LOCUS       NM_001407509            6646 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Mus musculus serine/arginine-rich protein specific kinase 2
            (Srpk2), transcript variant 20, mRNA.
ACCESSION   NM_001407509
VERSION     NM_001407509.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6646)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   2  (bases 1 to 6646)
  AUTHORS   Hong,Y., Chan,C.B., Kwon,I.S., Li,X., Song,M., Lee,H.P., Liu,X.,
            Sompol,P., Jin,P., Lee,H.G., Yu,S.P. and Ye,K.
  TITLE     SRPK2 phosphorylates tau and mediates the cognitive defects in
            Alzheimer's disease
  JOURNAL   J Neurosci 32 (48), 17262-17272 (2012)
   PUBMED   23197718
  REMARK    GeneRIF: SRPK2 may contribute to the formation of
            hyperphosphorylated tau and the pathogenesis of Alzheimer disease.
REFERENCE   3  (bases 1 to 6646)
  AUTHORS   Wong,J.C., Zhang,Y., Lieuw,K.H., Tran,M.T., Forgo,E.,
            Weinfurtner,K., Alzamora,P., Kogan,S.C., Akagi,K., Wolff,L., Le
            Beau,M.M., Killeen,N. and Shannon,K.
  TITLE     Use of chromosome engineering to model a segmental deletion of
            chromosome band 7q22 found in myeloid malignancies
  JOURNAL   Blood 115 (22), 4524-4532 (2010)
   PUBMED   20233966
REFERENCE   4  (bases 1 to 6646)
  AUTHORS   Nowak,D.G., Amin,E.M., Rennel,E.S., Hoareau-Aveilla,C., Gammons,M.,
            Damodoran,G., Hagiwara,M., Harper,S.J., Woolard,J., Ladomery,M.R.
            and Bates,D.O.
  TITLE     Regulation of vascular endothelial growth factor (VEGF) splicing
            from pro-angiogenic to anti-angiogenic isoforms: a novel
            therapeutic strategy for angiogenesis
  JOURNAL   J Biol Chem 285 (8), 5532-5540 (2010)
   PUBMED   19906640
REFERENCE   5  (bases 1 to 6646)
  AUTHORS   Jang,S.W., Liu,X., Fu,H., Rees,H., Yepes,M., Levey,A. and Ye,K.
  TITLE     Interaction of Akt-phosphorylated SRPK2 with 14-3-3 mediates cell
            cycle and cell death in neurons
  JOURNAL   J Biol Chem 284 (36), 24512-24525 (2009)
   PUBMED   19592491
  REMARK    GeneRIF: Interaction of Akt-phosphorylated SRPK2 with 14-3-3
            mediates cell cycle and cell death in neurons.
REFERENCE   6  (bases 1 to 6646)
  AUTHORS   Koizumi,J., Okamoto,Y., Onogi,H., Mayeda,A., Krainer,A.R. and
            Hagiwara,M.
  TITLE     The subcellular localization of SF2/ASF is regulated by direct
            interaction with SR protein kinases (SRPKs)
  JOURNAL   J Biol Chem 274 (16), 11125-11131 (1999)
   PUBMED   10196197
REFERENCE   7  (bases 1 to 6646)
  AUTHORS   Wang,H.Y., Arden,K.C., Bermingham,J.R. Jr., Viars,C.S., Lin,W.,
            Boyer,A.D. and Fu,X.D.
  TITLE     Localization of serine kinases, SRPK1 (SFRSK1) and SRPK2 (SFRSK2),
            specific for the SR family of splicing factors in mouse and human
            chromosomes
  JOURNAL   Genomics 57 (2), 310-315 (1999)
   PUBMED   10198174
REFERENCE   8  (bases 1 to 6646)
  AUTHORS   Kuroyanagi,N., Onogi,H., Wakabayashi,T. and Hagiwara,M.
  TITLE     Novel SR-protein-specific kinase, SRPK2, disassembles nuclear
            speckles
  JOURNAL   Biochem Biophys Res Commun 242 (2), 357-364 (1998)
   PUBMED   9446799
REFERENCE   9  (bases 1 to 6646)
  AUTHORS   Bedford,M.T., Chan,D.C. and Leder,P.
