LOCUS       NM_025573               1162 bp    mRNA    linear   ROD 16-OCT-2024
DEFINITION  Mus musculus serine and arginine-rich splicing factor 9 (Srsf9),
            transcript variant 1, mRNA.
ACCESSION   NM_025573
VERSION     NM_025573.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1162)
  AUTHORS   Yu,S., Sun,Z., Ju,T., Liu,Y., Mei,Z., Wang,C., Qu,Z., Li,N., Wu,F.,
            Liu,K., Lu,M., Huang,M., Pang,X., Jia,Y., Li,Y., Zhang,Y., Dou,S.,
            Jiang,J., Dong,X., Huang,C., Li,W., Zhang,Y., Yuan,Y., Yang,B. and
            Du,W.
  TITLE     The m7G Methyltransferase Mettl1 Drives Cardiac Hypertrophy by
            Regulating SRSF9-Mediated Splicing of NFATc4
  JOURNAL   Adv Sci (Weinh) 11 (29), e2308769 (2024)
   PUBMED   38810124
  REMARK    GeneRIF: The m7G Methyltransferase Mettl1 Drives Cardiac
            Hypertrophy by Regulating SRSF9-Mediated Splicing of NFATc4.
REFERENCE   2  (bases 1 to 1162)
  AUTHORS   Li,Z., Liu,X., Zhang,Y., Li,Y., Zhou,L. and Yuan,S.
  TITLE     FBXO24 modulates mRNA alternative splicing and MIWI degradation and
            is required for normal sperm formation and male fertility
  JOURNAL   Elife 12, 91666 (2024)
   PUBMED   38470475
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1162)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 1162)
  AUTHORS   Huang,H., Kapeli,K., Jin,W., Wong,Y.P., Arumugam,T.V., Koh,J.H.,
            Srimasorn,S., Mallilankaraman,K., Chua,J.J.E., Yeo,G.W. and
            Soong,T.W.
  TITLE     Tissue-selective restriction of RNA editing of CaV1.3 by splicing
            factor SRSF9
  JOURNAL   Nucleic Acids Res 46 (14), 7323-7338 (2018)
   PUBMED   29733375
  REMARK    GeneRIF: Data show that editing of Cav1.3 calcium channel (CaV1.3)
            was potently inhibited by serine/arginine-rich splicing factor 9
            (SRSF9).
REFERENCE   5  (bases 1 to 1162)
  AUTHORS   Roberts,J.M., Ennajdaoui,H., Edmondson,C., Wirth,B., Sanford,J.R.
            and Chen,B.
  TITLE     Splicing factor TRA2B is required for neural progenitor survival
  JOURNAL   J Comp Neurol 522 (2), 372-392 (2014)
   PUBMED   23818142
REFERENCE   6  (bases 1 to 1162)
  AUTHORS   Park,E., Han,J., Son,G.H., Lee,M.S., Chung,S., Park,S.H., Park,K.,
            Lee,K.H., Choi,S., Seong,J.Y. and Kim,K.
  TITLE     Cooperative actions of Tra2alpha with 9G8 and SRp30c in the RNA
            splicing of the gonadotropin-releasing hormone gene transcript
  JOURNAL   J Biol Chem 281 (1), 401-409 (2006)
   PUBMED   16249178
  REMARK    GeneRIF: cooperative action of multiple SR proteins in the
            regulation of GnRH pre-mRNA splicing; SRp30c specifically binds to
            both ESE3 and ESE4
REFERENCE   7  (bases 1 to 1162)
  AUTHORS   McKee,A.E., Minet,E., Stern,C., Riahi,S., Stiles,C.D. and
            Silver,P.A.
  TITLE     A genome-wide in situ hybridization map of RNA-binding proteins
            reveals anatomically restricted expression in the developing mouse
            brain
  JOURNAL   BMC Dev Biol 5, 14 (2005)
   PUBMED   16033648
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1162)
  AUTHORS   Stoss,O., Olbrich,M., Hartmann,A.M., Konig,H., Memmott,J.,
            Andreadis,A. and Stamm,S.
  TITLE     The STAR/GSG family protein rSLM-2 regulates the selection of
            alternative splice sites
  JOURNAL   J Biol Chem 276 (12), 8665-8673 (2001)
   PUBMED   11118435
REFERENCE   9  (bases 1 to 1162)
  AUTHORS   Screaton,G.R., Caceres,J.F., Mayeda,A., Bell,M.V., Plebanski,M.,
            Jackson,D.G., Bell,J.I. and Krainer,A.R.
  TITLE     Identification and characterization of three members of the human
            SR family of pre-mRNA splicing factors
  JOURNAL   EMBO J 14 (17), 4336-4349 (1995)
   PUBMED   7556075
REFERENCE   10 (bases 1 to 1162)
  AUTHORS   Ayane,M., Preuss,U., Kohler,G. and Nielsen,P.J.
  TITLE     A differentially expressed murine RNA encoding a protein with
            similarities to two types of nucleic acid binding motifs
  JOURNAL   Nucleic Acids Res 19 (6), 1273-1278 (1991)
   PUBMED   2030943
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC117735.8.
            
            On Nov 17, 2006 this sequence version replaced NM_025573.2.
            
