development of late head organizer
            tissues and body growth by functioning as an essential activator
            component of a Lim1 complex through interaction with Ldb1.
REFERENCE   7  (bases 1 to 3211)
  AUTHORS   van Meyel,D.J., Thomas,J.B. and Agulnick,A.D.
  TITLE     Ssdp proteins bind to LIM-interacting co-factors and regulate the
            activity of LIM-homeodomain protein complexes in vivo
  JOURNAL   Development 130 (9), 1915-1925 (2003)
   PUBMED   12642495
REFERENCE   8  (bases 1 to 3211)
  AUTHORS   Chen,L., Segal,D., Hukriede,N.A., Podtelejnikov,A.V.,
            Bayarsaihan,D., Kennison,J.A., Ogryzko,V.V., Dawid,I.B. and
            Westphal,H.
  TITLE     Ssdp proteins interact with the LIM-domain-binding protein Ldb1 to
            regulate development
  JOURNAL   Proc Natl Acad Sci U S A 99 (22), 14320-14325 (2002)
   PUBMED   12381786
REFERENCE   9  (bases 1 to 3211)
  AUTHORS   Bayarsaihan,D.
  TITLE     SSDP1 gene encodes a protein with a conserved N-terminal FORWARD
            domain
  JOURNAL   Biochim Biophys Acta 1599 (1-2), 152-155 (2002)
   PUBMED   12479417
REFERENCE   10 (bases 1 to 3211)
  AUTHORS   Raval-Fernandes,S., Kickhoefer,V.A. and Rome,L.H.
  TITLE     Cloning of a cDNA encoding a sequence-specific
            single-stranded-DNA-binding protein from Rattus norvegicus
  JOURNAL   Gene 237 (1), 201-207 (1999)
   PUBMED   10524251
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK017711.1, AK011853.1,
            CO429463.1, CX200383.1 and AI854733.1.
            
            On or before Aug 25, 2006 this sequence version replaced
            XM_993903.1, NM_023672.1.
            
            Summary: This gene encodes a member of the Ssdp (sequence-specific
            single-stranded DNA binding protein) family of proteins. The
            encoded protein binds specifically to single-stranded
            pyrimidine-rich DNA elements. The encoded protein has been shown to
            be important for head development and may play a role in the
            differentiation of spinal interneurons. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Apr
            2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK017711.1, AK011853.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-583               AK017711.1         2-584
            584-1114            AK011853.1         554-1084
            1115-1508           AK017711.1         1119-1512
            1509-1811           AK011853.1         1479-1781
            1812-2046           AK017711.1         1816-2050
            2047-2664           CO429463.1         11-628
            2665-3127           CX200383.1         103-565
            3128-3211           AI854733.1         1-84                c
FEATURES             Location/Qualifiers
     source          1..3211
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 49.9 cM"
     gene            1..3211
                     /gene="Ssbp3"
                     /gene_synonym="2610021L12Rik; 2610200M23Rik;
                     5730488C10Rik; LAST; SSDP1"
                     /note="single-stranded DNA binding protein 3"
                     /db_xref="GeneID:72475"
                     /db_xref="MGI:MGI:1919725"
     exon            1..443
                     /gene="Ssbp3"
                     /gene_synonym="2610021L12Rik; 2610200M23Rik;
                     5730488C10Rik; LAST; SSDP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             388..1554
                     /gene="Ssbp3"
                     /gene_synonym="2610021L12Rik; 2610200M23Rik;
                     5730488C10Rik; LAST; SSDP1"
                     /note="isoform a is encoded by transcript variant 1;
                     Lck-associated signal transducer; sequence-specific
                     single-stranded-DNA-binding protein"
                     /codon_start=1
                     /product="single-stranded DNA-binding protein 3 isoform a"
                     /protein_id="NP_076161.2"
                     /db_xref="CCDS:CCDS18427.1"
                     /db_xref="GeneID:72475"
                     /db_xref="MGI:MGI:1919725"
                     /translation="MFAKGKGSAVPSDGQAREKLALYVYEYLLHVGAQKSAQTFLSEI
                     RWEKNITLGEPPGFLHSWWCVFWDLYCAAPERRDTCEHSSEAKAFHDYSAAAAPSPVL
                     GNIPPNDGMPGGPIPPGFFQGPPGSQPSPHAQPPPHNPSSMMGPHSQPFMSPRYAGGP
