LOCUS       NM_001359173            6463 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus serine/arginine-rich protein specific kinase 2
            (Srpk2), transcript variant 2, mRNA.
ACCESSION   NM_001359173 XM_006535661
VERSION     NM_001359173.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6463)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   2  (bases 1 to 6463)
  AUTHORS   Hong,Y., Chan,C.B., Kwon,I.S., Li,X., Song,M., Lee,H.P., Liu,X.,
            Sompol,P., Jin,P., Lee,H.G., Yu,S.P. and Ye,K.
  TITLE     SRPK2 phosphorylates tau and mediates the cognitive defects in
            Alzheimer's disease
  JOURNAL   J Neurosci 32 (48), 17262-17272 (2012)
   PUBMED   23197718
  REMARK    GeneRIF: SRPK2 may contribute to the formation of
            hyperphosphorylated tau and the pathogenesis of Alzheimer disease.
REFERENCE   3  (bases 1 to 6463)
  AUTHORS   Wong,J.C., Zhang,Y., Lieuw,K.H., Tran,M.T., Forgo,E.,
            Weinfurtner,K., Alzamora,P., Kogan,S.C., Akagi,K., Wolff,L., Le
            Beau,M.M., Killeen,N. and Shannon,K.
  TITLE     Use of chromosome engineering to model a segmental deletion of
            chromosome band 7q22 found in myeloid malignancies
  JOURNAL   Blood 115 (22), 4524-4532 (2010)
   PUBMED   20233966
REFERENCE   4  (bases 1 to 6463)
  AUTHORS   Nowak,D.G., Amin,E.M., Rennel,E.S., Hoareau-Aveilla,C., Gammons,M.,
            Damodoran,G., Hagiwara,M., Harper,S.J., Woolard,J., Ladomery,M.R.
            and Bates,D.O.
  TITLE     Regulation of vascular endothelial growth factor (VEGF) splicing
            from pro-angiogenic to anti-angiogenic isoforms: a novel
            therapeutic strategy for angiogenesis
  JOURNAL   J Biol Chem 285 (8), 5532-5540 (2010)
   PUBMED   19906640
REFERENCE   5  (bases 1 to 6463)
  AUTHORS   Jang,S.W., Liu,X., Fu,H., Rees,H., Yepes,M., Levey,A. and Ye,K.
  TITLE     Interaction of Akt-phosphorylated SRPK2 with 14-3-3 mediates cell
            cycle and cell death in neurons
  JOURNAL   J Biol Chem 284 (36), 24512-24525 (2009)
   PUBMED   19592491
  REMARK    GeneRIF: Interaction of Akt-phosphorylated SRPK2 with 14-3-3
            mediates cell cycle and cell death in neurons.
REFERENCE   6  (bases 1 to 6463)
  AUTHORS   Koizumi,J., Okamoto,Y., Onogi,H., Mayeda,A., Krainer,A.R. and
            Hagiwara,M.
  TITLE     The subcellular localization of SF2/ASF is regulated by direct
            interaction with SR protein kinases (SRPKs)
  JOURNAL   J Biol Chem 274 (16), 11125-11131 (1999)
   PUBMED   10196197
REFERENCE   7  (bases 1 to 6463)
  AUTHORS   Wang,H.Y., Arden,K.C., Bermingham,J.R. Jr., Viars,C.S., Lin,W.,
            Boyer,A.D. and Fu,X.D.
  TITLE     Localization of serine kinases, SRPK1 (SFRSK1) and SRPK2 (SFRSK2),
            specific for the SR family of splicing factors in mouse and human
            chromosomes
  JOURNAL   Genomics 57 (2), 310-315 (1999)
   PUBMED   10198174
REFERENCE   8  (bases 1 to 6463)
  AUTHORS   Kuroyanagi,N., Onogi,H., Wakabayashi,T. and Hagiwara,M.
  TITLE     Novel SR-protein-specific kinase, SRPK2, disassembles nuclear
            speckles
  JOURNAL   Biochem Biophys Res Commun 242 (2), 357-364 (1998)
   PUBMED   9446799
REFERENCE   9  (bases 1 to 6463)
  AUTHORS   Bedford,M.T., Chan,D.C. and Leder,P.
