LOCUS       NM_001359602            3012 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus serrate RNA effector molecule homolog (Arabidopsis)
            (Srrt), transcript variant 4, mRNA.
ACCESSION   NM_001359602 XM_006504629
VERSION     NM_001359602.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3012)
  AUTHORS   O'Sullivan,C., Nickerson,P.E.B., Krupke,O., Christie,J., Chen,L.L.,
            Mesa-Peres,M., Zhu,M., Ryan,B., Chow,R.L. and Howard,P.L.
  TITLE     ARS2 is required for retinal progenitor cell S-phase progression
            and Muller glial cell fate specification
  JOURNAL   Biochem Cell Biol 98 (1), 50-60 (2020)
   PUBMED   30673303
  REMARK    GeneRIF: The Arsenic-resistance protein 2 (ARS2, also known as
            SRRT) is a component of the nuclear cap-binding complex involved in
            RNA Polymerase II transcription, and is required for cell cycle
            progression.
REFERENCE   2  (bases 1 to 3012)
  AUTHORS   Yu,Y., Andreu-Agullo,C., Liu,B.F., Barboza,L., Toth,M. and Lai,E.C.
  TITLE     Regulation of embryonic and adult neurogenesis by Ars2
  JOURNAL   Development 147 (2) (2020)
   PUBMED   31969356
  REMARK    GeneRIF: Ars2 is an essential neural regulator that interacts
            dynamically with DNA and controls neural lineage development.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3012)
  AUTHORS   Choo,H.J., Cutler,A., Rother,F., Bader,M. and Pavlath,G.K.
  TITLE     Karyopherin Alpha 1 Regulates Satellite Cell Proliferation and
            Survival by Modulating Nuclear Import
  JOURNAL   Stem Cells 34 (11), 2784-2797 (2016)
   PUBMED   27434733
REFERENCE   4  (bases 1 to 3012)
  AUTHORS   O'Sullivan,C., Christie,J., Pienaar,M., Gambling,J.,
            Nickerson,P.E., Alford,S.C., Chow,R.L. and Howard,P.L.
  TITLE     Mutagenesis of ARS2 Domains To Assess Possible Roles in Cell Cycle
            Progression and MicroRNA and Replication-Dependent Histone mRNA
            Biogenesis
  JOURNAL   Mol Cell Biol 35 (21), 3753-3767 (2015)
   PUBMED   26303529
  REMARK    GeneRIF: ARS2 plays a central role in RNA recognition and
            processing through multiple protein and RNA interactions.
REFERENCE   5  (bases 1 to 3012)
  AUTHORS   Olejniczak,S.H., La Rocca,G., Gruber,J.J. and Thompson,C.B.
  TITLE     Long-lived microRNA-Argonaute complexes in quiescent cells can be
            activated to regulate mitogenic responses
  JOURNAL   Proc Natl Acad Sci U S A 110 (1), 157-162 (2013)
   PUBMED   23248281
REFERENCE   6  (bases 1 to 3012)
  AUTHORS   Andreu-Agullo,C., Maurin,T., Thompson,C.B. and Lai,E.C.
  TITLE     Ars2 maintains neural stem-cell identity through direct
            transcriptional activation of Sox2
  JOURNAL   Nature 481 (7380), 195-198 (2011)
   PUBMED   22198669
  REMARK    GeneRIF: findings reveal Ars2 as a new transcription factor that
            controls the multipotent progenitor state of NSCs through direct
            activation of the pluripotency factor Sox2
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3012)
  AUTHORS   Gruber,J.J., Zatechka,D.S., Sabin,L.R., Yong,J., Lum,J.J., Kong,M.,
            Zong,W.X., Zhang,Z., Lau,C.K., Rawlings,J., Cherry,S., Ihle,J.N.,
            Dreyfuss,G. and Thompson,C.B.
  TITLE     Ars2 links the nuclear cap-binding complex to RNA interference and
            cell proliferation
  JOURNAL   Cell 138 (2), 328-339 (2009)
   PUBMED   19632182
  REMARK    GeneRIF: These findings provide evidence for a role for Ars2 in RNA
            interference regulation during cell proliferation.
