LOCUS       NM_009275               2991 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus signal recognition particle receptor, B subunit
            (Srprb), mRNA.
ACCESSION   NM_009275 XM_907561 XM_920477 XM_920484
VERSION     NM_009275.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2991)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2991)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   3  (bases 1 to 2991)
  AUTHORS   Lang,S., Benedix,J., Fedeles,S.V., Schorr,S., Schirra,C.,
            Schauble,N., Jalal,C., Greiner,M., Hassdenteufel,S., Tatzelt,J.,
            Kreutzer,B., Edelmann,L., Krause,E., Rettig,J., Somlo,S.,
            Zimmermann,R. and Dudek,J.
  TITLE     Different effects of Sec61alpha, Sec62 and Sec63 depletion on
            transport of polypeptides into the endoplasmic reticulum of
            mammalian cells
  JOURNAL   J Cell Sci 125 (Pt 8), 1958-1969 (2012)
   PUBMED   22375059
REFERENCE   4  (bases 1 to 2991)
  AUTHORS   Schlenker,O., Hendricks,A., Sinning,I. and Wild,K.
  TITLE     The structure of the mammalian signal recognition particle (SRP)
            receptor as prototype for the interaction of small GTPases with
            Longin domains
  JOURNAL   J Biol Chem 281 (13), 8898-8906 (2006)
   PUBMED   16439358
REFERENCE   5  (bases 1 to 2991)
  AUTHORS   Miller,J.D., Tajima,S., Lauffer,L. and Walter,P.
  TITLE     The beta subunit of the signal recognition particle receptor is a
            transmembrane GTPase that anchors the alpha subunit, a peripheral
            membrane GTPase, to the endoplasmic reticulum membrane
  JOURNAL   J Cell Biol 128 (3), 273-282 (1995)
   PUBMED   7844142
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK030437.1.
            
            On Apr 6, 2007 this sequence version replaced NM_009275.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK030437.1, AK167039.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2991              AK030437.1         2-2992
FEATURES             Location/Qualifiers
     source          1..2991
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 55.0 cM"
     gene            1..2991
                     /gene="Srprb"
                     /note="signal recognition particle receptor, B subunit"
                     /db_xref="GeneID:20818"
                     /db_xref="MGI:MGI:102964"
     exon            1..154
                     /gene="Srprb"
                     /inference="alignment:Splign:2.1.0"
     CDS             7..816
                     /gene="Srprb"
                     /note="SR-beta"
                     /codon_start=1
                     /product="signal recognition particle receptor subunit
                     beta"
                     /protein_id="NP_033301.1"
                     /db_xref="CCDS:CCDS23450.1"
                     /db_xref="GeneID:20818"
                     /db_xref="MGI:MGI:102964"
                     /translation="MASANTRRVGDGAGGAFQPYLDSLRQELQQRDPTLLSVAVALLA
                     VLLTLVFWKFIWSRKSSQRAVLFVGLCDSGKTLLFVRLLTGQYRDTQTSITDSSAIYK
                     VNNNRGNSLTLIDLPGHESLRFQLLDRFKSSARAVVFVVDSAAFQREVKDVAEFLYQV
                     LIDSMALKNSPSLLIACNKQDIAMAKSAKLIQQQLEKELNTLRVTRSAAPSTLDSSST
                     APAQLGKKGKEFEFSQLPLKVEFLECSAKGGRGDTGSADIQDLEKWLAKIA"
     exon            155..249
                     /gene="Srprb"
                     /inference="alignment:Splign:2.1.0"
     exon            250..327
                     /gene="Srprb"
                     /inference="alignment:Splign:2.1.0"
     exon            328..410
                     /gene="Srprb"
                     /inference="alignment:Splign:2.1.0"
     exon            411..547
                     /gene="Srprb"
                     /inference="alignment:Splign:2.1.0"
     exon            548..602
                     /gene="Srprb"
                     /inference="alignment:Splign:2.1.0"
     exon            603..2991
                     /gene="Srprb"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1918..1923
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Srprb"
                     /note="hexamer: GATAAA"
