LOCUS       NM_001080387            2753 bp    mRNA    linear   ROD 07-SEP-2024
DEFINITION  Mus musculus serine and arginine-rich splicing factor 10 (Srsf10),
            transcript variant 2, mRNA.
ACCESSION   NM_001080387 XM_987706
VERSION     NM_001080387.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2753)
  AUTHORS   Ma,A., Mu,Y., Wei,Z., Sun,M., Li,J., Jiang,H., Zhu,C. and Chen,X.
  TITLE     SRSF10 regulates migration of neural progenitor cells and granule
            cells and affects the formation of dentate gyrus during the
            development of mouse hippocampus
  JOURNAL   Neuroscience 552, 142-151 (2024)
   PUBMED   38960088
  REMARK    GeneRIF: SRSF10 regulates migration of neural progenitor cells and
            granule cells and affects the formation of dentate gyrus during the
            development of mouse hippocampus.
REFERENCE   2  (bases 1 to 2753)
  AUTHORS   Li,J., Jiang,H., Mu,Y., Wei,Z., Ma,A., Sun,M., Zhao,J., Zhu,C. and
            Chen,X.
  TITLE     SRSF10 regulates proliferation of neural progenitor cells and
            affects neurogenesis in developing mouse neocortex
  JOURNAL   iScience 26 (7), 107042 (2023)
   PUBMED   37360696
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2753)
  AUTHORS   Liu,W., Lu,X., Zhao,Z.H., Su,R., Li,Q.L., Xue,Y., Gao,Z., Sun,S.S.,
            Lei,W.L., Li,L., An,G., Liu,H., Han,Z., Ouyang,Y.C., Hou,Y.,
            Wang,Z.B., Sun,Q.Y. and Liu,J.
  TITLE     SRSF10 is essential for progenitor spermatogonia expansion by
            regulating alternative splicing
  JOURNAL   Elife 11, e78211 (2022)
   PUBMED   36355419
  REMARK    GeneRIF: SRSF10 is essential for progenitor spermatogonia expansion
            by regulating alternative splicing.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2753)
  AUTHORS   Jobbins,A.M., Haberman,N., Artigas,N., Amourda,C., Paterson,H.A.B.,
            Yu,S., Blackford,S.J.I., Montoya,A., Dore,M., Wang,Y.F.,
            Sardini,A., Cebola,I., Zuber,J., Rashid,S.T., Lenhard,B. and
            Vernia,S.
  TITLE     Dysregulated RNA polyadenylation contributes to metabolic
            impairment in non-alcoholic fatty liver disease
  JOURNAL   Nucleic Acids Res 50 (6), 3379-3393 (2022)
   PUBMED   35293570
  REMARK    GeneRIF: Dysregulated RNA polyadenylation contributes to metabolic
            impairment in non-alcoholic fatty liver disease.
REFERENCE   5  (bases 1 to 2753)
  AUTHORS   Meinke,S., Goldammer,G., Weber,A.I., Tarabykin,V., Neumann,A.,
            Preussner,M. and Heyd,F.
  TITLE     Srsf10 and the minor spliceosome control tissue-specific and
            dynamic SR protein expression
  JOURNAL   Elife 9, e56075 (2020)
   PUBMED   32338600
  REMARK    GeneRIF: Srsf10 and the minor spliceosome control tissue-specific
            and dynamic SR protein expression.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2753)
  AUTHORS   Cowper,A.E., Caceres,J.F., Mayeda,A. and Screaton,G.R.
  TITLE     Serine-arginine (SR) protein-like factors that antagonize authentic
            SR proteins and regulate alternative splicing
  JOURNAL   J Biol Chem 276 (52), 48908-48914 (2001)
   PUBMED   11684676
REFERENCE   7  (bases 1 to 2753)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   8  (bases 1 to 2753)
  AUTHORS   Yang,L., Embree,L.J. and Hickstein,D.D.
  TITLE     TLS-ERG leukemia fusion protein inhibits RNA splicing mediated by
            serine-arginine proteins
  JOURNAL   Mol Cell Biol 20 (10), 3345-3354 (2000)
   PUBMED   10779324
REFERENCE   9  (bases 1 to 2753)
  AUTHORS   Komatsu,M., Kominami,E., Arahata,K. and Tsukahara,T.
  TITLE     Cloning and characterization of two neural-salient
            serine/arginine-rich (NSSR) proteins involved in the regulation of
            alternative splicing in neurones
  JOURNAL   Genes Cells 4 (10), 593-606 (1999)
   PUBMED   10583508
REFERENCE   10 (bases 1 to 2753)
  AUTHORS   Yang,L., Embree,L.J., Tsai,S. and Hickstein,D.D.
  TITLE     Oncoprotein TLS interacts with serine-arginine proteins involved in
            RNA splicing
  JOURNAL   J Biol Chem 273 (43), 27761-27764 (1998)
   PUBMED   9774382
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY244789.1, BY717856.1, AK168558.1 and BC043060.1.
            
            On Sep 26, 2013 this sequence version replaced NM_001080387.1.
