LOCUS       NM_013761               6181 bp    mRNA    linear   ROD 18-FEB-2025
DEFINITION  Mus musculus serine racemase (Srr), transcript variant 1, mRNA.
ACCESSION   NM_013761
VERSION     NM_013761.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6181)
  AUTHORS   Wang,Y., Xu,D., Zhao,Y., Zhu,H., Xiu,X., Jiang,H., Liu,Y., Shan,G.
            and Wu,S.
  TITLE     Age- and Sex-Specific Regulation of Serine Racemase in the Retina
            of an Alzheimer's Disease Mouse
  JOURNAL   Invest Ophthalmol Vis Sci 66 (1), 36 (2025)
   PUBMED   39813057
REFERENCE   2  (bases 1 to 6181)
  AUTHORS   Barragan,E.V., Anisimova,M., Vijayakumar,V., Coblentz,A.,
            Park,D.K., Salaka,R.J., Nisan,A.F.K., Petshow,S., Dore,K., Zito,K.
            and Gray,J.A.
  TITLE     d-Serine Inhibits Non-ionotropic NMDA Receptor Signaling
  JOURNAL   J Neurosci 44 (32), e0140242024 (2024)
   PUBMED   38942470
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6181)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 6181)
  AUTHORS   Radzishevsky,I., Odeh,M., Bodner,O., Zubedat,S., Shaulov,L.,
            Litvak,M., Esaki,K., Yoshikawa,T., Agranovich,B., Li,W.H.,
            Radzishevsky,A., Gottlieb,E., Avital,A. and Wolosker,H.
  TITLE     Impairment of serine transport across the blood-brain barrier by
            deletion of Slc38a5 causes developmental delay and motor
            dysfunction
  JOURNAL   Proc Natl Acad Sci U S A 120 (42), e2302780120 (2023)
   PUBMED   37812701
REFERENCE   5  (bases 1 to 6181)
  AUTHORS   Ni,X., Inoue,R., Wu,Y., Yoshida,T., Yaku,K., Nakagawa,T., Saito,T.,
            Saido,T.C., Takao,K. and Mori,H.
  TITLE     Regional contributions of D-serine to Alzheimer's disease pathology
            in male AppNL-G-F/NL-G-F mice
  JOURNAL   Front Aging Neurosci 15, 1211067 (2023)
   PUBMED   37455930
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6181)
  AUTHORS   Cook,S.P., Galve-Roperh,I., Martinez del Pozo,A. and
            Rodriguez-Crespo,I.
  TITLE     Direct calcium binding results in activation of brain serine
            racemase
  JOURNAL   J Biol Chem 277 (31), 27782-27792 (2002)
   PUBMED   12021263
  REMARK    GeneRIF: Direct calcium binding results in activation in brain
REFERENCE   7  (bases 1 to 6181)
  AUTHORS   Panizzutti,R., De Miranda,J., Ribeiro,C.S., Engelender,S. and
            Wolosker,H.
  TITLE     A new strategy to decrease N-methyl-D-aspartate (NMDA) receptor
            coactivation: inhibition of D-serine synthesis by converting serine
            racemase into an eliminase
  JOURNAL   Proc Natl Acad Sci U S A 98 (9), 5294-5299 (2001)
   PUBMED   11309496
REFERENCE   8  (bases 1 to 6181)
  AUTHORS   De Miranda,J., Santoro,A., Engelender,S. and Wolosker,H.
  TITLE     Human serine racemase: moleular cloning, genomic organization and
            functional analysis
  JOURNAL   Gene 256 (1-2), 183-188 (2000)
   PUBMED   11054547
REFERENCE   9  (bases 1 to 6181)
  AUTHORS   Wolosker,H., Blackshaw,S. and Snyder,S.H.
  TITLE     Serine racemase: a glial enzyme synthesizing D-serine to regulate
            glutamate-N-methyl-D-aspartate neurotransmission
  JOURNAL   Proc Natl Acad Sci U S A 96 (23), 13409-13414 (1999)
   PUBMED   10557334
REFERENCE   10 (bases 1 to 6181)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL604066.9, AB232342.1, AK043738.1, AK079343.1 and BY475189.1.
