LOCUS       NM_029688               2828 bp    mRNA    linear   ROD 05-MAR-2024
DEFINITION  Mus musculus sulfiredoxin 1 homolog (S. cerevisiae) (Srxn1), mRNA.
ACCESSION   NM_029688
VERSION     NM_029688.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2828)
  AUTHORS   Yuan,J., Yu,Z., Zhang,P., Luo,K., Xu,Y., Lan,T., Zhang,M., Chen,Y.
            and Lu,Z.
  TITLE     DDAH1 recruits peroxiredoxin 1 and sulfiredoxin 1 to preserve its
            activity and regulate intracellular redox homeostasis
  JOURNAL   Redox Biol 70, 103080 (2024)
   PUBMED   38354630
  REMARK    GeneRIF: DDAH1 recruits peroxiredoxin 1 and sulfiredoxin 1 to
            preserve its activity and regulate intracellular redox homeostasis.
REFERENCE   2  (bases 1 to 2828)
  AUTHORS   Rius-Perez,S., Perez,S., Toledano,M.B. and Sastre,J.
  TITLE     p53 drives necroptosis via downregulation of sulfiredoxin and
            peroxiredoxin 3
  JOURNAL   Redox Biol 56, 102423 (2022)
   PUBMED   36029648
REFERENCE   3  (bases 1 to 2828)
  AUTHORS   Kim,T., Li,D., Terasaka,T., Nicholas,D.A., Knight,V.S., Yang,J.J.
            and Lawson,M.A.
  TITLE     SRXN1 Is Necessary for Resolution of GnRH-Induced Oxidative Stress
            and Induction of Gonadotropin Gene Expression
  JOURNAL   Endocrinology 160 (11), 2543-2555 (2019)
   PUBMED   31504396
  REMARK    GeneRIF: essential for normal responses to GnRH stimulation and
            plays an important role in reactive oxygen species management
REFERENCE   4  (bases 1 to 2828)
  AUTHORS   Shen,Y., Chen,S. and Zhao,Y.
  TITLE     Sulfiredoxin-1 alleviates high glucose-induced podocyte injury
            though promoting Nrf2/ARE signaling via inactivation of GSK-3beta
  JOURNAL   Biochem Biophys Res Commun 516 (4), 1137-1144 (2019)
   PUBMED   31284950
  REMARK    GeneRIF: These results demonstrated that Srxn1 protects podocytes
            from high glucose-induced injury by promoting the activation of
            Nrf2/ARE signaling associated with inactivating GSK-3beta,
            indicating a potential role of Srxn1 in diabetic nephropathy.
REFERENCE   5  (bases 1 to 2828)
  AUTHORS   Mishra,M., Jiang,H., Chawsheen,H.A., Gerard,M., Toledano,M.B. and
            Wei,Q.
  TITLE     Nrf2-activated expression of sulfiredoxin contributes to
            urethane-induced lung tumorigenesis
  JOURNAL   Cancer Lett 432, 216-226 (2018)
   PUBMED   29906488
REFERENCE   6  (bases 1 to 2828)
  AUTHORS   Diet,A., Abbas,K., Bouton,C., Guillon,B., Tomasello,F.,
            Fourquet,S., Toledano,M.B. and Drapier,J.C.
  TITLE     Regulation of peroxiredoxins by nitric oxide in immunostimulated
            macrophages
  JOURNAL   J Biol Chem 282 (50), 36199-36205 (2007)
   PUBMED   17921138
REFERENCE   7  (bases 1 to 2828)
  AUTHORS   Bondareva,A.A., Capecchi,M.R., Iverson,S.V., Li,Y., Lopez,N.I.,
            Lucas,O., Merrill,G.F., Prigge,J.R., Siders,A.M., Wakamiya,M.,
            Wallin,S.L. and Schmidt,E.E.
  TITLE     Effects of thioredoxin reductase-1 deletion on embryogenesis and
            transcriptome
  JOURNAL   Free Radic Biol Med 43 (6), 911-923 (2007)
   PUBMED   17697936
REFERENCE   8  (bases 1 to 2828)
  AUTHORS   Chang,T.S., Jeong,W., Woo,H.A., Lee,S.M., Park,S. and Rhee,S.G.
