LOCUS       NP_035611                507 aa            linear   ROD 02-JUN-2024
DEFINITION  tyrosine-protein kinase Srms [Mus musculus].
ACCESSION   NP_035611
VERSION     NP_035611.3
DBSOURCE    REFSEQ: accession NM_011481.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 507)
  AUTHORS   Park,J.M., Yang,S.W., Zhuang,W., Bera,A.K., Liu,Y., Gurbani,D., von
            Hoyningen-Huene,S.J., Sakurada,S.M., Gan,H., Pruett-Miller,S.M.,
            Westover,K.D. and Potts,M.B.
  TITLE     The nonreceptor tyrosine kinase SRMS inhibits autophagy and
            promotes tumor growth by phosphorylating the scaffolding protein
            FKBP51
  JOURNAL   PLoS Biol 19 (6), e3001281 (2021)
   PUBMED   34077419
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 507)
  AUTHORS   Goel,R.K., Miah,S., Black,K., Kalra,N., Dai,C. and Lukong,K.E.
  TITLE     The unique N-terminal region of SRMS regulates enzymatic activity
            and phosphorylation of its novel substrate docking protein 1
  JOURNAL   FEBS J 280 (18), 4539-4559 (2013)
   PUBMED   23822091
REFERENCE   3  (residues 1 to 507)
  AUTHORS   Kim,S.C., Sprung,R., Chen,Y., Xu,Y., Ball,H., Pei,J., Cheng,T.,
            Kho,Y., Xiao,H., Xiao,L., Grishin,N.V., White,M., Yang,X.J. and
            Zhao,Y.
  TITLE     Substrate and functional diversity of lysine acetylation revealed
            by a proteomics survey
  JOURNAL   Mol Cell 23 (4), 607-618 (2006)
   PUBMED   16916647
REFERENCE   4  (residues 1 to 507)
  AUTHORS   Serfas,M.S. and Tyner,A.L.
  TITLE     Brk, Srm, Frk, and Src42A form a distinct family of intracellular
            Src-like tyrosine kinases
  JOURNAL   Oncol Res 13 (6-10), 409-419 (2003)
   PUBMED   12725532
  REMARK    GeneRIF: The tyrosine kinases Brk/PTK6/Sik, Srm,
            Frk/Rak/Gtk/Iyk/Bsk, and Src42A/Dsrc41 have a low degree of
            sequence homology to other known kinases. The exon structure of
            these kinases, called the Brk family, is highly conserved and
            distinct.
            Review article
REFERENCE   5  (residues 1 to 507)
  AUTHORS   Robinson,D.R., Wu,Y.M. and Lin,S.F.
  TITLE     The protein tyrosine kinase family of the human genome
  JOURNAL   Oncogene 19 (49), 5548-5557 (2000)
   PUBMED   11114734
  REMARK    Review article
REFERENCE   6  (residues 1 to 507)
  AUTHORS   Kawachi,Y., Nakauchi,H. and Otsuka,F.
  TITLE     Isolation of a cDNA encoding a tyrosine kinase expressed in murine
            skin
  JOURNAL   Exp Dermatol 6 (3), 140-146 (1997)
   PUBMED   9226137
REFERENCE   7  (residues 1 to 507)
  AUTHORS   Laviola,L., Giorgino,F., Chow,J.C., Baquero,J.A., Hansen,H.,
            Ooi,J., Zhu,J., Riedel,H. and Smith,R.J.
  TITLE     The adapter protein Grb10 associates preferentially with the
            insulin receptor as compared with the IGF-I receptor in mouse
            fibroblasts
  JOURNAL   J Clin Invest 99 (5), 830-837 (1997)
   PUBMED   9062339
REFERENCE   8  (residues 1 to 507)
  AUTHORS   Kohmura,N., Yagi,T., Tomooka,Y., Oyanagi,M., Kominami,R.,
            Takeda,N., Chiba,J., Ikawa,Y. and Aizawa,S.
  TITLE     A novel nonreceptor tyrosine kinase, Srm: cloning and targeted
            disruption
  JOURNAL   Mol Cell Biol 14 (10), 6915-6925 (1994)
   PUBMED   7935409
REFERENCE   9  (residues 1 to 507)
  AUTHORS   Kawachi,Y., Nakauchi,H. and Otsuka,F.