            
            Transcript Variant: This variant (2) encodes the longest isoform
            (2).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849374,
                              SAMN00849375 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                BY244789.1         1-31
            32-43               BY717856.1         2-13
            44-1883             AK168558.1         2-1841
            1884-2753           BC043060.1         2208-3077
FEATURES             Location/Qualifiers
     source          1..2753
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 68.01 cM"
     gene            1..2753
                     /gene="Srsf10"
                     /gene_synonym="Fusip1; FUSIP2; Nssr; NSSR1; NSSR2;
                     Sfrs13a; SRrp40; Srsf13a; TASR; TASR1; TASR2"
                     /note="serine and arginine-rich splicing factor 10"
                     /db_xref="GeneID:14105"
                     /db_xref="MGI:MGI:1333805"
     exon            1..221
                     /gene="Srsf10"
                     /gene_synonym="Fusip1; FUSIP2; Nssr; NSSR1; NSSR2;
                     Sfrs13a; SRrp40; Srsf13a; TASR; TASR1; TASR2"
                     /inference="alignment:Splign:2.1.0"
     CDS             157..945
                     /gene="Srsf10"
                     /gene_synonym="Fusip1; FUSIP2; Nssr; NSSR1; NSSR2;
                     Sfrs13a; SRrp40; Srsf13a; TASR; TASR1; TASR2"
                     /note="isoform 2 is encoded by transcript variant 2;
                     Fus-associated protein with serine-arginine repeats;
                     TLS-associated SR protein; neural-specific SR protein;
                     TLS-associated protein with SR repeats; TLS-associated
                     serine-arginine protein; serine/arginine-rich splicing
                     factor 10; TLS-associated protein with Ser-Arg repeats;
                     neural-salient serine/arginine-rich protein;
                     FUS-interacting serine-arginine-rich protein 1;
                     serine/arginine-rich splicing factor 13A"
                     /codon_start=1
                     /product="serine/arginine-rich splicing factor 10 isoform
                     2"
                     /protein_id="NP_001073856.1"
                     /db_xref="CCDS:CCDS38922.1"
                     /db_xref="GeneID:14105"
                     /db_xref="MGI:MGI:1333805"
                     /translation="MSRYLRPPNTSLFVRNVADDTRSEDLRREFGRYGPIVDVYVPLD
                     FYTRRPRGFAYVQFEDVRDAEDALHNLDRKWICGRQIEIQFAQGDRKTPNQMKAKEGR
                     NVYSSSRYDDYDRYRRSRSRSYERRRSRSRSFDYNYRRSYSPRNSRPTGRPRRSRSHS
                     DNDRFKHRNRSFSRSKSNSRSRSKSQPKKEMKAKSRSRSASHTKTRGTSKTDSKTHYK
                     SGSRYEKESRKKEPPRSKSQSRSQSRSRSKSRSRSWTSPKSSGH"
     exon            222..326
                     /gene="Srsf10"
                     /gene_synonym="Fusip1; FUSIP2; Nssr; NSSR1; NSSR2;
                     Sfrs13a; SRrp40; Srsf13a; TASR; TASR1; TASR2"
                     /inference="alignment:Splign:2.1.0"
     exon            327..430
                     /gene="Srsf10"
                     /gene_synonym="Fusip1; FUSIP2; Nssr; NSSR1; NSSR2;
                     Sfrs13a; SRrp40; Srsf13a; TASR; TASR1; TASR2"
                     /inference="alignment:Splign:2.1.0"
     exon            431..593
                     /gene="Srsf10"
                     /gene_synonym="Fusip1; FUSIP2; Nssr; NSSR1; NSSR2;
                     Sfrs13a; SRrp40; Srsf13a; TASR; TASR1; TASR2"
                     /inference="alignment:Splign:2.1.0"
     exon            594..647
                     /gene="Srsf10"
                     /gene_synonym="Fusip1; FUSIP2; Nssr; NSSR1; NSSR2;
                     Sfrs13a; SRrp40; Srsf13a; TASR; TASR1; TASR2"
                     /inference="alignment:Splign:2.1.0"
     exon            648..2737
                     /gene="Srsf10"
                     /gene_synonym="Fusip1; FUSIP2; Nssr; NSSR1; NSSR2;
