LOCUS       NM_016911               2435 bp    mRNA    linear   ROD 06-JUN-2024
DEFINITION  Mus musculus sushi-repeat-containing protein (Srpx), transcript
            variant 1, mRNA.
ACCESSION   NM_016911 XM_906892 XM_920114 XM_920119
VERSION     NM_016911.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2435)
  AUTHORS   Inoue,Y., Ueda,M., Tasaki,M., Takeshima,A., Nagatoshi,A.,
            Masuda,T., Misumi,Y., Kosaka,T., Nomura,T., Mizukami,M.,
            Matsumoto,S., Yamashita,T., Takahashi,H., Kakita,A. and Ando,Y.
  TITLE     Sushi repeat-containing protein 1: a novel disease-associated
            molecule in cerebral amyloid angiopathy
  JOURNAL   Acta Neuropathol 134 (4), 605-617 (2017)
   PUBMED   28478503
  REMARK    GeneRIF: SRPX1 co-accumulated with Abeta deposits in cerebral blood
            vessels of all autopsied cases with severe cerebral amyloid
            angiopathy (CAA); no SRPX1 co-accumulated with Abeta deposits in
            senile plaques. Furthermore, we demonstrated that both Abeta40 and
            Abeta42 bound to SRPX1 in vitro and enhanced SRPX1 expression in
            primary cultures of cerebrovascular smooth muscle cells. SRPX1
            enhanced caspase activity induced by Abeta40.
REFERENCE   2  (bases 1 to 2435)
  AUTHORS   Tambe,Y., Hasebe,M., Kim,C.J., Yamamoto,A. and Inoue,H.
  TITLE     The drs tumor suppressor regulates glucose metabolism via lactate
            dehydrogenase-B
  JOURNAL   Mol Carcinog 55 (1), 52-63 (2016)
   PUBMED   25620379
  REMARK    GeneRIF: drs regulates glucose metabolism via LDH-B. Downregulating
            drs may contribute to the Warburg effect, which is closely
            associated with malignant progression of cancer cells.
REFERENCE   3  (bases 1 to 2435)
  AUTHORS   Tambe,Y., Okuyama,N., Nakagawa,T., Muramoto,A., Hasebe,M., Chano,T.
            and Inoue,H.
  TITLE     Suppression of viral replication by drs tumor suppressor via mTOR
            dependent pathway
  JOURNAL   Cancer Lett 314 (1), 82-91 (2012)
   PUBMED   21983129
  REMARK    GeneRIF: Drs suppresses viral replication via mTOR-dependent
            pathway.
REFERENCE   4  (bases 1 to 2435)
  AUTHORS   Tambe,Y., Yamamoto,A., Isono,T., Chano,T., Fukuda,M. and Inoue,H.
  TITLE     The drs tumor suppressor is involved in the maturation process of
            autophagy induced by low serum
  JOURNAL   Cancer Lett 283 (1), 74-83 (2009)
   PUBMED   19368996
  REMARK    GeneRIF: drs is involved in the maturation process of autophagy
            from autophagosomes to autolysosomes
REFERENCE   5  (bases 1 to 2435)
  AUTHORS   Tambe,Y., Yoshioka-Yamashita,A., Mukaisho,K., Haraguchi,S.,
            Chano,T., Isono,T., Kawai,T., Suzuki,Y., Kushima,R., Hattori,T.,
            Goto,M., Yamada,S., Kiso,M., Saga,Y. and Inoue,H.
  TITLE     Tumor prone phenotype of mice deficient in a novel
            apoptosis-inducing gene, drs
  JOURNAL   Carcinogenesis 28 (4), 777-784 (2007)
   PUBMED   17088259
  REMARK    GeneRIF: Tumor prone phenotype of mice deficient in a novel
            apoptosis-inducing gene, drs
REFERENCE   6  (bases 1 to 2435)
  AUTHORS   Kawai,T., Suzuki,Y., Yamashita,A. and Inoue,H.
  TITLE     Isolation of a novel mouse variant of the drs tumor suppressor gene
  JOURNAL   Cancer Lett 183 (1), 79-86 (2002)
   PUBMED   12049817
  REMARK    GeneRIF: Isolation of a novel variant of the tumor suppressor gene
            (mDRS-2)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX005236.16.