                     RPPIRMGNQPPGGVPGTQPLLPNSMDPTRQQGHPNMGGSMQRMNPPRGMGPMGPGPQN
                     YGSGMRPPPNSLGPAMPGINMGPGAGRPWPNPNSANSIPYSSSSPGTYVGPPGGGGPP
                     GTPIMPSPADSTNSSDNIYTMINPVPPGGSRSNFPMGPGSDGPMGGMGGMEPHHMNGS
                     LGSGDIDGLPKNSPNNISGISNPPGTPRDDGELGGNFLHSFQNDNYSPSMTMSV"
     exon            444..516
                     /gene="Ssbp3"
                     /gene_synonym="2610021L12Rik; 2610200M23Rik;
                     5730488C10Rik; LAST; SSDP1"
                     /inference="alignment:Splign:2.1.0"
     exon            517..578
                     /gene="Ssbp3"
                     /gene_synonym="2610021L12Rik; 2610200M23Rik;
                     5730488C10Rik; LAST; SSDP1"
                     /inference="alignment:Splign:2.1.0"
     exon            579..663
                     /gene="Ssbp3"
                     /gene_synonym="2610021L12Rik; 2610200M23Rik;
                     5730488C10Rik; LAST; SSDP1"
                     /inference="alignment:Splign:2.1.0"
     exon            664..753
                     /gene="Ssbp3"
                     /gene_synonym="2610021L12Rik; 2610200M23Rik;
                     5730488C10Rik; LAST; SSDP1"
                     /inference="alignment:Splign:2.1.0"
     exon            754..834
                     /gene="Ssbp3"
                     /gene_synonym="2610021L12Rik; 2610200M23Rik;
                     5730488C10Rik; LAST; SSDP1"
                     /inference="alignment:Splign:2.1.0"
     exon            835..894
                     /gene="Ssbp3"
                     /gene_synonym="2610021L12Rik; 2610200M23Rik;
                     5730488C10Rik; LAST; SSDP1"
                     /inference="alignment:Splign:2.1.0"
     exon            895..961
                     /gene="Ssbp3"
                     /gene_synonym="2610021L12Rik; 2610200M23Rik;
                     5730488C10Rik; LAST; SSDP1"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1038
                     /gene="Ssbp3"
                     /gene_synonym="2610021L12Rik; 2610200M23Rik;
                     5730488C10Rik; LAST; SSDP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1103
                     /gene="Ssbp3"
                     /gene_synonym="2610021L12Rik; 2610200M23Rik;
                     5730488C10Rik; LAST; SSDP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..1152
                     /gene="Ssbp3"
                     /gene_synonym="2610021L12Rik; 2610200M23Rik;
                     5730488C10Rik; LAST; SSDP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1153..1188
                     /gene="Ssbp3"
                     /gene_synonym="2610021L12Rik; 2610200M23Rik;
                     5730488C10Rik; LAST; SSDP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..1243
                     /gene="Ssbp3"
                     /gene_synonym="2610021L12Rik; 2610200M23Rik;
                     5730488C10Rik; LAST; SSDP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1244..1314
                     /gene="Ssbp3"
                     /gene_synonym="2610021L12Rik; 2610200M23Rik;
                     5730488C10Rik; LAST; SSDP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1393
                     /gene="Ssbp3"
                     /gene_synonym="2610021L12Rik; 2610200M23Rik;
                     5730488C10Rik; LAST; SSDP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1394..1422
                     /gene="Ssbp3"
                     /gene_synonym="2610021L12Rik; 2610200M23Rik;
                     5730488C10Rik; LAST; SSDP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1423..1524
                     /gene="Ssbp3"
                     /gene_synonym="2610021L12Rik; 2610200M23Rik;
                     5730488C10Rik; LAST; SSDP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1525..3195
                     /gene="Ssbp3"
                     /gene_synonym="2610021L12Rik; 2610200M23Rik;
                     5730488C10Rik; LAST; SSDP1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      3052
                     /gene="Ssbp3"
                     /gene_synonym="2610021L12Rik; 2610200M23Rik;
                     5730488C10Rik; LAST; SSDP1"
     regulatory      3171..3176
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ssbp3"
                     /gene_synonym="2610021L12Rik; 2610200M23Rik;
