LOCUS       NM_011481               2547 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus src-related kinase lacking C-terminal regulatory
            tyrosine and N-terminal myristylation sites (Srms), mRNA.
ACCESSION   NM_011481
VERSION     NM_011481.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2547)
  AUTHORS   Park,J.M., Yang,S.W., Zhuang,W., Bera,A.K., Liu,Y., Gurbani,D., von
            Hoyningen-Huene,S.J., Sakurada,S.M., Gan,H., Pruett-Miller,S.M.,
            Westover,K.D. and Potts,M.B.
  TITLE     The nonreceptor tyrosine kinase SRMS inhibits autophagy and
            promotes tumor growth by phosphorylating the scaffolding protein
            FKBP51
  JOURNAL   PLoS Biol 19 (6), e3001281 (2021)
   PUBMED   34077419
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2547)
  AUTHORS   Goel,R.K., Miah,S., Black,K., Kalra,N., Dai,C. and Lukong,K.E.
  TITLE     The unique N-terminal region of SRMS regulates enzymatic activity
            and phosphorylation of its novel substrate docking protein 1
  JOURNAL   FEBS J 280 (18), 4539-4559 (2013)
   PUBMED   23822091
REFERENCE   3  (bases 1 to 2547)
  AUTHORS   Kim,S.C., Sprung,R., Chen,Y., Xu,Y., Ball,H., Pei,J., Cheng,T.,
            Kho,Y., Xiao,H., Xiao,L., Grishin,N.V., White,M., Yang,X.J. and
            Zhao,Y.
  TITLE     Substrate and functional diversity of lysine acetylation revealed
            by a proteomics survey
  JOURNAL   Mol Cell 23 (4), 607-618 (2006)
   PUBMED   16916647
REFERENCE   4  (bases 1 to 2547)
  AUTHORS   Serfas,M.S. and Tyner,A.L.
  TITLE     Brk, Srm, Frk, and Src42A form a distinct family of intracellular
            Src-like tyrosine kinases
  JOURNAL   Oncol Res 13 (6-10), 409-419 (2003)
   PUBMED   12725532
  REMARK    GeneRIF: The tyrosine kinases Brk/PTK6/Sik, Srm,
            Frk/Rak/Gtk/Iyk/Bsk, and Src42A/Dsrc41 have a low degree of
            sequence homology to other known kinases. The exon structure of
            these kinases, called the Brk family, is highly conserved and
            distinct.
            Review article
REFERENCE   5  (bases 1 to 2547)
  AUTHORS   Robinson,D.R., Wu,Y.M. and Lin,S.F.
  TITLE     The protein tyrosine kinase family of the human genome
  JOURNAL   Oncogene 19 (49), 5548-5557 (2000)
   PUBMED   11114734
  REMARK    Review article
REFERENCE   6  (bases 1 to 2547)
  AUTHORS   Kawachi,Y., Nakauchi,H. and Otsuka,F.
  TITLE     Isolation of a cDNA encoding a tyrosine kinase expressed in murine
            skin
  JOURNAL   Exp Dermatol 6 (3), 140-146 (1997)
   PUBMED   9226137
REFERENCE   7  (bases 1 to 2547)
  AUTHORS   Laviola,L., Giorgino,F., Chow,J.C., Baquero,J.A., Hansen,H.,
            Ooi,J., Zhu,J., Riedel,H. and Smith,R.J.
  TITLE     The adapter protein Grb10 associates preferentially with the
            insulin receptor as compared with the IGF-I receptor in mouse
            fibroblasts
  JOURNAL   J Clin Invest 99 (5), 830-837 (1997)
   PUBMED   9062339
REFERENCE   8  (bases 1 to 2547)
  AUTHORS   Kohmura,N., Yagi,T., Tomooka,Y., Oyanagi,M., Kominami,R.,
            Takeda,N., Chiba,J., Ikawa,Y. and Aizawa,S.
  TITLE     A novel nonreceptor tyrosine kinase, Srm: cloning and targeted
            disruption
  JOURNAL   Mol Cell Biol 14 (10), 6915-6925 (1994)
   PUBMED   7935409
REFERENCE   9  (bases 1 to 2547)
  AUTHORS   Kawachi,Y., Nakauchi,H. and Otsuka,F.