  TITLE     FBP WW domains and the Abl SH3 domain bind to a specific class of
            proline-rich ligands
  JOURNAL   EMBO J 16 (9), 2376-2383 (1997)
   PUBMED   9171351
REFERENCE   10 (bases 1 to 6646)
  AUTHORS   Chan,D.C., Bedford,M.T. and Leder,P.
  TITLE     Formin binding proteins bear WWP/WW domains that bind proline-rich
            peptides and functionally resemble SH3 domains
  JOURNAL   EMBO J 15 (5), 1045-1054 (1996)
   PUBMED   8605874
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC117614.14 and AC122022.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17253014.663183.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-125               AC117614.14        99887-100011        c
            126-180             AC117614.14        99749-99803         c
            181-326             AC117614.14        53361-53506         c
            327-390             AC117614.14        40356-40419         c
            391-542             AC122022.4         144542-144693       c
            543-651             AC122022.4         127883-127991       c
            652-739             AC122022.4         126408-126495       c
            740-827             AC122022.4         124951-125038       c
            828-934             AC122022.4         119803-119909       c
            935-1073            AC122022.4         107352-107490       c
            1074-1099           AC122022.4         106218-106243       c
            1100-1349           AC122022.4         104924-105173       c
            1350-1817           AC122022.4         103576-104043       c
            1818-1918           AC122022.4         98047-98147         c
            1919-2026           AC122022.4         97844-97951         c
            2027-2096           AC122022.4         94062-94131         c
            2097-2189           AC122022.4         93380-93472         c
            2190-6646           AC122022.4         82692-87148         c
FEATURES             Location/Qualifiers
     source          1..6646
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 10.36 cM"
     gene            1..6646
                     /gene="Srpk2"
                     /gene_synonym="mSRPK2; Wbp6"
                     /note="serine/arginine-rich protein specific kinase 2"
                     /db_xref="GeneID:20817"
                     /db_xref="MGI:MGI:1201408"
     exon            1..125
                     /gene="Srpk2"
                     /gene_synonym="mSRPK2; Wbp6"
                     /inference="alignment:Splign:2.1.0"
     exon            126..180
                     /gene="Srpk2"
                     /gene_synonym="mSRPK2; Wbp6"
                     /inference="alignment:Splign:2.1.0"
     exon            181..326
                     /gene="Srpk2"
                     /gene_synonym="mSRPK2; Wbp6"
                     /inference="alignment:Splign:2.1.0"
     exon            327..390
                     /gene="Srpk2"
                     /gene_synonym="mSRPK2; Wbp6"
                     /inference="alignment:Splign:2.1.0"
     CDS             353..2374
                     /gene="Srpk2"
                     /gene_synonym="mSRPK2; Wbp6"
                     /EC_number="2.7.11.1"
                     /note="isoform d is encoded by transcript variant 20;
                     serine/threonine-protein kinase SRPK2; SFRS protein kinase
                     2; SR-protein-specific kinase 2; WW domain binding protein
