LOCUS       NM_001407500            6595 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus serine/arginine-rich protein specific kinase 2
            (Srpk2), transcript variant 11, mRNA.
ACCESSION   NM_001407500
VERSION     NM_001407500.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6595)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   2  (bases 1 to 6595)
  AUTHORS   Hong,Y., Chan,C.B., Kwon,I.S., Li,X., Song,M., Lee,H.P., Liu,X.,
            Sompol,P., Jin,P., Lee,H.G., Yu,S.P. and Ye,K.
  TITLE     SRPK2 phosphorylates tau and mediates the cognitive defects in
            Alzheimer's disease
  JOURNAL   J Neurosci 32 (48), 17262-17272 (2012)
   PUBMED   23197718
  REMARK    GeneRIF: SRPK2 may contribute to the formation of
            hyperphosphorylated tau and the pathogenesis of Alzheimer disease.
REFERENCE   3  (bases 1 to 6595)
  AUTHORS   Wong,J.C., Zhang,Y., Lieuw,K.H., Tran,M.T., Forgo,E.,
            Weinfurtner,K., Alzamora,P., Kogan,S.C., Akagi,K., Wolff,L., Le
            Beau,M.M., Killeen,N. and Shannon,K.
  TITLE     Use of chromosome engineering to model a segmental deletion of
            chromosome band 7q22 found in myeloid malignancies
  JOURNAL   Blood 115 (22), 4524-4532 (2010)
   PUBMED   20233966
REFERENCE   4  (bases 1 to 6595)
  AUTHORS   Nowak,D.G., Amin,E.M., Rennel,E.S., Hoareau-Aveilla,C., Gammons,M.,
            Damodoran,G., Hagiwara,M., Harper,S.J., Woolard,J., Ladomery,M.R.
            and Bates,D.O.
  TITLE     Regulation of vascular endothelial growth factor (VEGF) splicing
            from pro-angiogenic to anti-angiogenic isoforms: a novel
            therapeutic strategy for angiogenesis
  JOURNAL   J Biol Chem 285 (8), 5532-5540 (2010)
   PUBMED   19906640
REFERENCE   5  (bases 1 to 6595)
  AUTHORS   Jang,S.W., Liu,X., Fu,H., Rees,H., Yepes,M., Levey,A. and Ye,K.
  TITLE     Interaction of Akt-phosphorylated SRPK2 with 14-3-3 mediates cell
            cycle and cell death in neurons
  JOURNAL   J Biol Chem 284 (36), 24512-24525 (2009)
   PUBMED   19592491
  REMARK    GeneRIF: Interaction of Akt-phosphorylated SRPK2 with 14-3-3
            mediates cell cycle and cell death in neurons.
REFERENCE   6  (bases 1 to 6595)
  AUTHORS   Koizumi,J., Okamoto,Y., Onogi,H., Mayeda,A., Krainer,A.R. and
            Hagiwara,M.
  TITLE     The subcellular localization of SF2/ASF is regulated by direct
            interaction with SR protein kinases (SRPKs)
  JOURNAL   J Biol Chem 274 (16), 11125-11131 (1999)
   PUBMED   10196197
REFERENCE   7  (bases 1 to 6595)
  AUTHORS   Wang,H.Y., Arden,K.C., Bermingham,J.R. Jr., Viars,C.S., Lin,W.,
            Boyer,A.D. and Fu,X.D.
  TITLE     Localization of serine kinases, SRPK1 (SFRSK1) and SRPK2 (SFRSK2),
            specific for the SR family of splicing factors in mouse and human
            chromosomes
  JOURNAL   Genomics 57 (2), 310-315 (1999)
   PUBMED   10198174
REFERENCE   8  (bases 1 to 6595)
  AUTHORS   Kuroyanagi,N., Onogi,H., Wakabayashi,T. and Hagiwara,M.
  TITLE     Novel SR-protein-specific kinase, SRPK2, disassembles nuclear
            speckles
  JOURNAL   Biochem Biophys Res Commun 242 (2), 357-364 (1998)
   PUBMED   9446799
REFERENCE   9  (bases 1 to 6595)
  AUTHORS   Bedford,M.T., Chan,D.C. and Leder,P.
