LOCUS       NM_173374               5364 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus serine and arginine-rich splicing factor 1 (Srsf1),
            transcript variant 1, mRNA.
ACCESSION   NM_173374
VERSION     NM_173374.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5364)
  AUTHORS   Gan,T., Liu,W., Wang,Y., Huang,D., Hu,J., Wang,Y., Xiong,J.,
            Wang,X., Xu,Q., Xiong,N., Lu,S. and Wang,Z.
  TITLE     LncRNA MAAMT facilitates macrophage recruitment and proinflammatory
            activation and exacerbates autoimmune myocarditis through the
            SRSF1/NF-kappaB axis
  JOURNAL   Int J Biol Macromol 278 (Pt 1), 134193 (2024)
   PUBMED   39069042
  REMARK    GeneRIF: LncRNA MAAMT facilitates macrophage recruitment and
            proinflammatory activation and exacerbates autoimmune myocarditis
            through the SRSF1/NF-kappaB axis.
REFERENCE   2  (bases 1 to 5364)
  AUTHORS   Yuan,N., Shen,L., Peng,Q., Sha,R., Wang,Z., Xie,Z., You,X. and
            Feng,Y.
  TITLE     SRSF1 Is Required for Mitochondrial Homeostasis and Thermogenic
            Function in Brown Adipocytes Through its Control of Ndufs3 Splicing
  JOURNAL   Adv Sci (Weinh) 11 (21), e2306871 (2024)
   PUBMED   38569495
  REMARK    GeneRIF: SRSF1 Is Required for Mitochondrial Homeostasis and
            Thermogenic Function in Brown Adipocytes Through its Control of
            Ndufs3 Splicing.
REFERENCE   3  (bases 1 to 5364)
  AUTHORS   Sun,L., Lv,Z., Chen,X., Ye,R., Tian,S., Wang,C., Xie,X., Yan,L.,
            Yao,X., Shao,Y., Cui,S., Chen,J. and Liu,J.
  TITLE     Splicing factor SRSF1 is essential for homing of precursor
            spermatogonial stem cells in mice
  JOURNAL   Elife 12, 89316 (2024)
   PUBMED   38271475
  REMARK    GeneRIF: Splicing factor SRSF1 is essential for homing of precursor
            spermatogonial stem cells in mice.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5364)
  AUTHORS   Wu,C., Liu,H., Zhan,Z., Zhang,X., Zhang,M., You,J. and Ma,J.
  TITLE     Unveiling dysregulated lncRNAs and networks in non-syndromic cleft
            lip with or without cleft palate pathogenesis
  JOURNAL   Sci Rep 14 (1), 1047 (2024)
   PUBMED   38200098
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5364)
  AUTHORS   Yao,X., Wang,C., Yu,W., Sun,L., Lv,Z., Xie,X., Tian,S., Yan,L.,
            Zhang,H. and Liu,J.
  TITLE     SRSF1 is essential for primary follicle development by regulating
            granulosa cell survival via mRNA alternative splicing
  JOURNAL   Cell Mol Life Sci 80 (11), 343 (2023)
   PUBMED   37907803
  REMARK    GeneRIF: SRSF1 is essential for primary follicle development by
            regulating granulosa cell survival via mRNA alternative splicing.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5364)
  AUTHORS   Kaput,J., Klein,K.G., Reyes,E.J., Kibbe,W.A., Cooney,C.A.,
            Jovanovic,B., Visek,W.J. and Wolff,G.L.
  TITLE     Identification of genes contributing to the obese yellow Avy
            phenotype: caloric restriction, genotype, diet x genotype
            interactions
  JOURNAL   Physiol Genomics 18 (3), 316-324 (2004)
   PUBMED   15306695
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 5364)
  AUTHORS   Cartegni,L. and Krainer,A.R.
