LOCUS       NM_013663               2585 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Mus musculus serine and arginine-rich splicing factor 3 (Srsf3),
            transcript variant 1, mRNA.
ACCESSION   NM_013663 XM_991475
VERSION     NM_013663.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2585)
  AUTHORS   Wang,G., Ren,J., Zeng,X., Chen,X., Liang,A., Wang,X. and Xu,J.
  TITLE     Serine and Arginine-Rich Splicing Factor 3 Promotes the Activation
            of Quiescent Mouse Neural Stem Cells
  JOURNAL   Stem Cells Dev 33 (3-4), 79-88 (2024)
   PUBMED   38115601
  REMARK    GeneRIF: Serine and Arginine-Rich Splicing Factor 3 Promotes the
            Activation of Quiescent Mouse Neural Stem Cells.
REFERENCE   2  (bases 1 to 2585)
  AUTHORS   Wu,W., Hu,A., Xu,H. and Su,J.
  TITLE     LincRNA-EPS Alleviates Inflammation in TMJ Osteoarthritis by
            Binding to SRSF3
  JOURNAL   J Dent Res 102 (10), 1141-1151 (2023)
   PUBMED   37464762
  REMARK    GeneRIF: LincRNA-EPS Alleviates Inflammation in TMJ Osteoarthritis
            by Binding to SRSF3.
REFERENCE   3  (bases 1 to 2585)
  AUTHORS   Heazlewood,S.Y., Ahmad,T., Cao,B., Cao,H., Domingues,M., Sun,X.,
            Heazlewood,C.K., Li,S., Williams,B., Fulton,M., White,J.F.,
            Nebl,T., Nefzger,C.M., Polo,J.M., Kile,B.T., Kraus,F., Ryan,M.T.,
            Sun,Y.B., Choong,P.F.M., Ellis,S.L., Anko,M.L. and Nilsson,S.K.
  TITLE     High ploidy large cytoplasmic megakaryocytes are hematopoietic stem
            cells regulators and essential for platelet production
  JOURNAL   Nat Commun 14 (1), 2099 (2023)
   PUBMED   37055407
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2585)
  AUTHORS   Kumar,D., Das,M., Oberg,A., Sahoo,D., Wu,P., Sauceda,C., Jih,L.,
            Ellies,L.G., Langiewicz,M.T., Sen,S. and Webster,N.J.G.
  TITLE     Hepatocyte Deletion of IGF2 Prevents DNA Damage and Tumor Formation
            in Hepatocellular Carcinoma
  JOURNAL   Adv Sci (Weinh) 9 (21), e2105120 (2022)
   PUBMED   35615981
  REMARK    GeneRIF: Hepatocyte Deletion of IGF2 Prevents DNA Damage and Tumor
            Formation in Hepatocellular Carcinoma.
REFERENCE   5  (bases 1 to 2585)
  AUTHORS   Feng,S., Li,J., Wen,H., Liu,K., Gui,Y., Wen,Y., Wang,X. and Yuan,S.
  TITLE     hnRNPH1 recruits PTBP2 and SRSF3 to modulate alternative splicing
            in germ cells
  JOURNAL   Nat Commun 13 (1), 3588 (2022)
   PUBMED   35739118
  REMARK    GeneRIF: hnRNPH1 recruits PTBP2 and SRSF3 to modulate alternative
            splicing in germ cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2585)
  AUTHORS   Loebel,D.A., O'Rourke,M.P., Steiner,K.A., Banyer,J. and Tam,P.P.
  TITLE     Isolation of differentially expressed genes from wild-type and
            Twist mutant mouse limb buds
  JOURNAL   Genesis 33 (3), 103-113 (2002)
   PUBMED   12124942
REFERENCE   7  (bases 1 to 2585)
  AUTHORS   Vorbruggen,G., Onel,S. and Jackle,H.
  TITLE     Localized expression of the Drosophila gene Dxl6, a novel member of
            the serine/arginine rich (SR) family of splicing factors
  JOURNAL   Mech Dev 90 (2), 309-312 (2000)
   PUBMED   10640718
REFERENCE   8  (bases 1 to 2585)
  AUTHORS   Jumaa,H., Wei,G. and Nielsen,P.J.