  TITLE     FBP WW domains and the Abl SH3 domain bind to a specific class of
            proline-rich ligands
  JOURNAL   EMBO J 16 (9), 2376-2383 (1997)
   PUBMED   9171351
REFERENCE   10 (bases 1 to 6595)
  AUTHORS   Chan,D.C., Bedford,M.T. and Leder,P.
  TITLE     Formin binding proteins bear WWP/WW domains that bind proline-rich
            peptides and functionally resemble SH3 domains
  JOURNAL   EMBO J 15 (5), 1045-1054 (1996)
   PUBMED   8605874
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC117614.14 and AC122022.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422600.546241.1,
                                           SRR13422590.137084.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139, SAMN01164142
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-246               AC117614.14        40356-40601         c
            247-398             AC122022.4         144542-144693       c
            399-507             AC122022.4         127883-127991       c
            508-595             AC122022.4         126408-126495       c
            596-683             AC122022.4         124951-125038       c
            684-790             AC122022.4         119803-119909       c
            791-929             AC122022.4         107352-107490       c
            930-955             AC122022.4         106218-106243       c
            956-1205            AC122022.4         104924-105173       c
            1206-1673           AC122022.4         103576-104043       c
            1674-1774           AC122022.4         98047-98147         c
            1775-1882           AC122022.4         97844-97951         c
            1883-1952           AC122022.4         94062-94131         c
            1953-2045           AC122022.4         93380-93472         c
            2046-2138           AC122022.4         92918-93010         c
            2139-6595           AC122022.4         82692-87148         c
FEATURES             Location/Qualifiers
     source          1..6595
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 10.36 cM"
     gene            1..6595
                     /gene="Srpk2"
                     /gene_synonym="mSRPK2; Wbp6"
                     /note="serine/arginine-rich protein specific kinase 2"
                     /db_xref="GeneID:20817"
                     /db_xref="MGI:MGI:1201408"
     exon            1..246
                     /gene="Srpk2"
                     /gene_synonym="mSRPK2; Wbp6"
                     /inference="alignment:Splign:2.1.0"
     CDS             209..2323
                     /gene="Srpk2"
                     /gene_synonym="mSRPK2; Wbp6"
                     /EC_number="2.7.11.1"
                     /note="isoform i is encoded by transcript variant 11;
                     serine/threonine-protein kinase SRPK2; SFRS protein kinase
                     2; SR-protein-specific kinase 2; WW domain binding protein
                     6; SRSF protein kinase 2"
                     /codon_start=1
                     /product="SRSF protein kinase 2 isoform i"
                     /protein_id="NP_001394429.1"
                     /db_xref="GeneID:20817"
                     /db_xref="MGI:MGI:1201408"
                     /translation="MSVNSEKSSSSERPEPQQKAPLVPPPPPPPPPPPLPDPAPPEPE
                     EEILGSDDEEQEDPADYCKGGYHPVKIGDLFNGRYHVIRKLGWGHFSTVWLCWDMQGK
                     RFVAMKVVKSAQHYTETALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHV
                     CMVFEVLGHHLLKWIIKSNYQGLPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENI
                     LMCVDDAYVRRMAAEATEWQKAVSTAPQQKPIGKISKNKKKKLKKKQKRQAELLEKRL
                     QEIEELEREAERKILEENITSAEASGEQQDGEYQPEVTLKAADLEDTTEEETAKDNGE
                     VEDQEEKEDAEKENAEKDEDDVEQELANLDPTWVESPKANGHIENGPFSLEQQLEDEE
                     DDEDDCANPEEYNLDEPNAESDYTYSSSYEQFNGELPNGQHKTSEFPTPLFSGPLEPV
                     ACGSVISEGSPLTEQEESSPSHDRSRTVSASSTGDLPKTKTRAADLLVNPLDPRNADK
                     IRVKIADLGNACWVHKHFTEDIQTRQYRSIEVLIGAGYSTPADIWSTACMAFELATGD
                     YLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYSREFFNRRDHIALIIELLGK
                     VPRKYAMLGKYSKEFFTRKGELRHITKLKPWSLFDVLVEKYGWPHEDAAQFTDFLIPM
                     LEMVPEKRASAGECLRHPWLNS"
     exon            247..398
                     /gene="Srpk2"
                     /gene_synonym="mSRPK2; Wbp6"
                     /inference="alignment:Splign:2.1.0"
     exon            399..507
                     /gene="Srpk2"
                     /gene_synonym="mSRPK2; Wbp6"
                     /inference="alignment:Splign:2.1.0"
     exon            508..595
                     /gene="Srpk2"
                     /gene_synonym="mSRPK2; Wbp6"
                     /inference="alignment:Splign:2.1.0"
     exon            596..683
                     /gene="Srpk2"
                     /gene_synonym="mSRPK2; Wbp6"
                     /inference="alignment:Splign:2.1.0"
     exon            684..790
                     /gene="Srpk2"
                     /gene_synonym="mSRPK2; Wbp6"
                     /inference="alignment:Splign:2.1.0"
     exon            791..929
                     /gene="Srpk2"
                     /gene_synonym="mSRPK2; Wbp6"
                     /inference="alignment:Splign:2.1.0"
     exon            930..955
                     /gene="Srpk2"
                     /gene_synonym="mSRPK2; Wbp6"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1205
                     /gene="Srpk2"
                     /gene_synonym="mSRPK2; Wbp6"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1673
                     /gene="Srpk2"
                     /gene_synonym="mSRPK2; Wbp6"
                     /inference="alignment:Splign:2.1.0"
     exon            1674..1774
                     /gene="Srpk2"
                     /gene_synonym="mSRPK2; Wbp6"
                     /inference="alignment:Splign:2.1.0"
     exon            1775..1882
                     /gene="Srpk2"
                     /gene_synonym="mSRPK2; Wbp6"
                     /inference="alignment:Splign:2.1.0"
     exon            1883..1952
                     /gene="Srpk2"
                     /gene_synonym="mSRPK2; Wbp6"
                     /inference="alignment:Splign:2.1.0"
     exon            1953..2045
                     /gene="Srpk2"
                     /gene_synonym="mSRPK2; Wbp6"
                     /inference="alignment:Splign:2.1.0"
     exon            2046..2138
                     /gene="Srpk2"
                     /gene_synonym="mSRPK2; Wbp6"
                     /inference="alignment:Splign:2.1.0"
     exon            2139..6595
                     /gene="Srpk2"
                     /gene_synonym="mSRPK2; Wbp6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3691..3696
