LOCUS       NM_026838               2923 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus sushi-repeat-containing protein, X-linked 2 (Srpx2),
            transcript variant 1, mRNA.
ACCESSION   NM_026838
VERSION     NM_026838.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2923)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2923)
  AUTHORS   Cong,Q., Soteros,B.M., Huo,A., Li,Y., Tenner,A.J. and Sia,G.M.
  TITLE     C1q and SRPX2 regulate microglia mediated synapse elimination
            during early development in the visual thalamus but not the visual
            cortex
  JOURNAL   Glia 70 (3), 451-465 (2022)
   PUBMED   34762332
  REMARK    GeneRIF: C1q and SRPX2 regulate microglia mediated synapse
            elimination during early development in the visual thalamus but not
            the visual cortex.
REFERENCE   3  (bases 1 to 2923)
  AUTHORS   Cong,Q., Soteros,B.M., Wollet,M., Kim,J.H. and Sia,G.M.
  TITLE     The endogenous neuronal complement inhibitor SRPX2 protects against
            complement-mediated synapse elimination during development
  JOURNAL   Nat Neurosci 23 (9), 1067-1078 (2020)
   PUBMED   32661396
  REMARK    GeneRIF: The endogenous neuronal complement inhibitor SRPX2
            protects against complement-mediated synapse elimination during
            development.
REFERENCE   4  (bases 1 to 2923)
  AUTHORS   Estrada,S.M., Thagard,A.S., Dehart,M.J., Damicis,J.R.,
            Dornisch,E.M., Ippolito,D.L., Burd,I., Napolitano,P.G. and
            Ieronimakis,N.
  TITLE     The orphan nuclear receptor Nr4a1 mediates perinatal
            neuroinflammation in a murine model of preterm labor
  JOURNAL   Cell Death Dis 11 (1), 11 (2020)
   PUBMED   31907354
  REMARK    Erratum:[Cell Death Dis. 2020 Jun 30;11(6):495. doi:
            10.1038/s41419-020-2682-y.. PMID: 32606386]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2923)
  AUTHORS   Anwer,M., Bolkvadze,T., Puhakka,N., Ndode-Ekane,X.E. and
            Pitkanen,A.
  TITLE     Genotype and Injury Effect on the Expression of a Novel
            Hypothalamic Protein Sushi Repeat-Containing Protein X-Linked 2
            (SRPX2)
  JOURNAL   Neuroscience 415, 184-200 (2019)
   PUBMED   31362033
  REMARK    GeneRIF: Unsupervised hierarchical clustering using SRPX2
            expression did not identify genotype or injury-specific clusters.
            Data demonstrate that SRPX2 expression in the hypothalamus is
            resistant to genetic deficiencies in the urokinase-system or to the
            hypothalamus-affecting TBI.
REFERENCE   6  (bases 1 to 2923)
  AUTHORS   Sia,G.M., Clem,R.L. and Huganir,R.L.
  TITLE     The human language-associated gene SRPX2 regulates synapse
            formation and vocalization in mice
  JOURNAL   Science 342 (6161), 987-991 (2013)
   PUBMED   24179158
REFERENCE   7  (bases 1 to 2923)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   8  (bases 1 to 2923)
  AUTHORS   Naba,A., Clauser,K.R., Hoersch,S., Liu,H., Carr,S.A. and Hynes,R.O.
  TITLE     The matrisome: in silico definition and in vivo characterization by
            proteomics of normal and tumor extracellular matrices
  JOURNAL   Mol Cell Proteomics 11 (4), M111.014647 (2012)
   PUBMED   22159717
REFERENCE   9  (bases 1 to 2923)
  AUTHORS   Miljkovic-Licina,M., Hammel,P., Garrido-Urbani,S., Bradfield,P.F.,
            Szepetowski,P. and Imhof,B.A.
  TITLE     Sushi repeat protein X-linked 2, a novel mediator of angiogenesis
  JOURNAL   FASEB J 23 (12), 4105-4116 (2009)
   PUBMED   19667118
REFERENCE   10 (bases 1 to 2923)
  AUTHORS   Hackney,J.A., Charbord,P., Brunk,B.P., Stoeckert,C.J.,
            Lemischka,I.R. and Moore,K.A.
  TITLE     A molecular profile of a hematopoietic stem cell niche
  JOURNAL   Proc Natl Acad Sci U S A 99 (20), 13061-13066 (2002)
   PUBMED   12226475
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB843885.1, BB848735.1, CN539245.1, BQ830905.1, BF470209.1,
            BQ560499.1, AK136935.1 and AL691421.9.