  TITLE     Disruption of an SF2/ASF-dependent exonic splicing enhancer in SMN2
            causes spinal muscular atrophy in the absence of SMN1
  JOURNAL   Nat Genet 30 (4), 377-384 (2002)
   PUBMED   11925564
  REMARK    GeneRIF: Disruption of an SF2/ASF-dependent exonic splicing
            enhancer in SMN2 causes spinal muscular atrophy in the absence of
            SMN1
REFERENCE   8  (bases 1 to 5364)
  AUTHORS   Bermingham,J.R. Jr., Arden,K.C., Naumova,A.K., Sapienza,C.,
            Viars,C.S., Fu,X.D., Khotz,J., Manley,J.L. and Rosenfeld,M.G.
  TITLE     Chromosomal localization of mouse and human genes encoding the
            splicing factors ASF/SF2 (SFRS1) and SC-35 (SFRS2)
  JOURNAL   Genomics 29 (1), 70-79 (1995)
   PUBMED   8530103
REFERENCE   9  (bases 1 to 5364)
  AUTHORS   Tacke,R., Boned,A. and Goridis,C.
  TITLE     ASF alternative transcripts are highly conserved between mouse and
            man
  JOURNAL   Nucleic Acids Res 20 (20), 5482 (1992)
   PUBMED   1437571
REFERENCE   10 (bases 1 to 5364)
  AUTHORS   Ayane,M., Preuss,U., Kohler,G. and Nielsen,P.J.
  TITLE     A differentially expressed murine RNA encoding a protein with
            similarities to two types of nucleic acid binding motifs
  JOURNAL   Nucleic Acids Res 19 (6), 1273-1278 (1991)
   PUBMED   2030943
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CF739274.1, AK053674.1 and
            AL593853.12.
            
            On Sep 28, 2012 this sequence version replaced NM_173374.3.
            
            Summary: The protein encoded by this gene is a member of the
            serine/arginine (SR)-rich family of pre-mRNA splicing factors,
            which constitute part of the spliceosome. Each of these factors
            contains an RNA recognition motif (RRM) for binding RNA and an RS
            domain for binding other proteins. The RS domain is rich in serine
            and arginine residues and facilitates interaction between different
            SR splicing factors. In addition to being critical for mRNA
            splicing, the SR proteins have also been shown to be involved in
            mRNA export from the nucleus and in translation. Two transcript
            variants encoding different isoforms have been found for this gene.
            [provided by RefSeq, Sep 2010].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC058627.1, AK053674.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-312               CF739274.1         1-312
            313-807             AK053674.1         3-497
            808-3215            AK053674.1         499-2906
            3216-5364           AL593853.12        18552-20700
FEATURES             Location/Qualifiers
     source          1..5364
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 52.4 cM"
     gene            1..5364
                     /gene="Srsf1"
                     /gene_synonym="1110054N12Rik; 5730507C05Rik;
                     6330415C05Rik; Asf; Sf2; Sfrs1"
                     /note="serine and arginine-rich splicing factor 1"
                     /db_xref="GeneID:110809"
                     /db_xref="MGI:MGI:98283"
     exon            1..660
                     /gene="Srsf1"
                     /gene_synonym="1110054N12Rik; 5730507C05Rik;
                     6330415C05Rik; Asf; Sf2; Sfrs1"