            
            On Apr 27, 2018 this sequence version replaced NM_013761.4.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK043738.1, SRR17784651.1010227.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-150               AL604066.9         142362-142511       c
            151-245             AB232342.1         1-95
            246-2270            AK043738.1         2-2026
            2271-3412           AK043738.1         2028-3169
            3413-3699           AK079343.1         2547-2833
            3700-3849           BY475189.1         370-519
            3850-6181           AL604066.9         120590-122921       c
FEATURES             Location/Qualifiers
     source          1..6181
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 45.76 cM"
     gene            1..6181
                     /gene="Srr"
                     /gene_synonym="M100034; Rgsc34; Srs"
                     /note="serine racemase"
                     /db_xref="GeneID:27364"
                     /db_xref="MGI:MGI:1351636"
     exon            1..330
                     /gene="Srr"
                     /gene_synonym="M100034; Rgsc34; Srs"
                     /inference="alignment:Splign:2.1.0"
     exon            331..556
                     /gene="Srr"
                     /gene_synonym="M100034; Rgsc34; Srs"
                     /inference="alignment:Splign:2.1.0"
     exon            557..728
                     /gene="Srr"
                     /gene_synonym="M100034; Rgsc34; Srs"
                     /inference="alignment:Splign:2.1.0"
     CDS             561..1580
                     /gene="Srr"
                     /gene_synonym="M100034; Rgsc34; Srs"
                     /EC_number="4.3.1.17"
                     /EC_number="5.1.1.18"
                     /EC_number="4.3.1.18"
                     /note="isoform 1 is encoded by transcript variant 1;
                     D-serine dehydratase; L-serine dehydratase; D-serine
                     ammonia-lyase; L-serine ammonia-lyase"
                     /codon_start=1
                     /product="serine racemase isoform 1"
                     /protein_id="NP_038789.1"
                     /db_xref="CCDS:CCDS25038.1"
                     /db_xref="GeneID:27364"
                     /db_xref="MGI:MGI:1351636"
                     /translation="MCAQYCISFADVEKAHINIQDSIHLTPVLTSSILNQIAGRNLFF
                     KCELFQKTGSFKIRGALNAIRGLIPDTPEEKPKAVVTHSSGNHGQALTYAAKLEGIPA
                     YIVVPQTAPNCKKLAIQAYGASIVYCDPSDESREKVTQRIMQETEGILVHPNQEPAVI
                     AGQGTIALEVLNQVPLVDALVVPVGGGGMVAGIAITIKALKPSVKVYAAEPSNADDCY
                     QSKLKGELTPNLHPPETIADGVKSSIGLNTWPIIRDLVDDVFTVTEDEIKYATQLVWG
                     RMKLLIEPTAGVALAAVLSQHFQTVSPEVKNVCIVLSGGNVDLTSLNWVGQAERPAPY
                     QTVSV"
     exon            729..855
                     /gene="Srr"
                     /gene_synonym="M100034; Rgsc34; Srs"
                     /inference="alignment:Splign:2.1.0"
     exon            856..959
                     /gene="Srr"
