LOCUS       NM_016795               2540 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus serine/arginine-rich protein specific kinase 1
            (Srpk1), mRNA.
ACCESSION   NM_016795
VERSION     NM_016795.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2540)
  AUTHORS   Wei,X., Xu,S. and Chen,L.
  TITLE     LncRNA Neat1/miR-298-5p/Srpk1 Contributes to Sevoflurane-Induced
            Neurotoxicity
  JOURNAL   Neurochem Res 46 (12), 3356-3364 (2021)
   PUBMED   34524595
  REMARK    GeneRIF: LncRNA Neat1/miR-298-5p/Srpk1 Contributes to
            Sevoflurane-Induced Neurotoxicity.
REFERENCE   2  (bases 1 to 2540)
  AUTHORS   Bustos,F., Segarra-Fas,A., Nardocci,G., Cassidy,A., Antico,O.,
            Davidson,L., Brandenburg,L., Macartney,T.J., Toth,R., Hastie,C.J.,
            Moran,J., Gourlay,R., Varghese,J., Soares,R.F., Montecino,M. and
            Findlay,G.M.
  TITLE     Functional Diversification of SRSF Protein Kinase to Control
            Ubiquitin-Dependent Neurodevelopmental Signaling
  JOURNAL   Dev Cell 55 (5), 629-647 (2020)
   PUBMED   33080171
  REMARK    GeneRIF: Functional Diversification of SRSF Protein Kinase to
            Control Ubiquitin-Dependent Neurodevelopmental Signaling.
REFERENCE   3  (bases 1 to 2540)
  AUTHORS   Lin,J.C.
  TITLE     Multi-posttranscriptional regulations lessen the repressive effect
            of SRPK1 on brown adipogenesis
  JOURNAL   Biochim Biophys Acta Mol Cell Biol Lipids 1863 (5), 503-514 (2018)
   PUBMED   29474929
  REMARK    GeneRIF: Depletion of endogenous SRPK1 enhanced the development of
            C3H10T1/2 cells toward brown adipocytes.
REFERENCE   4  (bases 1 to 2540)
  AUTHORS   van Roosmalen,W., Le Devedec,S.E., Golani,O., Smid,M.,
            Pulyakhina,I., Timmermans,A.M., Look,M.P., Zi,D., Pont,C., de
            Graauw,M., Naffar-Abu-Amara,S., Kirsanova,C., Rustici,G.,
            Hoen,P.A., Martens,J.W., Foekens,J.A., Geiger,B. and van de
            Water,B.
  TITLE     Tumor cell migration screen identifies SRPK1 as breast cancer
            metastasis determinant
  JOURNAL   J Clin Invest 125 (4), 1648-1664 (2015)
   PUBMED   25774502
  REMARK    GeneRIF: In 2 independent murine models of breast tumor metastasis,
            stable shRNA-based SRPK1 knockdown suppressed metastasis to distant
            organs, including lung, liver, and spleen, and inhibited focal
            adhesion reorganization.
REFERENCE   5  (bases 1 to 2540)
  AUTHORS   Wang,P., Zhou,Z., Hu,A., Ponte de Albuquerque,C., Zhou,Y., Hong,L.,
            Sierecki,E., Ajiro,M., Kruhlak,M., Harris,C., Guan,K.L.,
            Zheng,Z.M., Newton,A.C., Sun,P., Zhou,H. and Fu,X.D.
  TITLE     Both decreased and increased SRPK1 levels promote cancer by
            interfering with PHLPP-mediated dephosphorylation of Akt
  JOURNAL   Mol Cell 54 (3), 378-391 (2014)
   PUBMED   24703948
  REMARK    GeneRIF: SRPK1 overexpression is also tumorigenic because excess
            SRPK1 squelches PHLPP1.
REFERENCE   6  (bases 1 to 2540)
  AUTHORS   Papoutsopoulou,S., Nikolakaki,E., Chalepakis,G., Kruft,V.,
            Chevaillier,P. and Giannakouros,T.
  TITLE     SR protein-specific kinase 1 is highly expressed in testis and
            phosphorylates protamine 1
  JOURNAL   Nucleic Acids Res 27 (14), 2972-2980 (1999)
   PUBMED   10390541
REFERENCE   7  (bases 1 to 2540)
  AUTHORS   Koizumi,J., Okamoto,Y., Onogi,H., Mayeda,A., Krainer,A.R. and
            Hagiwara,M.
  TITLE     The subcellular localization of SF2/ASF is regulated by direct
            interaction with SR protein kinases (SRPKs)
  JOURNAL   J Biol Chem 274 (16), 11125-11131 (1999)
   PUBMED   10196197
REFERENCE   8  (bases 1 to 2540)
  AUTHORS   Wang,H.Y., Arden,K.C., Bermingham,J.R. Jr., Viars,C.S., Lin,W.,
            Boyer,A.D. and Fu,X.D.