  TITLE     FBP WW domains and the Abl SH3 domain bind to a specific class of
            proline-rich ligands
  JOURNAL   EMBO J 16 (9), 2376-2383 (1997)
   PUBMED   9171351
REFERENCE   10 (bases 1 to 6463)
  AUTHORS   Chan,D.C., Bedford,M.T. and Leder,P.
  TITLE     Formin binding proteins bear WWP/WW domains that bind proline-rich
            peptides and functionally resemble SH3 domains
  JOURNAL   EMBO J 15 (5), 1045-1054 (1996)
   PUBMED   8605874
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC117614.14 and AC122022.4.
            
            On Jun 2, 2022 this sequence version replaced NM_001359173.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219381.181886.1,
                                           SRR9219382.192440.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-125               AC117614.14        99887-100011        c
            126-180             AC117614.14        99749-99803         c
            181-332             AC122022.4         144542-144693       c
            333-441             AC122022.4         127883-127991       c
            442-529             AC122022.4         126408-126495       c
            530-617             AC122022.4         124951-125038       c
            618-724             AC122022.4         119803-119909       c
            725-890             AC122022.4         107325-107490       c
            891-916             AC122022.4         106218-106243       c
            917-1166            AC122022.4         104924-105173       c
            1167-1634           AC122022.4         103576-104043       c
            1635-1735           AC122022.4         98047-98147         c
            1736-1843           AC122022.4         97844-97951         c
            1844-1913           AC122022.4         94062-94131         c
            1914-2006           AC122022.4         93380-93472         c
            2007-6463           AC122022.4         82692-87148         c
FEATURES             Location/Qualifiers
     source          1..6463
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 10.36 cM"
     gene            1..6463
                     /gene="Srpk2"
                     /gene_synonym="mSRPK2; Wbp6"
                     /note="serine/arginine-rich protein specific kinase 2"
                     /db_xref="GeneID:20817"
                     /db_xref="MGI:MGI:1201408"
     exon            1..125
                     /gene="Srpk2"
                     /gene_synonym="mSRPK2; Wbp6"
                     /inference="alignment:Splign:2.1.0"
     CDS             110..2191
                     /gene="Srpk2"
                     /gene_synonym="mSRPK2; Wbp6"
                     /EC_number="2.7.11.1"
                     /note="isoform b is encoded by transcript variant 2;
                     serine/threonine-protein kinase SRPK2; SFRS protein kinase
                     2; SR-protein-specific kinase 2; WW domain binding protein
                     6; SRSF protein kinase 2"
                     /codon_start=1
                     /product="SRSF protein kinase 2 isoform b"
                     /protein_id="NP_001346102.1"
                     /db_xref="GeneID:20817"
                     /db_xref="MGI:MGI:1201408"
                     /translation="MSSRKVLAIQARKRRPKREKHPKKPEPQQKAPLVPPPPPPPPPP
                     PLPDPAPPEPEEEILGSDDEEQEDPADYCKGGYHPVKIGDLFNGRYHVIRKLGWGHFS