                     6; SRSF protein kinase 2"
                     /codon_start=1
                     /product="SRSF protein kinase 2 isoform d"
                     /protein_id="NP_001394438.1"
                     /db_xref="GeneID:20817"
                     /db_xref="MGI:MGI:1201408"
                     /translation="MSVNSEKSSSSERPEPQQKAPLVPPPPPPPPPPPLPDPAPPEPE
                     EEILGSDDEEQEDPADYCKGGYHPVKIGDLFNGRYHVIRKLGWGHFSTVWLCWDMQGK
                     RFVAMKVVKSAQHYTETALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHV
                     CMVFEVLGHHLLKWIIKSNYQGLPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENI
                     LMCVDDAYVRRMAAEATEWQKAVSTAPQQKPIGKISKNKKKKLKKKQKRQAELLEKRL
                     QEIEELEREAERKILEENITSAEASGEQQDGEYQPEVTLKAADLEDTTEEETAKDNGE
                     VEDQEEKEDAEKENAEKDEDDVEQELANLDPTWVESPKANGHIENGPFSLEQQLEDEE
                     DDEDDCANPEEYNLDEPNAESDYTYSSSYEQFNGELPNGQHKTSEFPTPLFSGPLEPV
                     ACGSVISEGSPLTEQEESSPSHDRSRTVSASSTGDLPKTKTRAADLLVNPLDPRNADK
                     IRVKIADLGNACWVHKHFTEDIQTRQYRSIEVLIGAGYSTPADIWSTACMAFELATGD
                     YLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYSREFFNRRGELRHITKLKPW
                     SLFDVLVEKYGWPHEDAAQFTDFLIPMLEMVPEKRASAGECLRHPWLNS"
     exon            391..542
                     /gene="Srpk2"
                     /gene_synonym="mSRPK2; Wbp6"
                     /inference="alignment:Splign:2.1.0"
     exon            543..651
                     /gene="Srpk2"
                     /gene_synonym="mSRPK2; Wbp6"
                     /inference="alignment:Splign:2.1.0"
     exon            652..739
                     /gene="Srpk2"
                     /gene_synonym="mSRPK2; Wbp6"
                     /inference="alignment:Splign:2.1.0"
     exon            740..827
                     /gene="Srpk2"
                     /gene_synonym="mSRPK2; Wbp6"
                     /inference="alignment:Splign:2.1.0"
     exon            828..934
                     /gene="Srpk2"
                     /gene_synonym="mSRPK2; Wbp6"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1073
                     /gene="Srpk2"
                     /gene_synonym="mSRPK2; Wbp6"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1099
                     /gene="Srpk2"
                     /gene_synonym="mSRPK2; Wbp6"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1349
                     /gene="Srpk2"
                     /gene_synonym="mSRPK2; Wbp6"
                     /inference="alignment:Splign:2.1.0"
     exon            1350..1817
                     /gene="Srpk2"
                     /gene_synonym="mSRPK2; Wbp6"
                     /inference="alignment:Splign:2.1.0"
     exon            1818..1918
                     /gene="Srpk2"
                     /gene_synonym="mSRPK2; Wbp6"
                     /inference="alignment:Splign:2.1.0"
     exon            1919..2026
                     /gene="Srpk2"
                     /gene_synonym="mSRPK2; Wbp6"
                     /inference="alignment:Splign:2.1.0"
     exon            2027..2096
                     /gene="Srpk2"
                     /gene_synonym="mSRPK2; Wbp6"
                     /inference="alignment:Splign:2.1.0"
     exon            2097..2189
                     /gene="Srpk2"
                     /gene_synonym="mSRPK2; Wbp6"
                     /inference="alignment:Splign:2.1.0"
     exon            2190..6646