                     Sfrs13a; SRrp40; Srsf13a; TASR; TASR1; TASR2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2719..2724
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Srsf10"
                     /gene_synonym="Fusip1; FUSIP2; Nssr; NSSR1; NSSR2;
                     Sfrs13a; SRrp40; Srsf13a; TASR; TASR1; TASR2"
                     /note="hexamer: AACAAA"
     polyA_site      2737
                     /gene="Srsf10"
                     /gene_synonym="Fusip1; FUSIP2; Nssr; NSSR1; NSSR2;
                     Sfrs13a; SRrp40; Srsf13a; TASR; TASR1; TASR2"
                     /note="major polyA site"
ORIGIN      
        1 gaggcgggag ccaagtctcg cgagaagagg cagttgccgt agcggagccc tctgggtctg
       61 tgcgagtgtg gtgtgagtgg atgtgagccg ccgccggagc tgcggacggt ttgcccgagc
      121 ccgttagcgc cgccggccca gagtcccgcc gccaccatgt cccgatacct gcgcccccct
      181 aacacgtctc tgttcgtcag gaacgtggcg gacgacacca ggtctgaaga tttacgtcgg
      241 gaatttggtc gttatggtcc aatagtagat gtttatgtcc cacttgattt ctacactcgg
      301 cgtccaagag gatttgcata tgttcaattt gaggatgttc gtgatgctga agacgcttta
      361 cataatttgg acagaaaatg gatttgtggg cgtcagattg aaatccagtt cgcacagggg
      421 gatcggaaga caccaaatca aatgaaagcc aaggaaggga ggaatgtata cagctcttca
      481 cgatatgacg attatgaccg atatagacgc tctcgaagcc ggagttatga aaggagaaga
      541 tcgaggagtc gctcctttga ttataactat aggagatctt acagtcctag aaacagtaga
      601 ccgactggaa gaccacggcg tagccgaagc cattccgaca atgatagatt caaacaccga
      661 aatcgatctt tttcaagatc taaatccaat tcaagatcac ggtccaagtc ccagcccaag
      721 aaagaaatga aggctaaatc acgttctagg tctgcatctc acaccaaaac tagaggcacc
      781 tctaaaacag attccaaaac acattataag tctggctcaa gatatgaaaa ggaatcaagg
      841 aaaaaagaac cacctagatc caaatctcag tcaagatcac agtctaggtc taggtcaaaa
      901 tctaggtcaa ggtcttggac tagtcccaag tccagtggcc actgatagta taaattatga
      961 tacttctagg catgtatcat tcatttactc atagtttggt atacttaaat tatcaggaat
     1021 acaatgttgc aatgatgcgt ttaaaaacaa acaaacttaa cttgttagtt ttccctgtac
     1081 tgggcaatgg ttataattaa aaagatgcgc tgttgagaag ccactcttaa gagtccagtt
     1141 tgtttaatgt tatgggcagc taccaatttg tggtgtctct gtatattttt gtaaagattc
     1201 tcatttttta tgcttgaagt atttggtgaa aagatgttgg ttgaccataa tttgcaacat
     1261 tgtcttatta gaaataaatt ttcatatcca tatttggtag aactgttaac ctagaaatgt
     1321 agcttgctaa taagatagaa tgatacagaa gtgaagtggt agccacatta caacactgac
     1381 tgctcagaca catttaggtt cagggtggac ctttatgtct tgtcaagatg tctaagccca
     1441 tgatgattat ttatgatgca atgtggaata gttcttttgt taaatccacc atctggggat
     1501 tgatgccaac tgggttaaat agcgttttca gggagagtgc ccttttcact gaaacatgga
     1561 gccttcactg ctttccccac ctcaatccct gctggtttct aagatatgga acattaaagc
     1621 ataagggaaa accctccccc ttaagttgtg agtgagtcag tgatcacaga aaccattgta
     1681 aggggaaaag actgttctta gcatagttgc tctaaattta actattgttg atcattgtta
     1741 tttaggggtt ttgttttgtt gtttgttttt tctgttagaa acaagtgaac tgtttgaaaa
     1801 tacatttttg tttgtttata tgcatagtgt aaaacaaact gaattttgat gctcacagca
     1861 cttaccatgt gcgtttgtat caaaatctgc ctgttcttca taggggaggc ttgctcttca
     1921 cacctcagtt tattcatgtg agacaggctg agaagataac actcctaggt gattttgtgg
     1981 tgccgtggat ttttggggaa agttgagttt taagcaaaag ccacatcact tagtttttgg
     2041 taatgtagga catgactaaa aaataacgaa atgataccct taaatattta taatttctag
     2101 tatttcaaga ttgttttgga ggcaataaaa tgacttgaaa tgtccggtgt catttcagaa
     2161 tacaaagcta gtgtctctaa gatcttagat tcgttgctta cagatgtgag tgaagatact
     2221 gtgggggacg atcctcctgg aggattacct tatttttttc ctttcgattt tgtttttaga
     2281 aatttagtcc ttgcttgtag acaacaaaag atggttttaa gaactgtttg tggaatgtgt
     2341 ttggagggtt aattctagaa cctttgtata tttaatagta tttctaactt ttatttcttt
     2401 actgtttgca gttaatgttc ttgttctgct atgcaatcat ttatatgcac gtttctttaa
     2461 tttttttaga ttttcctgga tgtatagttt aaacaaagtc tatttaaaac tgtagcggta
     2521 gtttgcagtt ctagcaaaga ggaaagttgt ggggttaaac tttgtatttt ctttcttata
     2581 gaagcttcta aaaaggtatt tttatatgtt ctttttaaca aatattgtgt acaaccttta
     2641 aaacatcaat gtttggatca aaacaagacc cagcttattt tctgcttgct gtaaattaag
     2701 caaagatgct ataataaaaa caaaatgaag gaaataaaaa aaaaaaaaaa aaa
//