            
            On Feb 12, 2013 this sequence version replaced NM_026838.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein. The
            encoded protein contains an in-frame start site 41 codons upstream
            of the currently annotated site, but Kozak sequence considerations
            and the presence of a signal peptide in the shorter version make
            the shorter version the more likely protein product.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC028307.1, SRR13948564.5679097.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: downstream AUG is associated
                                                with N-terminal localization
                                                signal
            RefSeq Select criteria           :: based on conservation,
                                                expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 BB843885.1         2-2
            2-420               BB848735.1         3-421
            421-961             CN539245.1         184-724
            962-1350            BQ830905.1         121-509
            1351-1477           BF470209.1         161-287
            1478-2037           BQ560499.1         1-560
            2038-2410           AK136935.1         1841-2213
            2411-2411           AL691421.9         173683-173683
            2412-2923           AK136935.1         2215-2726
FEATURES             Location/Qualifiers
     source          1..2923
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 55.47 cM"
     gene            1..2923
                     /gene="Srpx2"
                     /gene_synonym="1110039C07Rik; SRP; SRPUL"
                     /note="sushi-repeat-containing protein, X-linked 2"
                     /db_xref="GeneID:68792"
                     /db_xref="MGI:MGI:1916042"
     exon            1..354
                     /gene="Srpx2"
                     /gene_synonym="1110039C07Rik; SRP; SRPUL"
                     /inference="alignment:Splign:2.1.0"
     exon            355..406
                     /gene="Srpx2"
                     /gene_synonym="1110039C07Rik; SRP; SRPUL"
                     /inference="alignment:Splign:2.1.0"
     exon            407..621
                     /gene="Srpx2"
                     /gene_synonym="1110039C07Rik; SRP; SRPUL"
                     /inference="alignment:Splign:2.1.0"
     CDS             537..1943
                     /gene="Srpx2"
                     /gene_synonym="1110039C07Rik; SRP; SRPUL"
                     /note="sushi-repeat containing protein; sushi
                     repeat-containing protein SRPX2"
                     /codon_start=1
                     /product="sushi repeat-containing protein SRPX2 precursor"
                     /protein_id="NP_081114.2"
                     /db_xref="CCDS:CCDS41119.2"
                     /db_xref="GeneID:68792"
                     /db_xref="MGI:MGI:1916042"
                     /translation="MMTSPLTQRGALSLLLLLMPAVTPTWYAGSGYSPDESYNEVYAE
                     EVPAARARALDYRVPRWCYTLNIQDGEATCYSPRGGNYHSSLGTRCELSCDRGFRLIG
                     RKSVQCLPSRRWSGTAYCRQIRCHTLPFITSGTYTCTNGMLLDSRCDYSCSSGYHLEG
                     DRSRICMEDGRWSGGEPVCVDIDPPKIRCPHSREKMAEPEKLTARVYWDPPLVKDSAD
                     GTITRVTLRGPEPGSHFPEGEHVIRYTAYDRAYNRASCKFIVKVQVRRCPILKPPQHG
                     YLTCSSAGDNYGAICEYHCDGGYERQGTPSRVCQSSRQWSGTPPVCTPMKINVNVNSA
                     AGLLDQFYEKQRLLIVSAPDPSNRYYKMQISMLQQSTCGLDLRHVTIIELVGQPPQEV
                     GRIREQQLSAGIIEELRQFQRLTRSYFNMVLIDKQGIDRERYMEPVTPEEIFTFIDDY
                     LLSNEELARRVEQRDLCE"
     exon            622..708
                     /gene="Srpx2"
                     /gene_synonym="1110039C07Rik; SRP; SRPUL"
                     /inference="alignment:Splign:2.1.0"
     exon            709..900
                     /gene="Srpx2"
                     /gene_synonym="1110039C07Rik; SRP; SRPUL"
                     /inference="alignment:Splign:2.1.0"
     exon            901..1077
                     /gene="Srpx2"
                     /gene_synonym="1110039C07Rik; SRP; SRPUL"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..1204
                     /gene="Srpx2"
                     /gene_synonym="1110039C07Rik; SRP; SRPUL"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..1326
                     /gene="Srpx2"
                     /gene_synonym="1110039C07Rik; SRP; SRPUL"
                     /inference="alignment:Splign:2.1.0"
     exon            1327..1506
                     /gene="Srpx2"
                     /gene_synonym="1110039C07Rik; SRP; SRPUL"