  TITLE     Blastocyst formation is blocked in mouse embryos lacking the
            splicing factor SRp20
  JOURNAL   Curr Biol 9 (16), 899-902 (1999)
   PUBMED   10469594
REFERENCE   9  (bases 1 to 2585)
  AUTHORS   Jumaa,H., Guenet,J.L. and Nielsen,P.J.
  TITLE     Regulated expression and RNA processing of transcripts from the
            Srp20 splicing factor gene during the cell cycle
  JOURNAL   Mol Cell Biol 17 (6), 3116-3124 (1997)
   PUBMED   9154810
REFERENCE   10 (bases 1 to 2585)
  AUTHORS   Ayane,M., Preuss,U., Kohler,G. and Nielsen,P.J.
  TITLE     A differentially expressed murine RNA encoding a protein with
            similarities to two types of nucleic acid binding motifs
  JOURNAL   Nucleic Acids Res 19 (6), 1273-1278 (1991)
   PUBMED   2030943
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY249648.1, AK078891.1 and
            BB008721.1.
            
            [WARNING] On Mar 14, 2024 this sequence was replaced by
            NM_013663.6.
            
            On Sep 10, 2010 this sequence version replaced NM_013663.4.
            
            Summary: The protein encoded by this gene is a member of the
            serine/arginine (SR)-rich family of pre-mRNA splicing factors,
            which constitute part of the spliceosome. Each of these factors
            contains an RNA recognition motif (RRM) for binding RNA and an RS
            domain for binding other proteins. The RS domain is rich in serine
            and arginine residues and facilitates interaction between different
            SR splicing factors. In addition to being critical for mRNA
            splicing, the SR proteins have also been shown to be involved in
            mRNA export from the nucleus and in translation. Two transcript
            variants, one protein-coding and the other not protein-coding, have
            been found for this gene. [provided by RefSeq, Sep 2010].
            
            Transcript Variant: This variant (1) represents the protein-coding
            transcript.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BU513700.1, AK078891.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                BY249648.1         5-17
            14-2579             AK078891.1         2-2567
            2580-2585           BB008721.1         272-277
FEATURES             Location/Qualifiers
     source          1..2585
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 15.03 cM"
     gene            1..2585
                     /gene="Srsf3"
                     /gene_synonym="Sfrs3; X16"
                     /note="serine and arginine-rich splicing factor 3"
                     /db_xref="GeneID:20383"
                     /db_xref="MGI:MGI:98285"
     exon            1..127
                     /gene="Srsf3"
                     /gene_synonym="Sfrs3; X16"
                     /inference="alignment:Splign:2.1.0"
     exon            128..335
                     /gene="Srsf3"
                     /gene_synonym="Sfrs3; X16"
                     /inference="alignment:Splign:2.1.0"
     exon            336..470
                     /gene="Srsf3"
                     /gene_synonym="Sfrs3; X16"
                     /inference="alignment:Splign:2.1.0"
     exon            471..509
                     /gene="Srsf3"
                     /gene_synonym="Sfrs3; X16"
                     /inference="alignment:Splign:2.1.0"
     exon            510..596
                     /gene="Srsf3"
                     /gene_synonym="Sfrs3; X16"