  TITLE     Characterization of mammalian sulfiredoxin and its reactivation of
            hyperoxidized peroxiredoxin through reduction of cysteine sulfinic
            acid in the active site to cysteine
  JOURNAL   J Biol Chem 279 (49), 50994-51001 (2004)
   PUBMED   15448164
REFERENCE   9  (bases 1 to 2828)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   10 (bases 1 to 2828)
  AUTHORS   Sun,Y., Hegamyer,G. and Colburn,N.H.
  TITLE     Molecular cloning of five messenger RNAs differentially expressed
            in preneoplastic or neoplastic JB6 mouse epidermal cells: one is
            homologous to human tissue inhibitor of metalloproteinases-3
  JOURNAL   Cancer Res 54 (5), 1139-1144 (1994)
   PUBMED   8118794
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC049957.1, AL845161.5 and AI851151.1.
            
            [WARNING] On Jun 12, 2024 this sequence was replaced by
            NM_029688.6.
            
            On Aug 31, 2012 this sequence version replaced NM_029688.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC049957.1, AK161066.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2026              BC049957.1         1-2026
            2027-2425           AL845161.5         211763-212161
            2426-2828           AI851151.1         1-403               c
FEATURES             Location/Qualifiers
     source          1..2828
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 74.83 cM"
     gene            1..2828
                     /gene="Srxn1"
                     /gene_synonym="1700127B04Rik; Npn3; Srx; Srx1; TX01"
                     /note="sulfiredoxin 1 homolog (S. cerevisiae)"
                     /db_xref="GeneID:76650"
                     /db_xref="MGI:MGI:104971"
     exon            1..424
                     /gene="Srxn1"
                     /gene_synonym="1700127B04Rik; Npn3; Srx; Srx1; TX01"
                     /inference="alignment:Splign:2.1.0"
     CDS             161..628
                     /gene="Srxn1"
                     /gene_synonym="1700127B04Rik; Npn3; Srx; Srx1; TX01"
                     /EC_number="1.8.98.2"
                     /note="neoplastic progression 3; neoplastic progression
                     protein 3"
                     /codon_start=1
                     /product="sulfiredoxin-1"
                     /protein_id="NP_083964.2"
                     /db_xref="CCDS:CCDS16877.2"
                     /db_xref="GeneID:76650"
                     /db_xref="MGI:MGI:104971"
                     /translation="MVQPGLVKRPGGTGHQGRGMGLRAGGALRRAGAGPGAPEGQGPG
                     GAQGGSIHSGCIATVHNVPIAVLIRPLPSVLDPAKVQSLVDTILADPDSVPPIDVLWI
                     KGAQGGDYYYSFGGCHRYAAYQQLQRETIPAKLVRSTLSDLRMYLGASTPDLQ"
     exon            425..2812
                     /gene="Srxn1"
                     /gene_synonym="1700127B04Rik; Npn3; Srx; Srx1; TX01"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcagagcgc cacggcgggc agtgggcagc taggtcagag tgagacacgc agggagggag
       61 gggcggcgag tcaagcggct cggggacagg taggatcaca gcgtgggccg agcactcggt
      121 cggggcaaac gcagagccgt cgcccccccg cggccacgcg atggtacagc ccggcctggt
      181 aaagaggccg ggcggcactg gccaccaagg aagaggtatg gggctacgcg cgggtggagc