                     /gene="Srpk2"
                     /gene_synonym="mSRPK2; Wbp6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3742..3747
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Srpk2"
                     /gene_synonym="mSRPK2; Wbp6"
                     /note="hexamer: ATTAAA"
     polyA_site      3770
                     /gene="Srpk2"
                     /gene_synonym="mSRPK2; Wbp6"
                     /note="major polyA site"
     regulatory      5334..5339
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Srpk2"
                     /gene_synonym="mSRPK2; Wbp6"
                     /note="hexamer: ATTAAA"
     regulatory      5341..5346
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Srpk2"
                     /gene_synonym="mSRPK2; Wbp6"
                     /note="hexamer: GATAAA"
     polyA_site      5352
                     /gene="Srpk2"
                     /gene_synonym="mSRPK2; Wbp6"
     polyA_site      5369
                     /gene="Srpk2"
                     /gene_synonym="mSRPK2; Wbp6"
     regulatory      5535..5540
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Srpk2"
                     /gene_synonym="mSRPK2; Wbp6"
                     /note="hexamer: AATAAA"
     polyA_site      5553
                     /gene="Srpk2"
                     /gene_synonym="mSRPK2; Wbp6"
     regulatory      6540..6545
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Srpk2"
                     /gene_synonym="mSRPK2; Wbp6"
                     /note="hexamer: AATGAA"
     polyA_site      6556
                     /gene="Srpk2"
                     /gene_synonym="mSRPK2; Wbp6"
     regulatory      6626..6631
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Srpk2"
                     /gene_synonym="mSRPK2; Wbp6"
                     /note="hexamer: AATAAA"
     polyA_site      6646
                     /gene="Srpk2"
                     /gene_synonym="mSRPK2; Wbp6"
ORIGIN      
        1 cccgcctcct cggccggcga gcgagtggag gctgcatccc ggtgcggctg actgtcgcgt
       61 cgccgccgcc tccgccgcgg agccccccgc ctggctgccc cgagtcggaa tgagctccag
      121 gaaagtgctg gccattcagg cccgaaagcg gaggccgaaa agagagaaac atccgaaaaa
      181 actccacaga caagaagaaa acaaagtaga ctgttggctg aggtatatgc ggtacttagt
      241 aatatcttgt agaacagcag agtcctggga gttgtttgta cagttgctgc tgaggaagag
      301 tttatagaag accactgaca cgtgagaaat caagcagaag actgagctgc tgatgtcagt
      361 taactctgag aagtcgtcct cttcagaaag gccggagcct caacagaaag ctcctttagt
      421 tcctcctcct ccaccaccac caccgccacc accactgcca gaccccgcac ccccagagcc
      481 agaggaggag attctggggt cagatgatga ggagcaggag gaccccgcag attactgcaa
      541 aggtggctat catccagtga aaattggaga tctcttcaat ggtcgatatc atgtcattag
      601 aaagctagga tgggggcact tttctactgt atggctgtgc tgggatatgc aagggaaaag
      661 atttgttgca atgaaagttg taaaaagtgc ccagcattat acagagacag ccttggatga
      721 aattaaacta ctcaaatgcg ttcgagaaag tgaccccagt gacccaaaca aagacatggt
      781 agttcagcta attgatgact tcaagatctc aggcatgaat gggatacatg tctgcatggt
      841 ctttgaagta cttggtcacc atctcctcaa atggatcatc aaatccaact atcaaggcct
      901 cccagtacgt tgtgtgaaga gtatcattcg acaggtcctt caagggttag attatctaca
      961 cagtaagtgc aagataattc acaccgacat aaagccggaa aacatcttga tgtgtgtgga
     1021 tgacgcttac gtgagaagaa tggcagccga agccacggag tggcagaaag cagtgagtac
     1081 ggctccacag caaaaaccta taggaaaaat atctaaaaac aaaaagaaaa agctgaaaaa
     1141 gaaacagaag agacaggctg agttgctgga gaaacgccta caggagattg aggaattgga
