LOCUS       NM_146083               2301 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Mus musculus serine and arginine-rich splicing factor 7 (Srsf7),
            transcript variant 1, mRNA.
ACCESSION   NM_146083
VERSION     NM_146083.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2301)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2301)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2301)
  AUTHORS   Schwich,O.D., Blumel,N., Keller,M., Wegener,M., Setty,S.T.,
            Brunstein,M.E., Poser,I., Mozos,I.R.L., Suess,B., Munch,C.,
            McNicoll,F., Zarnack,K. and Muller-McNicoll,M.
  TITLE     SRSF3 and SRSF7 modulate 3'UTR length through suppression or
            activation of proximal polyadenylation sites and regulation of CFIm
            levels
  JOURNAL   Genome Biol 22 (1), 82 (2021)
   PUBMED   33706811
  REMARK    GeneRIF: SRSF3 and SRSF7 modulate 3'UTR length through suppression
            or activation of proximal polyadenylation sites and regulation of
            CFIm levels.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2301)
  AUTHORS   Meinke,S., Goldammer,G., Weber,A.I., Tarabykin,V., Neumann,A.,
            Preussner,M. and Heyd,F.
  TITLE     Srsf10 and the minor spliceosome control tissue-specific and
            dynamic SR protein expression
  JOURNAL   Elife 9, e56075 (2020)
   PUBMED   32338600
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2301)
  AUTHORS   Kadota,Y., Jam,F.A., Yukiue,H., Terakado,I., Morimune,T., Tano,A.,
            Tanaka,Y., Akahane,S., Fukumura,M., Tooyama,I. and Mori,M.
  TITLE     Srsf7 Establishes the Juvenile Transcriptome through Age-Dependent
            Alternative Splicing in Mice
  JOURNAL   iScience 23 (3), 100929 (2020)
   PUBMED   32146325
  REMARK    Erratum:[iScience. 2020 Jun 26;23(6):101242. doi:
            10.1016/j.isci.2020.101242. PMID: 32559732]
REFERENCE   6  (bases 1 to 2301)
  AUTHORS   Tarantino,C., Paolella,G., Cozzuto,L., Minopoli,G., Pastore,L.,
            Parisi,S. and Russo,T.
  TITLE     miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic
            stem cells
  JOURNAL   FASEB J 24 (9), 3255-3263 (2010)
   PUBMED   20439489
REFERENCE   7  (bases 1 to 2301)
  AUTHORS   Park,E., Han,J., Son,G.H., Lee,M.S., Chung,S., Park,S.H., Park,K.,
            Lee,K.H., Choi,S., Seong,J.Y. and Kim,K.
  TITLE     Cooperative actions of Tra2alpha with 9G8 and SRp30c in the RNA
            splicing of the gonadotropin-releasing hormone gene transcript
  JOURNAL   J Biol Chem 281 (1), 401-409 (2006)
   PUBMED   16249178
  REMARK    GeneRIF: 9G8 binds to an element in exon 3 and strongly enhances
            the excision of GnRH intron A in the presence of minimal amount of
            other nuclear components
REFERENCE   8  (bases 1 to 2301)
  AUTHORS   McKee,A.E., Minet,E., Stern,C., Riahi,S., Stiles,C.D. and
            Silver,P.A.
  TITLE     A genome-wide in situ hybridization map of RNA-binding proteins
            reveals anatomically restricted expression in the developing mouse
            brain
  JOURNAL   BMC Dev Biol 5, 14 (2005)
   PUBMED   16033648
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 2301)
  AUTHORS   Zhang,H., Wada,J., Kanwar,Y.S., Tsuchiyama,Y., Hiragushi,K.,
            Hida,K., Shikata,K. and Makino,H.
  TITLE     Screening for genes up-regulated in 5/6 nephrectomized mouse kidney
  JOURNAL   Kidney Int 56 (2), 549-558 (1999)
   PUBMED   10432394
REFERENCE   10 (bases 1 to 2301)
  AUTHORS   Funke,B., Zuleger,B., Benavente,R., Schuster,T., Goller,M.,
            Stevenin,J. and Horak,I.
