LOCUS       NM_001413631            4233 bp    mRNA    linear   ROD 10-APR-2024
DEFINITION  Mus musculus signal recognition particle 54A (Srp54a), transcript
            variant 3, mRNA.
ACCESSION   NM_001413631
VERSION     NM_001413631.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4233)
  AUTHORS   Halic,M., Becker,T., Pool,M.R., Spahn,C.M., Grassucci,R.A.,
            Frank,J. and Beckmann,R.
  TITLE     Structure of the signal recognition particle interacting with the
            elongation-arrested ribosome
  JOURNAL   Nature 427 (6977), 808-814 (2004)
   PUBMED   14985753
REFERENCE   2  (bases 1 to 4233)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   3  (bases 1 to 4233)
  AUTHORS   Zopf,D., Bernstein,H.D., Johnson,A.E. and Walter,P.
  TITLE     The methionine-rich domain of the 54 kd protein subunit of the
            signal recognition particle contains an RNA binding site and can be
            crosslinked to a signal sequence
  JOURNAL   EMBO J 9 (13), 4511-4517 (1990)
   PUBMED   1702385
REFERENCE   4  (bases 1 to 4233)
  AUTHORS   Bernstein,H.D., Poritz,M.A., Strub,K., Hoben,P.J., Brenner,S. and
            Walter,P.
  TITLE     Model for signal sequence recognition from amino-acid sequence of
            54K subunit of signal recognition particle
  JOURNAL   Nature 340 (6233), 482-486 (1989)
   PUBMED   2502718
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC157515.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17253011.4675815.1,
                                           SRR12282455.37462353.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN00849374,
                                           SAMN00849375 [ECO:0000350]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-204               AC157515.2         71190-71393
            205-314             AC157515.2         79827-79936
            315-406             AC157515.2         80793-80884
            407-497             AC157515.2         81906-81996
            498-602             AC157515.2         86472-86576
            603-669             AC157515.2         87766-87832
            670-727             AC157515.2         87913-87970
            728-878             AC157515.2         90570-90720
            879-1027            AC157515.2         91997-92145
            1028-1128           AC157515.2         92480-92580
            1129-1215           AC157515.2         93125-93211
            1216-1289           AC157515.2         95848-95921
            1290-1398           AC157515.2         96274-96382
            1399-1569           AC157515.2         99159-99329
            1570-1665           AC157515.2         101743-101838
            1666-4233           AC157515.2         103457-106024
FEATURES             Location/Qualifiers
     source          1..4233
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 23.86 cM"
     gene            1..4233
                     /gene="Srp54a"
                     /gene_synonym="54kDa; Srp54"
                     /note="signal recognition particle 54A"
                     /db_xref="GeneID:24067"
                     /db_xref="MGI:MGI:1346087"
     exon            1..204
                     /gene="Srp54a"
                     /gene_synonym="54kDa; Srp54"
                     /inference="alignment:Splign:2.1.0"
     exon            205..314
                     /gene="Srp54a"
                     /gene_synonym="54kDa; Srp54"
                     /inference="alignment:Splign:2.1.0"
     CDS             237..1757
                     /gene="Srp54a"
                     /gene_synonym="54kDa; Srp54"
                     /EC_number="3.6.5.4"
                     /note="isoform 3 is encoded by transcript variant 3;
                     signal recognition particle 54 kDa protein; 54K subunit of
                     signal recognition particle; signal recognition particle
                     subunit SRP54"
                     /codon_start=1
                     /product="signal recognition particle 54 kDa protein
                     isoform 3"
                     /protein_id="NP_001400560.1"
                     /db_xref="GeneID:24067"
                     /db_xref="MGI:MGI:1346087"
