LOCUS       NM_012058               1388 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus signal recognition particle 9 (Srp9), mRNA.
ACCESSION   NM_012058
VERSION     NM_012058.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1388)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1388)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   3  (bases 1 to 1388)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   4  (bases 1 to 1388)
  AUTHORS   Hitzemann,R., Reed,C., Malmanger,B., Lawler,M., Hitzemann,B.,
            Cunningham,B., McWeeney,S., Belknap,J., Harrington,C., Buck,K.,
            Phillips,T. and Crabbe,J.
  TITLE     On the integration of alcohol-related quantitative trait loci and
            gene expression analyses
  JOURNAL   Alcohol Clin Exp Res 28 (10), 1437-1448 (2004)
   PUBMED   15597075
  REMARK    Erratum:[Alcohol Clin Exp Res. 2004 Dec;28(12):1930]
REFERENCE   5  (bases 1 to 1388)
  AUTHORS   Birse,D.E., Kapp,U., Strub,K., Cusack,S. and Aberg,A.
  TITLE     The crystal structure of the signal recognition particle Alu RNA
            binding heterodimer, SRP9/14
  JOURNAL   EMBO J 16 (13), 3757-3766 (1997)
   PUBMED   9233785
REFERENCE   6  (bases 1 to 1388)
  AUTHORS   Bovia,F., Wolff,N., Ryser,S. and Strub,K.
  TITLE     The SRP9/14 subunit of the human signal recognition particle binds
            to a variety of Alu-like RNAs and with higher affinity than its
            mouse homolog
  JOURNAL   Nucleic Acids Res 25 (2), 318-326 (1997)
   PUBMED   9016560
REFERENCE   7  (bases 1 to 1388)
  AUTHORS   Bovia,F., Bui,N. and Strub,K.
  TITLE     The heterodimeric subunit SRP9/14 of the signal recognition
            particle functions as permuted single polypeptide chain
  JOURNAL   Nucleic Acids Res 22 (11), 2028-2035 (1994)
   PUBMED   7518078
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ047061.1, AK051208.1 and AK146882.1.
            
            On Oct 3, 2007 this sequence version replaced NM_012058.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK146882.1, BC039648.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-54                CJ047061.1         2-55
            55-1361             AK051208.1         1-1307
            1362-1388           AK146882.1         1311-1337
FEATURES             Location/Qualifiers
     source          1..1388
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 84.93 cM"
     gene            1..1388
                     /gene="Srp9"
                     /gene_synonym="9kDa"
                     /note="signal recognition particle 9"
                     /db_xref="GeneID:27058"
                     /db_xref="MGI:MGI:1350930"
     exon            1..239
                     /gene="Srp9"
                     /gene_synonym="9kDa"
                     /inference="alignment:Splign:2.1.0"
     CDS             168..428
                     /gene="Srp9"
                     /gene_synonym="9kDa"
                     /EC_number="3.6.5.4"
                     /codon_start=1
                     /product="signal recognition particle 9 kDa protein"
                     /protein_id="NP_036188.1"
                     /db_xref="CCDS:CCDS35812.1"
                     /db_xref="GeneID:27058"
                     /db_xref="MGI:MGI:1350930"
                     /translation="MPQFQTWEEFSRAAEKLYLADPMKVRVVLKYRHVDGNLCIKVTD
                     DLVCLVYRTDQAQDVKKIEKFHSQLMRLMVAKESRNVTMETE"
     exon            240..308
                     /gene="Srp9"
                     /gene_synonym="9kDa"
                     /inference="alignment:Splign:2.1.0"
     exon            309..1388
                     /gene="Srp9"
                     /gene_synonym="9kDa"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1342..1347
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Srp9"
                     /gene_synonym="9kDa"
                     /note="hexamer: AATAAA"
     regulatory      1347..1352
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Srp9"
                     /gene_synonym="9kDa"
                     /note="hexamer: AATACA"
     polyA_site      1361
                     /gene="Srp9"
                     /gene_synonym="9kDa"
                     /note="major polyA site"
     polyA_site      1372
                     /gene="Srp9"
                     /gene_synonym="9kDa"
                     /note="major polyA site"
ORIGIN      
        1 ggacaggcgc gcggccgagg ctggccaatg gcgtgagcgc tcgtgagcct ccgtctttgc
       61 gccgccggag tgcagcgctg tgggcggttg cgggagagcg gcgggccgcc ggggcgacag
      121 cgccgtgact cgcttcgcgg ccttgttcct cgctgcctga agccacgatg cctcagttcc
      181 agacctggga ggagttcagc cgggcggccg agaagctcta cctggcggac cccatgaagg
      241 tacgggtggt tctcaaatac aggcatgttg atgggaattt gtgtatcaaa gtaacggatg
      301 atctagtttg tttggtgtac agaacagacc aagcgcaaga cgtaaagaag attgagaaat
      361 tccacagtca gttaatgcga cttatggtgg ccaaggaatc ccgcaatgtc actatggaaa
      421 cagaatgaat ggtttgacat gaagacgact gttccgttat tgggaagtaa tcagcttttg
      481 aaactgagag tgttgggaag gatatactta cgtaatggag ctgtcaaagc cgagagacca
      541 gcctgcgtcc taaagtttgc tttagagagt aggaatgtcg gggtttccag ttagaaaacc
      601 tttatttttg gaaacggaat aaaaatctct tagaaacttt tgcagataat ttgatgttgg
      661 gcaaatatat ataattattt tttctggtaa attcatgtca gtaatttgtt gaagagttaa
      721 caagaaaagg tctttctaga ttgtgtctaa gatgaaataa aatgtaactt ttgctgcagt
      781 ggtatgtttc ttttggagta caacatgtat gccgtttaca acacacacat ggtaacgggg
      841 atcacatgct ccatggtgcg cacgatcctg tggtgtgaag agcaggtctg ctttaccttt
      901 cttgccaggt tcaaactgtg tttttaaatg gaagggattt gtggcatcca cttgctgagc
      961 ggtgaacaga gcgagacgca gttatgtgtg caccggcaga tactgacact gatggctgac
     1021 agtgtgtgcg tccttcacgc cggtgtgcaa cgtacgcagt gtttactcag tgtggctccc
     1081 gcctcagact gaattaaagt attactatag catgcctctc agaactgcta gcttcctaat
     1141 aaaccacaaa tccaccgttt ctatgtagct tgtatttgta aagtctgagt ttaccgtctg
     1201 aatgtaaagt tccgtgttgt ccgctcacga cggaagtgaa gaagatactg cattcaagtg
     1261 ttttttgtaa aagtttgtca tggtgaataa cttgaaattt ttattagtta taagaatttt
     1321 agtctgtttt agaggtcagt aaataaaata caagcatcct ggttttgttg aagttttgga
     1381 tttcttgt
//