  TITLE     Localization of serine kinases, SRPK1 (SFRSK1) and SRPK2 (SFRSK2),
            specific for the SR family of splicing factors in mouse and human
            chromosomes
  JOURNAL   Genomics 57 (2), 310-315 (1999)
   PUBMED   10198174
REFERENCE   9  (bases 1 to 2540)
  AUTHORS   Kuroyanagi,N., Onogi,H., Wakabayashi,T. and Hagiwara,M.
  TITLE     Novel SR-protein-specific kinase, SRPK2, disassembles nuclear
            speckles
  JOURNAL   Biochem Biophys Res Commun 242 (2), 357-364 (1998)
   PUBMED   9446799
REFERENCE   10 (bases 1 to 2540)
  AUTHORS   Gui,J.F., Lane,W.S. and Fu,X.D.
  TITLE     A serine kinase regulates intracellular localization of splicing
            factors in the cell cycle
  JOURNAL   Nature 369 (6482), 678-682 (1994)
   PUBMED   8208298
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK141271.1, AK151152.1 and BE848006.1.
            
            On Jan 24, 2017 this sequence version replaced NM_016795.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK151152.1, BC050761.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 AK141271.1         1-5
            6-2522              AK151152.1         2-2518
            2523-2540           BE848006.1         1-18                c
FEATURES             Location/Qualifiers
     source          1..2540
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 14.78 cM"
     gene            1..2540
                     /gene="Srpk1"
                     /note="serine/arginine-rich protein specific kinase 1"
                     /db_xref="GeneID:20815"
                     /db_xref="MGI:MGI:106908"
     exon            1..122
                     /gene="Srpk1"
                     /inference="alignment:Splign:2.1.0"
     CDS             110..2056
                     /gene="Srpk1"
                     /EC_number="2.7.11.1"
                     /note="serine/threonine-protein kinase SRPK1; SFRS protein
                     kinase 1; SR-protein-specific kinase 1"
                     /codon_start=1
                     /product="SRSF protein kinase 1"
                     /protein_id="NP_058075.2"
                     /db_xref="CCDS:CCDS37531.1"
                     /db_xref="GeneID:20815"
                     /db_xref="MGI:MGI:106908"
                     /translation="MERKVLALQARKKRTKAKKDKAQRKPETQHRGSAPHSESDIPEQ
                     EEEILGSDDDEQEDPNDYCKGGYHLVKIGDLFNGRYHVIRKLGWGHFSTVWLSWDIQG
                     KKFVAMKVVKSAEHYTETALDEIRLLKSVRNSDPNDPNGEMVVQLLDDFKISGVNGTH
                     ICMVFEVLGHHLLKWIIKSNYQGLPLPCVKKIIQQVLQGLDYLHTKCRIIHTDIKPEN
                     ILLSVNEQYIRRLAAEATEWQRSGAPPPSGSAVSTAPQPKPADKMSKNKKKKLKKKQK
                     RQAELLEKRMQEIEEMEKESGPGQKRPNKQEESESPVDRPLTENPPNKMTQEKLEESN
                     SIGQDQTLTERGGEGGAPEINCNGVIGVVNYPENSNNETLRHKEDLHNANDCDVHTLK
                     QEPSFLNSSNGDSSPSQDTDSCTPTASETMVCQSSAEQSLTRQDITQLEESIRADTPS
                     GDEQEPNGALDSKGKFSAGNFLINPLEPKNAEKLQVKIADLGNACWVHKHFTEDIQTR
                     QYRSLEVLIGSGYNTPADIWSTACMAFELATGDYLFEPHSGEDYTRDEDHIALIIELL
                     GKVPRKLIVAGKYSKEFFTKKGDLKHITKLKPWGLLEVLVEKYEWPQEEAAGFTDFLL
                     PMLELMPEKRATAAECLRHPWLNS"
     exon            123..183
                     /gene="Srpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            184..302
                     /gene="Srpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            303..411
                     /gene="Srpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            412..499
                     /gene="Srpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            500..587
                     /gene="Srpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            588..694
                     /gene="Srpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            695..860
                     /gene="Srpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            861..886
                     /gene="Srpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            887..1100