            Summary: The protein encoded by this gene is a member of the
            serine/arginine (SR)-rich family of pre-mRNA splicing factors,
            which constitute part of the spliceosome. Each of these factors
            contains an RNA recognition motif (RRM) for binding RNA and an RS
            domain for binding other proteins. The RS domain is rich in serine
            and arginine residues and facilitates interaction between different
            SR splicing factors. In addition to being critical for mRNA
            splicing, the SR proteins have also been shown to be involved in
            mRNA export from the nucleus and in translation. Two transcript
            variants, one protein-coding and the other not protein-coding, have
            been found for this gene. [provided by RefSeq, Sep 2010].
            
            Transcript Variant: This variant (1) represents the protein-coding
            transcript.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC012217.1, AK159190.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-323               AC117735.8         152746-153068       c
            324-484             AC117735.8         149587-149747       c
            485-657             AC117735.8         147956-148128       c
            658-1162            AC117735.8         147165-147669       c
FEATURES             Location/Qualifiers
     source          1..1162
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 56.05 cM"
     gene            1..1162
                     /gene="Srsf9"
                     /gene_synonym="25kDa; 2610029M16Rik; Sfrs9; SRp30c"
                     /note="serine and arginine-rich splicing factor 9"
                     /db_xref="GeneID:108014"
                     /db_xref="MGI:MGI:104896"
     exon            1..323
                     /gene="Srsf9"
                     /gene_synonym="25kDa; 2610029M16Rik; Sfrs9; SRp30c"
                     /inference="alignment:Splign:2.1.0"
     CDS             133..801
                     /gene="Srsf9"
                     /gene_synonym="25kDa; 2610029M16Rik; Sfrs9; SRp30c"
                     /note="splicing factor, arginine/serine-rich 9"
                     /codon_start=1
                     /product="serine/arginine-rich splicing factor 9"
                     /protein_id="NP_079849.1"
                     /db_xref="CCDS:CCDS19587.1"
                     /db_xref="GeneID:108014"
                     /db_xref="MGI:MGI:104896"
                     /translation="MSSGWADERGGEGDGRIYVGNLPSDVREKDLEDLFYKYGRIREI
                     ELKNRHGLVPFAFVRFEDPRDAEDAIYGRNGYDYGQCRLRVEFPRTYGGRGGWPRGAR
                     NGPPTRRSDFRVLVSGLPPSGSWQDLKDHMREAGDVCYADVQKDGMGMVEYLRKEDME
                     YALRKLDDTKFRSHEGETSYIRVYPERSTSYGYSRSRSGSRGRDSPYQSRGSPHYFSP
                     FRPY"
     exon            324..484
                     /gene="Srsf9"
                     /gene_synonym="25kDa; 2610029M16Rik; Sfrs9; SRp30c"
                     /inference="alignment:Splign:2.1.0"
     exon            485..657
                     /gene="Srsf9"
                     /gene_synonym="25kDa; 2610029M16Rik; Sfrs9; SRp30c"
                     /inference="alignment:Splign:2.1.0"
     exon            658..1162
                     /gene="Srsf9"
                     /gene_synonym="25kDa; 2610029M16Rik; Sfrs9; SRp30c"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1140..1145
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Srsf9"
                     /gene_synonym="25kDa; 2610029M16Rik; Sfrs9; SRp30c"
                     /note="hexamer: AATATA"
     polyA_site      1162
                     /gene="Srsf9"
                     /gene_synonym="25kDa; 2610029M16Rik; Sfrs9; SRp30c"
                     /note="major polyA site"
ORIGIN      
        1 gcggctgagc gcctcgggag cccgcggggg aggctgcggc ggggggcccc gggctgagga
       61 ggcggcgtcg gcggcggagg cggctgcgac gggacgtggg ctgcggcggg cccgcggcgt
      121 cggccggtgc ggatgtcgtc gggctgggcg gacgagcgcg gcggcgaggg cgacgggcgc
      181 atctacgtgg gcaaccttcc gtccgacgtg cgcgagaagg acctcgagga cttgttctac
      241 aagtacggcc gcatccgcga gatcgagctc aagaaccggc acggcctcgt gcccttcgcc
      301 ttcgtgcgct tcgaggaccc gcgagatgct gaggatgcga tctatggaag aaacggttac
      361 gattatggcc agtgtcgact ccgtgtggag ttccccagga cttacggagg tcggggtggg
      421 tggccccgtg gtgcaaggaa cgggcctcct acaagacggt cagatttccg agttcttgtt
      481 tcaggacttc ctccatcagg cagctggcag gacctgaaag atcacatgcg agaagctggg
      541 gatgtctgtt atgcagacgt acagaaggac ggaatgggga tggttgaata tttgagaaaa
      601 gaggacatgg aatatgctct gcgtaaactg gatgacacca aattccgctc tcacgagggt
      661 gagacttcct acatccgagt gtatcctgag agaagcacca gctatggcta ctcacggtcg
      721 cggtctgggt ccaggggccg cgactcgcca taccaaagcc ggggctcgcc acactacttc
      781 tctcctttca ggccctactg agggggtggg aaggaagggt ctcttcagtt ttttagatga
      841 gctgggctac tttgtgctca gagtctacat tccagattga ttagagtctt aggacatttt
      901 ttttcttttc tttcctttta tttttatttt attttatttt ttttatttta aggaactaca
      961 taatttcggc tagagccacc atactagcag tgacctgtta ggctgcagag agaaggtgtg
     1021 tctgtggttc aggaacaagc tgtacatttt tcaccctgac tatgggacgg aaatcagtgc
     1081 tgcatcttca tgggctgctc tgctcggaga tggggcccga ggggcccgtt ttgttcagaa
     1141 atatatttta aatgtttagt aa
//
