LOCUS       NP_058607                464 aa            linear   ROD 27-APR-2025
DEFINITION  sushi-repeat-containing protein SRPX isoform 1 precursor [Mus
            musculus].
ACCESSION   NP_058607 XP_911985 XP_925207 XP_925212
VERSION     NP_058607.1
DBSOURCE    REFSEQ: accession NM_016911.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 464)
  AUTHORS   Inoue,Y., Ueda,M., Tasaki,M., Takeshima,A., Nagatoshi,A.,
            Masuda,T., Misumi,Y., Kosaka,T., Nomura,T., Mizukami,M.,
            Matsumoto,S., Yamashita,T., Takahashi,H., Kakita,A. and Ando,Y.
  TITLE     Sushi repeat-containing protein 1: a novel disease-associated
            molecule in cerebral amyloid angiopathy
  JOURNAL   Acta Neuropathol 134 (4), 605-617 (2017)
   PUBMED   28478503
  REMARK    GeneRIF: SRPX1 co-accumulated with Abeta deposits in cerebral blood
            vessels of all autopsied cases with severe cerebral amyloid
            angiopathy (CAA); no SRPX1 co-accumulated with Abeta deposits in
            senile plaques. Furthermore, we demonstrated that both Abeta40 and
            Abeta42 bound to SRPX1 in vitro and enhanced SRPX1 expression in
            primary cultures of cerebrovascular smooth muscle cells. SRPX1
            enhanced caspase activity induced by Abeta40.
REFERENCE   2  (residues 1 to 464)
  AUTHORS   Tambe,Y., Hasebe,M., Kim,C.J., Yamamoto,A. and Inoue,H.
  TITLE     The drs tumor suppressor regulates glucose metabolism via lactate
            dehydrogenase-B
  JOURNAL   Mol Carcinog 55 (1), 52-63 (2016)
   PUBMED   25620379
  REMARK    GeneRIF: drs regulates glucose metabolism via LDH-B. Downregulating
            drs may contribute to the Warburg effect, which is closely
            associated with malignant progression of cancer cells.
REFERENCE   3  (residues 1 to 464)
  AUTHORS   Tambe,Y., Okuyama,N., Nakagawa,T., Muramoto,A., Hasebe,M., Chano,T.
            and Inoue,H.
  TITLE     Suppression of viral replication by drs tumor suppressor via mTOR
            dependent pathway
  JOURNAL   Cancer Lett 314 (1), 82-91 (2012)
   PUBMED   21983129
  REMARK    GeneRIF: Drs suppresses viral replication via mTOR-dependent
            pathway.
REFERENCE   4  (residues 1 to 464)
  AUTHORS   Tambe,Y., Yamamoto,A., Isono,T., Chano,T., Fukuda,M. and Inoue,H.
  TITLE     The drs tumor suppressor is involved in the maturation process of
            autophagy induced by low serum
  JOURNAL   Cancer Lett 283 (1), 74-83 (2009)
   PUBMED   19368996
  REMARK    GeneRIF: drs is involved in the maturation process of autophagy
            from autophagosomes to autolysosomes
REFERENCE   5  (residues 1 to 464)
  AUTHORS   Tambe,Y., Yoshioka-Yamashita,A., Mukaisho,K., Haraguchi,S.,
            Chano,T., Isono,T., Kawai,T., Suzuki,Y., Kushima,R., Hattori,T.,
            Goto,M., Yamada,S., Kiso,M., Saga,Y. and Inoue,H.
  TITLE     Tumor prone phenotype of mice deficient in a novel
            apoptosis-inducing gene, drs
  JOURNAL   Carcinogenesis 28 (4), 777-784 (2007)
   PUBMED   17088259
  REMARK    GeneRIF: Tumor prone phenotype of mice deficient in a novel
            apoptosis-inducing gene, drs
REFERENCE   6  (residues 1 to 464)
  AUTHORS   Kawai,T., Suzuki,Y., Yamashita,A. and Inoue,H.