                     /gene="Srpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..1499
                     /gene="Srpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1500..1600
                     /gene="Srpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1601..1708
                     /gene="Srpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1709..1778
                     /gene="Srpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1779..1871
                     /gene="Srpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1872..2525
                     /gene="Srpk1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2480..2485
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Srpk1"
                     /note="hexamer: ATTAAA"
     polyA_site      2523
                     /gene="Srpk1"
                     /note="major polyA site"
ORIGIN      
        1 gaggcggggc cggcgcgcgc cgggaggaag agctgggatt tgggccgcgg cgggagcccg
       61 agtcggcgtc actcgagtgc gcaggcgcct ggcggttacc ggtctcgcca tggagcggaa
      121 agtgctcgcg ctccaggccc gaaagaaaag gaccaaggcc aagaaggaca aagcccaaag
      181 gaagcctgaa actcagcacc gaggctctgc accccactcc gagagcgaca tcccagagca
      241 ggaggaggag attctagggt ctgacgatga cgagcaggaa gaccccaatg actactgtaa
      301 aggaggttat catcttgtga aaattggaga tctatttaac gggagatacc atgtgattcg
      361 aaaattgggc tggggacact tttccacagt gtggttatca tgggatattc agggaaagaa
      421 gtttgtagca atgaaagtag ttaaaagtgc tgagcattac acagaaacag cactagatga
      481 aatccggctg ctgaaatcgg ttcgcaactc agacccgaat gatccaaatg gagaaatggt
      541 tgttcaacta ctagatgact ttaaaatatc aggcgttaat ggaacacata tctgcatggt
      601 gtttgaggtt ttggggcatc atctactcaa gtggatcatc aagtccaact atcaggggct
      661 tccgctgcct tgtgtcaaaa aaattattca gcaagtgcta cagggcctgg attacttaca
      721 caccaagtgc cggatcatcc acacggacat caaaccagag aacatcttgt tgtctgtgaa
      781 tgagcagtac attcgaaggc tggctgcaga ggccacagag tggcagcgct caggagctcc
      841 cccaccatcg gggtctgcag tcagcactgc tccacagcct aagccagctg acaaaatgtc
      901 aaagaataag aagaagaaat tgaagaagaa gcagaagcgc caggcagaat tactagagaa
      961 gcgaatgcag gaaattgagg aaatggagaa agagtcgggc cctgggcaaa aaagacctaa
     1021 caagcaagaa gaatcagaga gtcctgttga cagacccctg acagagaacc cacctaataa
     1081 aatgacccaa gagaaacttg aagagtcaaa ttccattggc caggaccaga cactcacgga
     1141 gcgtggtgga gagggtggtg cgccagagat taattgcaat ggagtgattg gagtcgttaa
     1201 ttaccctgag aacagtaata atgagacact gaggcataaa gaggatctgc ataatgctaa
     1261 tgactgtgat gtccacactt tgaagcagga acctagtttc ctaaactctt caaatggaga
     1321 cagcagtcca tctcaagaca cagactcttg cacacccacg gcctctgaga ccatggtgtg
     1381 ccaatcctct gcagagcagt cactcacccg acaggacatc acccagctgg aggagagcat
     1441 tcgggcagat acaccttctg gggatgagca ggagcccaat ggagccctgg acagcaaagg
     1501 aaaattctct gctggaaatt ttcttattaa tccccttgag ccaaaaaatg cagagaagct
     1561 ccaagtgaag atcgcagacc tcgggaacgc ctgctgggtg cacaagcatt tcactgaaga
     1621 tatccagaca cggcagtatc ggtctttgga agtcctgata ggatctggct acaacacccc
     1681 tgctgacatc tggagcacag catgcatggc ctttgaacta gccacagggg actatttgtt
     1741 tgagcctcat tcaggggagg attacacacg agatgaagac cacatcgccc tgatcataga
     1801 acttctgggg aaggtgcctc gcaagctcat tgtggcagga aaatactcca aggaattttt
     1861 caccaaaaaa ggtgacctga agcacatcac caagttgaag ccttggggtc ttctggaggt
     1921 tctggtggag aaatatgagt ggcctcagga ggaggctgcc ggcttcacag atttcctgct
     1981 gcccatgttg gagcttatgc ctgagaagag agccactgct gctgagtgtc tccggcatcc
     2041 ttggctaaac tcctaagcca gtcctgccac tgcagcagag ctcatcatat ggaccttccc
     2101 tccagcccac ccctcaaact tccctctcct ttttcagggc aaagctcttt ctttcaaggg
     2161 tttctatttt ttttttaaac caacatgttc atttgggttt gcttccttga tcctgtggaa
     2221 attcccacgg ccattgggca tcctaggtga atttggcctt ggttgggctc tgccaaagac
     2281 taaaagtgtg aacagcctca ccctctgccc tgccatctta ttaggttgtc agtgcccttt
     2341 ctaagaagag ctgtgaagat ctgtgagccc atccatcctc tttattcact gactctgaga
     2401 gtcacacttt ctcgtgcaca tccgccgcca gcacaagatt gaggagggga gggctgtgga
     2461 ttctgtgaac agcagagaca ttaaatgcgc tgtatccagg ctgcatcatc ttcctggatt
     2521 ctatcaaaaa aaaaaaaaaa
//