     polyA_site      1937
                     /gene="Srprb"
                     /note="major polyA site"
     regulatory      2564..2569
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Srprb"
                     /note="hexamer: AATAAA"
     polyA_site      2582
                     /gene="Srprb"
ORIGIN      
        1 tctttcatgg cttcggcgaa cacccggcga gttggcgatg gcgccggtgg cgccttccag
       61 ccttacctcg actccttacg acaggagctg cagcagaggg atccgacgct gctctccgtg
      121 gcggtggctc tcctggcggt gctgctgacg ctggtgttct ggaagttcat ctggagccga
      181 aagagcagtc agagagctgt tctcttcgtt ggtctctgtg actctgggaa aacgttgctg
      241 tttgtcaggt tgctaactgg ccagtacaga gacacacaga cttccattac cgatagttct
      301 gccatataca aagtcaacaa taacaggggt aacagcctga ctctgatcga cctccccggg
      361 catgagagct tgaggtttca gctcttagat cgctttaagt cttcagctag ggctgtggtg
      421 tttgtggtgg acagtgcggc gttccagcgg gaggtgaaag atgtggccga atttctgtac
      481 caggtcctca tcgacagcat ggctctgaag aactcaccgt ccttattaat agcctgcaat
      541 aagcaagata tcgcaatggc aaaatcagcg aagttgatcc agcagcagct tgagaaggag
      601 ctcaacacct tacgagtcac ccggtccgcg gctcccagca cactggacag ttccagcacc
      661 gcacctgctc agttggggaa gaaaggcaaa gaatttgaat tttcccagtt gccactcaaa
      721 gtggagttcc tggagtgtag tgccaagggt ggacgagggg acactggctc tgctgacatc
      781 caggacttgg agaagtggct ggccaagatt gcctgaggag catcgctggc cacaagcgtt
      841 ggtcatgtga gactgaccct gcagtttgag aaagggcggt ggtggtgtgg actgataaag
      901 agggggcatg tcgttgaagc atttcttgag ttcttgaaac aattgtacca cccccacccc
      961 acccccgtca gctcctttct cagctagtcc tttcttaatt cccatattct ttctcccttt
     1021 gctaggtgtt aggtgtagca tcatgttagt gtgagacata acagagaggg catcgctttg
     1081 agagtagggt cgcatctgag aagtccttgt ctcctgcctc tgtgttggtc ccttttcctg
     1141 ggaccagatc tgcctgcttg tggaataagt gaacttgcag ttgcccctgg tgtaggcata
     1201 atacagtgtc agttcttagt ggagtctggg gtgtgaaggt ctacagtgaa gacagcttca
     1261 aagccacagg cacagctgac agtgtgtcct tcacgggctc agtgaccatc ccacaccacc
     1321 ctagctgaca gtgtgtcctt cacgggctcg gtgaccatcc cacaccaccc tagctgacag
     1381 tgtgtccttc acgggctcgg tgaccatccc acaccaccct agctgacagt gtgtccttca
     1441 caggctcggt gaccatccca caccacccta gctgacagtg tgtccttcat gggctcggtg
     1501 accatcccac accaccctag ctgacagtgt gtccttcacg ggctcggtga ccatccccac
     1561 accaccctag gttcaaaagc tgccgcaacc ccgaagagtc accctcacaa ggtggctcta
     1621 ggagccaaat ccccagacac tcctaggtta gtgttctaga ggctccactg gggagagcag
     1681 ggagacagca cactgctgcc tcgggcgtgc gtgagcccag gctgtcccct gtgctacttg
     1741 atcagctcct gttgtgtcac cccagctaga gtgctatgga acaatacaaa ctgaagatgt
     1801 ccactgtgca ttttaaatac atatttattc atgatgcttt aaaaaatgtt acctttttaa
     1861 agtgatgctg tcttcaacat ttgtgttctc attgctttta taaatgactg gtatcttgat
     1921 aaatgactat actgaaagca ttgagtcaaa tgatgagtac aagtgggaac ctgagctaga
     1981 attgaacccc agctccaggt tactgagcct acagatcgct gcatatatga gactcttggt
     2041 ctcgtctcac actcagagtc aggcttcact aaagccacac taaagagaca ggcagagcat
     2101 tgactcaggt gcagtgctca gggaatatgt gtggcgctct gggctggcct ggaccagtga
     2161 gagggacagg ataaacacac aggtgttctc tgtgcagacc agcccaagcc tctgcctgct
     2221 gacacatggc ctccctgtgg gtcacctggg ctgataatag agtcccagac catgattccc
     2281 atcaagtact cagctcccca ctcctaaaat atctactggc cttgcttatg gtgtatgaga
     2341 cagatacagc acagcacagg acagataagc catgagatga ctcagttctc actgggaggc
     2401 agtattgctg ctaggattct tactgccctt tgcacactgc tgttcatgtt ggtcacggac
     2461 aaatgggaag ggcacgatga aggacgttca catcacagta ggtgctcatc aaaaaaacct
     2521 ttcagttaga aaatgtgttc gctggcctcc cttttgtctg cataataaag tgattttact
     2581 tagtgggaga atcagtacat caaaaaagtg acaaggatgg agagcaagga taaatgttat
     2641 ttatttattt atagcctgtg tcctgagcaa aaggtaagct gtgcagggct gggaaccagg
     2701 ttagtagaat gcctacctgg aacgcatggg tctggctttg ctgtgggctg ctgtaaaagc
     2761 cagctctaaa caggcagccg cagcaaagat tctatgtctg gactcttcca tggagccacg
     2821 gcagaagcag cttctcactg ctaggtgcct tgtggtctct cgggaggcct tggcccctgc
     2881 cactgcttcc cagggcctcc agcacctcct gacgtgagct gttctatcag aggggagggg
     2941 aggcagtggc ccagccattg agctatttca ggcacaataa aatataaggc t
//