     1201 gcgagaagcc gaaaggaaaa tcctagagga gaacatcacc tctgcagaag cttccgggga
     1261 gcagcaggat ggagagtacc agccggaggt gacactgaaa gcagccgact tagaggacac
     1321 aactgaggaa gagacagcaa aggataatgg tgaagttgaa gaccaggaag agaaagaaga
     1381 tgcagagaag gagaacgcgg agaaggatga agatgatgtt gaacaggaac ttgcaaactt
     1441 agaccctacc tgggtggagt ccccgaaagc caatggccat attgaaaatg gcccgttctc
     1501 actggagcag cagctggagg atgaagagga cgatgaagat gactgtgcaa atcccgagga
     1561 gtataacctc gatgagccaa atgcagagag tgattacacg tatagcagct cctatgaaca
     1621 attcaatggt gaattgccaa atggacaaca taagacttca gagtttccca caccgttgtt
     1681 ttctgggccc ttagaacctg tggcctgtgg ctctgtgatt tcagagggat cgccacttac
     1741 cgagcaggag gaaagcagtc cctcccatga cagaagcagg acagtttcag cctctagtac
     1801 tggagatttg ccaaaaacaa aaacccgggc ggctgacctg ttggtgaacc ctctggatcc
     1861 acggaatgca gataaaatta gagtaaaaat tgctgacctg ggaaatgctt gttgggtgca
     1921 taaacatttc acagaggata tccagacacg tcagtatagg tccatagagg ttttaatagg
     1981 agcaggctac agcacacctg cagacatttg gagtacagct tgcatggcat ttgagctcgc
     2041 cacaggagac tatttgttcg aaccgcattc tggggaagac tattccagag atgaagacca
     2101 catagcccac atcatagagc tgctaggcag tatcccaagg cactttgctc tgtctggaaa
     2161 atattctcgg gaattcttca atcgcagagg agaactgcgg cacatcacca agctgaagcc
     2221 ctggagcctc tttgatgtac ttgtggaaaa gtatggctgg ccccatgaag atgctgcaca
     2281 atttacagat ttcctgatcc caatgttaga gatggttcca gaaaaacgag cctcagctgg
     2341 cgaatgcctt cgacatcctt ggttgaattc ttagcagatt ctacaaatat agcattctga
     2401 gctagcaaat ttctcccagt acattggacc tacacagtgg ctctcattct ttaacaggat
     2461 taccagtgag ctggctccac cctcagacct ttgtagtgct ttgaggtact gttgtttgac
     2521 actttgcttc ctgtgcacca tggtcctggg gaaggctggt ctttgtcttc agctaagtag
     2581 tttactggcc attttcttct ggaaacaata acatgtctct aagcattgtt tcttgtgttg
     2641 tgtgacattc aaatgtcttt tttttttttt gaacgaaaaa tactttccct tttgtgtttt
     2701 ggcaggttct gtaactattt atgaagacat attttagctg agtattatat aatttacaat
     2761 cttaagaaat tatcagttgg aaccaagaaa gagcaaggaa atgtacaatt ttatcgtctg
     2821 gcaaagggaa atcattcctg tattatacta gtgtatgtaa ctattacttt gcataaatag
     2881 gggatgagga ttcacattca gaaaagctac ccagtcctga gcgctttttg gcctacattg
     2941 catgttgcag atttccactg cttcagaaag ttgcacaaac ttttcattcc ataacaaccc
     3001 aagtggttct ggacgaggtg ccatgccctc tgtggcactt taaagagaga aaaactttaa
     3061 aaatttgaca ctataatcta gcagttccat ttgtattttg catattttta agctatgttt
     3121 aaagtatcag tcatttccac ttaaaatgtg atggcccaat ccccggtagt gtcacctctc
     3181 accagcactg taagttaaat acgtagatta aattggacaa gagaaatatg ttcagtgtgt
     3241 ggaatgaaaa aaatattttt tgaaaagcat gatcgtgttt gtttaaaaca caaggcgtgg
     3301 cttagacagt ttgcaacgca gtggaccgag cactcctcac agcttcaagg taacagcgac
     3361 cgtgcccatg ccgtcctagg cagcttccct tccctcgcct tttccttacc tcccatgaat
     3421 gagaaggcca tttccccttt gcagaccgca tacagtttta gtttatgcat ttccttaaaa
     3481 ttaactgtag aatccaggat acaaaccatt agtaggcaat actattttag aatgtaacat
     3541 aggaggtgta tttagcctct tttagaagtc agtgggttga atgtcttttt tttaaaaatt
     3601 tttattcatt aaggtgcctc gtttttcttg actttgtcca ttaacattta ttcatatgcc
     3661 tttgcaataa ttagattgtg aaaagctaac aagtgttgta acaataatcc tttgtttggg
     3721 gtgcttgcac ttgtcttaaa aattaaagtg ttttggggtg tttttccaga cattgccttg
     3781 cttattaccc tgtatttcaa gagacagaat caacatacct ttgctctctg tagtgtcaac
     3841 aaagctaaag gagttgcaga ttgtcacaga acatacatta aggcagaatg gatttatgaa