                     /translation="MVLADLGRKITSALRSLSNATIINEEVLNAMLKEVCTALLEADV
                     NIKLVKQLRENVKSAIDLEEMASGLNKRKMIQHAVFKELVKVKLVDPGVKAWTPTKGK
                     QNVIMFVGLQGSGKTTTCSKLAYYYQRKGWKTCLICADTFRAGAFDQLKQNATKARIP
                     FYGSYTEMDPVIIASEGVEKFKNENFEIIIVDTSGRHKQEDSLFEEMLQVSNAIQPDN
                     IVYVMDASIGQACEAQAKAFKDKVDVASVIVTKLDGHAKGGGALSAVAATKSPIIFIG
                     TGEHIDDFEPFKTQPFISKLLGMGDIEGLIDKVNELKLDDNEALIEKLKHGQFTLRDM
                     YEQFQNIMKMGPFSQILGMIPGFGTDFMSKGNEQESMARLKKLMTIMDSMNDQELDST
                     DGAKVFSKQPGRIQRVARGSGVSTRDVQELLTQYTKFAQMVKKMGGIKGLFKGGDMSK
                     NVSQSQMAKLNQQMAKMMDPRVLHHMGGMAGLQSMMRQFQQGAAGNMKGMMGFNNM"
     exon            315..406
                     /gene="Srp54a"
                     /gene_synonym="54kDa; Srp54"
                     /inference="alignment:Splign:2.1.0"
     exon            407..497
                     /gene="Srp54a"
                     /gene_synonym="54kDa; Srp54"
                     /inference="alignment:Splign:2.1.0"
     exon            498..602
                     /gene="Srp54a"
                     /gene_synonym="54kDa; Srp54"
                     /inference="alignment:Splign:2.1.0"
     exon            603..669
                     /gene="Srp54a"
                     /gene_synonym="54kDa; Srp54"
                     /inference="alignment:Splign:2.1.0"
     exon            670..727
                     /gene="Srp54a"
                     /gene_synonym="54kDa; Srp54"
                     /inference="alignment:Splign:2.1.0"
     exon            728..878
                     /gene="Srp54a"
                     /gene_synonym="54kDa; Srp54"
                     /inference="alignment:Splign:2.1.0"
     exon            879..1027
                     /gene="Srp54a"
                     /gene_synonym="54kDa; Srp54"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1128
                     /gene="Srp54a"
                     /gene_synonym="54kDa; Srp54"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..1215
                     /gene="Srp54a"
                     /gene_synonym="54kDa; Srp54"
                     /inference="alignment:Splign:2.1.0"
     exon            1216..1289
                     /gene="Srp54a"
                     /gene_synonym="54kDa; Srp54"
                     /inference="alignment:Splign:2.1.0"
     exon            1290..1398
                     /gene="Srp54a"
                     /gene_synonym="54kDa; Srp54"
                     /inference="alignment:Splign:2.1.0"
     exon            1399..1569
                     /gene="Srp54a"
                     /gene_synonym="54kDa; Srp54"
                     /inference="alignment:Splign:2.1.0"
     exon            1570..1665
                     /gene="Srp54a"
                     /gene_synonym="54kDa; Srp54"
                     /inference="alignment:Splign:2.1.0"
     exon            1666..4233
                     /gene="Srp54a"
                     /gene_synonym="54kDa; Srp54"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcagtcgtc ggtgttccag ctggtgggag ttggcttcac tgtgttgggc gctgggcccc
       61 tagtttctgg agctgggaag ttgggcgacg ggctccgtcc ctgtccttca gcttccagcg
      121 ttcctgggtt tccttcggcg gcgtggggcc tcgctaaggg ctcgccggcc ctgtggggcc
      181 acggctttag tggcgccttt tgcgagttca cataaataca tcttaaaacc ttcaagatgg
      241 ttctagcaga tcttggaaga aaaataacat cagcattacg ctcattgagc aatgccacca
      301 ttatcaatga agaggtatta aatgctatgc tgaaagaagt atgtacagca ttattggaag
      361 cagatgttaa tattaaacta gtgaagcaac tcagagaaaa tgttaagtct gcaattgatc
      421 ttgaagagat ggcatctgga ctgaacaaaa gaaaaatgat tcagcatgct gtatttaaag
      481 aacttgtaaa ggtaaaactt gtagaccctg gagttaaagc gtggacaccg actaagggaa
      541 agcaaaatgt gatcatgttt gttggattgc aagggagtgg taaaacgaca acatgttcaa
      601 agttagcata ttattaccag aggaaaggtt ggaagacctg tttgatatgt gcagatacat
      661 tcagagcagg agcctttgac cagctaaaac agaatgccac caaagcaaga attccgttct
      721 atggcagcta tactgaaatg gatcctgtca tcattgcttc tgaaggagtg gagaaattca
      781 aaaatgaaaa ttttgaaatt attattgttg atacaagtgg tcgtcacaaa caagaagact
      841 ctttatttga agaaatgctt caagtttcta atgctataca acctgataac attgtttatg
