LOCUS       NM_009278               2088 bp    mRNA    linear   ROD 17-DEC-2022
DEFINITION  Mus musculus small RNA binding exonuclease protection factor La
            (Ssb), transcript variant 1, mRNA.
ACCESSION   NM_009278
VERSION     NM_009278.4
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2088)
  AUTHORS   Yang N, Zhang Q, Ye S, Lu T, Sun M, Wang L, Wang M, Pan YH, Dang S
            and Zhang W.
  TITLE     Adamts18 Deficiency Causes Spontaneous SMG Fibrogenesis in Adult
            Mice
  JOURNAL   J Dent Res 101 (2), 226-234 (2022)
   PUBMED   34323105
REFERENCE   2  (bases 1 to 2088)
  AUTHORS   Ha N, Ding N, Hong R, Liu R, Roca X, Luo Y, Duan X, Wang X, Ni P,
            Wu H, Zhang LF and Chen L.
  TITLE     The lupus autoantigen La/Ssb is an Xist-binding protein involved in
            Xist folding and cloud formation
  JOURNAL   Nucleic Acids Res 49 (20), 11596-11613 (2021)
   PUBMED   34723322
  REMARK    GeneRIF: The lupus autoantigen La/Ssb is an Xist-binding protein
            involved in Xist folding and cloud formation.
REFERENCE   3  (bases 1 to 2088)
  AUTHORS   Blewett NH, Iben JR, Gaidamakov S and Maraia RJ.
  TITLE     La Deletion from Mouse Brain Alters Pre-tRNA Metabolism and
            Accumulation of Pre-5.8S rRNA, with Neuron Death and Reactive
            Astrocytosis
  JOURNAL   Mol Cell Biol 37 (10), e00588-16 (2017)
   PUBMED   28223366
  REMARK    GeneRIF: La deletion is associated with Neuron Death and Reactive
            Astrocytosis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2088)
  AUTHORS   Gaidamakov S, Maximova OA, Chon H, Blewett NH, Wang H, Crawford AK,
            Day A, Tulchin N, Crouch RJ, Morse HC 3rd, Blitzer RD and Maraia
            RJ.
  TITLE     Targeted deletion of the gene encoding the La autoantigen
            (Sjogren's syndrome antigen B) in B cells or the frontal brain
            causes extensive tissue loss
  JOURNAL   Mol Cell Biol 34 (1), 123-131 (2014)
   PUBMED   24190965
  REMARK    GeneRIF: Data indicate that La antigen (Sjogren's syndrome antigen
            B) is essential in different cell types and required for normal
            development of various tissue types.
REFERENCE   5  (bases 1 to 2088)
  AUTHORS   Petz M, Them NC, Huber H and Mikulits W.
  TITLE     PDGF enhances IRES-mediated translation of Laminin B1 by
            cytoplasmic accumulation of La during epithelial to mesenchymal
            transition
  JOURNAL   Nucleic Acids Res 40 (19), 9738-9749 (2012)
   PUBMED   22904067
REFERENCE   6  (bases 1 to 2088)
  AUTHORS   Tran HB, Ohlsson M, Beroukas D, Hiscock J, Bradley J, Buyon JP and
            Gordon TP.
  TITLE     Subcellular redistribution of la/SSB autoantigen during physiologic
            apoptosis in the fetal mouse heart and conduction system: a clue to
            the pathogenesis of congenital heart block
  JOURNAL   Arthritis Rheum 46 (1), 202-208 (2002)
   PUBMED   11817591
REFERENCE   7  (bases 1 to 2088)
  AUTHORS   Maraia RJ and Intine RV.
  TITLE     Recognition of nascent RNA by the human La antigen: conserved and
            divergent features of structure and function
  JOURNAL   Mol Cell Biol 21 (2), 367-379 (2001)
   PUBMED   11134326
  REMARK    Review article
REFERENCE   8  (bases 1 to 2088)
  AUTHORS   Sobel SG and Wolin SL.
  TITLE     Two yeast La motif-containing proteins are RNA-binding proteins
            that associate with polyribosomes
  JOURNAL   Mol Biol Cell 10 (11), 3849-3862 (1999)
   PUBMED   10564276
REFERENCE   9  (bases 1 to 2088)
  AUTHORS   McIndoe RA, Bohlman B, Chi E, Schuster E, Lindhardt M and Hood L.
  TITLE     Localization of non-Mhc collagen-induced arthritis susceptibility
            loci in DBA/1j mice
  JOURNAL   Proc Natl Acad Sci U S A 96 (5), 2210-2214 (1999)
   PUBMED   10051620
REFERENCE   10 (bases 1 to 2088)
  AUTHORS   Topfer F, Gordon T and McCluskey J.