REFERENCE   8  (bases 1 to 3012)
  AUTHORS   Wilson,M.D., Wang,D., Wagner,R., Breyssens,H., Gertsenstein,M.,
            Lobe,C., Lu,X., Nagy,A., Burke,R.D., Koop,B.F. and Howard,P.L.
  TITLE     ARS2 is a conserved eukaryotic gene essential for early mammalian
            development
  JOURNAL   Mol Cell Biol 28 (5), 1503-1514 (2008)
   PUBMED   18086880
  REMARK    GeneRIF: These data indicate ARS2 is essential for early mammalian
            development and is likely involved in an essential cellular
            process.
REFERENCE   9  (bases 1 to 3012)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 3012)
  AUTHORS   Wilson,M.D., Riemer,C., Martindale,D.W., Schnupf,P., Boright,A.P.,
            Cheung,T.L., Hardy,D.M., Schwartz,S., Scherer,S.W., Tsui,L.C.,
            Miller,W. and Koop,B.F.
  TITLE     Comparative analysis of the gene-dense ACHE/TFR2 region on human
            chromosome 7q22 with the orthologous region on mouse chromosome 5
  JOURNAL   Nucleic Acids Res 29 (6), 1352-1365 (2001)
   PUBMED   11239002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC150682.2 and AC243288.2.
            
            On Jan 13, 2018 this sequence version replaced XM_006504629.1.
            
            Transcript Variant: This variant (4) uses an alternate in-frame
            splice junction in the 3' end compared to variant 1. The resulting
            isoform (4) has the same N- and C-termini but is shorter compared
            to isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7652917.632439.1,
                                           SRR1660813.98190.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-251               AC150682.2         35347-35597         c
            252-391             AC150682.2         34969-35108         c
            392-520             AC150682.2         30835-30963         c
            521-667             AC150682.2         30450-30596         c
            668-856             AC150682.2         30049-30237         c
            857-1026            AC150682.2         28167-28336         c
            1027-1211           AC150682.2         27890-28074         c
            1212-1310           AC150682.2         27677-27775         c
            1311-1425           AC150682.2         27481-27595         c
            1426-1583           AC243288.2         423-580
            1584-1645           AC243288.2         854-915
            1646-1724           AC243288.2         1000-1078
            1725-1913           AC243288.2         1319-1507
            1914-2087           AC243288.2         1793-1966
            2088-2241           AC243288.2         2074-2227
            2242-2435           AC243288.2         2338-2531
            2436-2592           AC243288.2         2683-2839
            2593-2682           AC243288.2         2999-3088
            2683-2809           AC243288.2         3193-3319
            2810-3012           AC243288.2         3400-3602
FEATURES             Location/Qualifiers
     source          1..3012
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 76.33 cM"
     gene            1..3012
                     /gene="Srrt"
                     /gene_synonym="2810019G02Rik; Ars2; Asr2; ASR2A; ASR2B;
                     ASR2C; ASR2D"
                     /note="serrate RNA effector molecule homolog
                     (Arabidopsis)"
                     /db_xref="GeneID:83701"
                     /db_xref="MGI:MGI:1933527"
     exon            1..251
                     /gene="Srrt"