  TITLE     Isolation of a novel mouse variant of the drs tumor suppressor gene
  JOURNAL   Cancer Lett 183 (1), 79-86 (2002)
   PUBMED   12049817
  REMARK    GeneRIF: Isolation of a novel variant of the tumor suppressor gene
            (mDRS-2)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX005236.16.
            
            On or before Dec 7, 2005 this sequence version replaced
            XP_925207.1, XP_925212.1, XP_911985.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK034696.1, BC022572.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..464
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 4.62 cM"
     Protein         1..464
                     /product="sushi-repeat-containing protein SRPX isoform 1
                     precursor"
                     /note="sushi-repeat-containing protein, X-chromosome;
                     sushi-repeat-containing protein SRPX"
                     /calculated_mol_wt=48419
     sig_peptide     1..30
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=3173
     mat_peptide     31..464
                     /product="Sushi-repeat-containing protein SRPX.
                     /id=PRO_0000022417"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R0M3.1)"
                     /calculated_mol_wt=48419
     Site            34
                     /site_type="glycosylation"
                     /note="O-linked (Xyl...) (chondroitin sulfate) serine.
                     /evidence=ECO:0000250|UniProtKB:P78539; propagated from
                     UniProtKB/Swiss-Prot (Q9R0M3.1)"
     Region          <53..175
                     /region_name="PHA02927"
                     /note="secreted complement-binding protein; Provisional"
                     /db_xref="CDD:222943"
     Region          120..175
                     /region_name="CCP"
                     /note="Complement control protein (CCP) modules (aka short
                     consensus repeats SCRs or SUSHI repeats) have been
                     identified in several proteins of the complement system;
                     cd00033"
                     /db_xref="CDD:153056"
     Site            order(130,148)
                     /site_type="active"
                     /note="receptor-ligand interactions [active]"
                     /db_xref="CDD:153056"
     Region          175..257
                     /region_name="HYR"
                     /note="HYR domain; pfam02494"
                     /db_xref="CDD:460572"
     Region          262..317
                     /region_name="CCP"
                     /note="Complement control protein (CCP) modules (aka short
                     consensus repeats SCRs or SUSHI repeats) have been
                     identified in several proteins of the complement system;
                     cd00033"
                     /db_xref="CDD:153056"
     Site            order(272,291)
                     /site_type="active"
                     /note="receptor-ligand interactions [active]"
                     /db_xref="CDD:153056"
     Region          332..451
                     /region_name="DUF4174"
                     /note="Domain of unknown function (DUF4174); pfam13778"
                     /db_xref="CDD:463980"
     CDS             1..464
                     /gene="Srpx"
                     /gene_synonym="drs; drs-1; DRS-1; drs-2; DRS-2"
                     /coded_by="NM_016911.5:101..1495"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS30013.1"
                     /db_xref="GeneID:51795"
                     /db_xref="MGI:MGI:1858306"
ORIGIN      
        1 mgspglrpel llpqvlplll allhvlpsqg fpgsgdsple ddgvwyshsl ykdtpwcspi
       61 kvkygdvycr appggyykta lgtrcdircr kgyelhgssq licqsnkrws dkvickqkrc
      121 ptltmpangg fkcvdgayfn srceyycspg ytlkgertvt cmdnkawsgr pascvdlepp
      181 rikcpsvker iaepnkltvr vswespegrd tadgiltdvi lkglppgsnf pegdhkieyt
      241 vydraenkgt ckfrvkvrvr rcgklnapen gymkcssdgd nygatcefsc iggyelqgsp
      301 arvcqsnlaw sgtepscaam nvnvgvrtaa alldqfyekr rllivstpta rnllyrlqlg
      361 mlqqaqcgld lrhvtvvelv gvfptligri rakimppala lqlrlllrip lysfsmvvvd
      421 khgmdkeryv slvtpmalfn lidtfplrke emilqaemgq tcnv
//