  TITLE     Identification of a novel cDNA clone encoding protein tyrosine
            kinase in murine skin
  JOURNAL   J Dermatol 21 (8), 533-538 (1994)
   PUBMED   7962951
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK038866.1 and AK049582.1.
            
            [WARNING] On Jun 8, 2024 this sequence was replaced by NM_011481.4.
            
            On Oct 18, 2004 this sequence version replaced NM_011481.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D26186.1, D49427.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN00849386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-800               AK038866.1         2-801
            801-2547            AK049582.1         62-1808
FEATURES             Location/Qualifiers
     source          1..2547
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 103.62 cM"
     gene            1..2547
                     /gene="Srms"
                     /gene_synonym="A230069J08Rik; srm"
                     /note="src-related kinase lacking C-terminal regulatory
                     tyrosine and N-terminal myristylation sites"
                     /db_xref="GeneID:20811"
                     /db_xref="MGI:MGI:101865"
     exon            1..800
                     /gene="Srms"
                     /gene_synonym="A230069J08Rik; srm"
                     /inference="alignment:Splign:2.1.0"
     CDS             400..1923
                     /gene="Srms"
                     /gene_synonym="A230069J08Rik; srm"
                     /EC_number="2.7.10.2"
                     /note="PTK70"
                     /codon_start=1
                     /product="tyrosine-protein kinase Srms"
                     /protein_id="NP_035611.3"
                     /db_xref="CCDS:CCDS17204.1"
                     /db_xref="GeneID:20811"
                     /db_xref="MGI:MGI:101865"
                     /translation="MRFRPQPGPLGMEPFLRKRLTFLSFFWDKIWPADESEEDIPRIQ
                     GHDDNPVPEQAAAVEPCSFPAPRARLFRALYDFTARCAEELSVSRGDRLYALKEEGDY
                     IFAQRLSGPPSTGLVPVTYLAKATPEPPSDQPWYFSGISRAQAQQLLLSPANAPGAFL
                     IRPSESSIGGYSLSVRAQAKVCHYRICMAPSGSLYLQEGQLFPSLDALLAYYKTNWKL
                     IQNPLLQPCIPQIPLVQDEWERPRSEFVLRRKLGEGFFGEVWEGLWLGSIPVAVKVIK
                     SADMKLADLTKEIEALKSLRHERLIRLHAICSLGEPVYIVTELMGKGNLQVYLGSSEG
                     KALSLPHLLGFACQVAEGMSYLEERRVVHRDLAARNVLVGDDLTCKVADFGLARLLKD
                     DVYSPSSGSKIPVKWTAPEAANYRVFSQKSDVWSFGILLYEVFTYGQCPYEGMTNHET
                     LQQISRGYRLPRPAVCPAEVYVLMVECWKGSPEERPTFAILREKLNAINRRLHLGLT"
     exon            801..922
                     /gene="Srms"
                     /gene_synonym="A230069J08Rik; srm"
                     /inference="alignment:Splign:2.1.0"
     exon            923..1089
                     /gene="Srms"
                     /gene_synonym="A230069J08Rik; srm"
                     /inference="alignment:Splign:2.1.0"
     exon            1090..1231
                     /gene="Srms"
                     /gene_synonym="A230069J08Rik; srm"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1390
                     /gene="Srms"
                     /gene_synonym="A230069J08Rik; srm"
                     /inference="alignment:Splign:2.1.0"
     exon            1391..1572
                     /gene="Srms"
                     /gene_synonym="A230069J08Rik; srm"
                     /inference="alignment:Splign:2.1.0"
     exon            1573..1729
                     /gene="Srms"
                     /gene_synonym="A230069J08Rik; srm"
                     /inference="alignment:Splign:2.1.0"