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Srpk2"
                     /gene_synonym="mSRPK2; Wbp6"
                     /note="hexamer: ATTAAA"
     polyA_site      3719
                     /gene="Srpk2"
                     /gene_synonym="mSRPK2; Wbp6"
                     /note="major polyA site"
     regulatory      5283..5288
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Srpk2"
                     /gene_synonym="mSRPK2; Wbp6"
                     /note="hexamer: ATTAAA"
     regulatory      5290..5295
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Srpk2"
                     /gene_synonym="mSRPK2; Wbp6"
                     /note="hexamer: GATAAA"
     polyA_site      5301
                     /gene="Srpk2"
                     /gene_synonym="mSRPK2; Wbp6"
     polyA_site      5318
                     /gene="Srpk2"
                     /gene_synonym="mSRPK2; Wbp6"
     regulatory      5484..5489
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Srpk2"
                     /gene_synonym="mSRPK2; Wbp6"
                     /note="hexamer: AATAAA"
     polyA_site      5502
                     /gene="Srpk2"
                     /gene_synonym="mSRPK2; Wbp6"
     regulatory      6489..6494
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Srpk2"
                     /gene_synonym="mSRPK2; Wbp6"
                     /note="hexamer: AATGAA"
     polyA_site      6505
                     /gene="Srpk2"
                     /gene_synonym="mSRPK2; Wbp6"
     regulatory      6575..6580
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Srpk2"
                     /gene_synonym="mSRPK2; Wbp6"
                     /note="hexamer: AATAAA"
     polyA_site      6595
                     /gene="Srpk2"
                     /gene_synonym="mSRPK2; Wbp6"
ORIGIN      
        1 aggcctggtg cctcggagcc gtttcccttt atagcaccat tgaatccgag tcctaagaga
       61 agtgctgtga atcttgtggc ctcattctga acaaaaggga ttagggaaga aaaatctctt
      121 gatataaggc ttgtaagcaa gggcgggcaa tcttggttgt gaatattttc tgatttttcc
      181 agaaatcaag cagaagactg agctgctgat gtcagttaac tctgagaagt cgtcctcttc
      241 agaaaggccg gagcctcaac agaaagctcc tttagttcct cctcctccac caccaccacc
      301 gccaccacca ctgccagacc ccgcaccccc agagccagag gaggagattc tggggtcaga
      361 tgatgaggag caggaggacc ccgcagatta ctgcaaaggt ggctatcatc cagtgaaaat
      421 tggagatctc ttcaatggtc gatatcatgt cattagaaag ctaggatggg ggcacttttc
      481 tactgtatgg ctgtgctggg atatgcaagg gaaaagattt gttgcaatga aagttgtaaa
      541 aagtgcccag cattatacag agacagcctt ggatgaaatt aaactactca aatgcgttcg
      601 agaaagtgac cccagtgacc caaacaaaga catggtagtt cagctaattg atgacttcaa
      661 gatctcaggc atgaatggga tacatgtctg catggtcttt gaagtacttg gtcaccatct
      721 cctcaaatgg atcatcaaat ccaactatca aggcctccca gtacgttgtg tgaagagtat
      781 cattcgacag gtccttcaag ggttagatta tctacacagt aagtgcaaga taattcacac
      841 cgacataaag ccggaaaaca tcttgatgtg tgtggatgac gcttacgtga gaagaatggc
      901 agccgaagcc acggagtggc agaaagcagt gagtacggct ccacagcaaa aacctatagg
      961 aaaaatatct aaaaacaaaa agaaaaagct gaaaaagaaa cagaagagac aggctgagtt
     1021 gctggagaaa cgcctacagg agattgagga attggagcga gaagccgaaa ggaaaatcct
     1081 agaggagaac atcacctctg cagaagcttc cggggagcag caggatggag agtaccagcc
     1141 ggaggtgaca ctgaaagcag ccgacttaga ggacacaact gaggaagaga cagcaaagga
     1201 taatggtgaa gttgaagacc aggaagagaa agaagatgca gagaaggaga acgcggagaa
