LOCUS       NM_001379533            2657 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus serine and arginine-rich splicing factor 11 (Srsf11),
            transcript variant 6, mRNA.
ACCESSION   NM_001379533
VERSION     NM_001379533.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2657)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2657)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2657)
  AUTHORS   Raihan,O., Brishti,A., Li,Q., Zhang,Q., Li,D., Li,X., Zhang,Q.,
            Xie,Z., Li,J., Zhang,J. and Liu,Q.
  TITLE     SFRS11 Loss Leads to Aging-Associated Cognitive Decline by
            Modulating LRP8 and ApoE
  JOURNAL   Cell Rep 28 (1), 78-90 (2019)
   PUBMED   31269452
  REMARK    GeneRIF: SFRS11 Loss Leads to Aging-Associated Cognitive Decline by
            Modulating LRP8 and ApoE.
REFERENCE   4  (bases 1 to 2657)
  AUTHORS   Zhou,J., Wang,R., Zhang,J., Zhu,L., Liu,W., Lu,S., Chen,P., Li,H.,
            Yin,B., Yuan,J., Qiang,B., Shu,P. and Peng,X.
  TITLE     Conserved expression of ultra-conserved noncoding RNA in mammalian
            nervous system
  JOURNAL   Biochim Biophys Acta Gene Regul Mech 1860 (12), 1159-1168 (2017)
   PUBMED   29055695
REFERENCE   5  (bases 1 to 2657)
  AUTHORS   Roberts,J.M., Ennajdaoui,H., Edmondson,C., Wirth,B., Sanford,J.R.
            and Chen,B.
  TITLE     Splicing factor TRA2B is required for neural progenitor survival
  JOURNAL   J Comp Neurol 522 (2), 372-392 (2014)
   PUBMED   23818142
REFERENCE   6  (bases 1 to 2657)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   7  (bases 1 to 2657)
  AUTHORS   McKee,A.E., Minet,E., Stern,C., Riahi,S., Stiles,C.D. and
            Silver,P.A.
  TITLE     A genome-wide in situ hybridization map of RNA-binding proteins
            reveals anatomically restricted expression in the developing mouse
            brain
  JOURNAL   BMC Dev Biol 5, 14 (2005)
   PUBMED   16033648
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2657)
  AUTHORS   Easterday,M.C., Dougherty,J.D., Jackson,R.L., Ou,J., Nakano,I.,
            Paucar,A.A., Roobini,B., Dianati,M., Irvin,D.K., Weissman,I.L.,
            Terskikh,A.V., Geschwind,D.H. and Kornblum,H.I.
  TITLE     Neural progenitor genes. Germinal zone expression and analysis of
            genetic overlap in stem cell populations
  JOURNAL   Dev Biol 264 (2), 309-322 (2003)
   PUBMED   14651920
REFERENCE   9  (bases 1 to 2657)
  AUTHORS   Geschwind,D.H., Ou,J., Easterday,M.C., Dougherty,J.D.,
            Jackson,R.L., Chen,Z., Antoine,H., Terskikh,A., Weissman,I.L.,
            Nelson,S.F. and Kornblum,H.I.
  TITLE     A genetic analysis of neural progenitor differentiation
  JOURNAL   Neuron 29 (2), 325-339 (2001)
   PUBMED   11239426
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC145301.4.
