LOCUS       NP_666144                625 aa            linear   ROD 27-APR-2025
DEFINITION  signal recognition particle subunit SRP68 [Mus musculus].
ACCESSION   NP_666144
VERSION     NP_666144.3
DBSOURCE    REFSEQ: accession NM_146032.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 625)
  AUTHORS   Vermeiren,S., Cabochette,P., Dannawi,M., Desiderio,S., San
            Jose,A.S., Achouri,Y., Kricha,S., Sitte,M., Salinas-Riester,G.,
            Vanhollebeke,B., Brunet,J.F. and Bellefroid,E.J.
  TITLE     Prdm12 represses the expression of the visceral neuron determinants
            Phox2a/b in developing somatosensory ganglia
  JOURNAL   iScience 26 (12), 108364 (2023)
   PUBMED   38025786
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 625)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC070422.1.
            
            On May 16, 2004 this sequence version replaced NP_666144.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC070422.1, AK033010.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..625
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 81.06 cM"
     Protein         1..625
                     /product="signal recognition particle subunit SRP68"
                     /note="signal recognition particle 68kDa; signal
                     recognition particle 68 kDa protein; likely ortholog of H.
                     sapiens signal recognition particle 68kDa (SRP68)"
                     /calculated_mol_wt=70443
     Region          1..52
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BMA6.2)"
     Site            47
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9UHB9; propagated from
                     UniProtKB/Swiss-Prot (Q8BMA6.2)"
     Region          51..251
                     /region_name="RNA-binding.
                     /evidence=ECO:0000250|UniProtKB:Q9UHB9"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BMA6.2)"
     Site            order(71,80..81,83,85,87..92,94..96,121,132,136,149..150,
                     152..153,156..157,160,163)
                     /site_type="other"
                     /note="RNA binding site [nucleotide binding]"
                     /db_xref="CDD:271252"
     Region          74..596
                     /region_name="SRP68"
                     /note="RNA-binding signal recognition particle 68;
                     pfam16969"
                     /db_xref="CDD:465323"
     Site            240
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9UHB9; propagated from
                     UniProtKB/Swiss-Prot (Q8BMA6.2)"
     Site            451
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q9UHB9; propagated from
                     UniProtKB/Swiss-Prot (Q8BMA6.2)"
     Region          586..608
                     /region_name="Required for interaction with SRP72.
                     /evidence=ECO:0000250|UniProtKB:Q9UHB9"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BMA6.2)"
     CDS             1..625
                     /gene="Srp68"
                     /gene_synonym="2610024I03Rik"
                     /coded_by="NM_146032.3:112..1989"
                     /db_xref="CCDS:CCDS25662.1"
                     /db_xref="GeneID:217337"
                     /db_xref="MGI:MGI:1917447"
ORIGIN      
        1 maaekqipgg gsggggsgsg gggggsgggr saggdenken erpsagskan kefgdslsle
       61 ilqiikesqq qhglrhgdfq ryrgycsrrq rrlrktlnfk mgnrhkftgk kvteelltdn
      121 rylllvlmda erawsyamql kqeanteprk rfhllsrlrk avkhaeeler lcesnrvdak
      181 tkleaqayta ylsgmlrfeh qewksaieaf nkcktiyekl asafteeqav lynqrveeis
      241 pnirycayni gdqsainelm qmrlrsggte gllaekleal itqtrakqaa tmsevewrgr
      301 tvpvkidkvr ifllgladne aaivqaesee tkerlfesml secrdalqav reelkpdqkq
      361 rdyaldgesg kvsnlqylhs yltyiklsta irrnenmakg lhrallqqqp eddskrsprp
      421 qdlirlydii lqnlvellql pgleedrtfq keislktlvf kayrcffiaq syvlvkkwse
      481 alvlydrvlk yanevsshgg asknslkdlp dvqelitqvr sekcslqaaa ildandshqt
      541 dtssqvkdnt plverfesfc ldpslvtkqa nlvhfppgfq pipckplffd lalnhvafpp
      601 ledkleqktk sgltgyikgi fgfrs
//
