LOCUS       NM_019684               2000 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus serine/arginine-rich protein specific kinase 3
            (Srpk3), transcript variant 2, mRNA.
ACCESSION   NM_019684
VERSION     NM_019684.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2000)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2000)
  AUTHORS   Seo,M.H. and Yeo,S.
  TITLE     Association Between Decreased Srpk3 Expression and Increased
            Substantia Nigra Alpha-Synuclein Level in an MPTP-Induced
            Parkinson's Disease Mouse Model
  JOURNAL   Mol Neurobiol 60 (2), 780-788 (2023)
   PUBMED   36369636
  REMARK    GeneRIF: Association Between Decreased Srpk3 Expression and
            Increased Substantia Nigra Alpha-Synuclein Level in an MPTP-Induced
            Parkinson's Disease Mouse Model.
REFERENCE   3  (bases 1 to 2000)
  AUTHORS   Seo,M.H. and Yeo,S.
  TITLE     Srpk3 Decrease Associated with Alpha-Synuclein Increase in Muscles
            of MPTP-Induced Parkinson's Disease Mice
  JOURNAL   Int J Mol Sci 22 (17), 9375 (2021)
   PUBMED   34502283
  REMARK    GeneRIF: Srpk3 Decrease Associated with Alpha-Synuclein Increase in
            Muscles of MPTP-Induced Parkinson's Disease Mice.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2000)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 2000)
  AUTHORS   Potthoff,M.J., Arnold,M.A., McAnally,J., Richardson,J.A.,
            Bassel-Duby,R. and Olson,E.N.
  TITLE     Regulation of skeletal muscle sarcomere integrity and postnatal
            muscle function by Mef2c
  JOURNAL   Mol Cell Biol 27 (23), 8143-8151 (2007)
   PUBMED   17875930
REFERENCE   6  (bases 1 to 2000)
  AUTHORS   Davie,J.K., Cho,J.H., Meadows,E., Flynn,J.M., Knapp,J.R. and
            Klein,W.H.
  TITLE     Target gene selectivity of the myogenic basic helix-loop-helix
            transcription factor myogenin in embryonic muscle
  JOURNAL   Dev Biol 311 (2), 650-664 (2007)
   PUBMED   17904117
REFERENCE   7  (bases 1 to 2000)
  AUTHORS   Nakagawa,O., Arnold,M., Nakagawa,M., Hamada,H., Shelton,J.M.,
            Kusano,H., Harris,T.M., Childs,G., Campbell,K.P., Richardson,J.A.,
            Nishino,I. and Olson,E.N.
  TITLE     Centronuclear myopathy in mice lacking a novel muscle-specific
            protein kinase transcriptionally regulated by MEF2
  JOURNAL   Genes Dev 19 (17), 2066-2077 (2005)
   PUBMED   16140986
  REMARK    GeneRIF: normal muscle growth and homeostasis require
            MEF2-dependent signaling by Srpk3
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY243709.1 and AF043288.1.
