LOCUS       NM_026499               3547 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus serine and arginine-rich splicing factor 6 (Srsf6),
            mRNA.
ACCESSION   NM_026499 XM_980333
VERSION     NM_026499.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3547)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3547)
  AUTHORS   Wagner,A.R., Weindel,C.G., West,K.O., Scott,H.M., Watson,R.O. and
            Patrick,K.L.
  TITLE     SRSF6 balances mitochondrial-driven innate immune outcomes through
            alternative splicing of BAX
  JOURNAL   Elife 11, e82244 (2022)
   PUBMED   36409059
  REMARK    GeneRIF: SRSF6 balances mitochondrial-driven innate immune outcomes
            through alternative splicing of BAX.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3547)
  AUTHORS   Li,Y., Xu,J., Lu,Y., Bian,H., Yang,L., Wu,H., Zhang,X., Zhang,B.,
            Xiong,M., Chang,Y., Tang,J., Yang,F., Zhao,L., Li,J., Gao,X.,
            Xia,M., Tan,M. and Li,J.
  TITLE     DRAK2 aggravates nonalcoholic fatty liver disease progression
            through SRSF6-associated RNA alternative splicing
  JOURNAL   Cell Metab 33 (10), 2004-2020 (2021)
   PUBMED   34614409
  REMARK    GeneRIF: DRAK2 aggravates nonalcoholic fatty liver disease
            progression through SRSF6-associated RNA alternative splicing.
REFERENCE   4  (bases 1 to 3547)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3547)
  AUTHORS   Mason,M.A., Gomez-Paredes,C., Sathasivam,K., Neueder,A.,
            Papadopoulou,A.S. and Bates,G.P.
  TITLE     Silencing Srsf6 does not modulate incomplete splicing of the
            huntingtin gene in Huntington's disease models
  JOURNAL   Sci Rep 10 (1), 14057 (2020)
   PUBMED   32820193
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3547)
  AUTHORS   Manley,J.L. and Krainer,A.R.
  TITLE     A rational nomenclature for serine/arginine-rich protein splicing
            factors (SR proteins)
  JOURNAL   Genes Dev 24 (11), 1073-1074 (2010)
   PUBMED   20516191
REFERENCE   7  (bases 1 to 3547)
  AUTHORS   McKee,A.E., Minet,E., Stern,C., Riahi,S., Stiles,C.D. and
            Silver,P.A.
  TITLE     A genome-wide in situ hybridization map of RNA-binding proteins
            reveals anatomically restricted expression in the developing mouse
            brain
  JOURNAL   BMC Dev Biol 5, 14 (2005)
   PUBMED   16033648
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 3547)
  AUTHORS   Carninci,P., Waki,K., Shiraki,T., Konno,H., Shibata,K., Itoh,M.,
            Aizawa,K., Arakawa,T., Ishii,Y., Sasaki,D., Bono,H., Kondo,S.,
            Sugahara,Y., Saito,R., Osato,N., Fukuda,S., Sato,K., Watahiki,A.,
            Hirozane-Kishikawa,T., Nakamura,M., Shibata,Y., Yasunishi,A.,
            Kikuchi,N., Yoshiki,A., Kusakabe,M., Gustincich,S., Beisel,K.,
            Pavan,W., Aidinis,V., Nakagawara,A., Held,W.A., Iwata,H., Kono,T.,
            Nakauchi,H., Lyons,P., Wells,C., Hume,D.A., Fagiolini,M.,
            Hensch,T.K., Brinkmeier,M., Camper,S., Hirota,J., Mombaerts,P.,
            Muramatsu,M., Okazaki,Y., Kawai,J. and Hayashizaki,Y.
  TITLE     Targeting a complex transcriptome: the construction of the mouse
            full-length cDNA encyclopedia
  JOURNAL   Genome Res 13 (6B), 1273-1289 (2003)
   PUBMED   12819125
REFERENCE   9  (bases 1 to 3547)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 3547)
  AUTHORS   Pazzaglia,S., Pariset,L., Rebessi,S., Saran,A., Coppola,M.,
            Covelli,V., Moody,J., Bouffler,S., Cox,R. and Silver,A.