                     TVWLCWDMQGKRFVAMKVVKSAQHYTETALDEIKLLKCVRESDPSDPNKDMVVQLIDD
                     FKISGMNGIHVCMVFEVLGHHLLKWIIKSNYQGLPVRCVKSIIRQVLQGLDYLHSKCK
                     IIHTDIKPENILMCVDDAYVRRMAAEATEWQKAGAPPPSGSAVSTAPQQKPIGKISKN
                     KKKKLKKKQKRQAELLEKRLQEIEELEREAERKILEENITSAEASGEQQDGEYQPEVT
                     LKAADLEDTTEEETAKDNGEVEDQEEKEDAEKENAEKDEDDVEQELANLDPTWVESPK
                     ANGHIENGPFSLEQQLEDEEDDEDDCANPEEYNLDEPNAESDYTYSSSYEQFNGELPN
                     GQHKTSEFPTPLFSGPLEPVACGSVISEGSPLTEQEESSPSHDRSRTVSASSTGDLPK
                     TKTRAADLLVNPLDPRNADKIRVKIADLGNACWVHKHFTEDIQTRQYRSIEVLIGAGY
                     STPADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKY
                     SREFFNRRGELRHITKLKPWSLFDVLVEKYGWPHEDAAQFTDFLIPMLEMVPEKRASA
                     GECLRHPWLNS"
     exon            126..180
                     /gene="Srpk2"
                     /gene_synonym="mSRPK2; Wbp6"
                     /inference="alignment:Splign:2.1.0"
     exon            181..332
                     /gene="Srpk2"
                     /gene_synonym="mSRPK2; Wbp6"
                     /inference="alignment:Splign:2.1.0"
     exon            333..441
                     /gene="Srpk2"
                     /gene_synonym="mSRPK2; Wbp6"
                     /inference="alignment:Splign:2.1.0"
     exon            442..529
                     /gene="Srpk2"
                     /gene_synonym="mSRPK2; Wbp6"
                     /inference="alignment:Splign:2.1.0"
     exon            530..617
                     /gene="Srpk2"
                     /gene_synonym="mSRPK2; Wbp6"
                     /inference="alignment:Splign:2.1.0"
     exon            618..724
                     /gene="Srpk2"
                     /gene_synonym="mSRPK2; Wbp6"
                     /inference="alignment:Splign:2.1.0"
     exon            725..890
                     /gene="Srpk2"
                     /gene_synonym="mSRPK2; Wbp6"
                     /inference="alignment:Splign:2.1.0"
     exon            891..916
                     /gene="Srpk2"
                     /gene_synonym="mSRPK2; Wbp6"
                     /inference="alignment:Splign:2.1.0"
     exon            917..1166
                     /gene="Srpk2"
                     /gene_synonym="mSRPK2; Wbp6"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1634
                     /gene="Srpk2"
                     /gene_synonym="mSRPK2; Wbp6"
                     /inference="alignment:Splign:2.1.0"
     exon            1635..1735
                     /gene="Srpk2"
                     /gene_synonym="mSRPK2; Wbp6"
                     /inference="alignment:Splign:2.1.0"
     exon            1736..1843
                     /gene="Srpk2"
                     /gene_synonym="mSRPK2; Wbp6"
                     /inference="alignment:Splign:2.1.0"
     exon            1844..1913
                     /gene="Srpk2"
                     /gene_synonym="mSRPK2; Wbp6"
                     /inference="alignment:Splign:2.1.0"
     exon            1914..2006
                     /gene="Srpk2"
                     /gene_synonym="mSRPK2; Wbp6"
                     /inference="alignment:Splign:2.1.0"
     exon            2007..6463
                     /gene="Srpk2"
