LOCUS       NM_009272               1328 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus spermidine synthase (Srm), mRNA.
ACCESSION   NM_009272
VERSION     NM_009272.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1328)
  AUTHORS   Gilhooley,M.J., Hickey,D.G., Lindner,M., Palumaa,T., Hughes,S.,
            Peirson,S.N., MacLaren,R.E. and Hankins,M.W.
  TITLE     ON-bipolar cell gene expression during retinal degeneration:
            Implications for optogenetic visual restoration
  JOURNAL   Exp Eye Res 207, 108553 (2021)
   PUBMED   33811915
  REMARK    GeneRIF: ON-bipolar cell gene expression during retinal
            degeneration: Implications for optogenetic visual restoration.
REFERENCE   2  (bases 1 to 1328)
  AUTHORS   Werber,M., Wittler,L., Timmermann,B., Grote,P. and Herrmann,B.G.
  TITLE     The tissue-specific transcriptomic landscape of the mid-gestational
            mouse embryo
  JOURNAL   Development 141 (11), 2325-2330 (2014)
   PUBMED   24803591
REFERENCE   3  (bases 1 to 1328)
  AUTHORS   Shi,C., Welsh,P.A., Sass-Kuhn,S., Wang,X., McCloskey,D.E.,
            Pegg,A.E. and Feith,D.J.
  TITLE     Characterization of transgenic mice with overexpression of
            spermidine synthase
  JOURNAL   Amino Acids 42 (2-3), 495-505 (2012)
   PUBMED   21809077
  REMARK    GeneRIF: results indicate that SpdS levels are not rate limiting in
            vivo for polyamine biosynthesis and are unlikely to exert
            significant regulatory effects on cellular polyamine content and
            function
REFERENCE   4  (bases 1 to 1328)
  AUTHORS   Tarantino,C., Paolella,G., Cozzuto,L., Minopoli,G., Pastore,L.,
            Parisi,S. and Russo,T.
  TITLE     miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic
            stem cells
  JOURNAL   FASEB J 24 (9), 3255-3263 (2010)
   PUBMED   20439489
REFERENCE   5  (bases 1 to 1328)
  AUTHORS   Lopez-Garcia,C., Lopez-Contreras,A.J., Cremades,A., Castells,M.T.
            and Penafiel,R.
  TITLE     Transcriptomic analysis of polyamine-related genes and polyamine
            levels in placenta, yolk sac and fetus during the second half of
            mouse pregnancy
  JOURNAL   Placenta 30 (3), 241-249 (2009)
   PUBMED   19131104
REFERENCE   6  (bases 1 to 1328)
  AUTHORS   Lopez-Garcia,C., Lopez-Contreras,A.J., Cremades,A., Castells,M.T.,
            Marin,F., Schreiber,F. and Penafiel,R.
  TITLE     Molecular and morphological changes in placenta and embryo
            development associated with the inhibition of polyamine synthesis
            during midpregnancy in mice
  JOURNAL   Endocrinology 149 (10), 5012-5023 (2008)
   PUBMED   18583422
REFERENCE   7  (bases 1 to 1328)
  AUTHORS   Wada,M., Amano,D., Hosoda,H., Shirahata,A., Samejima,K. and
            Pegg,A.E.
  TITLE     Primary structure of rat spermidine synthase: an example of
            refining the cDNA-derived amino acid sequence
  JOURNAL   Biol Pharm Bull 22 (9), 889-895 (1999)
   PUBMED   10513607
REFERENCE   8  (bases 1 to 1328)
  AUTHORS   Myohanen,S., Wahlfors,J., Alhonen,L. and Janne,J.
  TITLE     Nucleotide sequence of mouse spermidine synthase cDNA
  JOURNAL   DNA Seq 4 (5), 343-346 (1994)
   PUBMED   7803821
REFERENCE   9  (bases 1 to 1328)
  AUTHORS   Kauppinen,L., Myohanen,S., Halmekyto,M., Alhonen,L. and Janne,J.
  TITLE     Transgenic mice over-expressing the human spermidine synthase gene
  JOURNAL   Biochem J 293 (Pt 2) (Pt 2), 513-516 (1993)
   PUBMED   8343131
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AL606969.26.