  TITLE     Somatic cell hybrids for high-density mapping of chromosome 2
            breakpoints in radiation-induced myeloid leukemia cell lines from
            inbred mice
  JOURNAL   Mol Carcinog 27 (3), 219-228 (2000)
   PUBMED   10708484
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY783855.1, AK133872.1,
            AL590418.16 and AL606473.6.
            
            On Mar 13, 2009 this sequence version replaced NM_026499.3.
            
            Summary: The protein encoded by this gene is a member of the
            serine/arginine (SR)-rich family of pre-mRNA splicing factors,
            which constitute part of the spliceosome. Each of these factors
            contains an RNA recognition motif (RRM) for binding RNA and an RS
            domain for binding other proteins. The RS domain is rich in serine
            and arginine residues and facilitates interaction between different
            SR splicing factors. In addition to being critical for mRNA
            splicing, the SR proteins have also been shown to be involved in
            mRNA export from the nucleus and in translation. [provided by
            RefSeq, Sep 2010].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC012039.2, AK159519.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                BY783855.1         2-21
            21-1504             AK133872.1         2-1485
            1505-3230           AL590418.16        173320-175045
            3231-3547           AL606473.6         2001-2317
FEATURES             Location/Qualifiers
     source          1..3547
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 83.87 cM"
     gene            1..3547
                     /gene="Srsf6"
                     /gene_synonym="1210001E11Rik; Sfrs6"
                     /note="serine and arginine-rich splicing factor 6"
                     /db_xref="GeneID:67996"
                     /db_xref="MGI:MGI:1915246"
     exon            1..270
                     /gene="Srsf6"
                     /gene_synonym="1210001E11Rik; Sfrs6"
                     /inference="alignment:Splign:2.1.0"
     CDS             164..1183
                     /gene="Srsf6"
                     /gene_synonym="1210001E11Rik; Sfrs6"
                     /note="splicing factor, arginine/serine-rich 6;
                     pre-mRNA-splicing factor SRP55"
                     /codon_start=1
                     /product="serine/arginine-rich splicing factor 6"
                     /protein_id="NP_080775.3"
                     /db_xref="CCDS:CCDS17002.1"
                     /db_xref="GeneID:67996"
                     /db_xref="MGI:MGI:1915246"
                     /translation="MPRVYIGRLSYNVREKDIQRFFSGYGRLLEIDLKNGYGFVEFED
                     SRDADDAVYELNSKELCGERVIVEHARGPRRDRDGYSYGSRSGGGGYSSRRTSGRDKY
                     GPPVRTEYRLIVENLSSRCSWQDLKDFMRQAGEVTYADAHKERTNEGVIEFRSYSDMK
                     RALDKLDGTEINGRNIRLIEDKPRTSHRRSYSGSRSRSRSRRRSRSRSRRSSRSRSRS
                     ISKSRSRSRSRSKGRSRSRSKGRKSRSKSKSKPKSDRGSHSHSRSRSKDKYGKSRSRS
                     RSRSPKENGKGDIKSKSRSRSQSRSHSPLPAPPSKARSMSPPPKRASRSRSRSRSRSR
                     SSSRD"
     exon            271..419