                     /gene_synonym="2810019G02Rik; Ars2; Asr2; ASR2A; ASR2B;
                     ASR2C; ASR2D"
                     /inference="alignment:Splign:2.1.0"
     exon            252..391
                     /gene="Srrt"
                     /gene_synonym="2810019G02Rik; Ars2; Asr2; ASR2A; ASR2B;
                     ASR2C; ASR2D"
                     /inference="alignment:Splign:2.1.0"
     CDS             270..2885
                     /gene="Srrt"
                     /gene_synonym="2810019G02Rik; Ars2; Asr2; ASR2A; ASR2B;
                     ASR2C; ASR2D"
                     /note="isoform 4 is encoded by transcript variant 4;
                     arsenate resistance protein 2; arsenite-resistance protein
                     2"
                     /codon_start=1
                     /product="serrate RNA effector molecule homolog isoform 4"
                     /protein_id="NP_001346531.1"
                     /db_xref="GeneID:83701"
                     /db_xref="MGI:MGI:1933527"
                     /translation="MGDSDDEYDRRRRDKFRRERSDYDRSRERDERRRGDDWNDREWD
                     RGRERRSRGEYRDYDRNRRERFSPPRHELSPPQKRMRRDWDEHSSDPYHSGYDMPYAG
                     GGGGPTYGPPQPWGHPDVHIMQHHVLPIQARLGSIAEIDLGVPPPIMKSFKEFLLSLD
                     DSVDETEAVKRYNDYKLDFRRQQMQDFFLAHKDEEWFRSKYHPDEVGKRRQEARGALQ
                     NRLKVFLSLMESGWFDNLLLDIDKADAIVKMLDAAVIKMEGGTENDLRILEQEEEEEQ
                     AGKTGEASKKEEARAGPALGEGERKANDKDEKKEDGKQAENDSSNDDKTKKSEGDGDK
                     EEKKEEAEKEAKKSKKRNRKQSGDDSFDEGSVSESESESEGGQAEEEKEEAEEALKEK
                     EKPKEEEKEKPKDAAGLECKPRPLHKTCSLFMRNIAPNISRAEIISLCKRYPGFMRVA
                     LSEPQPERRFFRRGWVTFDRSVNIKEICWNLQNIRLRECELSPGVNRDLTRRVRNING
                     ITQHKQIVRNDIKLAAKLIHTLDDRTQLWASEPGTPPVPTSLPSQNPILKNITDYLIE
                     EVSAEEEELLGSSGGPPPEEPPKEGNPAEINVERDEKLIKVLDKLLLYLRIVHSLDYY
                     NTCEYPNEDEMPNRCGIIHVRGPMPPNRISHGEVLEWQKTFEEKLTPLLSVRESLSEE
                     EAQKMGRKDPEQEVEKFVTSNTQELGKDKWLCPLSGKKFKGPEFVRKHIFNKHAEKIE
                     EVKKEVAFFNNFLTDAKRPALPEIKPAQPPGPAQSLTPGLPYPHQTPQGLMPYGQPRP
                     PILGYGAGAVRPAVPTGGPPYPHAPYGAGRGNYDAFRGQGGYPGKPRNRMVRGDPRAI
                     VEYRDLDAPDDVDFF"
     exon            392..520
                     /gene="Srrt"
                     /gene_synonym="2810019G02Rik; Ars2; Asr2; ASR2A; ASR2B;
                     ASR2C; ASR2D"
                     /inference="alignment:Splign:2.1.0"
     exon            521..667
                     /gene="Srrt"
                     /gene_synonym="2810019G02Rik; Ars2; Asr2; ASR2A; ASR2B;
                     ASR2C; ASR2D"
                     /inference="alignment:Splign:2.1.0"
     exon            668..856
                     /gene="Srrt"
                     /gene_synonym="2810019G02Rik; Ars2; Asr2; ASR2A; ASR2B;
                     ASR2C; ASR2D"
                     /inference="alignment:Splign:2.1.0"
     exon            857..1026
                     /gene="Srrt"
                     /gene_synonym="2810019G02Rik; Ars2; Asr2; ASR2A; ASR2B;
                     ASR2C; ASR2D"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1211
                     /gene="Srrt"
                     /gene_synonym="2810019G02Rik; Ars2; Asr2; ASR2A; ASR2B;
                     ASR2C; ASR2D"
                     /inference="alignment:Splign:2.1.0"
     exon            1212..1310
                     /gene="Srrt"
                     /gene_synonym="2810019G02Rik; Ars2; Asr2; ASR2A; ASR2B;
                     ASR2C; ASR2D"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..1425