                     /inference="alignment:Splign:2.1.0"
     CDS             467..1213
                     /gene="Srsf1"
                     /gene_synonym="1110054N12Rik; 5730507C05Rik;
                     6330415C05Rik; Asf; Sf2; Sfrs1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ASF/SF2; splicing factor, arginine/serine-rich 1
                     (ASF/SF2); pre-mRNA-splicing factor SRp30a;
                     serine/arginine-rich splicing factor 1"
                     /codon_start=1
                     /product="serine/arginine-rich splicing factor 1 isoform
                     1"
                     /protein_id="NP_775550.2"
                     /db_xref="CCDS:CCDS36273.1"
                     /db_xref="GeneID:110809"
                     /db_xref="MGI:MGI:98283"
                     /translation="MSGGGVIRGPAGNNDCRIYVGNLPPDIRTKDIEDVFYKYGAIRD
                     IDLKNRRGGPPFAFVEFEDPRDAEDAVYGRDGYDYDGYRLRVEFPRSGRGTGRGGGGG
                     GGGGAPRGRYGPPSRRSENRVVVSGLPPSGSWQDLKDHMREAGDVCYADVYRDGTGVV
                     EFVRKEDMTYAVRKLDNTKFRSHEGETAYIRVKVDGPRSPSYGRSRSRSRSRSRSRSR
                     SNSRSRSYSPRRSRGSPRYSPRHSRSRSRT"
     exon            661..845
                     /gene="Srsf1"
                     /gene_synonym="1110054N12Rik; 5730507C05Rik;
                     6330415C05Rik; Asf; Sf2; Sfrs1"
                     /inference="alignment:Splign:2.1.0"
     exon            846..1018
                     /gene="Srsf1"
                     /gene_synonym="1110054N12Rik; 5730507C05Rik;
                     6330415C05Rik; Asf; Sf2; Sfrs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..5364
                     /gene="Srsf1"
                     /gene_synonym="1110054N12Rik; 5730507C05Rik;
                     6330415C05Rik; Asf; Sf2; Sfrs1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3078..3083
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Srsf1"
                     /gene_synonym="1110054N12Rik; 5730507C05Rik;
                     6330415C05Rik; Asf; Sf2; Sfrs1"
                     /note="hexamer: AATAAA"
     polyA_site      3100
                     /gene="Srsf1"
                     /gene_synonym="1110054N12Rik; 5730507C05Rik;
                     6330415C05Rik; Asf; Sf2; Sfrs1"
                     /note="major polyA site"
     regulatory      3213..3218
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Srsf1"
                     /gene_synonym="1110054N12Rik; 5730507C05Rik;
                     6330415C05Rik; Asf; Sf2; Sfrs1"
                     /note="hexamer: AATAAA"
     polyA_site      3221
                     /gene="Srsf1"
                     /gene_synonym="1110054N12Rik; 5730507C05Rik;
                     6330415C05Rik; Asf; Sf2; Sfrs1"
     regulatory      5336..5341
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Srsf1"
                     /gene_synonym="1110054N12Rik; 5730507C05Rik;
                     6330415C05Rik; Asf; Sf2; Sfrs1"
                     /note="hexamer: AATAAA"
     polyA_site      5358
                     /gene="Srsf1"
                     /gene_synonym="1110054N12Rik; 5730507C05Rik;
                     6330415C05Rik; Asf; Sf2; Sfrs1"
ORIGIN      
        1 atctttttag agcgccgagc tgctttcaga gagggtctac ccccgaggtg gccgacgatt
       61 ctggactcag tggggattaa taataaccgc tttaaccaga gcatgtgatt tttactaaac