      241 gctccggagg gcgggtgcgg ggcccggggc gcccgaggga cagggacccg gtggcgccca
      301 gggcggcagc atccactcgg gctgcatcgc cacggtgcac aacgtaccaa tcgccgtgct
      361 catccggccg ctgccgtccg tgctggaccc ggccaaagtg cagagcctgg tggacacgat
      421 cctggcggac cctgacagtg tgccccccat cgacgtcctc tggatcaaag gggcccaggg
      481 tggcgactac tactattcct ttgggggctg ccaccgctat gcagcctacc agcagctgca
      541 gagagagacc attcctgcca agctcgtgag gtccaccctt tcagacctga ggatgtacct
      601 gggagcatcc acaccagact tgcaatagca acctcctgat agccccctgc ccctctccac
      661 atcagcacca ctacccggcg ctcagaagac acatgcagcc cccagtgggc agaagctgta
      721 gatgggatat gttctcttta ttcttaaggg aggtctgcct cttggtgcct ctgcactagc
      781 tcccaggggc tagctcccag gaatgagggg gttcagttct tctgtctatg gaaagatatc
      841 atggccttga ccctgaagga gtaccaggaa ggaagaaagg agatggactt ggagacaagg
      901 actctcattt taatctttat gatagcacta tatgaactat gtactaggaa gtaaaggaaa
      961 acccaggtca ccatggcttc agtgagagaa gctggttatc catccccata gcctgaactc
     1021 tggaaccggc agctaacaca gcactgacta acacagtatt gtgtcaacag ctcagtgaag
     1081 gcagggcttc ctctcgggag tcctttggcc ttgtcctcct tgctccttac ttcgtagtcg
     1141 ctgttgctgt gtttctagga accgtgtctg tgctcaagga agaaacccac tggaccaact
     1201 tctgtcagaa aggaaaacct tgttcaaagt ttcaggaccc tgttctttgc ttatttgcac
     1261 atggtcacct tggtctgagc tagccaccat tgtcacccac agctgcaaag aaagcagacc
     1321 ttaggaaaca ctgtcacggc tgagtgtgac tgccttgttc atcccctgga ctggtactgt
     1381 gttgcctgca gtaccattgg gatcccatag caagagaggg agagggagat gttagttagc
     1441 ctttgctacg aaccaagctg tccccaagct caacagctaa acaggtattc atttacccat
     1501 gattctatgg gttagctaag ctcctttgag cagctcctct gatgtggcct ggtcctgctc
     1561 atgagcccat agtcaattgt cacctcagct ggggctggtt gggctggggt caccttcacc
     1621 attgtggcaa gtgttggctg cattggcttg gttactcttg ttgcctctct caaaggtcag
     1681 ttcaggagaa ttctcaagat ggcctcaggg ttccaagaga gagtagtagt gagagggcct
     1741 ggagcggaga ctcagctgtt aagagcacct acatggtgat tcacaacact gtcatccctg
     1801 ttccagatga cctgatgccc tcttctaggc tctgtgggca cagacaaaca cattcgagca
     1861 aagcacccaa ttgcttttct tttgcttttt gagacacggg gtttttctgt gtaaccctgg
     1921 ctgtcctgga actcactgtg cagtaccagg ctggccttga cctcacggag atttgcctct
     1981 cctgcatccc gagtgctggt attaaagaag gtgtgcacta ctatcaccca ggtacatttt
     2041 tttaaggtga caaggtttct tcagcccctg tgccaagaat gtgtttctgt tggtcagttc
     2101 gttccttaga ttcaagggtt gcaaatggac cgagctctca gcgggaggaa ccacaaagaa
     2161 cattgggcta tcgttcatca cagatgaatc ttggtgggca agagacagaa ttcctcactc
     2221 ccacacataa gtactccctt ttcataagtt tgtcacagaa gcacacaagg ggccttggca
     2281 tgtcagcctt taagtaacgg ttctcaaaac ctagaagtca tggcatggtg tcttcgagag
     2341 ctgggtaccc cagccctaag gatgtctcag aggcacaatg aggtggataa tgaggtgggc
     2401 attcagaggg gcttctgcaa acctagagtc caggaggcaa tgggtgcagc agtgaggtag
     2461 ctatgccaca cagagaccat agtcacttgt cattttcaag cctctgtttt cccagctcca
     2521 tggtgaggac accagctttc ccacccaccg agtgtcccag aaaatgaaat tggaaggaat
     2581 aagatgcatc gtggtgctgg attgattctt gggaccaaaa agagactagg gagagaaagc
     2641 acattagcag gtcaaccagg actcatacct tccagtttgg gtaatcttat ctctggggtg
     2701 ggctggatga agaatgtatg ggaactctag tctctgcaac ttttctgtaa atccaaagtc
     2761 attctaaaat aaaagtgtat ttaattaaca cacacaccat gcaatagcct taaaaaaaaa
     2821 aaaaaaaa
//