                     /gene_synonym="mSRPK2; Wbp6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3559..3564
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Srpk2"
                     /gene_synonym="mSRPK2; Wbp6"
                     /note="hexamer: ATTAAA"
     polyA_site      3587
                     /gene="Srpk2"
                     /gene_synonym="mSRPK2; Wbp6"
                     /note="major polyA site"
     regulatory      5151..5156
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Srpk2"
                     /gene_synonym="mSRPK2; Wbp6"
                     /note="hexamer: ATTAAA"
     regulatory      5158..5163
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Srpk2"
                     /gene_synonym="mSRPK2; Wbp6"
                     /note="hexamer: GATAAA"
     polyA_site      5169
                     /gene="Srpk2"
                     /gene_synonym="mSRPK2; Wbp6"
     polyA_site      5186
                     /gene="Srpk2"
                     /gene_synonym="mSRPK2; Wbp6"
     regulatory      5352..5357
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Srpk2"
                     /gene_synonym="mSRPK2; Wbp6"
                     /note="hexamer: AATAAA"
     polyA_site      5370
                     /gene="Srpk2"
                     /gene_synonym="mSRPK2; Wbp6"
     regulatory      6357..6362
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Srpk2"
                     /gene_synonym="mSRPK2; Wbp6"
                     /note="hexamer: AATGAA"
     polyA_site      6373
                     /gene="Srpk2"
                     /gene_synonym="mSRPK2; Wbp6"
     regulatory      6443..6448
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Srpk2"
                     /gene_synonym="mSRPK2; Wbp6"
                     /note="hexamer: AATAAA"
     polyA_site      6463
                     /gene="Srpk2"
                     /gene_synonym="mSRPK2; Wbp6"
ORIGIN      
        1 cccgcctcct cggccggcga gcgagtggag gctgcatccc ggtgcggctg actgtcgcgt
       61 cgccgccgcc tccgccgcgg agccccccgc ctggctgccc cgagtcggaa tgagctccag
      121 gaaagtgctg gccattcagg cccgaaagcg gaggccgaaa agagagaaac atccgaaaaa
      181 gccggagcct caacagaaag ctcctttagt tcctcctcct ccaccaccac caccgccacc
      241 accactgcca gaccccgcac ccccagagcc agaggaggag attctggggt cagatgatga
      301 ggagcaggag gaccccgcag attactgcaa aggtggctat catccagtga aaattggaga
      361 tctcttcaat ggtcgatatc atgtcattag aaagctagga tgggggcact tttctactgt
      421 atggctgtgc tgggatatgc aagggaaaag atttgttgca atgaaagttg taaaaagtgc
      481 ccagcattat acagagacag ccttggatga aattaaacta ctcaaatgcg ttcgagaaag
      541 tgaccccagt gacccaaaca aagacatggt agttcagcta attgatgact tcaagatctc
      601 aggcatgaat gggatacatg tctgcatggt ctttgaagta cttggtcacc atctcctcaa
      661 atggatcatc aaatccaact atcaaggcct cccagtacgt tgtgtgaaga gtatcattcg
      721 acaggtcctt caagggttag attatctaca cagtaagtgc aagataattc acaccgacat
      781 aaagccggaa aacatcttga tgtgtgtgga tgacgcttac gtgagaagaa tggcagccga
      841 agccacggag tggcagaaag caggtgctcc tcctccctct gggtctgcag tgagtacggc
      901 tccacagcaa aaacctatag gaaaaatatc taaaaacaaa aagaaaaagc tgaaaaagaa
      961 acagaagaga caggctgagt tgctggagaa acgcctacag gagattgagg aattggagcg
     1021 agaagccgaa aggaaaatcc tagaggagaa catcacctct gcagaagctt ccggggagca
     1081 gcaggatgga gagtaccagc cggaggtgac actgaaagca gccgacttag aggacacaac