     exon            1730..2547
                     /gene="Srms"
                     /gene_synonym="A230069J08Rik; srm"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2523..2528
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Srms"
                     /gene_synonym="A230069J08Rik; srm"
                     /note="putative"
ORIGIN      
        1 tcaagcccag cggcttttaa ccccagcaga gatccagctc accagaccgc acagctgtag
       61 aagagtatgt agactaggag gagcagcccg tgtggtcctg ggacggaggt caccgtccgc
      121 cccacgcatt gatacaccat ccgggaaact gactgttgta tgcctgatta aggagcactc
      181 tgtagtgacc tccggggtta gggttagggt ccgtgtcacc tgtcgcttcc cattctgtac
      241 caaataggga cgtgggcaga aagcccgggg taagcctggc tgtcccacca gcctttccgg
      301 tttctctctt gcaccctggg atcctggtgc atggttgtag tgctcagctt cttcagcggc
      361 agcacggagg tcccagagta ctgacccgag gtcggctcca tgcgctttcg tccgcaacca
      421 ggccccctag gcatggagcc cttcctcagg aagcggctca ctttcttgtc ctttttctgg
      481 gataagatat ggccagcgga tgaatcggag gaagacatcc ccaggatcca gggacacgac
      541 gacaacccag tgccggagca agccgctgcc gttgaacctt gtagcttccc agccccacgc
      601 gcccgactct tccgcgcgct ctacgacttc actgctcgat gtgcagagga actgagcgtc
      661 agccgtgggg acagactcta cgccctcaag gaggaggggg actacatctt tgcccaaagg
      721 ctctctggtc cacccagcac cggactagtt cctgtcacct accttgccaa ggctaccccg
      781 gagccgccct cagaccaacc ttggtacttc agtgggatca gcagggctca ggcccagcag
      841 ttgctcttgt ctcctgccaa tgcaccaggg gccttcctca tccggcccag cgaaagcagc
      901 atcgggggct attctctatc agtcagggcc caggccaaag tctgccacta ccgcatctgc
      961 atggcaccca gtggcagcct ctatctgcag gagggccaac tcttccccag cctggatgca
     1021 ctgctggctt actacaagac caactggaag ctgatccaga accctctgct gcagccctgc
     1081 ataccccaga tacccttggt tcaggacgag tgggaacgac cacgttcaga atttgtcctt
     1141 cggagaaagc tgggtgaagg tttcttcggg gaggtgtggg aaggcctgtg gctgggctct
     1201 atccctgtgg cagtgaaggt tatcaaatca gctgacatga agctggcaga cctcaccaag
     1261 gagattgagg cactgaagag cttgaggcat gagaggctga tccggctgca cgctatatgt
     1321 tccctcggtg aacctgtgta catcgttact gaactcatgg gcaagggcaa cttgcaagtc
     1381 tacctgggca gctctgaggg aaaggccctg agcctgcccc atctactggg atttgcctgc
     1441 caggtagctg agggcatgag ctacctggag gagcggcgtg tcgtccaccg ggacttggct
     1501 gccaggaacg tgctggtggg tgatgacctc acctgcaagg tagctgattt tggcctggcc
     1561 agactgctca aggatgatgt ctactcccca agcagtggct ccaagatccc tgtcaagtgg
     1621 acggcacctg aggctgctaa ttaccgtgtc ttttcccaaa agtcagatgt ctggtccttt
     1681 ggcatcctgc tgtatgaggt cttcacttat ggccagtgtc cctatgaagg aatgaccaac
     1741 catgagacgc tacagcagat tagtcgtgga taccggctgc cacgcccagc tgtctgccca
     1801 gcagaggtct atgtgctcat ggtagagtgc tggaagggca gccctgagga gcgtcccacc
     1861 tttgccatac tgagggagaa gctgaatgcc ataaacagac gcctccatct gggcctcacg
     1921 tgaccaggtc tccagaccct cagtagcagc tagggctgcc gcttcctgaa gggtgtctcc
     1981 caaggaaaca tttgtcacca gtgcccatgg gaaatactgc acaactgaga atgataggag
     2041 cctctgggct ccaacactgc ggctccttca ctgacacagg ctggtgccta catatgcaca
     2101 ccagagagac tcatgcaact acatgtgcac accagagaga ctcatgtacc tacatgtgca
     2161 catcggatgg atgtgttcag actggtcctg gtcatgagca cttacacaga tatgaaggct
     2221 gatgccctcc tcctggcaca gtctccaaag tgttgataaa gcatagagga ggagccgcaa
     2281 ggatgtgctt tgacagacga gagccagcag tttcctcctt gccctcacct cagctccctc
     2341 ctagaaccaa ggatgaaaaa gctcactttc cccaggtctt gttgtggatt gggttaagta
     2401 gccgatacta gggctggctg tgggccatta catgctatgt acttttaggg gacagcagca
     2461 tcacctgccc ctacccagtg cccacaggta ccagtaaacc ttaggaacac aaagtcagct
     2521 tcaataaaca tgttctggtg gtttcac
//
