LOCUS       NM_011358               1903 bp    mRNA    linear   ROD 11-DEC-2024
DEFINITION  Mus musculus serine and arginine-rich splicing factor 2 (Srsf2),
            mRNA.
ACCESSION   NM_011358
VERSION     NM_011358.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1903)
  AUTHORS   You,X., Peng,Q., Qian,W., Duan,H., Xie,Z. and Feng,Y.
  TITLE     SRSF2 is essential for maintaining pancreatic beta-cell identity
            and regulating glucose homeostasis in mice
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1871 (8), 119845 (2024)
   PUBMED   39265887
  REMARK    GeneRIF: SRSF2 is essential for maintaining pancreatic beta-cell
            identity and regulating glucose homeostasis in mice.
REFERENCE   2  (bases 1 to 1903)
  AUTHORS   Wagner,R.E., Arnetzl,L., Britto-Borges,T., Heit-Mondrzyk,A.,
            Bakr,A., Sollier,E., Gkatza,N.A., Panten,J., Delaunay,S., Sohn,D.,
            Schmezer,P., Odom,D.T., Muller-Decker,K., Plass,C., Dieterich,C.,
            Lutsik,P., Bornelov,S. and Frye,M.
  TITLE     SRSF2 safeguards efficient transcription of DNA damage and repair
            genes
  JOURNAL   Cell Rep 43 (11), 114869 (2024)
   PUBMED   39446588
REFERENCE   3  (bases 1 to 1903)
  AUTHORS   Zhang,F., Sun,J., Zhang,L., Li,R., Wang,Y., Geng,H., Shen,C., Li,L.
            and Chen,L.
  TITLE     PARP inhibition leads to synthetic lethality with key
            splicing-factor mutations in myelodysplastic syndromes
  JOURNAL   Br J Cancer 131 (2), 231-242 (2024)
   PUBMED   38806724
  REMARK    GeneRIF: PARP inhibition leads to synthetic lethality with key
            splicing-factor mutations in myelodysplastic syndromes.
REFERENCE   4  (bases 1 to 1903)
  AUTHORS   Liu,X., Devadiga,S.A., Stanley,R.F., Morrow,R.M., Janssen,K.A.,
            Quesnel-Vallieres,M., Pomp,O., Moverley,A.A., Li,C., Skuli,N.,
            Carroll,M., Huang,J., Wallace,D.C., Lynch,K.W., Abdel-Wahab,O. and
            Klein,P.S.
  TITLE     A mitochondrial surveillance mechanism activated by SRSF2 mutations
            in hematologic malignancies
  JOURNAL   J Clin Invest 134 (12), e175619 (2024)
   PUBMED   38713535
  REMARK    GeneRIF: A mitochondrial surveillance mechanism activated by SRSF2
            mutations in hematologic malignancies.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1903)
  AUTHORS   Li,Z., Liu,X., Zhang,Y., Li,Y., Zhou,L. and Yuan,S.
  TITLE     FBXO24 modulates mRNA alternative splicing and MIWI degradation and
            is required for normal sperm formation and male fertility
  JOURNAL   Elife 12, 91666 (2024)
   PUBMED   38470475
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1903)
  AUTHORS   Bermingham,J.R. Jr., Arden,K.C., Naumova,A.K., Sapienza,C.,
            Viars,C.S., Fu,X.D., Khotz,J., Manley,J.L. and Rosenfeld,M.G.
  TITLE     Chromosomal localization of mouse and human genes encoding the
            splicing factors ASF/SF2 (SFRS1) and SC-35 (SFRS2)
  JOURNAL   Genomics 29 (1), 70-79 (1995)
   PUBMED   8530103
REFERENCE   7  (bases 1 to 1903)
  AUTHORS   Ferreira,J. and Carmo-Fonseca,M.
  TITLE     The biogenesis of the coiled body during early mouse development
  JOURNAL   Development 121 (2), 601-612 (1995)
   PUBMED   7768196
REFERENCE   8  (bases 1 to 1903)
  AUTHORS   Haque,N.S., Buchberg,A.M. and Khalili,K.