     1141 tgaggaagag acagcaaagg ataatggtga agttgaagac caggaagaga aagaagatgc
     1201 agagaaggag aacgcggaga aggatgaaga tgatgttgaa caggaacttg caaacttaga
     1261 ccctacctgg gtggagtccc cgaaagccaa tggccatatt gaaaatggcc cgttctcact
     1321 ggagcagcag ctggaggatg aagaggacga tgaagatgac tgtgcaaatc ccgaggagta
     1381 taacctcgat gagccaaatg cagagagtga ttacacgtat agcagctcct atgaacaatt
     1441 caatggtgaa ttgccaaatg gacaacataa gacttcagag tttcccacac cgttgttttc
     1501 tgggccctta gaacctgtgg cctgtggctc tgtgatttca gagggatcgc cacttaccga
     1561 gcaggaggaa agcagtccct cccatgacag aagcaggaca gtttcagcct ctagtactgg
     1621 agatttgcca aaaacaaaaa cccgggcggc tgacctgttg gtgaaccctc tggatccacg
     1681 gaatgcagat aaaattagag taaaaattgc tgacctggga aatgcttgtt gggtgcataa
     1741 acatttcaca gaggatatcc agacacgtca gtataggtcc atagaggttt taataggagc
     1801 aggctacagc acacctgcag acatttggag tacagcttgc atggcatttg agctcgccac
     1861 aggagactat ttgttcgaac cgcattctgg ggaagactat tccagagatg aagaccacat
     1921 agcccacatc atagagctgc taggcagtat cccaaggcac tttgctctgt ctggaaaata
     1981 ttctcgggaa ttcttcaatc gcagaggaga actgcggcac atcaccaagc tgaagccctg
     2041 gagcctcttt gatgtacttg tggaaaagta tggctggccc catgaagatg ctgcacaatt
     2101 tacagatttc ctgatcccaa tgttagagat ggttccagaa aaacgagcct cagctggcga
     2161 atgccttcga catccttggt tgaattctta gcagattcta caaatatagc attctgagct
     2221 agcaaatttc tcccagtaca ttggacctac acagtggctc tcattcttta acaggattac
     2281 cagtgagctg gctccaccct cagacctttg tagtgctttg aggtactgtt gtttgacact
     2341 ttgcttcctg tgcaccatgg tcctggggaa ggctggtctt tgtcttcagc taagtagttt
     2401 actggccatt ttcttctgga aacaataaca tgtctctaag cattgtttct tgtgttgtgt
     2461 gacattcaaa tgtctttttt tttttttgaa cgaaaaatac tttccctttt gtgttttggc
     2521 aggttctgta actatttatg aagacatatt ttagctgagt attatataat ttacaatctt
     2581 aagaaattat cagttggaac caagaaagag caaggaaatg tacaatttta tcgtctggca
     2641 aagggaaatc attcctgtat tatactagtg tatgtaacta ttactttgca taaatagggg
     2701 atgaggattc acattcagaa aagctaccca gtcctgagcg ctttttggcc tacattgcat
     2761 gttgcagatt tccactgctt cagaaagttg cacaaacttt tcattccata acaacccaag
     2821 tggttctgga cgaggtgcca tgccctctgt ggcactttaa agagagaaaa actttaaaaa
     2881 tttgacacta taatctagca gttccatttg tattttgcat atttttaagc tatgtttaaa
     2941 gtatcagtca tttccactta aaatgtgatg gcccaatccc cggtagtgtc acctctcacc
     3001 agcactgtaa gttaaatacg tagattaaat tggacaagag aaatatgttc agtgtgtgga
     3061 atgaaaaaaa tattttttga aaagcatgat cgtgtttgtt taaaacacaa ggcgtggctt
     3121 agacagtttg caacgcagtg gaccgagcac tcctcacagc ttcaaggtaa cagcgaccgt
     3181 gcccatgccg tcctaggcag cttcccttcc ctcgcctttt ccttacctcc catgaatgag
     3241 aaggccattt cccctttgca gaccgcatac agttttagtt tatgcatttc cttaaaatta
     3301 actgtagaat ccaggataca aaccattagt aggcaatact attttagaat gtaacatagg
     3361 aggtgtattt agcctctttt agaagtcagt gggttgaatg tctttttttt aaaaattttt
     3421 attcattaag gtgcctcgtt tttcttgact ttgtccatta acatttattc atatgccttt
     3481 gcaataatta gattgtgaaa agctaacaag tgttgtaaca ataatccttt gtttggggtg
     3541 cttgcacttg tcttaaaaat taaagtgttt tggggtgttt ttccagacat tgccttgctt
     3601 attaccctgt atttcaagag acagaatcaa catacctttg ctctctgtag tgtcaacaaa
     3661 gctaaaggag ttgcagattg tcacagaaca tacattaagg cagaatggat ttatgaacga
     3721 ggctttagtt atagcttcat tatctacaat gtgggtgttc ccttttttta atcagtgttt
     3781 catcgtaagt gcaatggttt cctcccctgt cccctccaat ctttccctgt gtgaacaaga
