LOCUS       NM_001409837            1622 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus serine and arginine-rich splicing factor 5 (Srsf5),
            transcript variant 10, mRNA.
ACCESSION   NM_001409837 XM_006515630
VERSION     NM_001409837.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1622)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1622)
  AUTHORS   Li,Q., Jiang,Z., Ren,S., Guo,H., Song,Z., Chen,S., Gao,X., Meng,F.,
            Zhu,J., Liu,L., Tong,Q., Sun,H., Sun,Y., Pu,J., Chang,K.C. and
            Liu,J.
  TITLE     SRSF5-Mediated Alternative Splicing of M Gene is Essential for
            Influenza A Virus Replication: A Host-Directed Target Against
            Influenza Virus
  JOURNAL   Adv Sci (Weinh) 9 (34), e2203088 (2022)
   PUBMED   36257906
  REMARK    GeneRIF: SRSF5-Mediated Alternative Splicing of M Gene is Essential
            for Influenza A Virus Replication: A Host-Directed Target Against
            Influenza Virus.
REFERENCE   3  (bases 1 to 1622)
  AUTHORS   Zhang,M., Yang,C., Ruan,X., Liu,X., Wang,D., Liu,L., Shao,L.,
            Wang,P., Dong,W. and Xue,Y.
  TITLE     CPEB2 m6A methylation regulates blood-tumor barrier permeability by
            regulating splicing factor SRSF5 stability
  JOURNAL   Commun Biol 5 (1), 908 (2022)
   PUBMED   36064747
  REMARK    GeneRIF: CPEB2 m6A methylation regulates blood-tumor barrier
            permeability by regulating splicing factor SRSF5 stability.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1622)
  AUTHORS   Zhang,X., Wang,Z., Xu,Q., Chen,Y., Liu,W., Zhong,T., Li,H.,
            Quan,C., Zhang,L. and Cui,C.P.
  TITLE     Splicing factor Srsf5 deletion disrupts alternative splicing and
            causes noncompaction of ventricular myocardium
  JOURNAL   iScience 24 (10), 103097 (2021)
   PUBMED   34622152
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1622)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1622)
  AUTHORS   McKee,A.E., Minet,E., Stern,C., Riahi,S., Stiles,C.D. and
            Silver,P.A.
  TITLE     A genome-wide in situ hybridization map of RNA-binding proteins
            reveals anatomically restricted expression in the developing mouse
            brain
  JOURNAL   BMC Dev Biol 5, 14 (2005)
   PUBMED   16033648
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1622)
  AUTHORS   Patel,N.A., Kaneko,S., Apostolatos,H.S., Bae,S.S., Watson,J.E.,
            Davidowitz,K., Chappell,D.S., Birnbaum,M.J., Cheng,J.Q. and
            Cooper,D.R.
  TITLE     Molecular and genetic studies imply Akt-mediated signaling promotes
            protein kinase CbetaII alternative splicing via phosphorylation of
            serine/arginine-rich splicing factor SRp40
  JOURNAL   J Biol Chem 280 (14), 14302-14309 (2005)
   PUBMED   15684423
  REMARK    GeneRIF: Data show that Akt-mediated signaling promotes protein
            kinase CbetaII alternative splicing via phosphorylation of SRp40.
REFERENCE   8  (bases 1 to 1622)
  AUTHORS   Cazalla,D., Newton,K. and Caceres,J.F.
  TITLE     A novel SR-related protein is required for the second step of
            Pre-mRNA splicing
  JOURNAL   Mol Cell Biol 25 (8), 2969-2980 (2005)
   PUBMED   15798186
REFERENCE   9  (bases 1 to 1622)
  AUTHORS   Du,K., Leu,J.I., Peng,Y. and Taub,R.
  TITLE     Transcriptional up-regulation of the delayed early gene HRS/SRp40
            during liver regeneration. Interactions among YY1, GA-binding
            proteins, and mitogenic signals
  JOURNAL   J Biol Chem 273 (52), 35208-35215 (1998)
   PUBMED   9857059
REFERENCE   10 (bases 1 to 1622)
  AUTHORS   Du,K. and Taub,R.
  TITLE     Alternative splicing and structure of the human and mouse
            SFRS5/HRS/SRp40 genes
  JOURNAL   Gene 204 (1-2), 243-249 (1997)
   PUBMED   9434190
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC125092.4.
            
            On Jul 22, 2022 this sequence version replaced XM_006515630.4.
            
            Summary: The protein encoded by this gene is a member of the
            serine/arginine (SR)-rich family of pre-mRNA splicing factors,
            which constitute part of the spliceosome. Each of these factors
            contains an RNA recognition motif (RRM) for binding RNA and an RS
            domain for binding other proteins. The RS domain is rich in serine
            and arginine residues and facilitates interaction between different
            SR splicing factors. In addition to being critical for mRNA
            splicing, the SR proteins have also been shown to be involved in
            mRNA export from the nucleus and in translation. [provided by
            RefSeq, Nov 2016].
            