      121 gcctggacgt tccagcagcc agtcaacccg ccaggacgcg agggactttt tcccctccgt
      181 gcggagggtg acgtcgcgcg tgcgcgagcg tgcttctcag cacccgttag aggcgtgcgc
      241 ctgcgcactg ggagggacga gccgcttcct ccggcttctc ttcctccccc tcccccccgg
      301 tatcagtgcg ccgagctgat aaaggcgcca ttttggagcg gccgcgggag acgtggtgcc
      361 gctgagggct cgctctgccg tacgctaggc ttggtaggaa ggcctctttt tttttttttc
      421 cttccccccc cccgagtccg cgcttttcgt cgtcgccgcc gccgccatgt cgggaggtgg
      481 tgtgatccgt ggcccggcgg ggaacaacga ctgccgcatc tacgtgggta acctacctcc
      541 ggatatccga accaaggaca tcgaggacgt gttttacaaa tacggcgcca tccgcgacat
      601 cgacctgaag aaccgccgcg ggggaccgcc cttcgccttc gttgagttcg aggacccgcg
      661 agacgcggaa gatgcggtgt acggtcgcga cggctacgac tacgacggct accggctgcg
      721 ggtagagttt ccccgaagcg gccgcgggac cggccgaggc ggcggcgggg gtggaggcgg
      781 cggcgccccg agaggccgct atggcccgcc gtccaggcgg tccgagaaca gagtggttgt
      841 ctctggactg cctccgagtg gaagctggca ggacttaaag gatcacatgc gtgaggcagg
      901 tgatgtatgt tacgctgatg tttaccgaga tggcactggt gtcgtggagt ttgtacggaa
      961 agaagatatg acgtatgcag ttcgaaaact ggataacact aagtttagat ctcacgaggg
     1021 agaaactgcc tacatccggg ttaaagttga tgggcccaga agtccaagtt atggaagatc
     1081 tcgatctcga agccgtagtc gtagcagaag ccgtagcaga agcaacagca ggagtcgcag
     1141 ttactcccca aggagaagca gaggatcacc acgctattct ccccgtcata gcagatctcg
     1201 ctctcgtaca taagatgatt ggtgacactt tttgtagaac ccatgttgta tacagttttc
     1261 ctttactcag tacaatcttt tcattttttt aattcaagct gttttgttca gaatgggcta
     1321 aagtgttgaa ttgcattctt gtgtaatatc cccttgctcc taacatctac attcccctca
     1381 tgtctttggt aacttgtatt ttaagtgatg tcatagacag gattgtttaa atttagttaa
     1441 tttccatgct cttcagactg tgatattatg taaatgtcta ttctgctctg gtttgtgtga
     1501 aatgggatgt tgggggtgtt tgtggttatc ttacttgggg gaagttctta tgtttatctt
     1561 gcttttcatg tgtctttctg tagacatatc tgaagagatg gattaagaat gctttggatt
     1621 aaggattgtg gagcacattt caatcatttt aggattgtca aaaggaggat tgaggaggat
     1681 cagatcaata atggaggcaa tggtatgact ccaagtgcta ttgtcacaga tgaaattggc
     1741 agtattgacc ttatactaga aggcgagggt taaaaattta tctaccttaa aagatttgca
     1801 aacacttaat gcagttatct tcagctacaa ttgctttgct ttttaaaacc ttggcaattg
     1861 tggtagaatt gcccattttg taacaattat ttgctccctt cccccctttt tgttttaata
     1921 gggactaatg tgggaagaat ggctaatttg tcacagtgct tagttacaac tgttaatgtg
     1981 tggcctgctg ttggtgtaca tgtgggtaca gggtgtcaat ttccaaacag agtataatat
     2041 caatactgct aaatctgcat gtcctctgtg tgactgatag agcattgtta tttcattttt
     2101 taaagacaaa atgacagcaa aataatagaa ttccaacgta ttagtgtaga taatctagtt
     2161 gggagtactt taagtctcac cttccctttt aatattcata attgactcat gtttaaaaca
     2221 ctttaattta caagctaaat tgcagatggg agcaatagtt taggtttagg tgggtagtaa
     2281 taccagtaaa cttcaattat ataactttgc aaccacaaaa cctgtgatac ctgtacagta
     2341 acaagtgttg gcattatcag ttgaactgta aatataaagt gcttcttcca gttagtctct
     2401 atagttatta agtttctaaa atttatctga acaccataca gaaacttgtt ttggggaatt
     2461 tgatagttat tgatgtgcat ctgtaaactg atgacagaca taactcatca ttccccagaa
     2521 actttttttg gttacagtgt ctaacatttt gcctcctctt ttttggtttt gctggttata
     2581 aaggtttgga ttggagaggg ctcactggat cccaatcctt ggagctggat cattggattc
     2641 aaatcataat gtggatagga tagggaggat gaattaccag gattcatgga gcgggatcag
     2701 attaccagga acataggagt ggattccttc ctgccccaac caaaccgcat tcgtgtggat
