LOCUS       NM_011564               1188 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus sex determining region of Chr Y (Sry), mRNA.
ACCESSION   NM_011564
VERSION     NM_011564.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1188)
  AUTHORS   Bobotis,B.C., Khakpour,M., Braniff,O., de Andrade,E.G., Gargus,M.,
            Allen,M., Carrier,M., Baillargeon,J., Rangachari,M. and
            Tremblay,M.E.
  TITLE     Sex chromosomes and sex hormones differently shape microglial
            properties during normal physiological conditions in the adult
            mouse hippocampus
  JOURNAL   J Neuroinflammation 22 (1), 18 (2025)
   PUBMED   39856696
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1188)
  AUTHORS   Zhang,P., Munier,J.J., Wiese,C.B., Vergnes,L., Link,J.C.,
            Abbasi,F., Ronquillo,E., Scheker,K., Munoz,A., Kuang,Y.L.,
            Theusch,E., Lu,M., Sanchez,G., Oni-Orisan,A., Iribarren,C.,
            McPhaul,M.J., Nomura,D.K., Knowles,J.W., Krauss,R.M., Medina,M.W.
            and Reue,K.
  TITLE     X chromosome dosage drives statin-induced dysglycemia and
            mitochondrial dysfunction
  JOURNAL   Nat Commun 15 (1), 5571 (2024)
   PUBMED   38956041
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1188)
  AUTHORS   Fang,P., Yu,L.W., Espey,H., Agirman,G., Kazmi,S.A., Li,K., Deng,Y.,
            Lee,J., Hrncir,H., Romero-Lopez,A., Arnold,A.P. and Hsiao,E.Y.
  TITLE     Sex-dependent interactions between prodromal intestinal
            inflammation and LRRK2 G2019S in mice promote endophenotypes of
            Parkinson's disease
  JOURNAL   Commun Biol 7 (1), 570 (2024)
   PUBMED   38750146
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1188)
  AUTHORS   Morin-Grandmont,A., Walsh-Wilkinson,E., Labbe,E.A., Thibodeau,S.E.,
            Dupont,E., Boudreau,D.K., Arsenault,M., Bosse,Y. and Couet,J.
  TITLE     Biological sex, sex steroids and sex chromosomes contribute to
            mouse cardiac aging
  JOURNAL   Aging (Albany NY) 16 (9), 7553-7577 (2024)
   PUBMED   38742935
REFERENCE   5  (bases 1 to 1188)
  AUTHORS   Hurtado,A., Mota-Gomez,I., Lao,M., Real,F.M., Jedamzick,J.,
            Burgos,M., Lupianez,D.G., Jimenez,R. and Barrionuevo,F.J.
  TITLE     Complete male-to-female sex reversal in XY mice lacking the
            miR-17~92 cluster
  JOURNAL   Nat Commun 15 (1), 3809 (2024)
   PUBMED   38714644
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1188)
  AUTHORS   Denny,P., Swift,S., Connor,F. and Ashworth,A.
  TITLE     An SRY-related gene expressed during spermatogenesis in the mouse
            encodes a sequence-specific DNA-binding protein
  JOURNAL   EMBO J 11 (10), 3705-3712 (1992)
   PUBMED   1396566
REFERENCE   7  (bases 1 to 1188)
  AUTHORS   Gubbay,J., Vivian,N., Economou,A., Jackson,D., Goodfellow,P. and
            Lovell-Badge,R.
  TITLE     Inverted repeat structure of the Sry locus in mice
  JOURNAL   Proc Natl Acad Sci U S A 89 (17), 7953-7957 (1992)
   PUBMED   1518820
REFERENCE   8  (bases 1 to 1188)
  AUTHORS   Kunieda,T. and Toyoda,Y.
  TITLE     Nucleotide sequence of mouse Sry gene is different between Y
            chromosome originating from Mus musculus musculus and Mus musculus
            domesticus
  JOURNAL   Genomics 13 (1), 236-237 (1992)
   PUBMED   1349578
REFERENCE   9  (bases 1 to 1188)
  AUTHORS   Jackson-Grusby,L., Kuo,A. and Leder,P.
  TITLE     A variant limb deformity transcript expressed in the embryonic
            mouse limb defines a novel formin
  JOURNAL   Genes Dev 6 (1), 29-37 (1992)
   PUBMED   1339380
REFERENCE   10 (bases 1 to 1188)
  AUTHORS   Nagamine,C.M., Nishioka,Y., Moriwaki,K., Boursot,P., Bonhomme,F.
            and Lau,Y.F.