            Transcript Variant: Variants 4, 5 and 10 encode the same isoform
            (2).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189679.101684.1,
                                           SRR17253012.7716957.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-265               AC125092.4         82920-83184
            266-410             AC125092.4         83962-84106
            411-481             AC125092.4         84697-84767
            482-580             AC125092.4         84882-84980
            581-650             AC125092.4         85182-85251
            651-724             AC125092.4         86481-86554
            725-835             AC125092.4         86880-86990
            836-1622            AC125092.4         87103-87889
FEATURES             Location/Qualifiers
     source          1..1622
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 37.2 cM"
     gene            1..1622
                     /gene="Srsf5"
                     /gene_synonym="Sfrs5"
                     /note="serine and arginine-rich splicing factor 5"
                     /db_xref="GeneID:20384"
                     /db_xref="MGI:MGI:98287"
     exon            1..265
                     /gene="Srsf5"
                     /gene_synonym="Sfrs5"
                     /inference="alignment:Splign:2.1.0"
     exon            266..410
                     /gene="Srsf5"
                     /gene_synonym="Sfrs5"
                     /inference="alignment:Splign:2.1.0"
     exon            411..481
                     /gene="Srsf5"
                     /gene_synonym="Sfrs5"
                     /inference="alignment:Splign:2.1.0"
     exon            482..580
                     /gene="Srsf5"
                     /gene_synonym="Sfrs5"
                     /inference="alignment:Splign:2.1.0"
     exon            581..650
                     /gene="Srsf5"
                     /gene_synonym="Sfrs5"
                     /inference="alignment:Splign:2.1.0"
     exon            651..724
                     /gene="Srsf5"
                     /gene_synonym="Sfrs5"
                     /inference="alignment:Splign:2.1.0"
     exon            725..835
                     /gene="Srsf5"
                     /gene_synonym="Sfrs5"
                     /inference="alignment:Splign:2.1.0"
     exon            836..1622
                     /gene="Srsf5"
                     /gene_synonym="Sfrs5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1599..1604
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Srsf5"
                     /gene_synonym="Sfrs5"
                     /note="hexamer: AATAAA"
     polyA_site      1622
                     /gene="Srsf5"
                     /gene_synonym="Sfrs5"
                     /note="major polyA site"
ORIGIN      
        1 gtcagttgtg gagagactgt agacgagttg ggttcgtgtg tatgtgtgtt gtgtgtgtgt
       61 ttgtgtaggg aggcagacag ctccgtcgca gactacggac ctctccgggg tctcagccgc
      121 caaagaccct gtccggtagg tgagtggcac gctttgaggg caaggcttct cggatcgagg
      181 cttcttcatg gccgctcggg tcgcaagtgg ccggggcttc gctctttgcg gaggacggcg
      241 actcagagag cgcagttgat ttgaggaaac actagccggg catcatgagt ggctgtcgag
      301 tgttcattgg gagactaaat ccagcagcga gggagaaaga tgtggaaaga ttcttcaagg
      361 gttacggacg gatccgagat attgacttga aaagaggttt tggttttgtg gaatttgagg
      421 acccaaggga tgcagatgat gctgtttatg aacttgatgg gaaggaactt tgcagtgaaa
      481 gggtgacgat tgaacatgcc cgggctcggt ctcgaggtgg aagaggtaga ggacgatact
      541 ccgaccgttt tagcagtcgc agacctcgaa atgatagacg aaatgctcca cctgtaagaa
      601 cagaaaatcg acttatagtt gagaatttat cctcaagagt cagctggcag gatctcaaag
      661 atttcatgag acaagctggg gaagtaacct ttgcggatgc acatcgacct aaactaaatg
      721 aaggggtagt tgagtttgcc tcttatggtg acttaaagaa tgctattgag aaactttctg
      781 gaaaggaaat taacgggaga aaaatcaaat taattgaagg cagcaaaagg cacagcaggt
      841 caagaagcag gtcacgatct cggaccagaa gttcctctag gtcccgtagc cgatcccgtt
      901 cacgaaggag caagtcttac agccgatcaa ggagcaggag ccggagccgg agcaagtccc
      961 gttctggtag taggtctcct gtgcctgaga agagccagaa acgtggttct tcgagtagat
     1021 ctaaatctcc agcatctgtg gatcgccaga ggtcccgatc ccggtccagg tccagatcag
     1081 ttgacagtgg caattaaact gtaaataact tgccctgggg gccttttttt aaaaaacaaa
     1141 acaaattccc aaaccatact tgctaaaagt tctggtaagt atgtgctttt ctgtggggtg
     1201 ggatttggag ggggttgggc tggatttctt tgtagatgtg gaccaccaag gggttgttga
     1261 aaactaattg tattaaatgt cttttgataa gccttctgct cacacttttg tgactgtctg
     1321 aagtatatag tttgtgtata ttgatagagc tcttttataa ctaaagcatt taattttttg
     1381 tactagaaaa acttttgaat attttagttc attgttcaga tatgttaact caagattagt
     1441 ttaattaaac taacgaatag ttttggacac tttaaaagag ctctaaattt gcttgtatat
     1501 aaaggcttaa tatgagtttt acttgttagg gtcaagggtg tcttgcccat taacagctgt
     1561 agatagacat taaagtaaag cagctgtttg ttattgataa taaaatacta agtattataa
     1621 aa
//