     3901 cgaggcttta gttatagctt cattatctac aatgtgggtg ttcccttttt ttaatcagtg
     3961 tttcatcgta agtgcaatgg tttcctcccc tgtcccctcc aatctttccc tgtgtgaaca
     4021 agacacatat ccttcttagg gtttaacatt tttatatcat acactgtagt aagatagacg
     4081 atgccactca ttcacaaact atgcatgctg ggtttttcca atgaggctgt gcgtttcctt
     4141 atagagccta tgacaaatgg tggctgctga gtcatgattt ctatagaaac attcctataa
     4201 gaaccacaga gtgtgtttat gttttcccta cctctgaaag aacttttacc atttgaatga
     4261 aatttgtcta atgaggttag aaatgtcaaa ttggaaaagg aagctagaat attaatctta
     4321 aggtggttct tctattaata ataccctagc gagtgtatga tataccaagg agttctagca
     4381 tacacttttg tgattgggta ccatatggtt atatctgatt cttggtagca tgatgataaa
     4441 gaataaatgt aaaggttggg tgtggtggtg cactccttta atatcagcac ttgggaggca
     4501 gaggcaggaa gatctctgag gccagcctgt tctgcataag ctccaggcca cccaaggtta
     4561 tatagtgaag gaaaatctag gaagaaaaaa gaataaaagc ttaaagtgaa ccattggtta
     4621 tttggaacat tatagccaag tcagtctttt tagtgaaaag accctatgaa atcttcatgg
     4681 aaaattacaa gcagtgggtc tcacatgtga ctttagcaga tccagaaata gctaatctaa
     4741 aaaatggcag aaccatccag agaaaaagta gtagggagtg taaaagaagt ctactcttta
     4801 acgagatctg cttgtttgtc catattccct gcaccatgca taacttaaca ggtatgagta
     4861 aaaaaaactt tcattggaat agaaaacacg ttcggattat ttttcttttc ttattttgtg
     4921 aggcaaggac tcggagatct gcctacctag gcatgccacc cctcactacc ccccccccca
     4981 cacacacaca atctctctct gaattagaag tttgtagagt gtgtccatta aagattctat
     5041 ttagttgaag tgtttcagtt tgcagaagag ctctcgttat gaattactta gctagctggc
     5101 tactttaagt ctgtggacaa gtgattttaa gggtgaatat tgccatttct ttggtctgtc
     5161 tgaaattgtc atggagggac acaatgtgaa cctgtcagtt ttcagattca ggtttctttg
     5221 gtaagcatcc taaggagaac atgggcaagt ttcttcagaa acttgggtca ctgattttaa
     5281 gccctaaatg agctgtattc tcgaatatca tcagagttaa ttttcaaatg ggaattaaat
     5341 gataaaacat gatttaagtc actaccaaat ctaatttctt gagtttgctg tttttcctga
     5401 tgcacaaaat ttatatactg ggcccaattg tgtcacatgt ttggaaggtg gtaaataggg
     5461 ccactcctga gaggtagaca gcagaagctg ataattaaaa aaaaaaagtc acaactggta
     5521 tatcttcttt cagtaataaa atattcactg aaaccctctt cattctattt gacgtatttc
     5581 agaataatgc ctttcgccct tggttttgtt taaagagacc tattttctac aacttaaagc
     5641 cctaaagcta gtattaaaca tattttcata tcagttttga ttagtggagc tatttcagtc
     5701 atattttata ctgtacaaat taaatctccc tgttttaagt aaattactcc ttttcaaact
     5761 gcgttaaact gcagtgtgca actatacagt atggaatgca tcaataatgt ggattaatgt
     5821 tgtagtagaa tgttaggttc ttagactgtt agctaagtcg catagagtgg ctatttaatt
     5881 tcctctgacc cgtgcttcta aaggaaaggc aagcagtaga gaggaccgtg agactcaccc
     5941 agatcggctg ctggtagcct gcagtgcagc tgaggtagca gctaccgaag aaaatgaatg
     6001 attctttact tacaaattat atttgaaaat cttaactttt gtaaaatcat taagcagacc
     6061 tcaatctcag aagttgtaca gaacaattta gtaaaactga cataattgtg gtttattaac
     6121 atgaattaaa atgcccaacc agtgcttcaa tgtgacagcg tattgaaata aaaaggaaag
     6181 gtcatgtgct gtactacttt cacagagatc acacgtttgc agcagacttg ccatatgtac
     6241 agtgctatat tccaaatgaa aagggcggga gcaattatat acgcaaagga aattcagtat
     6301 ttacagtctg tcaggagaca ctaaaaatta tctatacatt aaattacatt ttgcttgcaa
     6361 aaaactgata aaacaatatg agccatgtcc acaccaaatc ataaaaacct gtattgcatt
     6421 ttcagaccta agatgcactc aaataactgc tgaccataaa aaaaaaagga aatccttagt
     6481 gctttcttta actgtatact taatgcatat gtataaaata atacagaaaa tattcattaa
     6541 atgaatttaa ctgcaacaat gaaatttaaa ggtcatgtat catcagatct atggtcagaa
     6601 aaacagttgg aatgttcact tacaaaataa agatacctac agctgg
//