                     /gene_synonym="M100034; Rgsc34; Srs"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1079
                     /gene="Srr"
                     /gene_synonym="M100034; Rgsc34; Srs"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1154
                     /gene="Srr"
                     /gene_synonym="M100034; Rgsc34; Srs"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1364
                     /gene="Srr"
                     /gene_synonym="M100034; Rgsc34; Srs"
                     /inference="alignment:Splign:2.1.0"
     exon            1365..6181
                     /gene="Srr"
                     /gene_synonym="M100034; Rgsc34; Srs"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3395..3400
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Srr"
                     /gene_synonym="M100034; Rgsc34; Srs"
                     /note="hexamer: AATAAA"
     polyA_site      3415
                     /gene="Srr"
                     /gene_synonym="M100034; Rgsc34; Srs"
                     /note="major polyA site"
     regulatory      6161..6166
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Srr"
                     /gene_synonym="M100034; Rgsc34; Srs"
                     /note="hexamer: AATAAA"
     polyA_site      6181
                     /gene="Srr"
                     /gene_synonym="M100034; Rgsc34; Srs"
ORIGIN      
        1 ggagatccgc acacgctcca acccctccgc catcttcgcg gcggctgcta cagctgcggc
       61 gactcggcca ccgccgcgcg cagccaggaa accacgacgg acgggcggcg cgcgctcacc
      121 cactcccacc cttttccccg cccccctcct gcctgccctc cccaaacgac ggtggccgca
      181 ctgggagcaa aagcattcag cacgttcaac tagggccttg ccggagcggg cgaatcggcc
      241 gcggagacgg cgtgtgcgcg tgcgcagagg tgtaaagcta ggacggtccg ccgaggctcg
      301 gaggtggagg cgcagcgctc tggaggcgag tatttcctaa atgaccttac accctttgcc
      361 acactggtcc tgggccaaga tgggccaatc aaagtcctta cccagaattt tttgaactga
      421 aattgagaga gaatccctct tcagtatgga agccataaaa tgtaaaacac aggagctgtc
      481 agcagccatg tgtcctgcag tacggagcca gctggtctgc tgtgagaagg aagccgccgt
      541 gccagaggca gcagagaacc atgtgtgctc agtactgcat ctcctttgct gatgttgaaa
      601 aagctcatat caacattcaa gactctatcc acctcacccc agtgctaaca agctccattt
      661 tgaatcaaat agcagggcgc aatcttttct tcaaatgtga gctcttccag aaaactgggt
      721 cttttaagat tcgaggtgcc cttaatgcca tcagaggctt aattcctgac acgccagaag
      781 agaagcccaa agccgtagtt actcacagca gcggaaacca tggccaagct ctcacctatg
      841 ctgctaaact ggaaggaatt cctgcttaca ttgtggttcc ccaaacagct cccaactgca
      901 agaaactggc aatccaagcc tatggagcat cgatagtata ctgtgaccca agtgacgagt
      961 ccagagaaaa ggtcactcaa agaattatgc aagaaacaga aggcatcttg gtccatccca
     1021 accaggagcc tgcagtgata gctggacaag gaacaattgc cctggaagtg ctgaaccagg
     1081 ttcccttggt agatgcactg gtggtaccag taggaggagg aggaatggtt gctggaatag
     1141 ccattacaat taaggccctg aaacctagtg tgaaggtata cgctgctgag ccctcgaatg
     1201 cagatgactg ctaccagtct aaactgaaag gagaactgac ccccaatctt catcctccag
     1261 aaaccatagc agatggtgtc aaatccagca ttggcttgaa tacctggcct attataagag