  TITLE     Characterization of the mouse autoantigen La (SS-B). Identification
            of conserved RNA-binding motifs, a putative ATP binding site and
            reactivity of recombinant protein with poly(U) and human
            autoantibodies
  JOURNAL   J Immunol 150 (7), 3091-3100 (1993)
   PUBMED   8454877
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL845261.17, BX322634.4 and AL929249.15.
            
            [WARNING] On May 10, 2023 this sequence was replaced by
            NM_009278.5.
            
            On Oct 25, 2007 this sequence version replaced NM_009278.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (a). Variants 1 and 2
            both encode the same isoform (a).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L00993.1, SRR1660813.64149.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN00849385
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-178               AL845261.17        178424-178601
            179-270             AL845261.17        180086-180177
            271-374             BX322634.4         2682-2785
            375-549             BX322634.4         2980-3154
            550-657             BX322634.4         3764-3871
            658-708             BX322634.4         3944-3994
            709-758             AL929249.15        2001-2050
            759-830             AL929249.15        3277-3348
            831-870             AL929249.15        3640-3679
            871-1011            AL929249.15        4378-4518
            1012-1207           AL929249.15        4883-5078
            1208-1363           AL929249.15        5176-5331
            1364-2088           AL929249.15        5620-6344
FEATURES             Location/Qualifiers
     source          1..2088
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 40.95 cM"
     gene            1..2088
                     /gene="Ssb"
                     /gene_synonym="SS-B"
                     /note="small RNA binding exonuclease protection factor La"
                     /db_xref="GeneID:20823"
                     /db_xref="MGI:MGI:98423"
     exon            1..178
                     /gene="Ssb"
                     /gene_synonym="SS-B"
                     /inference="alignment:Splign:2.1.0"
     exon            179..270
                     /gene="Ssb"
                     /gene_synonym="SS-B"
                     /inference="alignment:Splign:2.1.0"
     CDS             205..1452
                     /gene="Ssb"
                     /gene_synonym="SS-B"
                     /note="isoform a is encoded by transcript variant 1; la
                     ribonucleoprotein; la autoantigen homolog; autoantigen La;
                     La protein; Lupus LA protein homolog (LA
                     ribonucleoprotein) (LA autoantigen homolog); Sjogren
                     syndrome antigen B"
                     /codon_start=1
                     /product="lupus La protein homolog isoform a"
                     /protein_id="NP_033304.1"
                     /db_xref="CCDS:CCDS16101.1"
                     /db_xref="GeneID:20823"
                     /db_xref="MGI:MGI:98423"
                     /translation="MAENGDNEKMTALEAKICHQIEYYFGDFNLPRDKFLKEQIKLDE
                     GWVPLETMIKFNRLNRLTTDFNVIVQALSKSKAKLMEVSADKTKIRRSPSRPLPEVTD
                     EYKNDVKNRSVYIKGFPTDATLDDIKEWLDDKGQILNIQMRRTLHKTFKGSIFAVFDS
                     IQSAKKFVEIPGQKYKDTNLLILFKEDYFAKKNEERKQSKVEAKLKAKQEHEGRHKPG
                     STETRALEGKMGCLLKFSGDLDDQTCREDLHFLFSNHGEIKWVDFARGAKEGIILFKE
                     KAKEALEKARNANNGNLLLRNKKVTWKVLEGHAEKEALKKITDDQQESLNKWKSKGGH
                     AGGRFKGSHVFTAARRFKGKGKGNRPGYAGAPKGRGQFHGRRTRFDDDDRRRGPMKRG
                     RDGRDREEPASKHKKRENGARDK"
     exon            271..374
                     /gene="Ssb"
                     /gene_synonym="SS-B"
                     /inference="alignment:Splign:2.1.0"
     exon            375..549
                     /gene="Ssb"
                     /gene_synonym="SS-B"
                     /inference="alignment:Splign:2.1.0"