                     /inference="alignment:Splign:2.1.0"
     exon            597..2585
                     /gene="Srsf3"
                     /gene_synonym="Sfrs3; X16"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acggtggtgg tccgccattt cgtgacgccg cgagaccgag aatctgtagg agcagaacca
       61 gagggaagcg ggtgggcctg tcggagcgtt aggatttgag cttgggcctt ttgaacccag
      121 gatctcgaaa tgcatcgtga ttcctgtccc ttggattgta aggtttatgt aggtaatctt
      181 ggaaataatg gaaacaagac tgaattagaa cgggcttttg gctattatgg accactcaga
      241 agtgtgtggg ttgctcgaaa ccctcctggc tttgctttcg tcgaatttga ggatccccga
      301 gatgctgctg atgctgtccg ggaactagat ggaagaacac tgtgtggctg ccgtgtaaga
      361 gtggaactgt cgaatggtga aaagagaagt cggaatcgtg ggccgcctcc ctcttggggt
      421 cgtcgtcctc gagatgatta ccgcaggagg agtcctccac ctcggcgcag atccccaaga
      481 aggagaagct tttcccgaag ccggagcagg tcactttcta gagataggag aagagaaagg
      541 tctctgtctc gtgagagaaa tcacaagccg tctcgatcct tctctaggtc tcgtagccga
      601 tctaggtcaa atgaaaggaa atagaagacc agtttgcaaa agtggtgtac aggaaataac
      661 ttcatctgac aggagtatgt acaggaaatt aaagttttgt ttgagacttc ataagcttgg
      721 tgcattttta agatggttta gctgtttaaa tttgttttgt ctcttggaac agtgacacac
      781 aaaacaatgt aattctctat ggttttcaga tggatcataa gaggcacgtg atatcaagaa
      841 ttgttacttt acaatgttcc cttaagcaag atttaatttt ctttgaattt tagtttttca
      901 tagactgaaa taaaccttag gtcctgccca gttttaagtg tgatgtacta atgatataaa
      961 gcaactggcg gaaattgaaa gaagctatag tcctctagta gctgagacac tgtggcactg
     1021 tgggtggaat gataaagcgg tgtttaagag ctgctgtgaa cacaagccaa cagataaggg
     1081 taggaaccac actgaagatt tgcaaagggg ttccttcctg gtttctctat ggggatgcag
     1141 agctattgta acgtctttat ttggaaatgt aaaactcaga tgccagtgtc ctttcagttt
     1201 aagggtacat tgtagagctc aacttttcag ttactgtgca agattgtttt tcatgctgtc
     1261 atttgtaata tgtttgtgag aatctttggg attaaagttt tggttacaaa ttgttgttta
     1321 acttgaaagc ctgtttttcc ttgcacactc aaaatctgtg agcttggtat caagtccagg
     1381 taaaacattc ctattggaag ccatacttat attttcttgt aaagtgcttt tgaattaata
     1441 aagtactagc ataattgtgt agtagtcagt cgagcgaacc actgttgcca ttgttcttat
     1501 ccctgggaaa gtagttggtt acccagttca ttctttgtaa gaaacacaac tgagaagcac
     1561 tacattagtg aaggaatttt tttttcccct ttgcttgtca cttatgagag ttagccattt
     1621 tttaggtgtt gaagccagtt caggattatg gctgttagtg actaacattt taaagtaagc
     1681 tccagtatgg taggtatatt gtaattccct taagttgccc ataaaaagtg gctttgatct
     1741 tcagcatgaa aacattcaaa attttaaaat ttattttata acttgaggtg ttgcatggga
     1801 ttccaaattg atccatcatg atgtaaaatc cccaatatgg ttaattgtaa tgatgcacag
     1861 ttgaaatgga ggcatgcata tcctttctct tagaatctgg aggagttgtg gtttcaggta
     1921 tttgtgtgca actagattaa atcataatgc aacagtcttg tggcttaagt ttccttaaat
     1981 gtgttctttt gagataagat tctactgtac tgacttggtc tatgtaagag ccattgcact
     2041 aagttaaatc tgtaagctta taaatctccc ccattgttat ctttaaacaa taaatttcag
     2101 taaaaaagga gagagttgtg tctagaaggt tccaacatga gcctttgaaa gaagtaccca
     2161 tcttctttga aggtactttt aaattagcta cccttgatca ttctgagtat aatactaaaa
     2221 ggatgattcc aggtgtttgc tagaggtcat tattagtact taatgatgat taagaaaggc
     2281 acctgagaat atgggtaacc tcagatatta catacacaat gtaggttctc ttcatttacc
     2341 atctaggtgc ctaagtgtca tgatggcatc tctaccctgt attggactgt aataaacagc
     2401 catagttgtc ttagccactg gcttagtgcc ttgtcttaac tgtgctttgc ttttctgaat
     2461 ccagatgaga tttaggtatc aatctattcc agtgtatatt tttgtactac cagactcttg
     2521 tcttctggtt ttcttttagg gtaggaacat aaaagattat tattaaaaga cactgactta
     2581 aagtt
//