  TITLE     Identification of a novel cDNA clone encoding protein tyrosine
            kinase in murine skin
  JOURNAL   J Dermatol 21 (8), 533-538 (1994)
   PUBMED   7962951
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK038866.1 and AK049582.1.
            
            [WARNING] On Jun 8, 2024 this sequence was replaced by NP_035611.4.
            
            On Oct 18, 2004 this sequence version replaced NP_035611.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D26186.1, D49427.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN00849386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 103.62 cM"
     Protein         1..507
                     /product="tyrosine-protein kinase Srms"
                     /EC_number="2.7.10.2"
                     /note="PTK70"
                     /calculated_mol_wt=56865
     Region          70..124
                     /region_name="SH3"
                     /note="Src Homology 3 domain superfamily; cl17036"
                     /db_xref="CDD:473055"
     Site            order(75,77,80,84,101..102,118,120..121)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212780"
     Region          134..212
                     /region_name="SH2_Srm"
                     /note="Src homology 2 (SH2) domain found in Src-related
                     kinase lacking C-terminal regulatory tyrosine and
                     N-terminal myristoylation sites (srm); cd10360"
                     /db_xref="CDD:198223"
     Site            order(142,162,183,185)
                     /site_type="other"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]"
                     /db_xref="CDD:198223"
     Site            order(184,211)
                     /site_type="other"
                     /note="hydrophobic binding pocket [polypeptide binding]"
                     /db_xref="CDD:198223"
     Region          238..498
                     /region_name="PTKc_Srm_Brk"
                     /note="Catalytic domain of the Protein Tyrosine Kinases,
                     Src-related kinase lacking C-terminal regulatory tyrosine
                     and N-terminal myristylation sites (Srm) and Breast tumor
                     kinase (Brk); cd05148"
                     /db_xref="CDD:133248"
     Site            order(251,253..255,259,271,273,317..320,324,365,369..370,
                     372,383,399,401..404,413,447)
                     /site_type="active"
                     /db_xref="CDD:133248"
     Site            order(251,254,259,271,273,317..320,324,365,367,370,372,
                     383)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:133248"
     Site            order(265,267,299,302,304,318,344,348,376,496)
                     /site_type="other"
                     /note="SH3/SH2 domain interface [polypeptide binding]"
                     /db_xref="CDD:133248"
     Site            order(354,357..358,421,483..485,487,489..490,493,497)
                     /site_type="other"
                     /note="CSK binding interface [polypeptide binding]"
                     /db_xref="CDD:133248"
     Site            order(365,369,399,401..404,413,447)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:133248"
     Site            order(382..399,401..406)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:133248"
     CDS             1..507
                     /gene="Srms"
                     /gene_synonym="A230069J08Rik; srm"
                     /coded_by="NM_011481.3:400..1923"
                     /db_xref="CCDS:CCDS17204.1"
                     /db_xref="GeneID:20811"
                     /db_xref="MGI:MGI:101865"
ORIGIN      
        1 mrfrpqpgpl gmepflrkrl tflsffwdki wpadeseedi priqghddnp vpeqaaavep
       61 csfpaprarl fralydftar caeelsvsrg drlyalkeeg dyifaqrlsg ppstglvpvt
      121 ylakatpepp sdqpwyfsgi sraqaqqlll spanapgafl irpsessigg yslsvraqak
      181 vchyricmap sgslylqegq lfpsldalla yyktnwkliq npllqpcipq iplvqdewer
      241 prsefvlrrk lgegffgevw eglwlgsipv avkviksadm kladltkeie alkslrherl
      301 irlhaicslg epvyivtelm gkgnlqvylg ssegkalslp hllgfacqva egmsyleerr
      361 vvhrdlaarn vlvgddltck vadfglarll kddvyspssg skipvkwtap eaanyrvfsq
      421 ksdvwsfgil lyevftygqc pyegmtnhet lqqisrgyrl prpavcpaev yvlmvecwkg
      481 speerptfai lreklnainr rlhlglt
//