     2761 ttttttttca ttcaacttaa ttggctattc caaagaattt ttttcctatt tttgacgatt
     2821 ggagccctta agatgcacga tggaattgtg ttttgcattt tttggtaaaa ggagcaaagc
     2881 gaggacctgg agatatacgc tggagcaatc tccttggaag gattcagcac gagtagatgg
     2941 taaacattta aaggggaaaa gggggggttt gtttaaaata gtaaatcagt aagtcacttc
     3001 taaatttaaa gaaaacaaaa ttggagttga agaataagta ggtttccaat tggctattgc
     3061 cgtttttctt tgaaaaaaat aaacattttt taaaaaacga tgcatggttg tcctttttcc
     3121 tcttgtaaaa ttttgattgg gtaactagtg tatcagttat ttaatttgat aagattctga
     3181 ttctgtttat gtgttagtaa attaaagatt ctaataaatg atgactgtct ctgttgtgga
     3241 agtcttaaga gcataataaa ctgagtgtaa ggcagttaca tacgtaacag ttgtgtagag
     3301 ggtaatgatc tggaaagtaa tctttcatat tttgctaaag aacttacagt tgctgtttat
     3361 tttggtaatg ctttagacaa aataggcttt tgtacaaagt ttgatagcta atcaatttta
     3421 gctttgagat tctcagtgga actcaaattc agtattaaca ttaggagaca aaatagacta
     3481 cacagttttt ttttttttaa attttggata gtgtgctgtc aaatgcttat tgggttaata
     3541 aatacattat aaatcttttc agccatagag tgttctgtcg ccaaactgtt ctgtattgag
     3601 tcagcaatta tatatatatc ttagtctagt ctactgttgt atctctactg ataacccctt
     3661 gaagcttaat cttcatctta attggtttgg agaatggaac ttttatttaa aatcccaagc
     3721 ttgtgatttc ctcctggcta gaatgaatag accactattc accacagtag aaatagctag
     3781 atctttaact ttccttgagt tgcaggctaa atatgatatt gttcagatgt aatgtagaat
     3841 ataggggaga ccagaaattt ttgctagtga aagaaacagg tttcaagaaa tttgcatgag
     3901 atctcagcct gctcatttta atgaccgcat acactgtcct gaaagagaaa ctaattcttt
     3961 taagttcaaa actaggattt cacttcagga gatgtgttta gtagatgcat taaggttagg
     4021 tagctgtgtt acagaactca aagtacaact aaaaggatga ggaattagca tagttaaaca
     4081 tggtataatt ggaaatttat ggtgttttaa aatacattgt tttcctccag agaacctcac
     4141 tctactctgg tctagactgg gcccaaaact ccaaagtaaa tccagtctcc cagattctgg
     4201 gattagccat gaagcaccat gcccagctta ctaaagtagt attaaaaggt taaagccagc
     4261 tagataaatg caaatgtggg tttactttga atgctttgga aacgggacca agaatggcct
     4321 gtttatagta gttcagttgt agattgaaat gagcaaagtg ttctttgcct cactgtaggc
     4381 ttatgtttga acactagtga gcacagcgta ggttttaaag cttaggaaat agggctgtac
     4441 ccatactgac agttgatacc actttggaac tacaaatact ttgatttcta ctccccgccc
     4501 ccctctgttc ccttaggata ttgtagggaa acctatgatt agtttttcta accacgaaag
     4561 cacttaaatc tctttaagca agtactttca taacttctga ttgaataacc caacttgctg
     4621 ttcagctcat cctactggag acaaaggtaa gacacatttt ctgataccta gtttgggatc
     4681 tggattttaa gaactaaagt tgtgatgaat aattgctcct gacttgcaat gttcctctct
     4741 tcctcccagc tttatatttt taatagtttt gagtgtataa atctactcat ctcaattctg
     4801 gagttgaata tgataaattc caagatctgt ctatgagcca tgcttttgta ggggtggtgc
     4861 tattttcagc attctgaggt caaggtcaac ttttggtgtt tgcctttttg ctttgtatat
     4921 gaaatttgta gtgaaattac aaatgaaata aattatatgt atttaaatag tattaaaagg
     4981 agagaaagta ttagactgag ttctgttata acaacaacca cttgtagctt atttccatca
     5041 taatttgatg atagattgat aacccacaat actggaatac cacagattgt ttttattgag
     5101 caaaatgaat gtaaaatctg gccagagtag atgcctttat tgtgtaattt gtgtaaaagt
     5161 cacataggca ttgttgaagg tgttttatat atatgaagta tatgtgataa gatcttcatg
     5221 taaagtctga acaaccatgg atcccaaata tatatctagt ttgggtgagc aaggagttgt
     5281 agaattgtac tagtactgca gaggattaat gttactatat gtaattttgg gagtgaataa
     5341 aaagctgtta atttggaacc ttta
//