     1321 accttgtgga tgatgtcttc actgtcaccg aagatgaaat caagtatgca acccagctgg
     1381 tgtgggggag aatgaaactg ctcattgagc cgactgctgg cgtggcactg gctgcagtgc
     1441 tgtctcagca tttccaaaca gtctctccag aagtaaagaa cgtctgcatt gtactcagtg
     1501 gggggaatgt agacctaacc tccctgaact gggtggggca ggctgaacgg ccagctcctt
     1561 accagacggt ttctgtttaa attcaggcaa gattgtctct agatgaaaat tttgtttcca
     1621 tcttcccttt aaaaattatg ttcaaaatcc taatgaagaa agtgtaagta atcatgtaaa
     1681 ttctgtactt agcagagaca tggacaactg aaatacagag cacaagctgc ctggtcacaa
     1741 cccagactcc aacactggag ttttggttgg ttgcagtaga gacagaaccc aactgagtct
     1801 cttactccat gtctacttca gacactgttg aagagatgtc acttttaacc caaggtactg
     1861 gctctggtac atatgggtca taagtccact tgggaaatac tcgcttatag agattcatta
     1921 atactgtgtc ctgagatttc agcttcccat caaaactgca cttcatatgg ccatgggtac
     1981 ctaaaagtta aacagataat tggtcaaaat aaagtggaca cgtccaagca gtgaacttac
     2041 agcccacagt ctccgatagc caacccctgg gaatcccagg ctcttaccta gaggctcttt
     2101 gatatgtccc cggcggcccc acttggttct cagttccaca ggcttaaacc acatcacatc
     2161 ctcttagaat ggaaaaacaa agtcaaacat ttgcccacac agccgcaagg ccatcttccc
     2221 accactctcc ttctcacacc tacctctgtt gaagaacatg taccgcacta ctgccatctt
     2281 ggtaaatatt ttaaaaggat gaccacttag aaccactctc tttatgacca tcctgtctgg
     2341 gtccactgaa aacagatggc ctgtagcgat gaggctgtgc attcctgaga aagagagcac
     2401 tgtcaatcta aggccaagtc cgtagctcta gtctacttta agggcccatc catccactac
     2461 tatgctactt tcccgaggca aaggaagacc actaaaagac atttataatg agccagtccc
     2521 tcacacccac cttacatata ttgaatatat tgattagtgt gtacttaagt atgccaacag
     2581 gtaacaactg atgtatcact ctgggcttac accctcaatg aggctaaaac tggtatttaa
     2641 aacaaacaaa acaccagtat tccttaatac agcaagaccc catgcctaag tacagaagag
     2701 ttatggtgct agtgggtact tgtatgttcg gtatttacat cccaaatcca acataccatt
     2761 tcttctctgc ttgaaaagca gcacagatgc aggagggaac gtgattggcg caaacactgt
     2821 caccacgaag gcagcatcag cagtcaggaa tctttgaaat ttatgtttat cagcttccat
     2881 aataagggtg caaaataagt aaatagaaaa gcaaaaggcc ttgtgagata ccataagcaa
     2941 tgcaagtgtc aaaagctgta ctgctgcaac atgtggcccc accctttaaa ctttcagcaa
     3001 tggagatgaa acccagggct gtgtccacac taagtgctct gccatagacc cacagcatat
     3061 cctcagtgtt tgtattttta ttaatgtgta tgcatctgaa tgcaggtgcc tctctccaca
     3121 ttgacaatgt ggatgctggg aatccaacct gggtcctcta caggctcctg tctgcttagt
     3181 tttgagagga gctcagtact gcatgctggc cttgaagttg ctgtgtacct tctgccatca
     3241 agggctaaag ttcccagttc atttttggtt tctctatact actaactctc gggctttttc
     3301 cgtgtcagtg aacatggctg tgagatgact gcttctgtgc tgggtgtagg agagtaagct
     3361 agtagggaaa ctgttcacct tactttctca aaacaataaa aagccttgta atacatctca
     3421 tttatttggg ggtgtggggg catatatgca tagaagtcag aggacagttc tctgctccac
     3481 catgggggtc agggcactcg ctgactgtag gtcctcaggt tcagcaacta gtccatgtta
     3541 ctttatattt cactcactca ggtatgtcag tgtgcctctg taacaaagtt gccagctggg
     3601 catggtagtg tacccccccc cctccacctc aataccccaa gcattctgaa ggtcaaggcc
     3661 agcttgggca acatattaag acctagtctc tcaattacca aataaaataa aaatagaaag
     3721 taaaacaaga cagctacaca caagttactt aaacaagcaa gtaataacag taacactaag