                     5730488C10Rik; LAST; SSDP1"
                     /note="hexamer: ATTAAA"
     polyA_site      3195
                     /gene="Ssbp3"
                     /gene_synonym="2610021L12Rik; 2610200M23Rik;
                     5730488C10Rik; LAST; SSDP1"
                     /note="major polyA site"
ORIGIN      
        1 agccacgttc ggttgagctc caagtagacc agcggcggcg gcggcggcag cggcagcggt
       61 gctgaaggcg cagagggcgg cgcaggcgga gccgggcggc gggcgcgcgg gccgcgagca
      121 agcgagctgc aggcttcggg cgggcggcgg cgcagctcag gccgagccgg cgcgggagga
      181 gttccagggc gatggggccg cggccggggc tgacgctttg acagctggaa agagcgcgga
      241 gcctgcgcct gggagggagg gagcgcggcg agcggagtgc gagcgagcgg gcgagcgccg
      301 ggagggggcc gggagcaggg cagctcggga gaccggacgg tagcggcggc ggcggcggcg
      361 ggctcggcgc cctcttctct gcaagccatg tttgccaaag gcaaaggctc ggcggtgccc
      421 tcggacgggc aggctcggga aaagttagct ttatacgtct acgaatattt actgcacgta
      481 ggagcacaga aatctgcaca gaccttctta tcagagattc gatgggaaaa aaacatcaca
      541 ctgggtgaac cgcctgggtt cctgcactcg tggtggtgtg tattttggga cctttactgt
      601 gcagctcctg aaaggagaga cacttgtgaa cattcaagtg aagcaaaagc ctttcatgat
      661 tatagtgcag cagctgcccc aagccctgtg cttggcaaca ttccccccaa tgatgggatg
      721 cccggaggcc ccatcccgcc aggtttcttt cagggtcctc cggggtcaca gccctcgccg
      781 cacgcacagc ctccacctca caatcccagc agcatgatgg gaccccacag tcagcctttt
      841 atgtcaccgc gatatgcagg cggccccagg cccccgatca gaatgggaaa ccagcctcca
      901 ggaggagttc ctgggacaca gccactgctg cccaattcca tggatcccac acgacaacaa
      961 ggtcacccca acatgggagg atcaatgcag agaatgaacc ctccccgagg catggggccc
     1021 atggggcctg gcccacagaa ttacggcagc ggcatgagac caccacccaa ctccctcggc
     1081 cccgccatgc ctgggattaa catgggccca ggagctggca gaccctggcc caatcccaac
     1141 agtgctaact caatcccgta ctcctcatca tcacccggaa cctatgtggg accccctggt
     1201 ggtggtggcc ctccaggaac ccccatcatg cctagtcctg cagattcaac aaattccagt
     1261 gacaacatct acacaatgat taatcctgtg ccgcctggag gcagccggtc taactttcca
     1321 atgggtcctg gctcagacgg cccaatggga ggcatgggcg gcatggagcc ccaccacatg
     1381 aatggatccc taggatcagg tgacatagat ggacttccaa aaaattctcc taacaacata
     1441 agtggcatta gcaatcctcc aggcacccct cgcgatgacg gcgagctagg ggggaacttc
     1501 ctccactcct tccagaacga caattattct ccgagcatga cgatgagcgt gtgaccccct
     1561 ccgagacgct gggagccagc attgcaggca gaagatgcca agaattatgc aagaagtgag
     1621 gtgtccatac caggagctgg gggagggcat ctcctgctcc ctccaccctc ccattcactc
     1681 ccccaccttc cccaatttta gtttcatgca ataaaaaggc caaactttta ttccgtaaaa
     1741 catgaaggac aaaactcaaa aatatatttc aagtcaacgg ccagaaaact ctcaccttct
     1801 tcccgcccaa aaggaccttt ctgtacatga cactttttgt tggttttttt gtttgtttgg
     1861 gattttaccg ttgctgggat tttaaatttg tttttttttt cccggggtgg ggggtgttct
     1921 ttgggggaat ttttttttta atggaagctt ctagcaagcc ctatgcccca ccccaatcaa
     1981 cctctttgct ttcttcttta aaaaaaggaa aaaaggaaaa agaaaaaaaa ggaaaaagaa
     2041 aaaaaaggcc aaaaaaaaaa aaaaaaaagg aagaaaaccc cacaagccct gctgtctgtc
     2101 cccaagtcct accaccagaa aagctggtct aggtgtgcag tgtcacactg acgttgtagc
     2161 catctaaaat aataataata aactggacag tttgcaattg ctggtttatt tcaaaagctg
     2221 tttggggaaa aggaacagaa accaaccctt tccacatggg ccttggggtt tgcaaagctg
     2281 ggcgaggaga tgcaggtgtc agctttgctc tggcttgact ggccatcaca acacactggg
     2341 ccagaggacc cagagcctgc tgtcacccaa cagagaccat cgctgtgatc cagcgtacac
     2401 actgttccag gatggctgcc tcttctccag acctctcgtg ccaagccact ggggcctcca
     2461 gtctttcgat ccccaccgtt tcctggcaag agtcctgctg gctgggtagt ggcccaggcc
     2521 aaggaggaga ggccccgcca acgggatgac tacaatctgg gccatagccc tgacctccat
     2581 attctggtcc cgagctcctc acatagtgcg cactggcagg gcaggctgag gttgtggttt
     2641 tctttttttt cctcctgttt gtcctttttc agagatgggt gttggttgga attgctctgt
     2701 atttgcttgg gactggatgg acagacttcg gcattgctgt gggggtgggg gagcaccagc
     2761 aaccaaacag acactgtttc tggtcctgtt tttattttca aaaaccgatg aacctgatga
     2821 tggagcctgt cccctccgag gaggggtgac ttggctgccc tggcctctcc ccgtggcaac
     2881 ctttgtgtct tgccccggaa gacactgagt tcattgtaca tgtacaccct ctgcgccctg
     2941 cccacccttg tagctggtct ttgttttctt acctcccctt tctgacccat gtatatcata
     3001 ttatgtgaga taccatctgc ctgaaaaaag accttgtgcg gattcttggg aacattgtag
     3061 ctgtttctgt gttttttctt accttgtagt ctggttctga attatgagag gaaaaaaaaa
     3121 gtaattatga tacattgtag tttgtgtacg atatatgttg ataacgtttt attaaaggga
     3181 catctttttt ccgcaaaaaa aaaaaaaaaa a
//
