LOCUS       NP_062658                565 aa            linear   ROD 27-APR-2025
DEFINITION  SRSF protein kinase 3 isoform 2 [Mus musculus].
ACCESSION   NP_062658
VERSION     NP_062658.1
DBSOURCE    REFSEQ: accession NM_019684.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 565)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 565)
  AUTHORS   Seo,M.H. and Yeo,S.
  TITLE     Association Between Decreased Srpk3 Expression and Increased
            Substantia Nigra Alpha-Synuclein Level in an MPTP-Induced
            Parkinson's Disease Mouse Model
  JOURNAL   Mol Neurobiol 60 (2), 780-788 (2023)
   PUBMED   36369636
  REMARK    GeneRIF: Association Between Decreased Srpk3 Expression and
            Increased Substantia Nigra Alpha-Synuclein Level in an MPTP-Induced
            Parkinson's Disease Mouse Model.
REFERENCE   3  (residues 1 to 565)
  AUTHORS   Seo,M.H. and Yeo,S.
  TITLE     Srpk3 Decrease Associated with Alpha-Synuclein Increase in Muscles
            of MPTP-Induced Parkinson's Disease Mice
  JOURNAL   Int J Mol Sci 22 (17), 9375 (2021)
   PUBMED   34502283
  REMARK    GeneRIF: Srpk3 Decrease Associated with Alpha-Synuclein Increase in
            Muscles of MPTP-Induced Parkinson's Disease Mice.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 565)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (residues 1 to 565)
  AUTHORS   Potthoff,M.J., Arnold,M.A., McAnally,J., Richardson,J.A.,
            Bassel-Duby,R. and Olson,E.N.
  TITLE     Regulation of skeletal muscle sarcomere integrity and postnatal
            muscle function by Mef2c
  JOURNAL   Mol Cell Biol 27 (23), 8143-8151 (2007)
   PUBMED   17875930
REFERENCE   6  (residues 1 to 565)
  AUTHORS   Davie,J.K., Cho,J.H., Meadows,E., Flynn,J.M., Knapp,J.R. and
            Klein,W.H.
  TITLE     Target gene selectivity of the myogenic basic helix-loop-helix
            transcription factor myogenin in embryonic muscle
  JOURNAL   Dev Biol 311 (2), 650-664 (2007)
   PUBMED   17904117
REFERENCE   7  (residues 1 to 565)
  AUTHORS   Nakagawa,O., Arnold,M., Nakagawa,M., Hamada,H., Shelton,J.M.,
            Kusano,H., Harris,T.M., Childs,G., Campbell,K.P., Richardson,J.A.,
            Nishino,I. and Olson,E.N.
  TITLE     Centronuclear myopathy in mice lacking a novel muscle-specific
            protein kinase transcriptionally regulated by MEF2
  JOURNAL   Genes Dev 19 (17), 2066-2077 (2005)
   PUBMED   16140986
  REMARK    GeneRIF: normal muscle growth and homeostasis require
            MEF2-dependent signaling by Srpk3
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY243709.1 and AF043288.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF043288.1, BC120883.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..565
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 37.41 cM"
     Protein         1..565
                     /product="SRSF protein kinase 3 isoform 2"
                     /EC_number="2.7.11.1"
                     /note="muscle-specific serine kinase 1;
                     serine/threonine-protein kinase SRPK3; serine/threonine
                     kinase 23, muscle-specific serine kinase 1 70;
                     SR-protein-specific kinase 3; SRSF protein kinase 3;
                     serine/threonine-protein kinase 23"
                     /calculated_mol_wt=62234
     Region          1..44
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z0G2.1)"
     Site            49
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9Z0G2.1)"
     Region          67..563
                     /region_name="STKc_SRPK3"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     Serine-aRginine Protein Kinase 3; cd14218"
                     /db_xref="CDD:271120"
     Site            order(84..88,92,105,107,121,143,163..166,169,171..172,211,
                     213,215..216,218,407,410,419,421..424,426,463)
                     /site_type="active"
                     /db_xref="CDD:271120"
     Site            order(84..88,92,105,107,143,163..166,169,211,213,215..216,
                     218,407)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:271120"
     Site            order(121,171,211,213,410,419,421..424,426,463)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:271120"
     Site            order(179..180,456,458,460,469,474,477..478,481..482,510,
                     514,516,525..526)
                     /site_type="other"
                     /note="kinase-docking site [polypeptide binding]"
                     /db_xref="CDD:271120"
     Region          236..280
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z0G2.1)"
     Region          295..350
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z0G2.1)"
     Site            328
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9Z0G2.1)"
     Site            406..426
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:271120"
     CDS             1..565
                     /gene="Srpk3"
                     /gene_synonym="Mssk1; Stk23"
                     /coded_by="NM_019684.2:47..1744"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS30211.1"
                     /db_xref="GeneID:56504"
                     /db_xref="MGI:MGI:1891338"
ORIGIN      
        1 msanaggsgs vdcggsssss qtscgpessg seltpatpap rllqgllgsd deeqedpkdy
       61 ckggyypvki gdlfngryhv vrklgwghfs tvwlcwdiqr krfvalkvvk saghytetav
      121 deikllkcvr dsdpsdpkre tivqliddfr isgvngvhvc mvlevlghql lkwiiksnyq
      181 glpvpcvksi vrqvlhgldy lhtkckiiht dikpenillc vgdayirrla aeatewqqsg
      241 aqppsrstvs tapqevligk lsknkrkkmr rkrkqqkrll eerlrdlqrl eameaavqae
      301 dsssrlergs gstsssgchp egtragpspa ssspvpgger slspssqtsg fsgslfstas
      361 csilsgssnq retggllsps tpfgasnllv nplepqnadk ikikiadlgn acwvhkhfte
      421 diqtrqyrav evligaeygp padiwstacm afelatgdyl fephsgedys rdedhiahiv
      481 ellgdippaf alsgrysref fnrrgelrhi pnlkhwglye vlmekyewpl eqatqfsafl
      541 lpmmeyipek rasaadclqh pwlnp
//