  TITLE     Isolation and characterization of MRF-1, a brain-derived
            DNA-binding protein with a capacity to regulate expression of
            myelin basic protein gene
  JOURNAL   J Biol Chem 269 (49), 31149-31156 (1994)
   PUBMED   7527040
REFERENCE   9  (bases 1 to 1903)
  AUTHORS   Yan,C. and Tamm,I.
  TITLE     Molecular cloning and characterization of additional factors that
            bind to the interferon-alpha/beta response element B of the murine
            (2'-5')oligoadenylate synthetase ME-12 gene
  JOURNAL   Proc Natl Acad Sci U S A 89 (19), 8859-8863 (1992)
   PUBMED   1409578
REFERENCE   10 (bases 1 to 1903)
  AUTHORS   Ayane,M., Preuss,U., Kohler,G. and Nielsen,P.J.
  TITLE     A differentially expressed murine RNA encoding a protein with
            similarities to two types of nucleic acid binding motifs
  JOURNAL   Nucleic Acids Res 19 (6), 1273-1278 (1991)
   PUBMED   2030943
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CJ043688.1, AK086103.1 and
            BG093253.1.
            
            On Apr 18, 2009 this sequence version replaced NM_011358.1.
            
            Summary: The protein encoded by this gene is a member of the
            serine/arginine (SR)-rich family of pre-mRNA splicing factors,
            which constitute part of the spliceosome. Each of these factors
            contains an RNA recognition motif (RRM) for binding RNA and an RS
            domain for binding other proteins. The RS domain is rich in serine
            and arginine residues and facilitates interaction between different
            SR splicing factors. In addition to being critical for mRNA
            splicing, the SR proteins have also been shown to be involved in
            mRNA export from the nucleus and in translation. [provided by
            RefSeq, Sep 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK086103.1, AK088042.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 CJ043688.1         2-4
            4-1901              AK086103.1         2-1899
            1902-1903           BG093253.1         5-6                 c
FEATURES             Location/Qualifiers
     source          1..1903
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 81.49 cM"
     gene            1..1903
                     /gene="Srsf2"
                     /gene_synonym="D11Wsu175e; MRF-1; Pr264; SC35; Sfrs10;
                     Sfrs2"
                     /note="serine and arginine-rich splicing factor 2"
                     /db_xref="GeneID:20382"
                     /db_xref="MGI:MGI:98284"
     exon            1..527
                     /gene="Srsf2"
                     /gene_synonym="D11Wsu175e; MRF-1; Pr264; SC35; Sfrs10;
                     Sfrs2"
                     /inference="alignment:Splign:2.1.0"
     CDS             166..831
                     /gene="Srsf2"
                     /gene_synonym="D11Wsu175e; MRF-1; Pr264; SC35; Sfrs10;
                     Sfrs2"
                     /note="splicing factor Sc35; myelin regulatory factor 1;
                     splicing component, 35 kDa; putative myelin regulatory
                     factor 1; splicing factor, arginine/serine-rich 2 (SC-35)"
                     /codon_start=1
                     /product="serine/arginine-rich splicing factor 2"
                     /protein_id="NP_035488.1"
                     /db_xref="CCDS:CCDS25680.1"
                     /db_xref="GeneID:20382"
                     /db_xref="MGI:MGI:98284"
                     /translation="MSYGRPPPDVEGMTSLKVDNLTYRTSPDTLRRVFEKYGRVGDVY