            
            On Jul 26, 2018 this sequence version replaced NM_016911.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK034696.1, BC022572.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-197               BX005236.16        100589-100785       c
            198-257             BX005236.16        56914-56973         c
            258-449             BX005236.16        52518-52709         c
            450-626             BX005236.16        50570-50746         c
            627-753             BX005236.16        42098-42224         c
            754-875             BX005236.16        38824-38945         c
            876-1055            BX005236.16        37997-38176         c
            1056-1189           BX005236.16        32761-32894         c
            1190-1311           BX005236.16        30820-30941         c
            1312-2435           BX005236.16        21122-22245         c
FEATURES             Location/Qualifiers
     source          1..2435
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 4.62 cM"
     gene            1..2435
                     /gene="Srpx"
                     /gene_synonym="drs; drs-1; DRS-1; drs-2; DRS-2"
                     /note="sushi-repeat-containing protein"
                     /db_xref="GeneID:51795"
                     /db_xref="MGI:MGI:1858306"
     exon            1..197
                     /gene="Srpx"
                     /gene_synonym="drs; drs-1; DRS-1; drs-2; DRS-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             101..1495
                     /gene="Srpx"
                     /gene_synonym="drs; drs-1; DRS-1; drs-2; DRS-2"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; sushi-repeat-containing protein, X-chromosome;
                     sushi-repeat-containing protein SRPX"
                     /codon_start=1
                     /product="sushi-repeat-containing protein SRPX isoform 1
                     precursor"
                     /protein_id="NP_058607.1"
                     /db_xref="CCDS:CCDS30013.1"
                     /db_xref="GeneID:51795"
                     /db_xref="MGI:MGI:1858306"
                     /translation="MGSPGLRPELLLPQVLPLLLALLHVLPSQGFPGSGDSPLEDDGV
                     WYSHSLYKDTPWCSPIKVKYGDVYCRAPPGGYYKTALGTRCDIRCRKGYELHGSSQLI
                     CQSNKRWSDKVICKQKRCPTLTMPANGGFKCVDGAYFNSRCEYYCSPGYTLKGERTVT
                     CMDNKAWSGRPASCVDLEPPRIKCPSVKERIAEPNKLTVRVSWESPEGRDTADGILTD
                     VILKGLPPGSNFPEGDHKIEYTVYDRAENKGTCKFRVKVRVRRCGKLNAPENGYMKCS
                     SDGDNYGATCEFSCIGGYELQGSPARVCQSNLAWSGTEPSCAAMNVNVGVRTAAALLD
                     QFYEKRRLLIVSTPTARNLLYRLQLGMLQQAQCGLDLRHVTVVELVGVFPTLIGRIRA
                     KIMPPALALQLRLLLRIPLYSFSMVVVDKHGMDKERYVSLVTPMALFNLIDTFPLRKE
                     EMILQAEMGQTCNV"
     exon            198..257
                     /gene="Srpx"
                     /gene_synonym="drs; drs-1; DRS-1; drs-2; DRS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            258..449
                     /gene="Srpx"
                     /gene_synonym="drs; drs-1; DRS-1; drs-2; DRS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            450..626
                     /gene="Srpx"
                     /gene_synonym="drs; drs-1; DRS-1; drs-2; DRS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            627..753
                     /gene="Srpx"
                     /gene_synonym="drs; drs-1; DRS-1; drs-2; DRS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            754..875
                     /gene="Srpx"
                     /gene_synonym="drs; drs-1; DRS-1; drs-2; DRS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            876..1055
                     /gene="Srpx"
                     /gene_synonym="drs; drs-1; DRS-1; drs-2; DRS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1189
                     /gene="Srpx"
                     /gene_synonym="drs; drs-1; DRS-1; drs-2; DRS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..1311
                     /gene="Srpx"