                     /gene="Srrt"
                     /gene_synonym="2810019G02Rik; Ars2; Asr2; ASR2A; ASR2B;
                     ASR2C; ASR2D"
                     /inference="alignment:Splign:2.1.0"
     exon            1426..1583
                     /gene="Srrt"
                     /gene_synonym="2810019G02Rik; Ars2; Asr2; ASR2A; ASR2B;
                     ASR2C; ASR2D"
                     /inference="alignment:Splign:2.1.0"
     exon            1584..1645
                     /gene="Srrt"
                     /gene_synonym="2810019G02Rik; Ars2; Asr2; ASR2A; ASR2B;
                     ASR2C; ASR2D"
                     /inference="alignment:Splign:2.1.0"
     exon            1646..1724
                     /gene="Srrt"
                     /gene_synonym="2810019G02Rik; Ars2; Asr2; ASR2A; ASR2B;
                     ASR2C; ASR2D"
                     /inference="alignment:Splign:2.1.0"
     exon            1725..1913
                     /gene="Srrt"
                     /gene_synonym="2810019G02Rik; Ars2; Asr2; ASR2A; ASR2B;
                     ASR2C; ASR2D"
                     /inference="alignment:Splign:2.1.0"
     exon            1914..2087
                     /gene="Srrt"
                     /gene_synonym="2810019G02Rik; Ars2; Asr2; ASR2A; ASR2B;
                     ASR2C; ASR2D"
                     /inference="alignment:Splign:2.1.0"
     exon            2088..2241
                     /gene="Srrt"
                     /gene_synonym="2810019G02Rik; Ars2; Asr2; ASR2A; ASR2B;
                     ASR2C; ASR2D"
                     /inference="alignment:Splign:2.1.0"
     exon            2242..2435
                     /gene="Srrt"
                     /gene_synonym="2810019G02Rik; Ars2; Asr2; ASR2A; ASR2B;
                     ASR2C; ASR2D"
                     /inference="alignment:Splign:2.1.0"
     exon            2436..2592
                     /gene="Srrt"
                     /gene_synonym="2810019G02Rik; Ars2; Asr2; ASR2A; ASR2B;
                     ASR2C; ASR2D"
                     /inference="alignment:Splign:2.1.0"
     exon            2593..2682
                     /gene="Srrt"
                     /gene_synonym="2810019G02Rik; Ars2; Asr2; ASR2A; ASR2B;
                     ASR2C; ASR2D"
                     /inference="alignment:Splign:2.1.0"
     exon            2683..2809
                     /gene="Srrt"
                     /gene_synonym="2810019G02Rik; Ars2; Asr2; ASR2A; ASR2B;
                     ASR2C; ASR2D"
                     /inference="alignment:Splign:2.1.0"
     exon            2810..3012
                     /gene="Srrt"
                     /gene_synonym="2810019G02Rik; Ars2; Asr2; ASR2A; ASR2B;
                     ASR2C; ASR2D"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2979..2984
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Srrt"
                     /gene_synonym="2810019G02Rik; Ars2; Asr2; ASR2A; ASR2B;
                     ASR2C; ASR2D"
                     /note="hexamer: AGTAAA"
     polyA_site      3007
                     /gene="Srrt"
                     /gene_synonym="2810019G02Rik; Ars2; Asr2; ASR2A; ASR2B;
                     ASR2C; ASR2D"
                     /note="major polyA site"
ORIGIN      
        1 ggagttttag tttggtccgg gggtcttgtt ttgtagttgg aggccgagct ccgggagtga
       61 cgtaggacgc gcgcgcgcct ccttgccccc cccccccccc cgcggtcccg ctcttctctt
      121 ccccttcgtc tccgggctga gaatcccagc gtctccttcc aaccctcttt gtggtccatt
      181 gtcgctcgtt ccggtccgcc cggaaaacaa gcccgccggc gcgcgcttcc aacggccccg