     exon            550..657
                     /gene="Ssb"
                     /gene_synonym="SS-B"
                     /inference="alignment:Splign:2.1.0"
     exon            658..758
                     /gene="Ssb"
                     /gene_synonym="SS-B"
                     /inference="alignment:Splign:2.1.0"
     exon            759..830
                     /gene="Ssb"
                     /gene_synonym="SS-B"
                     /inference="alignment:Splign:2.1.0"
     exon            831..870
                     /gene="Ssb"
                     /gene_synonym="SS-B"
                     /inference="alignment:Splign:2.1.0"
     exon            871..1011
                     /gene="Ssb"
                     /gene_synonym="SS-B"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1207
                     /gene="Ssb"
                     /gene_synonym="SS-B"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1363
                     /gene="Ssb"
                     /gene_synonym="SS-B"
                     /inference="alignment:Splign:2.1.0"
     exon            1364..2088
                     /gene="Ssb"
                     /gene_synonym="SS-B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1732..1737
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ssb"
                     /gene_synonym="SS-B"
     polyA_site      1752
                     /gene="Ssb"
                     /gene_synonym="SS-B"
ORIGIN      
        1 tgcgtccgcg gccacgccca cctgtccgca agggctgccg ggaaagcccc catctttaag
       61 cgcgtttggc tggcccgccg gcgctcggaa gtccaggcgc ttctgtcgtt gttcttgaag
      121 ctgtggtgac cgtgggatcc gaatctttga ggtgagcttc ttggaaactg aggagaagtg
      181 tgagaaactt tacagatagc cacaatggct gaaaatggag ataatgaaaa aatgactgct
      241 ttggaggcca aaatctgtca tcaaattgag tattattttg gagacttcaa tttgccacga
      301 gacaagtttt taaaagaaca gatcaaattg gatgaaggct gggtaccttt ggaaacaatg
      361 ataaaattca acaggctaaa ccggctgaca acagacttta atgtaattgt gcaagcactg
      421 agcaaatcta aggcaaaact catggaagtc agtgcagaca aaactaaaat tagaagatca
      481 ccaagcagac cactccctga agtgacggat gagtataaga atgatgtaaa aaacagatct
      541 gtttatatta aaggtttccc aactgacgcc acccttgatg atataaaaga atggctagac
      601 gataaaggcc aaatactgaa tattcaaatg agaagaacat tacacaaaac atttaagggg
      661 tcaatatttg ctgtgtttga tagtattcag tctgcaaaga agtttgtgga gatccctggc
      721 cagaagtaca aagacactaa cctgctaata ctctttaagg aagattactt tgcaaaaaaa
      781 aatgaagaaa gaaagcagag caaagtggaa gctaaattaa aagctaaaca agagcatgaa
      841 ggaagacaca agccaggaag tactgaaacc agagctctag aaggaaagat gggatgctta
      901 ctgaagtttt caggtgactt ggatgaccag acctgtagag aagatttaca cttccttttc
      961 tcaaatcatg gtgaaataaa atgggtcgac tttgccagag gagcaaaaga gggaataatt
     1021 ctcttcaaag aaaaggctaa ggaagcactt gagaaagcca gaaatgcaaa taatggtaac
     1081 ctactgttaa ggaacaaaaa ggtgacttgg aaagtactag aaggacatgc ggaaaaagaa
     1141 gcattgaaaa aaatcacaga tgatcagcaa gaatccctaa acaaatggaa gtcaaaagga
     1201 gggcatgcag gtggaagatt taaaggaagc catgttttta cagcagcccg cagatttaaa
     1261 ggaaaaggga agggtaatag gcctggttat gctggggcac ccaaaggaag aggacagttt
     1321 catggaagga ggacaagatt tgatgatgat gatcgtcgtc gtggaccaat gaaaagagga
     1381 agagatggaa gagacagaga agaacccgca tcaaagcata agaaaagaga aaatggtgct
     1441 agagacaagt agtttattta gtaagcagtg tttttattcc ttagttagat tttaagctgc
     1501 tttttgtctt cagaagcttt taaaaagaaa agcgaattag gtccacttcg atgtccacct
     1561 gtataaaagg aaaaaatttt tgttttactt gtcttctttt tgttgttatc caaatgaaag
     1621 ttttttaaaa tgtatagttc tgtttgtgtt tggatgatta aaatatgaga aggaagattc
     1681 ttcctcttaa ttgcctttgt aatatgagaa tgtattagta cagacttgta aaatatatac
     1741 tgtataaaaa tagccaatag ttctttcttc tttttatttc tcttaaaacg tttcacaaag
     1801 aacttcaact aaaatattga ctcttgcgag tataagccct tcttcccaca gctaatttgt
     1861 ctaatctctc aggctgactt tatatttacc catttacctt ggtaagagtg gaaatgacca
     1921 ttacaaaagc ttttgaatac tggatgtaca cagactacaa ttggaaaact tacagatttc
     1981 tttttatgaa agttgtataa tgctggtaga tcatatcgaa gctctgttaa aaaaaaaagc
     2041 caaacattca tatttaagat attaaatact gatatgcata acatctga
//