                     /gene_synonym="drs; drs-1; DRS-1; drs-2; DRS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..2435
                     /gene="Srpx"
                     /gene_synonym="drs; drs-1; DRS-1; drs-2; DRS-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1826..1831
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Srpx"
                     /gene_synonym="drs; drs-1; DRS-1; drs-2; DRS-2"
                     /note="hexamer: AATAAA"
     polyA_site      1846
                     /gene="Srpx"
                     /gene_synonym="drs; drs-1; DRS-1; drs-2; DRS-2"
                     /note="major polyA site"
     regulatory      2412..2417
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Srpx"
                     /gene_synonym="drs; drs-1; DRS-1; drs-2; DRS-2"
                     /note="hexamer: AATAAA"
     polyA_site      2430
                     /gene="Srpx"
                     /gene_synonym="drs; drs-1; DRS-1; drs-2; DRS-2"
ORIGIN      
        1 agaggctctg tctcactaca cagcccctcg gtctcttggc ctcctccagc cccttaagtg
       61 agctgtgcag cctgccctgc gggggaagcg ccggctcacc atggggagcc cgggacttcg
      121 gcccgagctg ctgctgcctc aagtactgcc gctgttgctg gcgctgctgc acgtcctgcc
      181 gagccagggc ttcccaggat ctggagactc accactagaa gacgatggag tctggtattc
      241 acactctcta tataaagaca ctccgtggtg ctctcccatc aaggtgaagt atggggatgt
      301 gtactgcagg gcacctcctg ggggatacta caaaacagcc ttgggaacca gatgtgacat
      361 tcgctgccga aagggctatg agcttcatgg ctcttcccag ctcatctgcc agtcaaacaa
      421 gcgctggtca gataaggtca tctgcaaaca gaagcgatgt cctaccctta ccatgccggc
      481 aaatggaggg tttaagtgtg tcgatggtgc ctactttaac tctcggtgtg agtactattg
      541 ttcaccagga tatacattga aaggggagcg aacagtcaca tgtatggaca acaaggcctg
      601 gagtggccga ccagcctcct gtgtagatct ggaacctcct agaatcaagt gcccaagtgt
      661 gaaagaacgt atagctgagc ccaataagct gacagtccgg gtgtcctggg aaagcccaga
      721 gggaagagat acagcggatg ggattcttac tgatgttatt ctgaaaggcc ttcctccggg
      781 ctcaaatttt ccagaaggag accacaagat tgagtacaca gtctatgaca gagccgagaa
      841 caagggaact tgcaagtttc gagttaaagt aagagtcaga cgttgtggca agctcaatgc
      901 cccagaaaat ggttacatga agtgttccag cgatggtgac aattatggag ccacctgtga
      961 attctcctgt attggcggct atgagcttca gggtagtcct gcccgagtat gccaatccaa
     1021 tctggcttgg tccggcacag agcccagctg tgcagcgatg aatgtcaatg ttggtgtcag
     1081 aacagcagct gcacttctgg atcagtttta tgagaaaagg cgactcctca ttgtatctac
     1141 acccacagct cgaaacctcc tctacagatt gcagctggga atgctacagc aagcacagtg
     1201 tggcctcgat ctccgacatg tcaccgtggt ggagctggta ggggtcttcc caactctcat
     1261 cggcaggatc agagcaaaga ttatgcctcc agctctagct ctacagctca ggctgttgct
     1321 tcgaattcct ctctactcct tcagcatggt ggtagtggat aagcatggca tggataaaga
     1381 acgttatgtc tccttagtga cacccatggc tctcttcaac ctcattgaca ctttccccct
     1441 gagaaaagaa gagatgatcc tgcaggctga gatgggccag acttgcaacg tctgatgtgc
     1501 tgttacattc atggtggctc ctcatctctt attctatact acagtgcctg tgggaaggcc
     1561 ttaaaatacc tttgatgtac agattttcat ttgtaatttt aaaagtctat tttattatgt
     1621 gctttctttg ctcttagaca ttggcacaag gcttttttta aactttgaaa tgttaaaaaa
     1681 atacgaatat atctattcta actctccttt tagtccattg tggctgatga aattagaagc
     1741 tacagccaca ctcatgcact cagaatattc ctcagtgtga aacatgtttt cctttttctt
     1801 ttattgttta tataagtctt ttgttaataa aataatttga agcaaactta ctaaaactca
     1861 cctttaaaaa atactcaagc accaggctta tttgcttggc atgatcagta gttttaaaac
     1921 tgtgattctt tgtttatctt aagaaaggga aactagtcct gtcaaggggt caactgagct
     1981 gagagagaga gctacgttcc caagtgggag aatagcaaat tgaaaatatt cagacaaagc
     2041 tacatgatgt tcatactgaa actgagtaga ctttttcccc aatgtaatat aaaaaaaact
     2101 atttacaaat cacttccctc atatgaggta ctataagtag tccagagagg tttaaagtat
     2161 acaaggggat tcacatggat tccatgtaag tactggacga tttgatatca caagtcgaat
     2221 gactgttggg atcctggaac caatcattcc tgagtttgtg aatgaacaag catgatgggc
     2281 cagtagggct gtattcttga ctgcacccca cccagagagg tgacaattca gaggttgtac
     2341 atcagacccc ttttcagata tttctatttt taaatgattg agcctagaaa aaaaatcaca
     2401 cattggcatt taataaacaa ttagattgta ctcct
//