            
            On Aug 27, 2015 this sequence version replaced NM_019684.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF043288.1, BC120883.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                BY243709.1         2-18
            18-2000             AF043288.1         1-1983
FEATURES             Location/Qualifiers
     source          1..2000
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 37.41 cM"
     gene            1..2000
                     /gene="Srpk3"
                     /gene_synonym="Mssk1; Stk23"
                     /note="serine/arginine-rich protein specific kinase 3"
                     /db_xref="GeneID:56504"
                     /db_xref="MGI:MGI:1891338"
     exon            1..102
                     /gene="Srpk3"
                     /gene_synonym="Mssk1; Stk23"
                     /inference="alignment:Splign:2.1.0"
     CDS             47..1744
                     /gene="Srpk3"
                     /gene_synonym="Mssk1; Stk23"
                     /EC_number="2.7.11.1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     muscle-specific serine kinase 1; serine/threonine-protein
                     kinase SRPK3; serine/threonine kinase 23, muscle-specific
                     serine kinase 1 70; SR-protein-specific kinase 3; SRSF
                     protein kinase 3; serine/threonine-protein kinase 23"
                     /codon_start=1
                     /product="SRSF protein kinase 3 isoform 2"
                     /protein_id="NP_062658.1"
                     /db_xref="CCDS:CCDS30211.1"
                     /db_xref="GeneID:56504"
                     /db_xref="MGI:MGI:1891338"
                     /translation="MSANAGGSGSVDCGGSSSSSQTSCGPESSGSELTPATPAPRLLQ
                     GLLGSDDEEQEDPKDYCKGGYYPVKIGDLFNGRYHVVRKLGWGHFSTVWLCWDIQRKR
                     FVALKVVKSAGHYTETAVDEIKLLKCVRDSDPSDPKRETIVQLIDDFRISGVNGVHVC
                     MVLEVLGHQLLKWIIKSNYQGLPVPCVKSIVRQVLHGLDYLHTKCKIIHTDIKPENIL
                     LCVGDAYIRRLAAEATEWQQSGAQPPSRSTVSTAPQEVLIGKLSKNKRKKMRRKRKQQ
                     KRLLEERLRDLQRLEAMEAAVQAEDSSSRLERGSGSTSSSGCHPEGTRAGPSPASSSP
                     VPGGERSLSPSSQTSGFSGSLFSTASCSILSGSSNQRETGGLLSPSTPFGASNLLVNP
                     LEPQNADKIKIKIADLGNACWVHKHFTEDIQTRQYRAVEVLIGAEYGPPADIWSTACM
                     AFELATGDYLFEPHSGEDYSRDEDHIAHIVELLGDIPPAFALSGRYSREFFNRRGELR
                     HIPNLKHWGLYEVLMEKYEWPLEQATQFSAFLLPMMEYIPEKRASAADCLQHPWLNP"
     exon            103..233
                     /gene="Srpk3"
                     /gene_synonym="Mssk1; Stk23"
                     /inference="alignment:Splign:2.1.0"
     exon            234..342
                     /gene="Srpk3"
                     /gene_synonym="Mssk1; Stk23"
                     /inference="alignment:Splign:2.1.0"
     exon            343..430
                     /gene="Srpk3"
                     /gene_synonym="Mssk1; Stk23"
                     /inference="alignment:Splign:2.1.0"
     exon            431..518
                     /gene="Srpk3"
                     /gene_synonym="Mssk1; Stk23"
                     /inference="alignment:Splign:2.1.0"
     exon            519..625
                     /gene="Srpk3"
                     /gene_synonym="Mssk1; Stk23"
                     /inference="alignment:Splign:2.1.0"
     exon            626..791
                     /gene="Srpk3"
                     /gene_synonym="Mssk1; Stk23"
                     /inference="alignment:Splign:2.1.0"
     exon            792..817
                     /gene="Srpk3"
                     /gene_synonym="Mssk1; Stk23"
                     /inference="alignment:Splign:2.1.0"
     exon            818..947
                     /gene="Srpk3"
                     /gene_synonym="Mssk1; Stk23"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1187