     3841 cacatatcct tcttagggtt taacattttt atatcataca ctgtagtaag atagacgatg
     3901 ccactcattc acaaactatg catgctgggt ttttccaatg aggctgtgcg tttccttata
     3961 gagcctatga caaatggtgg ctgctgagtc atgatttcta tagaaacatt cctataagaa
     4021 ccacagagtg tgtttatgtt ttccctacct ctgaaagaac ttttaccatt tgaatgaaat
     4081 ttgtctaatg aggttagaaa tgtcaaattg gaaaaggaag ctagaatatt aatcttaagg
     4141 tggttcttct attaataata ccctagcgag tgtatgatat accaaggagt tctagcatac
     4201 acttttgtga ttgggtacca tatggttata tctgattctt ggtagcatga tgataaagaa
     4261 taaatgtaaa ggttgggtgt ggtggtgcac tcctttaata tcagcacttg ggaggcagag
     4321 gcaggaagat ctctgaggcc agcctgttct gcataagctc caggccaccc aaggttatat
     4381 agtgaaggaa aatctaggaa gaaaaaagaa taaaagctta aagtgaacca ttggttattt
     4441 ggaacattat agccaagtca gtctttttag tgaaaagacc ctatgaaatc ttcatggaaa
     4501 attacaagca gtgggtctca catgtgactt tagcagatcc agaaatagct aatctaaaaa
     4561 atggcagaac catccagaga aaaagtagta gggagtgtaa aagaagtcta ctctttaacg
     4621 agatctgctt gtttgtccat attccctgca ccatgcataa cttaacaggt atgagtaaaa
     4681 aaaactttca ttggaataga aaacacgttc ggattatttt tcttttctta ttttgtgagg
     4741 caaggactcg gagatctgcc tacctaggca tgccacccct cactaccccc ccccccacac
     4801 acacacaatc tctctctgaa ttagaagttt gtagagtgtg tccattaaag attctattta
     4861 gttgaagtgt ttcagtttgc agaagagctc tcgttatgaa ttacttagct agctggctac
     4921 tttaagtctg tggacaagtg attttaaggg tgaatattgc catttctttg gtctgtctga
     4981 aattgtcatg gagggacaca atgtgaacct gtcagttttc agattcaggt ttctttggta
     5041 agcatcctaa ggagaacatg ggcaagtttc ttcagaaact tgggtcactg attttaagcc
     5101 ctaaatgagc tgtattctcg aatatcatca gagttaattt tcaaatggga attaaatgat
     5161 aaaacatgat ttaagtcact accaaatcta atttcttgag tttgctgttt ttcctgatgc
     5221 acaaaattta tatactgggc ccaattgtgt cacatgtttg gaaggtggta aatagggcca
     5281 ctcctgagag gtagacagca gaagctgata attaaaaaaa aaaagtcaca actggtatat
     5341 cttctttcag taataaaata ttcactgaaa ccctcttcat tctatttgac gtatttcaga
     5401 ataatgcctt tcgcccttgg ttttgtttaa agagacctat tttctacaac ttaaagccct
     5461 aaagctagta ttaaacatat tttcatatca gttttgatta gtggagctat ttcagtcata
     5521 ttttatactg tacaaattaa atctccctgt tttaagtaaa ttactccttt tcaaactgcg
     5581 ttaaactgca gtgtgcaact atacagtatg gaatgcatca ataatgtgga ttaatgttgt
     5641 agtagaatgt taggttctta gactgttagc taagtcgcat agagtggcta tttaatttcc
     5701 tctgacccgt gcttctaaag gaaaggcaag cagtagagag gaccgtgaga ctcacccaga
     5761 tcggctgctg gtagcctgca gtgcagctga ggtagcagct accgaagaaa atgaatgatt
     5821 ctttacttac aaattatatt tgaaaatctt aacttttgta aaatcattaa gcagacctca
     5881 atctcagaag ttgtacagaa caatttagta aaactgacat aattgtggtt tattaacatg
     5941 aattaaaatg cccaaccagt gcttcaatgt gacagcgtat tgaaataaaa aggaaaggtc
     6001 atgtgctgta ctactttcac agagatcaca cgtttgcagc agacttgcca tatgtacagt
     6061 gctatattcc aaatgaaaag ggcgggagca attatatacg caaaggaaat tcagtattta
     6121 cagtctgtca ggagacacta aaaattatct atacattaaa ttacattttg cttgcaaaaa
     6181 actgataaaa caatatgagc catgtccaca ccaaatcata aaaacctgta ttgcattttc
     6241 agacctaaga tgcactcaaa taactgctga ccataaaaaa aaaaggaaat ccttagtgct
     6301 ttctttaact gtatacttaa tgcatatgta taaaataata cagaaaatat tcattaaatg
     6361 aatttaactg caacaatgaa atttaaaggt catgtatcat cagatctatg gtcagaaaaa
     6421 cagttggaat gttcacttac aaaataaaga tacctacagc tgg
//
