LOCUS       NM_020587               2254 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus serine and arginine-rich splicing factor 4 (Srsf4),
            transcript variant 5, mRNA.
ACCESSION   NM_020587
VERSION     NM_020587.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2254)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2254)
  AUTHORS   Larrasa-Alonso,J., Villalba-Orero,M., Marti-Gomez,C.,
            Ortiz-Sanchez,P., Lopez-Olaneta,M.M., Rey-Martin,M.A.,
            Sanchez-Cabo,F., McNicoll,F., Muller-McNicoll,M., Garcia-Pavia,P.
            and Lara-Pezzi,E.
  TITLE     The SRSF4-GAS5-Glucocorticoid Receptor Axis Regulates Ventricular
            Hypertrophy
  JOURNAL   Circ Res 129 (6), 669-683 (2021)
   PUBMED   34333993
  REMARK    GeneRIF: The SRSF4-GAS5-Glucocorticoid Receptor Axis Regulates
            Ventricular Hypertrophy.
REFERENCE   3  (bases 1 to 2254)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2254)
  AUTHORS   Guo,H., Li,Y., Luo,M., Lin,S., Chen,J., Ma,Q., Gu,Y., Jiang,Z. and
            Gui,Y.
  TITLE     Androgen receptor binding to an androgen-responsive element in the
            promoter of the Srsf4 gene inhibits its expression in mouse Sertoli
            cells
  JOURNAL   Mol Reprod Dev 82 (12), 976-985 (2015)
   PUBMED   26308373
  REMARK    GeneRIF: these results demonstrate that Srsf4 is a direct
            downstream target of the androgen receptor in mouse Sertoli cells.
REFERENCE   5  (bases 1 to 2254)
  AUTHORS   Nagamachi,A., Matsui,H., Asou,H., Ozaki,Y., Aki,D., Kanai,A.,
            Takubo,K., Suda,T., Nakamura,T., Wolff,L., Honda,H. and Inaba,T.
  TITLE     Haploinsufficiency of SAMD9L, an endosome fusion facilitator,
            causes myeloid malignancies in mice mimicking human diseases with
            monosomy 7
  JOURNAL   Cancer Cell 24 (3), 305-317 (2013)
   PUBMED   24029230
REFERENCE   6  (bases 1 to 2254)
  AUTHORS   Manley,J.L. and Krainer,A.R.
  TITLE     A rational nomenclature for serine/arginine-rich protein splicing
            factors (SR proteins)
  JOURNAL   Genes Dev 24 (11), 1073-1074 (2010)
   PUBMED   20516191
REFERENCE   7  (bases 1 to 2254)
  AUTHORS   Guo,Y., Zhang,X., Huang,J., Zeng,Y., Liu,W., Geng,C., Li,K.W.,
            Yang,D., Wu,S., Wei,H., Han,Z., Qian,X., Jiang,Y. and He,F.
  TITLE     Relationships between hematopoiesis and hepatogenesis in the
            midtrimester fetal liver characterized by dynamic transcriptomic
            and proteomic profiles
  JOURNAL   PLoS One 4 (10), e7641 (2009)
   PUBMED   19865483
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2254)
  AUTHORS   Yomoda,J., Muraki,M., Kataoka,N., Hosoya,T., Suzuki,M., Hagiwara,M.
            and Kimura,H.
  TITLE     Combination of Clk family kinase and SRp75 modulates alternative
            splicing of Adenovirus E1A
  JOURNAL   Genes Cells 13 (3), 233-244 (2008)
   PUBMED   18298798
REFERENCE   9  (bases 1 to 2254)
  AUTHORS   McKee,A.E., Minet,E., Stern,C., Riahi,S., Stiles,C.D. and
            Silver,P.A.
  TITLE     A genome-wide in situ hybridization map of RNA-binding proteins
            reveals anatomically restricted expression in the developing mouse
            brain
  JOURNAL   BMC Dev Biol 5, 14 (2005)
   PUBMED   16033648
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 2254)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY107258.1, AK077648.1,
            AK075769.1 and AV016063.1.
            
            On Jan 16, 2008 this sequence version replaced NM_020587.1.