            
            Summary: The protein encoded by this gene is a member of the
            serine/arginine (SR)-rich family of pre-mRNA splicing factors,
            which constitute part of the spliceosome. Each of these factors
            contains an RNA recognition motif (RRM) for binding RNA and an RS
            domain for binding other proteins. The RS domain is rich in serine
            and arginine residues and facilitates interaction between different
            SR splicing factors. In addition to being critical for mRNA
            splicing, the SR proteins have also been shown to be involved in
            mRNA export from the nucleus and in translation. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Nov 2014].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660815.10145.1,
                                           SRR7345562.3082820.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-297               AC145301.4         141032-141328
            298-431             AC145301.4         145922-146055
            432-541             AC145301.4         149830-149939
            542-634             AC145301.4         150728-150820
            635-684             AC145301.4         151355-151404
            685-812             AC145301.4         153341-153468
            813-894             AC145301.4         154889-154970
            895-1026            AC145301.4         156327-156458
            1027-1116           AC145301.4         158739-158828
            1117-1233           AC145301.4         159884-160000
            1234-1372           AC145301.4         160332-160470
            1373-2657           AC145301.4         160577-161861
FEATURES             Location/Qualifiers
     source          1..2657
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 81.63 cM"
     gene            1..2657
                     /gene="Srsf11"
                     /gene_synonym="0610009J05Rik; 2610019N13Rik; Sfrs11"
                     /note="serine and arginine-rich splicing factor 11"
                     /db_xref="GeneID:69207"
                     /db_xref="MGI:MGI:1916457"
     exon            1..297
                     /gene="Srsf11"
                     /gene_synonym="0610009J05Rik; 2610019N13Rik; Sfrs11"
                     /inference="alignment:Splign:2.1.0"
     exon            298..431
                     /gene="Srsf11"
                     /gene_synonym="0610009J05Rik; 2610019N13Rik; Sfrs11"
                     /inference="alignment:Splign:2.1.0"
     exon            432..541
                     /gene="Srsf11"
                     /gene_synonym="0610009J05Rik; 2610019N13Rik; Sfrs11"
                     /inference="alignment:Splign:2.1.0"
     exon            542..634
                     /gene="Srsf11"
                     /gene_synonym="0610009J05Rik; 2610019N13Rik; Sfrs11"
                     /inference="alignment:Splign:2.1.0"
     exon            635..684
                     /gene="Srsf11"
                     /gene_synonym="0610009J05Rik; 2610019N13Rik; Sfrs11"
                     /inference="alignment:Splign:2.1.0"
     exon            685..812
                     /gene="Srsf11"
                     /gene_synonym="0610009J05Rik; 2610019N13Rik; Sfrs11"
                     /inference="alignment:Splign:2.1.0"
     exon            813..894
                     /gene="Srsf11"
                     /gene_synonym="0610009J05Rik; 2610019N13Rik; Sfrs11"
                     /inference="alignment:Splign:2.1.0"
     exon            895..1026
                     /gene="Srsf11"
                     /gene_synonym="0610009J05Rik; 2610019N13Rik; Sfrs11"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1116
                     /gene="Srsf11"
                     /gene_synonym="0610009J05Rik; 2610019N13Rik; Sfrs11"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..1233
                     /gene="Srsf11"
                     /gene_synonym="0610009J05Rik; 2610019N13Rik; Sfrs11"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..1372
                     /gene="Srsf11"