                     /gene="Srpk3"
                     /gene_synonym="Mssk1; Stk23"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1288
                     /gene="Srpk3"
                     /gene_synonym="Mssk1; Stk23"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..1396
                     /gene="Srpk3"
                     /gene_synonym="Mssk1; Stk23"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..1466
                     /gene="Srpk3"
                     /gene_synonym="Mssk1; Stk23"
                     /inference="alignment:Splign:2.1.0"
     exon            1467..1559
                     /gene="Srpk3"
                     /gene_synonym="Mssk1; Stk23"
                     /inference="alignment:Splign:2.1.0"
     exon            1560..1981
                     /gene="Srpk3"
                     /gene_synonym="Mssk1; Stk23"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1963..1968
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Srpk3"
                     /gene_synonym="Mssk1; Stk23"
                     /note="hexamer: AATAAA"
     polyA_site      1981
                     /gene="Srpk3"
                     /gene_synonym="Mssk1; Stk23"
                     /note="major polyA site"
ORIGIN      
        1 aggaacagcg gtccagtgca ccagagcttt gggctgcgac atcaggatga gtgccaatgc
       61 cggtggtagt ggtagtgtgg attgtggcgg cagcagcagc agctctcaga cttcctgtgg
      121 gcctgagtcc tcaggctctg aattaactcc agccacacca gcacctcgtt tgctgcaggg
      181 actcctgggc tctgatgatg aggaacagga agaccctaag gactattgca agggtggtta
      241 ctacccagtg aagatcggtg atttgttcaa tgggcggtac catgtggtgc gaaagctagg
      301 ctggggccat ttctctacag tctggctctg ctgggatatt cagcgcaagc gctttgtggc
      361 cctgaaagtg gtgaagagtg caggacatta cactgagaca gccgtggatg agatcaagct
      421 cctgaaatgt gtcagggaca gtgaccctag tgaccccaaa agggagacca ttgttcaact
      481 tatcgatgac ttcaggatct caggagtaaa tggagtccat gtatgcatgg tgctagaggt
      541 cctgggccac cagctcctca agtggatcat caaatccaac taccagggtc tgcctgtgcc
      601 ctgtgttaag agcattgtta gacaggtgct gcatggtctg gattacctcc atactaagtg
      661 caagatcatc catacggaca tcaagcctga gaacatctta ctgtgtgttg gagatgccta
      721 catcaggcgc ctggctgctg aagccacaga gtggcagcag tcaggggccc agcccccatc
      781 ccgttccaca gtcagcactg ccccccagga ggtcttgatt ggcaagctgt ccaaaaacaa
      841 gaggaagaag atgaggcgca aaaggaagca acagaagagg ctgctggagg agcggctgag
      901 ggacttgcag aggctagagg ctatggaggc cgcagtacaa gctgaggact ccagctcaag
      961 actagaacgg ggcagcggct ccacctcttc ttcaggctgc cacccggagg gcaccagagc
     1021 tggcccttct ccagcctctt cttcccctgt gcctgggggg gaacgaagcc ttagtcccag
     1081 ctcgcagacc tcaggttttt cagggtccct gttctccacg gcttcctgct ccatcctctc
     1141 aggttcatct aatcagcgtg agactggagg tcttctatct cctagcacac catttggtgc
     1201 ttccaatctc ctagtgaacc ctctggagcc ccaaaatgca gacaagatca agatcaagat
     1261 tgcagacctt ggcaacgcct gctgggtgca caagcacttc actgaggata ttcagactcg
     1321 gcagtacagg gccgtggagg tgctgatcgg tgccgagtat gggcccccag ctgacatctg
     1381 gagcacagca tgcatggctt ttgagctggc cactggtgac tacctatttg agccccactc
     1441 tggagaagac tacagtcgtg atgaggacca cattgctcat atcgtggaac ttctaggaga
     1501 catccctcca gcttttgccc tctcaggccg atattcacgg gagttcttca accgtagagg
     1561 agagctgcgc cacatcccca acctcaagca ctggggccta tatgaggtgc tcatggagaa
     1621 gtatgagtgg cccctggagc aggccacaca gttcagtgcc ttcctgttgc ccatgatgga
     1681 gtacatccct gagaagcggg ccagtgctgc cgactgcctc cagcatccct ggcttaatcc
     1741 ataggttttg ctgcagctgt ggacagtaga gactatgcta gctcttggtg ccttgaggga
     1801 aagcaggcaa cttcttccac cctgtgggag ctgctcttcc atcctgctgg gtgctcaccc
     1861 ccatgacagg atgagatgct ggggcaaggc ccatatctca acctgtctac ttgtgatcct
     1921 tctagatgct cctgaatggg gaaaactgcc tgtttgtttc ttaataaagt gggaactgaa
     1981 aaaaaaaaaa aaaaaaaaaa
//