      241 accgctgcca ggcctcctct gacagcacca tgggtgacag tgatgatgaa tacgaccgaa
      301 gacgcaggga caaatttcga agagagcgca gcgattatga ccgttcccgg gaaagggatg
      361 aaagacggcg aggggacgat tggaatgacc gagagtggga ccgtggccgg gagcgccgca
      421 gtcggggtga atatcgagac tacgacagga accgaaggga gcgcttctct ccccctcgac
      481 acgaactaag ccccccccag aagcgcatgc ggagagactg ggatgagcac agctctgacc
      541 cataccacag tggctatgac atgccctatg ctgggggggg tgggggacca acttacggcc
      601 cccctcagcc ctggggccac ccagacgtcc acatcatgca gcaccatgtc ctgcccatcc
      661 aggccaggct gggcagcatc gcagagattg acttgggggt gccaccgccc ataatgaagt
      721 ccttcaaaga gttcctcctg tctctggatg actctgtgga tgagacagag gcagttaaac
      781 gctacaatga ctacaagctg gacttccgaa ggcagcagat gcaggacttt ttcctggctc
      841 acaaagacga ggagtggttc cgatctaagt accaccctga tgaggtggga aagcgtcggc
      901 aggaggcccg gggggccctg cagaaccggc tgaaggtgtt cctgtccctc atggagagtg
      961 gctggtttga taaccttctc ttggacatag acaaagctga tgccattgtc aagatgctag
     1021 atgcagctgt cattaagatg gaaggtggca cagagaacga tctccgaatt ttggagcagg
     1081 aggaggagga ggaacaggca ggcaagactg gggaggccag caagaaagag gaggcccgtg
     1141 ctggaccagc cctgggagaa ggagagcgca aagccaatga taaggatgag aagaaagaag
     1201 atggaaaaca ggctgagaat gacagttcca acgatgacaa aactaaaaaa tctgagggtg
     1261 atggggacaa ggaggagaag aaagaagagg ctgagaagga agccaaaaag agcaagaagc
     1321 ggaacaggaa gcagagtggc gatgacagct tcgatgaggg cagtgtgtcc gagtctgagt
     1381 ccgagtctga gggtggccag gccgaggagg agaaggagga ggccgaagaa gcacttaaag
     1441 aaaaggagaa gcccaaagag gaggagaagg agaagcctaa ggatgctgca gggttggagt
     1501 gtaagccccg gcccttgcat aagacttgct ctctcttcat gcgcaacatc gcacccaaca
     1561 tttcaagggc agagatcatt tctctttgta aacgataccc aggctttatg cgagtggcac
     1621 tgtcagagcc ccagccagag aggaggtttt ttcgccgtgg ctgggtgact tttgaccgca
     1681 gtgttaacat taaggagatc tgttggaacc tgcagaacat tcggctccgg gagtgtgaac
     1741 tgagtcccgg tgtgaacaga gacctgaccc gtcgtgtccg caacataaat ggcattacac
     1801 agcacaagca gatagtgcgc aatgacatca agttggcagc caagctaatc cacacactgg
     1861 atgacaggac ccagctctgg gcctctgagc ctgggacgcc tcctgtgccc acaagcctcc
     1921 cctcgcaaaa ccccatcctg aagaacatca ctgactacct gattgaggaa gtgagtgcgg
     1981 aggaggagga gcttctgggg agcagtgggg gaccccctcc tgaggagcct cccaaggagg
     2041 gcaacccagc cgagatcaac gtggagagag atgagaagct gatcaaggtc ttggataaac
     2101 ttcttctcta tttgcgtatt gtgcattctc tggattatta taacacctgt gagtacccta
     2161 atgaagacga gatgcccaac cgctgtggca taatccacgt tcgggggccc atgcctccca
     2221 accgaattag tcacggagaa gtgctggagt ggcagaagac atttgaggag aaactgactc
     2281 cactgttgag tgtgcgtgaa tccctttctg aggaagaggc ccagaagatg ggtcgaaaag
     2341 acccagagca ggaagtggag aagtttgtca cctccaacac gcaggaactg ggcaaggata
     2401 agtggctatg tcctctcagt ggcaagaaat tcaagggccc ggagtttgtg cgcaagcata
     2461 tcttcaataa gcatgccgag aagatcgagg aggtgaagaa ggaggtggcg ttcttcaata
     2521 actttctcac agacgccaag cgcccagctt tgcctgagat caagccagct cagccacctg
     2581 gccctgccca gagcctgacc ccaggacttc cctacccaca tcagacgcca cagggcttga
     2641 tgccatatgg tcagccccgg cctcccatct tgggctatgg agctggtgct gtccgccctg
     2701 cagtcccaac aggagggcct ccataccccc atgctccata tggtgccggc cgtgggaact
     2761 atgatgcttt tcgaggccaa ggcggttatc ctgggaaacc tcggaacagg atggttcgag
     2821 gagacccaag ggccatagtg gagtatcggg acctggatgc cccggatgat gttgacttct
     2881 tttgagccat ccatgtcccc tcctgcattg ctacatcagt acccgtgacc actttatccc
     2941 atcagctgaa aagttttttg tacgttattt tacccgctag taaaaacact ttggtagtgt
     3001 gtgttaactg tg
//