            
            Summary: The protein encoded by this gene is a member of the
            serine/arginine (SR)-rich family of pre-mRNA splicing factors,
            which constitute part of the spliceosome. Each of these factors
            contains an RNA recognition motif (RRM) for binding RNA and an RS
            domain for binding other proteins. The RS domain is rich in serine
            and arginine residues and facilitates interaction between different
            SR splicing factors. In addition to being critical for mRNA
            splicing, the SR proteins have also been shown to be involved in
            mRNA export from the nucleus and in translation. [provided by
            RefSeq, Sep 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK077648.1, AK075769.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                BY107258.1         2-31
            31-1790             AK077648.1         17-1776
            1791-1831           AK075769.1         1756-1796
            1832-2229           AK077648.1         1818-2215
            2230-2254           AV016063.1         268-292
FEATURES             Location/Qualifiers
     source          1..2254
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 64.53 cM"
     gene            1..2254
                     /gene="Srsf4"
                     /gene_synonym="5730499P16Rik; MNCb-2616; Sfrs4; SRp75"
                     /note="serine and arginine-rich splicing factor 4"
                     /db_xref="GeneID:57317"
                     /db_xref="MGI:MGI:1890577"
     exon            1..232
                     /gene="Srsf4"
                     /gene_synonym="5730499P16Rik; MNCb-2616; Sfrs4; SRp75"
                     /inference="alignment:Splign:2.1.0"
     exon            233..375
                     /gene="Srsf4"
                     /gene_synonym="5730499P16Rik; MNCb-2616; Sfrs4; SRp75"
                     /inference="alignment:Splign:2.1.0"
     exon            376..488
                     /gene="Srsf4"
                     /gene_synonym="5730499P16Rik; MNCb-2616; Sfrs4; SRp75"
                     /inference="alignment:Splign:2.1.0"
     exon            489..703
                     /gene="Srsf4"
                     /gene_synonym="5730499P16Rik; MNCb-2616; Sfrs4; SRp75"
                     /inference="alignment:Splign:2.1.0"
     exon            704..793
                     /gene="Srsf4"
                     /gene_synonym="5730499P16Rik; MNCb-2616; Sfrs4; SRp75"
                     /inference="alignment:Splign:2.1.0"
     exon            794..2254
                     /gene="Srsf4"
                     /gene_synonym="5730499P16Rik; MNCb-2616; Sfrs4; SRp75"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2209..2214
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Srsf4"
                     /gene_synonym="5730499P16Rik; MNCb-2616; Sfrs4; SRp75"
                     /note="hexamer: AATAAA"
     polyA_site      2235
                     /gene="Srsf4"
                     /gene_synonym="5730499P16Rik; MNCb-2616; Sfrs4; SRp75"
                     /note="major polyA site"
ORIGIN      
        1 gtgctcgcgt acgtcgccgg gcttcggctg cgtccgtccc gccgcccgcc cgttaccgcc
       61 gccgccgcgt tttcccttcg ccggccgccg cctgaggggg gccggggcca gctgccgccg
      121 ccggaatgcc gcgggtgtac atcggccgcc tgagctacca ggcccgggag cgcgatgtgg
      181 agcgcttctt taagggctac gggaagatcc tggaggtgga tctgaagaac gggtatggct
      241 ttgtggagtt tgatgatctg cgtgatgcag acgatgctgt ttatgaactg aacggcaaag
      301 acctgtgtgg cgagcgagtc attgttgagc acgctcgagg cccgcggcgg gatggcagct
      361 acggctcggg acgcagtgga tatggttatc gaagaagtgg ccgagataaa tacggtcccc
      421 ctactcgcac agaatacaga cttattgtgg agaatttgtc aagtcgatgc agctggcagg
      481 acctaaagga ttacatgcgt caggcaggag aagtgacgta tgcagatgct cacaagggac
      541 gcaaaaacga aggagtgatt gaatttgtgt cttactctga tatgaaaaga gctttggaaa
      601 agctggacgg aactgaagtc aacggcagaa aaatcagatt agttgaagac aagccaggtt
      661 ctaggcggcg ccggtcttac tccagaagcc ggagtcactc aaggtctcgc tctcgaagca
      721 gacattcccg gaagagcaga agccggagtg gtagcagtaa aagcagccat tcgaagagcc
      781 ggtctcgatc caggtcaggt tcccactccc gcagcaagag ccgcagtcgc agtcagagcc
      841 gcagccgcag taagaaggag aaaagccgga gccccagcaa agacaacaag agccgcagtc
      901 gcagccgcag ccctgacaag agccgcagta agagtaaaga ccacgccgag gacaagctcc
      961 aaaacaacga cagcgccggc aaagccaaga gccacagccc cagccgccat gacagtaaaa
     1021 gtcggagcag gagccaggag aggagagcag aggaggagag gcgaaggagc gtgagcaggg
     1081 ctcgcagcca ggagaagagc cgcagccagg agaagagcct tctcaagagc cgcagccgca
     1141 gccggagcaa ggtgggcagc cggagccgca gccgcagcaa ggacaagcgg aagggaagga
     1201 agagaagcag ggacgaaagt cgaagccgca gccgcagcaa gagcgagcgc agccgaaaac
     1261 acagcagcaa gcgggacagc aaagtcagta gcagcagcag caagaagaag aaggacaccg
     1321 accactcccg gtcaccgtcc cgctcggtgt caaaggagcg cgaacatgcc aaggcagagt
     1381 ctggccagag ggaaagccgg gcagagggtg agagcgaggc ccccaatcca gagccccggg
     1441 ccaggtcaag atccacctcc aaatccaaac ccaatgtccc ggcagagtcg cgctccaggt
     1501 caaaatcggc ttcaaaaaca cgctctcggt ccaagtctcc atccaggtct gcttccaggt
     1561 cgccctcccg gtctagatcc aggtcccact caaggtccta actggctctg ccacgctgga
     1621 actgccgaga agtgttttgt acatgttggt agccgtagca caagagtgaa gtagaacacc
     1681 cgtcactgct gtacattaac tccctaaagg tgtgtctcag ttgttcaatc tcagtgcttc
     1741 ctcggtcagc ctccaggcgc caggccttcc cgctctactg aaagcagctc ctcagacctc
     1801 cccttactca cagtaggaca cccagacgcc tgcctttcag gcctggccac ggctataggg
     1861 agctcggcac ccagacggct ggcttctcag gctggagtga tggcgtaggt aggtgtgctg
     1921 agctcagccg tctgcccttg aatcgatgcc ctttgatgtg tgccacgtag tgaaagtgca
     1981 agtcttcagt ctcccaccac ttcggtttcc tgtttctgga cttaccaacg ttgtgaatag
     2041 cacagtggag agaaacggat ccctgcgtag cccctaggaa gtaacactgt aggagctcca
     2101 cattctggta ttgtgattat attgttttat attaaaagga aagatttttt ttaattttat
     2161 ttttccccgt cttgcaaagt atagtgaccc ctgtttccat taaatttgaa taaagactat
     2221 ttttgcttga caaaatttca ccgcgcttga atct
//