                     /inference="alignment:Splign:2.1.0"
     exon            1507..1640
                     /gene="Srpx2"
                     /gene_synonym="1110039C07Rik; SRP; SRPUL"
                     /inference="alignment:Splign:2.1.0"
     exon            1641..1762
                     /gene="Srpx2"
                     /gene_synonym="1110039C07Rik; SRP; SRPUL"
                     /inference="alignment:Splign:2.1.0"
     exon            1763..2923
                     /gene="Srpx2"
                     /gene_synonym="1110039C07Rik; SRP; SRPUL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2267..2272
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Srpx2"
                     /gene_synonym="1110039C07Rik; SRP; SRPUL"
                     /note="hexamer: AGTAAA"
     polyA_site      2291
                     /gene="Srpx2"
                     /gene_synonym="1110039C07Rik; SRP; SRPUL"
                     /note="major polyA site"
ORIGIN      
        1 actccaccca gagcttgaaa ccagtgacag tcacacttcc cctcttctgc agcagacagc
       61 actagctcct ctaatcctct tgcttccccc tcccccaacc atttcttggg gaataacaaa
      121 tatagctttg gggataatat agctttaaga cgacttttgg caaatgtaaa tgtcctaaca
      181 tctgggcagt gttaccagaa tcccggaggc cctgacagac caggagccac tggttctagg
      241 aatgttaaag tacaagggct ttttcccacc cccgactgac tgatgagagg agcagagagc
      301 aaagaaaaag aagagagatg aacgagacca caaaaatcat aaaataaaaa gcagatgcat
      361 gttcctgctc ttttcaaagc ttccagtaga acgatagctc cctccgatgt catatgcctg
      421 cttcctctca cttttgggag ttcatagctg gttctgctct gaaagtcatt cccctttatc
      481 ctggtacttc tggccacata gccctagtct tgtcttctga agcttccctg tcgacgatga
      541 tgaccagtcc actgactcag agaggtgctc tctcactgct gctcctccta atgcccgcag
      601 tgacaccaac atggtacgca ggctcaggtt actctccaga tgaaagctac aatgaagtat
      661 atgcagaaga ggtccccgct gcccgtgccc gtgccctgga ctacagagtc ccccgatggt
      721 gttacacatt gaatatccag gatggagaag ccacatgcta ctcaccaagg ggaggaaatt
      781 atcacagtag cctaggcaca cgttgtgagc tctcctgtga ccggggcttt cgattgattg
      841 gacggaagtc agtgcaatgt ttgccaagcc ggcgttggtc tggaactgcc tactgcaggc
      901 agataaggtg ccacacactg ccattcatca ctagtggcac ctatacgtgc accaatggaa
      961 tgctgcttga ctcccgttgt gactatagct gttctagtgg ctaccaccta gaaggagatc
     1021 gcagccgcat ctgcatggaa gatgggcgat ggagtggagg cgagcctgta tgtgtagaca
     1081 tagatccacc caagatccgt tgtcctcact ctcgtgagaa aatggcagag ccagagaaac
     1141 taactgctcg agtatactgg gacccaccct tagtgaaaga ttctgctgat ggtaccatca
     1201 ccagggtgac acttcggggt ccagagcctg gttctcactt ccctgaagga gaacatgtga
     1261 ttcgttatac tgcctatgac cgagcctaca accgggccag ctgcaaattc attgtaaaag
     1321 tacaagtgag acgctgtccc attctgaagc caccacagca cggctacctc acctgcagct
     1381 cagcggggga caactatggt gccatctgtg aataccactg tgatggtggt tatgaacgcc
     1441 aggggacccc atcccgagtc tgccagtcaa gtcgacagtg gtcaggaaca ccacctgtct
     1501 gtactcctat gaagattaat gtcaatgtta actcggctgc tggcctcctg gatcagttct
     1561 atgagaaaca gcgactcctc atagtctctg ctcctgatcc ctccaatcgg tactacaaaa
     1621 tgcaaatctc tatgctgcag caatccacct gtggactcga cctgcggcat gtgaccatta
     1681 ttgagctggt gggacagcca cctcaggagg tggggcgcat ccgggagcaa caactatcag
     1741 caggcatcat tgaggagctc aggcaattcc agcgcctcac tcgttcctac ttcaacatgg
     1801 tgttaattga caagcagggt attgaccggg aacgctatat ggaacctgtc acccctgagg
     1861 aaatcttcac attcatcgat gactacctgc tgagcaatga ggagctggca cggagagtgg
     1921 agcagaggga cctatgcgag tgaccttgag tcagggtgtg gctgaagcac ctgtcctagg
     1981 gagcttaaac taaggaggaa atgtcgtgtc ctcccccccc cacacacaca cacacacact
     2041 gttgggagca gccctcgggt gggggtgagg tttgccaaat ctaggacagt tccaggcagc
     2101 attttagggc agaatattca tttccctaag caagtctcca cttcgggtag cactggagga
     2161 gcctatgaaa ctgaggacat gccctgggtg gtgagttgta gaccgaaggc cttcttcacc
     2221 tgcctggagc ctctctctct agactcttcc caaagccttt cagataagta aataccaaat
     2281 tcattccttt acggtgttgt aaatggttcc tctaccctac aataacagca gggggcagca
     2341 ttgcaacaga caaacaagac actttgacca agtataaata gatttccctc acagttagtt
     2401 atgtgaggaa caggagagag gagactagga tctacaaaac attcttgaag ctgctcgtca
     2461 tcctctagga tgctggcctt aaaaacaatg ttgcttgagc catttcttca tcaagagtta
     2521 gaaaaacatt ttctccaggg ggagtttggg aagcaacgtc tagccatagc tggctgttcc
     2581 ctcctagatg ctccaactag cttgtaggca agaacttcta ataactgagg tgtttagtac
     2641 cctggtgaca gctcttcctt agaggattct gcagtctgtg aacaacatta cctctaagaa
     2701 ttagggagat ggctccgttg gtgaagtgct tgctatcaag cactgagacc cgagtgattc
     2761 ccagaaccca tgtaaaatag ccagatgtgg tggtgtgcac ttggaatccc agcagagagg
     2821 tagacataaa cagatctgtg gggatcactg cttagcaagc caagtctaat gatgagtacc
     2881 aggtcatgta agaaacacta tctcaaaaac catggtaaat ggc
//