            
            On Apr 27, 2007 this sequence version replaced NM_009272.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC005566.1, AK028359.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-274               AL606969.26        11495-11768
            275-395             AL606969.26        12026-12146
            396-488             AL606969.26        12464-12556
            489-642             AL606969.26        13270-13423
            643-872             AL606969.26        13750-13979
            873-995             AL606969.26        14065-14187
            996-1328            AL606969.26        14269-14601
FEATURES             Location/Qualifiers
     source          1..1328
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 78.76 cM"
     gene            1..1328
                     /gene="Srm"
                     /gene_synonym="SpdST; SpdSy"
                     /note="spermidine synthase"
                     /db_xref="GeneID:20810"
                     /db_xref="MGI:MGI:102690"
     exon            1..274
                     /gene="Srm"
                     /gene_synonym="SpdST; SpdSy"
                     /inference="alignment:Splign:2.1.0"
     exon            275..395
                     /gene="Srm"
                     /gene_synonym="SpdST; SpdSy"
                     /inference="alignment:Splign:2.1.0"
     exon            396..488
                     /gene="Srm"
                     /gene_synonym="SpdST; SpdSy"
                     /inference="alignment:Splign:2.1.0"
     exon            489..642
                     /gene="Srm"
                     /gene_synonym="SpdST; SpdSy"
                     /inference="alignment:Splign:2.1.0"
     exon            643..872
                     /gene="Srm"
                     /gene_synonym="SpdST; SpdSy"
                     /inference="alignment:Splign:2.1.0"
     exon            873..995
                     /gene="Srm"
                     /gene_synonym="SpdST; SpdSy"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1328
                     /gene="Srm"
                     /gene_synonym="SpdST; SpdSy"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1288..1293
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Srm"
                     /gene_synonym="SpdST; SpdSy"
                     /note="hexamer: AATACA"
     polyA_site      1314
                     /gene="Srm"
                     /gene_synonym="SpdST; SpdSy"
                     /note="major polyA site"
ORIGIN      
        1 ggttgcggcg cgggcagcgg gcagagctgg tcacgttgtg ctgggggggg tccgcgcgcc
       61 ctgcagtccc gaacccgcta cgcgctccgt cggcccgccc gcccgccatg gagcctggcc
      121 ccgacggccc agccgcgccc ggccccgccg ccatccgtga gggctggttc cgagagacct
      181 gcagcctgtg gcccggccag gccctgtcgc tgcaagtgga gcagctgctt caccaccggc
      241 gatcgcggta ccaagacatc ctcgtcttcc gcagtaaaac ctacggcaac gtgctggttc
      301 tggatggcgt catccagtgt actgagaggg atgagttctc ctaccaggag atgatcgcca
      361 acctgccgct ctgcagccac cccaacccgc ggaaggtgct gatcatcggg ggtggagatg
      421 ggggcgtcct acgggaagtg gtgaagcacc cctctgtgga gtcggtggtc cagtgcgaga
      481 ttgatgagga tgtcattgaa gtctctaaga agttcctgcc tggcatggcc gttggcttct
      541 ccagctcaaa gctgactctc cacgtgggcg atggctttga gttcatgaaa cagaaccaag
      601 atgcctttga cgtcatcatc accgactcct cagaccccat gggccctgct gagagcctct
      661 tcaaggagtc ctattaccag ctcatgaaga cagcactcaa agaagatggc atcctgtgct
      721 gccagggtga gtgccagtgg ctgcacctgg acctcatcaa ggagatgagg cacttctgca
      781 aatctctctt ccccgtggtg gactacgcct actgtagcat tcctacctat cccagcggcc
      841 agatcggctt catgctgtgt agcaaaaacc cgagcaccaa cttccgggag ccagtgcagc
      901 agttgacaca ggcccaggtg gagcagatgc agctgaaata ctataactcg gacatgcacc
      961 gtgccgcctt cgtactgccc gagttcaccc ggaaggccct caatgacata agctgaatcc
     1021 aggtgccact gtgacaccac ccgagacctc aatcggattg gaccaaggat cttccaagtt
     1081 gtctggggac caccagtcct ggaccagact cccagatgac tcttgcccac caaccaagtg
     1141 ttacaggccc cacgatgctg cctggcctgg cctggcctgg cctgccctgc tgggtggact
     1201 cagtctctgt ctgtctatct ctgtggcgtt cagccccacg cctataccag ctctgtacag
     1261 caccgcctat gccctgtgac ccaacaaaat acatgtgtat ttataacaag ctcagtcatg
     1321 acctctga
//