  TITLE     The musculus-type Y chromosome of the laboratory mouse is of Asian
            origin
  JOURNAL   Mamm Genome 3 (2), 84-91 (1992)
   PUBMED   1352158
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from X67204.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1188
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="129"
                     /db_xref="taxon:10090"
                     /chromosome="Y"
                     /map="Y"
     gene            1..1188
                     /gene="Sry"
                     /gene_synonym="Tdf; Tdy"
                     /note="sex determining region of Chr Y"
                     /db_xref="GeneID:21674"
                     /db_xref="MGI:MGI:98660"
     CDS             1..1188
                     /gene="Sry"
                     /gene_synonym="Tdf; Tdy"
                     /function="sexual differentiation"
                     /note="testis-determining factor; testis determining-Y"
                     /codon_start=1
                     /product="sex-determining region Y protein"
                     /protein_id="NP_035694.1"
                     /db_xref="CCDS:CCDS30545.1"
                     /db_xref="GeneID:21674"
                     /db_xref="MGI:MGI:98660"
                     /translation="MEGHVKRPMNAFMVWSRGERHKLAQQNPSMQNTEISKQLGCRWK
                     SLTEAEKRPFFQEAQRLKILHREKYPNYKYQPHRRAKVSQRSGILQPAVASTKLYNLL
                     QWDRNPHAITYRQDWSRAAHLYSKNQQSFYWQPVDIPTGHLQQQQQQQQQQQFHNHHQ
                     QQQQFYDHHQQQQQQQQQQQQFHDHHQQKQQFHDHHQQQQQFHDHHHHHQEQQFHDHH
                     QQQQQFHDHQQQQQQQQQQQFHDHHQQKQQFHDHHHHQQQQQFHDHQQQQQQFHDHQQ
                     QQHQFHDHPQQKQQFHDHPQQQQQFHDHHHQQQQKQQFHDHHQQKQQFHDHHQQKQQF
                     HDHHQQQQQFHDHHQQQQQQQQQQQQQFHDQQLTYLLTADITGEHTPYQEHLSTALWL
                     AVS"
     exon            1..1188
                     /gene="Sry"
                     /gene_synonym="Tdf; Tdy"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggagggcc atgtcaagcg ccccatgaat gcatttatgg tgtggtcccg tggtgagagg
       61 cacaagttgg cccagcagaa tcccagcatg caaaatacag agatcagcaa gcagctggga
      121 tgcaggtgga aaagccttac agaagccgaa aaaaggccct ttttccagga ggcacagaga
      181 ttgaagatcc tacacagaga gaaataccca aactataaat atcagcctca tcggagggct
      241 aaagtgtcac agaggagtgg cattttacag cctgcagttg cctcaacaaa actgtacaac
      301 cttctgcagt gggacaggaa cccacatgcc atcacataca ggcaagactg gagtagagct
      361 gcacacctgt actccaaaaa ccagcaaagc ttttattggc agcctgttga tatccccact
      421 gggcacctgc agcagcagca gcagcagcag cagcagcagc agttccataa ccaccaccag
      481 cagcaacagc agttctatga ccaccaccag cagcagcagc agcagcagca gcagcagcag
      541 cagttccatg accaccacca gcagaagcag cagtttcatg accaccacca gcagcaacag
      601 cagttccatg accaccacca ccaccaccag gagcagcagt tccatgacca ccaccagcag
      661 caacagcagt tccatgacca ccagcagcag cagcagcagc agcagcagca gcagttccat
      721 gaccaccacc agcagaagca gcagttccat gaccaccacc accaccaaca gcagcagcag
      781 ttccatgacc accagcagca gcagcagcag ttccatgacc accagcagca gcagcatcag
      841 ttccatgacc acccccagca gaagcagcag ttccatgacc acccccagca gcaacagcag
      901 ttccatgacc accaccacca gcagcagcag aagcagcagt tccatgacca ccaccagcag
      961 aagcagcagt tccatgacca ccaccagcag aagcagcagt tccatgacca ccaccagcag
     1021 caacagcagt tccatgacca ccaccagcag cagcagcagc agcagcagca gcagcagcag
     1081 cagttccacg accagcagct tacctactta ctaacagctg acatcactgg tgagcataca
     1141 ccataccagg agcacctcag cacagccctg tggttggcag tctcatga
//