                     /gene="Srsf6"
                     /gene_synonym="1210001E11Rik; Sfrs6"
                     /inference="alignment:Splign:2.1.0"
     exon            420..544
                     /gene="Srsf6"
                     /gene_synonym="1210001E11Rik; Sfrs6"
                     /inference="alignment:Splign:2.1.0"
     exon            545..753
                     /gene="Srsf6"
                     /gene_synonym="1210001E11Rik; Sfrs6"
                     /inference="alignment:Splign:2.1.0"
     exon            754..837
                     /gene="Srsf6"
                     /gene_synonym="1210001E11Rik; Sfrs6"
                     /inference="alignment:Splign:2.1.0"
     exon            838..3547
                     /gene="Srsf6"
                     /gene_synonym="1210001E11Rik; Sfrs6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1618..1623
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Srsf6"
                     /gene_synonym="1210001E11Rik; Sfrs6"
                     /note="hexamer: AATAAA"
     polyA_site      1636
                     /gene="Srsf6"
                     /gene_synonym="1210001E11Rik; Sfrs6"
                     /note="major polyA site"
     regulatory      1752..1757
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Srsf6"
                     /gene_synonym="1210001E11Rik; Sfrs6"
                     /note="hexamer: AATAAA"
     polyA_site      1774
                     /gene="Srsf6"
                     /gene_synonym="1210001E11Rik; Sfrs6"
                     /note="major polyA site"
     regulatory      3525..3530
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Srsf6"
                     /gene_synonym="1210001E11Rik; Sfrs6"
                     /note="hexamer: AATAAA"
     polyA_site      3547
                     /gene="Srsf6"
                     /gene_synonym="1210001E11Rik; Sfrs6"
                     /note="major polyA site"
ORIGIN      
        1 aggccggcgc gcgcgcgcgc accattgtgt ggctgactcg gccgccgctg cggtgtgagg
       61 cgcgtgttcg ggccttcgcc gtccccgcac ccgcaccgca gccctgcccc gcggcccgcc
      121 gcccctccgc cagcctcccg gaggacaccc gtgggtcacg gccatgccgc gcgtctacat
      181 aggacgcctg agctacaacg tccgcgagaa ggacatccag cgctttttca gcggctacgg
      241 ccgcctcctc gagatcgacc tcaaaaatgg gtacggtttc gtggagttcg aggactcccg
      301 ggatgccgac gatgccgtgt acgagctcaa cagcaaggag ctgtgcggcg agcgcgtgat
      361 cgtagagcac gcccggggcc cgcgccgcga ccgcgatggc tacagctacg gaagccgcag
      421 tggtggaggt ggatacagca gtcggagaac ttctggcaga gacaaatatg gaccacctgt
      481 tcgtacagag tacaggctta ttgtagaaaa tctgtctagt cgttgcagtt ggcaagactt
      541 aaaggatttc atgcggcaag caggagaagt gacttatgca gatgctcaca aagaacgaac
      601 aaatgagggt gtgattgaat ttagatccta ctccgacatg aagcgtgctt tggataaact
      661 ggatggtaca gaaataaatg gcagaaatat taggcttatt gaagataagc caagaacaag
      721 ccataggcgc tcctactctg gcagtagatc cagatcacgg tctagaagaa ggtctcggag
      781 taggagtcgc agaagcagcc gcagtagatc tcgaagtatc tcaaaaagtc gctcccgatc
      841 taggtctcgg agcaaaggtc gatcccgatc ccgctcaaaa ggcaggaaat ccagatcaaa
      901 gagcaaatcg aagcccaagt ctgaccgggg ctcccattcc cactcaagaa gcaggtctaa
      961 ggataagtat gggaagtcac gtagtaggtc acggtctcgg tcccccaaag agaacggcaa