                     /gene_synonym="0610009J05Rik; 2610019N13Rik; Sfrs11"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..2657
                     /gene="Srsf11"
                     /gene_synonym="0610009J05Rik; 2610019N13Rik; Sfrs11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2636..2641
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Srsf11"
                     /gene_synonym="0610009J05Rik; 2610019N13Rik; Sfrs11"
                     /note="hexamer: AATAAA"
     polyA_site      2657
                     /gene="Srsf11"
                     /gene_synonym="0610009J05Rik; 2610019N13Rik; Sfrs11"
                     /note="major polyA site"
ORIGIN      
        1 gtgggccggc tgcgctgcgc gaggtccgcg gccgtttgtg tgcggccggc ggccggtgcc
       61 gcgcgctctc actctgtctt gtgtttgatg tgttgagcag gaggcagccc gcgccatgag
      121 cagcacggca gtggtcccca gcgcgccagg cccgggccca ggccccagtg gcgggccagg
      181 cggcggcacc gaggtgatcc aggtgaccaa cgtgtctccg agcgccagct cagagcagat
      241 gcgtacgctc ttcggcttcc tgggcaagat cgacgagctg cgcctcttcc cgccggatga
      301 ctcacctttg ccagtctcct ctcgtgtctg ctttgttaag ttccatgatc cagactcagc
      361 agttgtggca cagcatctga caaacactgt gttcgttgac agagctttga tagtcgtacc
      421 atatgctgaa ggagttattc ctgatgagac taaggctttg tctctattgg caccagctaa
      481 tgcagtggca ggtcttctgc ctggtggtgg actcctgcct acccccaacc cacttaccca
      541 gattggcgct gttcccctgg ctgcgttggg agctccagct cttgatcctg cccttgctgc
      601 tcttgggctt ccaggaacaa acttgaactc tcagtccctt gctgcagacc agctattgaa
      661 acttatgagt actgttgatc ccaaattgaa tcatgtagca gctggtcttg tttcaccaag
      721 tctgaagtca gacacctcta gtaaagaaat agaggaagcc atgaagagag tgcgtgaagc
      781 ccagtccctg atttctgccg ctattgagcc agacaagaag gaagaaaaga gaagacattc
      841 gagatcaaga tctcgctcga ggaggaggag gaccccctca tcctccagac acaggcggtc
      901 acgaagccgg tcaaggaggc ggtcacactc caaatccagg agtagaagga gatccaaaag
      961 tccaagacgg agacgatctc attcccgaga gaggggtaga aggtcaagga gcacatccaa
     1021 agccagagac aaaaagaaag aagataaaga aaagaaacgt tccaaaactc caccaaaaag
     1081 ctacagcaca gccagacgct ctcggagtgc aagcagtttg cacgtttgtg attctagaga
     1141 gagaagacga cggcgaagta ggagtggtac aagatcccct aaaaagccca ggtctcctaa
     1201 aagaaagctg tctcgctcac catccccaag gagacataaa aaagagaaga agaaagataa
     1261 ggacaaagaa agaagcagag atgaaaggga acgatcaaca agtaaaaaga agaggagcaa
     1321 agacaaggag aaggagcgag aaaggaagtc tgagagtgac aaagacgtca aacaggtgac
     1381 tcgggattat gatgaagagg agcaaggcta tgacagtgag aaggaaaaga aagaggagaa
     1441 gagaccaaca gaagcagtgt cccctaaaac aaaggagtgc tctgtggaga agggggtggg
     1501 cgaccttcga gagtccaaag tgaacgggga tgatcaccac gaagaagaca tggatatgag
     1561 tgactgagcc caaggctggc tgcagatggt cctcagtgtc attccttgtg atctctaatg
     1621 ctgtgtgtgt tcatctcacc taggtgtata cagctgcaca ttaccaatgg cttcagaaca
     1681 cctgattgtg acctctagtg ctttatagca aaagctataa agtggtaccc gggtgaccag
     1741 cattgccatg gttacatcca tttgcgtgat caagcagctg tgcaactgct gctttaacac
     1801 agatgaacag ctgcatgcat ctccagcagg catggattgt ctctgtctat gatcctcagt
     1861 gcgttcactt agaatatttc tagagtttga gtccttgccg tgatagagcc atgtagggaa
     1921 tgcactgatt gcatgttacc ccaaacgtca tgaaactttc tgacacggtg acctatttaa
     1981 tggtcttgtt tgttgacatg acaaattaac attcttagag ttacatctga aaaaaaacat
     2041 ttgtgataga taagcctttt gagccttgtg gctaaatttt tgtggctttg tttaactttc
     2101 aaaggttata tatgcactaa ccttttttga tggctaagta ggctttaaat tacagtaaaa
     2161 atttttcaaa gaaaactggc tgtaaaatat gatgttttga attagttgtt cactttttca
     2221 tagctactta tgtttttccc ccaataattt atttcacatc tctaccagtg aacgcagccc
     2281 atcactagaa aatgaccttg tcctgatttt cagttttcaa cttttagttt ttaaagctca
     2341 ctgttgaaca agaagtggtg gtgcatttta aattgacctt catgtgcttt taaaatacga
     2401 cagctctcct tgataatgta cttttatttg atctcaagtt gtataaaacc aataaacttg
     2461 tgttactttg attgcagtag tatcttatgc acagtgattc catgttatat gcagactagg
     2521 taggcaactg ttttcttagt tacaagcttt acttttgtgc agttaaaaca aaagtaggct
     2581 acagtctgtg ccatgttgat gtacagtttc tgaaattgtt ttacaagact ttgataataa
     2641 aacccttaaa ctcacaa
//