     1261 ggatgaagat gatgttgaac aggaacttgc aaacttagac cctacctggg tggagtcccc
     1321 gaaagccaat ggccatattg aaaatggccc gttctcactg gagcagcagc tggaggatga
     1381 agaggacgat gaagatgact gtgcaaatcc cgaggagtat aacctcgatg agccaaatgc
     1441 agagagtgat tacacgtata gcagctccta tgaacaattc aatggtgaat tgccaaatgg
     1501 acaacataag acttcagagt ttcccacacc gttgttttct gggcccttag aacctgtggc
     1561 ctgtggctct gtgatttcag agggatcgcc acttaccgag caggaggaaa gcagtccctc
     1621 ccatgacaga agcaggacag tttcagcctc tagtactgga gatttgccaa aaacaaaaac
     1681 ccgggcggct gacctgttgg tgaaccctct ggatccacgg aatgcagata aaattagagt
     1741 aaaaattgct gacctgggaa atgcttgttg ggtgcataaa catttcacag aggatatcca
     1801 gacacgtcag tataggtcca tagaggtttt aataggagca ggctacagca cacctgcaga
     1861 catttggagt acagcttgca tggcatttga gctcgccaca ggagactatt tgttcgaacc
     1921 gcattctggg gaagactatt ccagagatga agaccacata gcccacatca tagagctgct
     1981 aggcagtatc ccaaggcact ttgctctgtc tggaaaatat tctcgggaat tcttcaatcg
     2041 cagagatcac atagcattga tcattgaact gctggggaaa gtccctcgaa aatacgctat
     2101 gttggggaaa tattccaagg agtttttcac cagaaaagga gaactgcggc acatcaccaa
     2161 gctgaagccc tggagcctct ttgatgtact tgtggaaaag tatggctggc cccatgaaga
     2221 tgctgcacaa tttacagatt tcctgatccc aatgttagag atggttccag aaaaacgagc
     2281 ctcagctggc gaatgccttc gacatccttg gttgaattct tagcagattc tacaaatata
     2341 gcattctgag ctagcaaatt tctcccagta cattggacct acacagtggc tctcattctt
     2401 taacaggatt accagtgagc tggctccacc ctcagacctt tgtagtgctt tgaggtactg
     2461 ttgtttgaca ctttgcttcc tgtgcaccat ggtcctgggg aaggctggtc tttgtcttca
     2521 gctaagtagt ttactggcca ttttcttctg gaaacaataa catgtctcta agcattgttt
     2581 cttgtgttgt gtgacattca aatgtctttt tttttttttg aacgaaaaat actttccctt
     2641 ttgtgttttg gcaggttctg taactattta tgaagacata ttttagctga gtattatata
     2701 atttacaatc ttaagaaatt atcagttgga accaagaaag agcaaggaaa tgtacaattt
     2761 tatcgtctgg caaagggaaa tcattcctgt attatactag tgtatgtaac tattactttg
     2821 cataaatagg ggatgaggat tcacattcag aaaagctacc cagtcctgag cgctttttgg
     2881 cctacattgc atgttgcaga tttccactgc ttcagaaagt tgcacaaact tttcattcca
     2941 taacaaccca agtggttctg gacgaggtgc catgccctct gtggcacttt aaagagagaa
     3001 aaactttaaa aatttgacac tataatctag cagttccatt tgtattttgc atatttttaa
     3061 gctatgttta aagtatcagt catttccact taaaatgtga tggcccaatc cccggtagtg
     3121 tcacctctca ccagcactgt aagttaaata cgtagattaa attggacaag agaaatatgt
     3181 tcagtgtgtg gaatgaaaaa aatatttttt gaaaagcatg atcgtgtttg tttaaaacac
     3241 aaggcgtggc ttagacagtt tgcaacgcag tggaccgagc actcctcaca gcttcaaggt
     3301 aacagcgacc gtgcccatgc cgtcctaggc agcttccctt ccctcgcctt ttccttacct
     3361 cccatgaatg agaaggccat ttcccctttg cagaccgcat acagttttag tttatgcatt
     3421 tccttaaaat taactgtaga atccaggata caaaccatta gtaggcaata ctattttaga
     3481 atgtaacata ggaggtgtat ttagcctctt ttagaagtca gtgggttgaa tgtctttttt
     3541 ttaaaaattt ttattcatta aggtgcctcg tttttcttga ctttgtccat taacatttat
     3601 tcatatgcct ttgcaataat tagattgtga aaagctaaca agtgttgtaa caataatcct
     3661 ttgtttgggg tgcttgcact tgtcttaaaa attaaagtgt tttggggtgt ttttccagac
     3721 attgccttgc ttattaccct gtatttcaag agacagaatc aacatacctt tgctctctgt
     3781 agtgtcaaca aagctaaagg agttgcagat tgtcacagaa catacattaa ggcagaatgg
     3841 atttatgaac gaggctttag ttatagcttc attatctaca atgtgggtgt tccctttttt