     1021 aggagacata aagtcaaagt ccagatcccg gagccagtct cggtcccact cgcctctacc
     1081 tgctccaccc tcaaaggctc ggtccatgtc ccctccgcca aaaagagctt caaggtcccg
     1141 ttctagatct cgttcaaggt ccagatcaag ttccagagat taaccctgac ctcgacgttc
     1201 tttgcacact ataacagaac actttcctac ttgcttaggc agttactctt ccgagtttat
     1261 actcgcctct tctttaagag gatttcctga aaagggaaca ccggaatttg atttgtggcc
     1321 aaatttactg agaaaaagat gaggttctaa aatggtggta tgaagccctc tcccttcttt
     1381 gtagaattaa gataattttg attttgtagc ctttgagcta aaataacttt tgtaaagatt
     1441 aagctcattt agattttttt taaagtattg cagcaggatc tgctgcaggg ttctgttgtt
     1501 ttgttttgct tatttttaaa ttaactgttc aggctttgga tactgcaggc tttagaggga
     1561 gaacccaaat tttcaattat gttggctttt tataaagctt gagttatgta agatttaaat
     1621 aaaagtttgc taccaagatg attgccttat tgaataggtc actactaagg cccttaagtg
     1681 ttgatacctg ccatgtgtgg agacagtgta aattctacat gagtgtgaaa caaggcaagt
     1741 ctcagaccag caataaatta ttcagtttgg ctaaccttat tttgtgctgt taatctacca
     1801 aagtgttttg tctacccctt taataagttg agttaaaagt aaaaggaact ttatagttag
     1861 tgccacaaga taaataaaag aaactaaagg attacaattt gaacttttca agaagtaggt
     1921 cctagtactt gggatcttgt tagatctgtg ctctggaggt ggtctgcgtg attagtgtta
     1981 gtgtatggtt tggtggtctt taatgttttg aaaaacggaa gtgattagaa gttaagttac
     2041 tgttcaaagt tgaaaagcat atatgctaca ttttctgctg aaaggtgatt atatttgaca
     2101 ggtgcttaga catttggcta agatattttc caatcagtcc cctttgtatt agtggggcat
     2161 ttgtggttag tttgaaaaac agacatggat aaactaaaat gcttcatact ttataagtaa
     2221 agcgctatga atgctgtgga gaccaaggtg aaataaatag tgcaaatgtg taggaataat
     2281 tagattgcag tttccataca tccgcaagcc cagttagttg aaactgcaat caatatttac
     2341 cttacaacct ttccattatt cagacatttg taaagtcatt tcatcccaaa tacttaacct
     2401 cattctttag taatggtgta ggtggattgg ctcaggttta atacatctgt tattatataa
     2461 tctagcaaaa gttggattat agattataac gtagagttgg tttgtagggc caaataatca
     2521 gaggacatgc aataaggcaa ggctgagtgg aaaatagagg ttcaagggcc taggtaggtg
     2581 tctgtagctg ggaatacttg ggaacagggg aaggggaatg ttttcaagac atttatcctg
     2641 ttagaaaatc ttacagacta gctttaggaa catagtgtca aacaaagctg ctgctttagt
     2701 cttcttttct ttgatgcttt gtttagatgt ttataagaaa taggtttatt tttccagtgt
     2761 aaatttcaga atttaaagaa aactggttgt agtttactat tttacctacc taaaaacaga
     2821 tgtgatggct ctttaagaat tgggtttgac caaagttctc tttgttttca gggaaaacta
     2881 tataaaagct ttctgagcca cagcctttta aaaggggaaa ggctaatagt aaaatttgac
     2941 tttctgactg catgcaactg ctgggcttgc cttctgttag tgtggtagta catgacagag
     3001 gcattagact attttttagc tgccctcata aatatataac gaataggtaa atgccaatac
     3061 ccatacagtt tttctagtgg ggacaaaggc cgttttatta gaaatttagg ctttcatgcc
     3121 tgtagaccct agttattaaa tgcactaaac aaacaactgc atttaaagca ttggccttag
     3181 cagaagtgac tgacttaaag tgttttagtt tcttactgat gagtgaattc agttccctac
     3241 caactaatgc gcagaattga agaatcccat cctgcacaca ttggttggtg ccctgggtgg
     3301 aatagcaacg acaccaactg ataaaagcac aagagaagtg gggaacatct tgagtcctgt
     3361 tggacgtgat agtgtttctt gatctgtatg ccacagtgcc tttatggcca gtttgagtcc
     3421 tacctacttc agtttttatg ttcccactcc tcctgtgtta ataacattgc tttcatcttg
     3481 gatatttttt ttctactttg ttaacctact ttatgcttta tctcaataaa atgcttacca
     3541 agggaaa
//