     3781 aggggaaggt gggaggaccc agctcagtgc aacaagatac gccatctctt caataaaact
     3841 tttgtttaca aacacacgat ggtaagagaa tgtacccaga gcaccagtga agctgtcacc
     3901 atcttgtctc ctgtcactga aaggcaaaag ccccaagtga gcaggcaaca catattccta
     3961 ctcctgaagc tacactggga tttaatacct actctggaac aatactcata gcagagaagc
     4021 ctcagtacaa cattttgcat cactgggatg cttcagacag gttcagacat tttgaataaa
     4081 aacattattg gctcctaagt cagagtactc aaaatatttc taatctcaga gactttcgac
     4141 cacaaagaag aggtggcaag gctccagcag ctgtctgtgc ttacctgctg tgtgctgaga
     4201 gaacaaaggc gaagctcgga agcgcctgaa cccacagtgg aagatcaatt cttctttcgc
     4261 cttcacaggt tccgtgttgc cagggttccg gctcaccacc atgttcaata cagacatctg
     4321 aggaccaaac aagaaaaaac ttcacagtct aggcatacaa cagcctaacc tgaaaggcaa
     4381 agcaagccaa catcagtcac tctaagaact gaccatgcta ctaacaagtc ctttgtatcc
     4441 accaactgac atcatggtga tttaggcctc atcggtgctt ccgtgcacat gtgtcagcac
     4501 tgttccatag taatattaaa gagccacctc accaccacat accctcccag ccacaaccat
     4561 tcaagcttct tcaaccttta tgccagcctt cccactccca gtatacatga ctataggcta
     4621 cctagagaag agatctatac atgggcatag acatttacaa ctgctaaccc ccattttgat
     4681 ctgaaaaaca catttagaga agtctcagaa ccacatagac tacatcaaaa agatgcttca
     4741 gacaggttca gacatcttgg gcatgaccat cattgacttc tctatcttaa ttcctcaatc
     4801 aaaaaggtag gctctcatcc caatgagcaa agtgttgtac acttgggaaa ggtatttgta
     4861 cctctccatt tcccataaaa cactgattta ccttctgttc ataaggtagc aaagaaaatg
     4921 caatcaaggg cgctccttgc ctgaaatact caaccactga gacagggaca tcagaaacat
     4981 ggagtgtgac ataccagccc acctgccagg agaaagcaca atagtcacag ggtgccgata
     5041 atgatgaaac ctttctccag gtatgtgcta agcctcatct ctcaagactg acactcatag
     5101 acgcatcaac cacccagatt caacctcggc tactcatctc tgactgctcc atactcccaa
     5161 acaagcagca tgataccaaa caagaacaac ttagaaggtg ggcagaaggc aggtacctca
     5221 gctccttcag cttctttttc ctcaatctct ttaaaaattc tttttctagt attaacaaaa
     5281 ttctgaaact gaaatatccg agcataatct ctaggaaggt tttctttagg atcccaagga
     5341 gatgtccgga aactcttgag gcctctatat ttctgaaatc tagaacggaa gttttaaaga
     5401 aagcaagagg tttagtacta cataaaactc acctcacttg taaaatggtt agttaaggct
     5461 ctaggttttt caaagtactc ttactaggga tgtaactcac tggtataatg cttatctagt
     5521 atgcacgtgg gcccagggtt caatccccag catagcacaa ctaagcactg gggatgccgg
     5581 ggcaggatca tggttccaca tcagcctaaa ctgtctcaag aaactaaggc accaaaatgg
     5641 tctaataggc tagaactggg catggaaagg cacacctaca ttctcagctc ttgaaacata
     5701 gtggcaaagg atcaaggctg gcctggtctg catgagagcc tatccttcac acaatctcca
     5761 gactaatagc tttagcaaaa accatgttct acaacagctt ctaacaagta tttcagaatc
     5821 aacccaggct tttcaaaggt gacaagtact tacaagtacc tgtcaggaat atggctcttc
     5881 aacctgcctt acattagagc cttacatttt cttgctttta caagctttct ttcaaaatat
     5941 acactcttac tttccaaaag aattttttct gcgcatttac tcccacaagg attatctgct
     6001 aattaacctt catgtctctc tttctagggc cctctgaaca attctaaacc ttgatagtat
     6061 gttgctactt ctcatatagc atgttagtcc ttccttcaag gacaagaaca gtgtttttct
     6121 ctatttgctt tctgctcaca gacttctgtt attggtttta aataaaactt gtttgaaatc
     6181 a
//