  TITLE     The mouse poly(C)-binding protein exists in multiple isoforms and
            interacts with several RNA-binding proteins
  JOURNAL   Nucleic Acids Res 24 (19), 3821-3828 (1996)
   PUBMED   8871564
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK137795.1, AK045884.1 and
            BX519093.1.
            
            On Sep 11, 2010 this sequence version replaced NM_146083.1.
            
            Summary: The protein encoded by this gene is a member of the
            serine/arginine (SR)-rich family of pre-mRNA splicing factors,
            which constitute part of the spliceosome. Each of these factors
            contains an RNA recognition motif (RRM) for binding RNA and an RS
            domain for binding other proteins. The RS domain is rich in serine
            and arginine residues and facilitates interaction between different
            SR splicing factors. In addition to being critical for mRNA
            splicing, the SR proteins have also been shown to be involved in
            mRNA export from the nucleus and in translation. Multiple
            protein-coding and non-protein-coding transcript variants have been
            found for this gene. [provided by RefSeq, Apr 2022].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC025529.1, AK161652.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164137, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1248              AK137795.1         2-1249
            1249-2243           AK045884.1         1411-2405
            2244-2301           BX519093.1         248-305
FEATURES             Location/Qualifiers
     source          1..2301
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 50.63 cM"
     gene            1..2301
                     /gene="Srsf7"
                     /gene_synonym="35kDa; 9430065L19Rik; 9G8; NX-96; Sfrs7"
                     /note="serine and arginine-rich splicing factor 7"
                     /db_xref="GeneID:225027"
                     /db_xref="MGI:MGI:1926232"
     exon            1..131
                     /gene="Srsf7"
                     /gene_synonym="35kDa; 9430065L19Rik; 9G8; NX-96; Sfrs7"
                     /inference="alignment:Splign:2.1.0"
     exon            132..312
                     /gene="Srsf7"
                     /gene_synonym="35kDa; 9430065L19Rik; 9G8; NX-96; Sfrs7"
                     /inference="alignment:Splign:2.1.0"
     exon            313..489
                     /gene="Srsf7"
                     /gene_synonym="35kDa; 9430065L19Rik; 9G8; NX-96; Sfrs7"
                     /inference="alignment:Splign:2.1.0"
     exon            490..564
                     /gene="Srsf7"
                     /gene_synonym="35kDa; 9430065L19Rik; 9G8; NX-96; Sfrs7"
                     /inference="alignment:Splign:2.1.0"
     exon            565..675
                     /gene="Srsf7"
                     /gene_synonym="35kDa; 9430065L19Rik; 9G8; NX-96; Sfrs7"
                     /inference="alignment:Splign:2.1.0"
     exon            676..729
                     /gene="Srsf7"
                     /gene_synonym="35kDa; 9430065L19Rik; 9G8; NX-96; Sfrs7"
                     /inference="alignment:Splign:2.1.0"
     exon            730..765
                     /gene="Srsf7"
                     /gene_synonym="35kDa; 9430065L19Rik; 9G8; NX-96; Sfrs7"
                     /inference="alignment:Splign:2.1.0"
     exon            766..2288
                     /gene="Srsf7"
                     /gene_synonym="35kDa; 9430065L19Rik; 9G8; NX-96; Sfrs7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1038..1043