     3901 taatcagtgt ttcatcgtaa gtgcaatggt ttcctcccct gtcccctcca atctttccct
     3961 gtgtgaacaa gacacatatc cttcttaggg tttaacattt ttatatcata cactgtagta
     4021 agatagacga tgccactcat tcacaaacta tgcatgctgg gtttttccaa tgaggctgtg
     4081 cgtttcctta tagagcctat gacaaatggt ggctgctgag tcatgatttc tatagaaaca
     4141 ttcctataag aaccacagag tgtgtttatg ttttccctac ctctgaaaga acttttacca
     4201 tttgaatgaa atttgtctaa tgaggttaga aatgtcaaat tggaaaagga agctagaata
     4261 ttaatcttaa ggtggttctt ctattaataa taccctagcg agtgtatgat ataccaagga
     4321 gttctagcat acacttttgt gattgggtac catatggtta tatctgattc ttggtagcat
     4381 gatgataaag aataaatgta aaggttgggt gtggtggtgc actcctttaa tatcagcact
     4441 tgggaggcag aggcaggaag atctctgagg ccagcctgtt ctgcataagc tccaggccac
     4501 ccaaggttat atagtgaagg aaaatctagg aagaaaaaag aataaaagct taaagtgaac
     4561 cattggttat ttggaacatt atagccaagt cagtcttttt agtgaaaaga ccctatgaaa
     4621 tcttcatgga aaattacaag cagtgggtct cacatgtgac tttagcagat ccagaaatag
     4681 ctaatctaaa aaatggcaga accatccaga gaaaaagtag tagggagtgt aaaagaagtc
     4741 tactctttaa cgagatctgc ttgtttgtcc atattccctg caccatgcat aacttaacag
     4801 gtatgagtaa aaaaaacttt cattggaata gaaaacacgt tcggattatt tttcttttct
     4861 tattttgtga ggcaaggact cggagatctg cctacctagg catgccaccc ctcactaccc
     4921 ccccccccac acacacacaa tctctctctg aattagaagt ttgtagagtg tgtccattaa
     4981 agattctatt tagttgaagt gtttcagttt gcagaagagc tctcgttatg aattacttag
     5041 ctagctggct actttaagtc tgtggacaag tgattttaag ggtgaatatt gccatttctt
     5101 tggtctgtct gaaattgtca tggagggaca caatgtgaac ctgtcagttt tcagattcag
     5161 gtttctttgg taagcatcct aaggagaaca tgggcaagtt tcttcagaaa cttgggtcac
     5221 tgattttaag ccctaaatga gctgtattct cgaatatcat cagagttaat tttcaaatgg
     5281 gaattaaatg ataaaacatg atttaagtca ctaccaaatc taatttcttg agtttgctgt
     5341 ttttcctgat gcacaaaatt tatatactgg gcccaattgt gtcacatgtt tggaaggtgg
     5401 taaatagggc cactcctgag aggtagacag cagaagctga taattaaaaa aaaaaagtca
     5461 caactggtat atcttctttc agtaataaaa tattcactga aaccctcttc attctatttg
     5521 acgtatttca gaataatgcc tttcgccctt ggttttgttt aaagagacct attttctaca
     5581 acttaaagcc ctaaagctag tattaaacat attttcatat cagttttgat tagtggagct
     5641 atttcagtca tattttatac tgtacaaatt aaatctccct gttttaagta aattactcct
     5701 tttcaaactg cgttaaactg cagtgtgcaa ctatacagta tggaatgcat caataatgtg
     5761 gattaatgtt gtagtagaat gttaggttct tagactgtta gctaagtcgc atagagtggc
     5821 tatttaattt cctctgaccc gtgcttctaa aggaaaggca agcagtagag aggaccgtga
     5881 gactcaccca gatcggctgc tggtagcctg cagtgcagct gaggtagcag ctaccgaaga
     5941 aaatgaatga ttctttactt acaaattata tttgaaaatc ttaacttttg taaaatcatt
     6001 aagcagacct caatctcaga agttgtacag aacaatttag taaaactgac ataattgtgg
     6061 tttattaaca tgaattaaaa tgcccaacca gtgcttcaat gtgacagcgt attgaaataa
     6121 aaaggaaagg tcatgtgctg tactactttc acagagatca cacgtttgca gcagacttgc
     6181 catatgtaca gtgctatatt ccaaatgaaa agggcgggag caattatata cgcaaaggaa
     6241 attcagtatt tacagtctgt caggagacac taaaaattat ctatacatta aattacattt
     6301 tgcttgcaaa aaactgataa aacaatatga gccatgtcca caccaaatca taaaaacctg
     6361 tattgcattt tcagacctaa gatgcactca aataactgct gaccataaaa aaaaaaggaa
     6421 atccttagtg ctttctttaa ctgtatactt aatgcatatg tataaaataa tacagaaaat
     6481 attcattaaa tgaatttaac tgcaacaatg aaatttaaag gtcatgtatc atcagatcta
     6541 tggtcagaaa aacagttgga atgttcactt acaaaataaa gatacctaca gctgg
//