                     IPRDRYTKESRGFAFVRFHDKRDAEDAMDAMDGAVLDGRELRVQMARYGRPPDSHHSR
                     RGPPPRRYGGGGYGRRSRSPRRRRRSRSRSRSRSRSRSRSRYSRSKSRSRTRSRSRST
                     SKSRSARRSKSKSSSVSRSRSRSRSRSRSRSPPPVSKRESKSRSRSKSPPKSPEEEGA
                     VSS"
     exon            528..838
                     /gene="Srsf2"
                     /gene_synonym="D11Wsu175e; MRF-1; Pr264; SC35; Sfrs10;
                     Sfrs2"
                     /inference="alignment:Splign:2.1.0"
     exon            839..1903
                     /gene="Srsf2"
                     /gene_synonym="D11Wsu175e; MRF-1; Pr264; SC35; Sfrs10;
                     Sfrs2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1864..1869
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Srsf2"
                     /gene_synonym="D11Wsu175e; MRF-1; Pr264; SC35; Sfrs10;
                     Sfrs2"
                     /note="hexamer: ATTAAA"
     polyA_site      1896
                     /gene="Srsf2"
                     /gene_synonym="D11Wsu175e; MRF-1; Pr264; SC35; Sfrs10;
                     Sfrs2"
                     /note="major polyA site"
ORIGIN      
        1 gcttagttgc tgctcaggcg tccgtcaggt tcgggtgctc tgcggcggcc ttgcggctcc
       61 ctccctaccc acgaggactg tagctaccga gcgcctgacg gagctgcgtt tccggagagc
      121 gagggcctgt ccggggcgtt agggtctcgg cgccgcttcg cagccatgag ctacggccgc
      181 ccgcctcccg atgtggaggg catgacctcc ctcaaggtgg acaacctgac ctaccgcacc
      241 tcgcccgaca ccctgaggcg cgtcttcgag aaatacgggc gcgtcggcga cgtgtacatt
      301 ccgcgggacc gctacaccaa ggagtcccgg ggcttcgcct tcgtccggtt ccacgacaag
      361 cgcgacgccg aagacgccat ggacgccatg gacggggcgg tgctcgacgg ccgcgagctg
      421 cgggtgcaga tggcgcgcta cggccgcccg cccgactcgc accacagccg ccggggcccg
      481 ccaccccgtc ggtacggcgg cggcggctac gggcggcgga gccgcagccc tcggcgacgc
      541 cggcgcagcc gatctcgaag ccggagtcgg tccaggtcgc gaagccgctc ccgctacagc
      601 cgctccaagt ctcggtcccg cactcgctcg cgctccagat caacctccaa gtccagatct
      661 gcccgaagat ccaagtccaa gtcctcctcc gtctccagat cccgctcgag gtcaaggtcc
      721 aggtcgcgat cgagaagccc tccgcccgtg tcgaagcgag agtccaagtc taggtcgcgg
      781 tccaagagcc cacccaagtc tccagaagaa gagggagcag tttcttccta agaaaatgat
      841 gaatcggcaa gcggcttaac agaggacatt gggggaaagg accacaaact cagtccatcg
      901 gtccatggaa gagtccttgg aacaagcaac tggctattaa aaaggttatt ttgtaacatt
      961 tgtctaactt tttacttgtt ttaatctgcc tcaggtggca aacttcattt tatgtgccat
     1021 tttgttgctg ttattcaaat ttcttgtaat ttagtgaggt gagcgacttc agatttcatt
     1081 attggattgg atatttgagg taaaatttca tttttgttta tagtgctgac ttttttgttt
     1141 gaaattaaac agattggtaa cctaatttgt ggcctcctga cttaataagg aaacatgtac
     1201 agccattaca tacagcctaa agctgtcagc agaatgactc aacattgcct tcacttctta
     1261 ataattaaaa acctatgaaa gttggtgtaa tttgttcata tatgttattt accttcaggt
     1321 ctatatgata atctgaaccc aaatttgtat aaagactttt caggtgaaaa gacttaattt
     1381 tttttttaaa ggattgttta cccaacacaa ttctaatctc ttctcttatg tatttttgtg
     1441 cactaggcgc agttgtgtag cagttgagta atgctggtta gctgttaagg tggcgtgttg
     1501 cagtgcagag tgcttggctg tttcctgttt tctcctgatt gctcctgtgt aaagatgcct
     1561 tgtcgtgcag aaacaaatgg ctgtccagtt tattaaaatg cctgacaact gcacttccag
     1621 tcacccgggc cttgcatata aataatggag catacagtga gcacatctag ctgatgataa
     1681 atataccccc cttccctcaa aaaatgcaaa atggtaaatc tgatcatcct tgtgttgtga
     1741 acttttaaaa aaaaaatcaa aatgttaagg aagcaaatgg tttgtaactt tgtaagtact
     1801 taaaacatgg tgtatctttt gcttatggat attctgtact ataaccattg tttctgtagt
     1861 ttgattaaag tgttttcttg gtgttagctt ttttgagaat gtg
//