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Srsf7"
                     /gene_synonym="35kDa; 9430065L19Rik; 9G8; NX-96; Sfrs7"
                     /note="hexamer: AATAAA"
     polyA_site      1056
                     /gene="Srsf7"
                     /gene_synonym="35kDa; 9430065L19Rik; 9G8; NX-96; Sfrs7"
                     /note="major polyA site"
     regulatory      2261..2266
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Srsf7"
                     /gene_synonym="35kDa; 9430065L19Rik; 9G8; NX-96; Sfrs7"
                     /note="hexamer: AATAAA"
     polyA_site      2288
                     /gene="Srsf7"
                     /gene_synonym="35kDa; 9430065L19Rik; 9G8; NX-96; Sfrs7"
ORIGIN      
        1 gtagtgccgc cgggattgca ggcagaggag gttgcgcagc cgcttccgtg ctactcgcgc
       61 tgtgagcatt ccaagctaga gccgagtaca cgggccggcc atcatgtcac gctacgggcg
      121 gtatggagga gaaaccaagg tatatgttgg taacctggga actggtgctg gtaaaggaga
      181 gttagaaagg gcattcagtt actatgggcc cttaagaact gtgtggattg ccagaaatcc
      241 tccaggattc gcctttgtgg aatttgaaga ccctagagat gcagaggatg cagttcgagg
      301 attggatggg aaagtgattt gtggttctcg agtgagggtt gaactatcaa caggcatgcc
      361 tcggagatct cgttttgata ggccacctgc ccgtcgtccc tttgatccta atgatagatg
      421 ctatgagtgt ggtgaaaagg gacattatgc ttatgactgt catcgctata gccgacgaag
      481 aagaagcagg tcacgatcta gatcccattc ccgatccagg ggaaggcgat actctcgctc
      541 ccgcagcagg agccgaggac ggaggtcaag atcagcatct cctcgccgat caaggtctgt
      601 gtctcttcgt agatcaagat cagcttcact cagaagatct aggtctggtt ctataatagg
      661 atcgaggtat ttccaatccc gctcaaggtc gagatcaaga tccaggtcta tttcacgacc
      721 aagaagcagc cgatcaaaat ccagatctcc atctcctaaa agaagtcgtt ccccatcagg
      781 aagtccacac agaagtgcaa gtccagaaag aatggactga agttctcaag ttcacccgtt
      841 agggaaaagt tattttgttt acattattat aagggatttg ttatgtctgt aaagtgtaac
      901 ctaggaagga tcatcaacca tctaatcaaa atggatctgg attattactc tgtaaaattc
      961 acagcagtaa atattgtttt gttgaatgta ttaacatctt atggtctgaa aatgtgggtt
     1021 tttatttgac acgtttaaat aaaatgtttc taactagatg ttttgatttt tgtgttcaat
     1081 attaatactt ttcaattggg taagcatcag gcaaggtaac aatcaagaga attattggcc
     1141 atatttatat gggcctgtat tcaaagttta atggtgttag ttaaacatca ttaactgttc
     1201 tatacgtaac actggccagg atctgaaagg actttgaaat tttcatttta ctcttgtacc
     1261 tttgggtaag atgatctttg agtccttaat agcatgagtg catcatgtca gatctctaaa
     1321 ttgagaattg gtgttaacaa tttggaattg tcaagcttag agggaccact gataagccta
     1381 caaattggtg catgacagaa aataagcaga gttactgaca tgtcagtaga aactgatttc
     1441 tagcggctga gattttagta gtgtagtttt tcaggctatt aagttgggtt aattctgctc
     1501 aatgtacttt tttcctttca aacaaccaat ttaataccaa aaaatgcatg tttgaggaat
     1561 tgtctgaatt tggaacaaaa ccttgtaaac cagctttgca aaattatcca gccccagtcc
     1621 tctgttcttt tgaatggatt gccttatcct gtgcaaaaac ctgttaatat ctgagctaga
     1681 ttttgtatga agctatgtgt aattggcaga cttatctgtt gcacttggtt agcttggtta
     1741 ctgacattgt tctattttgc caagctggta taaagagatg tcaagcaaag tgttaataag
     1801 ataaagcagt tttgtaaacc ttacatatta gcatttcatg tagctaagga ttgttatgtt
     1861 tttgttttgg gtttttcctc ctttggtagt gtctggtaga ccttagaatg gtgtagccag
     1921 taggttctta ctcagacttt aaatatatta tgcataatag ggcagtaatg gtcattttca
     1981 aacgtttttt ggacaagctt tttactatat ttcttagcct tggtgtaaaa acaatagcac
     2041 aggaatctgt ccttgtctat tttaggcttt ttcatcgaag ttgtctgccc caaatttatt
     2101 tggctgagtg gtcactagta tgttgaaagt catttgggtt ctgtttttag aatttgactg
     2161 gttgaataag tggttggtat gaagctatgt gtaattggca gacttatctg ttgcacttgg
     2221 ttagctttaa ttgttctgta ttcaaaaatt aagtttgttc aataaatctg cagagattga
     2281 acaaataaaa aaaaaaaaaa a
//