      901 tgatggatgc atccatcgga caggcttgtg aggcccaggc gaaggccttt aaagacaaag
      961 tagatgtagc ttcagtaata gtgacaaaac tcgacggtca tgcgaaagga ggcggtgctc
     1021 ttagtgcagt tgctgccaca aaaagtccaa ttattttcat tggtacaggg gaacatatag
     1081 atgattttga acctttcaaa acacaacctt tcatcagcaa actccttgga atgggtgata
     1141 ttgaaggact gattgataaa gtcaatgaat tgaagttgga tgataatgag gcacttatag
     1201 agaagttgaa gcacggtcag tttacattgc gagacatgta tgaacagttt cagaatatta
     1261 tgaaaatggg cccattcagt cagatattgg ggatgattcc tggctttggc acagatttta
     1321 tgagcaaagg gaatgagcag gagtcaatgg caaggctgaa gaaactgatg acaatcatgg
     1381 acagtatgaa cgatcaagaa ctggacagta cagatggtgc caaggttttc agtaagcaac
     1441 cagggagaat ccaaagagtt gcccggggat caggtgtgtc aacaagagat gttcaagaac
     1501 ttctgaccca gtataccaag tttgcacaga tggtcaaaaa gatgggaggt atcaaaggac
     1561 ttttcaaagg cggtgatatg tctaagaatg tgagtcagtc acagatggca aaattaaacc
     1621 aacaaatggc caaaatgatg gacccacgag ttcttcatca catgggtggc atggccggcc
     1681 ttcagtcaat gatgcggcag tttcagcagg gtgctgctgg caacatgaaa ggcatgatgg
     1741 gattcaataa catgtaaaga cgccccctta ctaggaactg acaaggtgga tgatgtcatc
     1801 tgctgagacc tcacactttc tctccctctt gcaaacgggg aagaaggata ttcttgcctg
     1861 tcttgccttc gttcttttgt ctcaccgttt tccttgtctc ccttcccttc tgaagttcgg
     1921 gaagagtgcc tggtttttgt ggaagtcatc atttctgctt taaatctatt agttttcaac
     1981 gtcctaacac ttcttaagtt aaacaaatca tgatgtaaaa ttttggtatt taaaggtttt
     2041 taattgtctc aaaggccaag cattacattt ataaacagtt gcgatcagta aattacatga
     2101 tattgaagaa aagtgctgca aaataaactt caagtgataa gttaaagggt tcgttaactt
     2161 tctttaaggt ttgatgtggc agcgtaccac ccagaaaata ggcaaaaagc cagcaggtac
     2221 atttaaagga atatatattg aaaaatttaa tcatgagtat tagaaaatgt tattttagga
     2281 tgaaataact ttattccaag aaactttagc tttaccattt aaaattgaaa tcaagaattt
     2341 ggttacagtt cgtaatgtat gatgttttgt atcaaactta aattttttac atattttgga
     2401 gtctcgtggt ccttgattgt ttttaaagcc atttttatgt ttcttacata ctattgaaaa
     2461 ataatatgtt ttgataatag ataatacata aatttgctaa tggaaagtaa tactaaacta
     2521 ttaggctaca gtattacaca ttaaaaataa ggccgtagca gcattggttg gttcattgat
     2581 aactattgct gtgtgtctgt cctggaatct cagatgagta agcttcaatt ccagtgacgg
     2641 ttggatgtgt tagcacttgc accatagcac atgtgtgaag gtcagagagc aaccatgttc
     2701 tttattcttt ttttgtttgt ttctttgaga catggtctca ctatagctct ggttatcctt
     2761 ggaactcact atgtggacca ggctggcctc aaactcacag agctccgcct tcctctgcct
     2821 cctgagtgct gagattaaaa gcacaagtga catgttgggt ttcagaggac aacttgcaga
     2881 agtcagttct catttcacca tgtgggtcca gggtttaaac tcagctcagt cacacttggc
     2941 accaagtgcc tttatccata gagccatgtc attggccaca gttccaaaga aagagaggaa
     3001 ggaaggaaag ggagggaggg agggagggag ggagggaggg agggagggag ggatctgtgt
     3061 gtatgagtgg ttttgagtgc attcttctac atgctcgggt acacattgtt gaagtcaaga
     3121 caacctcagg tgctcgtccc tgccttctac gctgtttaaa cagggtctct tgttcatgtt
     3181 ccagagagct gggctagctg gccttcaagc tcttaggatc ctggttttcg agccctacct
     3241 tgctgtagaa gtactgggac tacattgcta ccgtgtctac ctttttttgg tttggggaga
     3301 aaggctcagg ctgtcctgga actcatgaca aatctcctgc ttcagcctcc taaattcagg
     3361 aattttagta aatttaccat tcttagaaaa gtattctcat aaagaatgca gttcagctgg
     3421 gcatggtagc acttagcaaa tcccactatt taaatagagg ctgaggtagg aagatcatga
     3481 tttgaaggcc agcctaagtt atgtagacca tgtctcaaaa gccaaaaacg taacaaaaag
     3541 tgcatctgat tttgtggttt gcagagggtt ggatgtttta gctaagaatt gtttagtaga
     3601 ggactaggat ttccctagtg ggcactgtat gtatttgtgg gaaattacac attttatgtt
     3661 ttgccagagt ggcctagtaa ggtacagtta tagaaatcca aaactagaga aaatggtaat
     3721 taaactctgt acactacctt ttctgggtat gtgtcttagt gatttctgtt ttctggatat
     3781 tttgttctga ctaaataaag gtaaatgaga tgaacctttg gacatagcat cccgaatgcc
     3841 ttctgcatga gttttgatat ttttatgtct ggttgaactt tatttttcag aatctgaatg
     3901 gtgacaaaaa agacaattaa agatcatgat gccttaattt ggagtattac taggggttct
     3961 ctagagtcac agaactatgg aatgactcag tagttgatca gtcctgcgag gctggatggc
     4021 tcatctggta tctatatata ctggaatccc aaataagtag gctttgatgc cagtgaaaga
     4081 atggacgtgt tagcaaggtg aaggacaagc aggctaggag caaacgcttc cttctgtgtt
     4141 cttgtctaga cttccagcag aagctatggt ccattttaaa ggtgtttttc tgccttcaag
     4201 tttggaataa aagtatgtgt cttcccacct caa
//
