LOCUS       NM_175347               5007 bp    mRNA    linear   ROD 04-MAR-2025
DEFINITION  Mus musculus sarcalumenin (Srl), transcript variant 1, mRNA.
ACCESSION   NM_175347
VERSION     NM_175347.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5007)
  AUTHORS   Emerson,J.I., Shi,W., Paredes-Larios,J., Walker,W.G., Hutton,J.E.,
            Cristea,I.M., Marzluff,W.F. and Conlon,F.L.
  TITLE     X-Chromosome-Linked miRNAs Regulate Sex Differences in Cardiac
            Physiology
  JOURNAL   Circ Res 136 (3), 258-275 (2025)
   PUBMED   39772608
REFERENCE   2  (bases 1 to 5007)
  AUTHORS   Wu,W., Ren,Z., Zhang,L., Liu,Y., Li,H. and Xiong,Y.
  TITLE     Overexpression of Six1 gene suppresses proliferation and enhances
            expression of fast-type muscle genes in C2C12 myoblasts
  JOURNAL   Mol Cell Biochem 380 (1-2), 23-32 (2013)
   PUBMED   23613228
  REMARK    GeneRIF: Results indicated that sine oculis homeobox 1 (Six1)
            overexpression could significantly promote the expression of
            fast-type muscle genes Atp2a1, Srl, and Mylpf.
REFERENCE   3  (bases 1 to 5007)
  AUTHORS   Jiao,Q., Takeshima,H., Ishikawa,Y. and Minamisawa,S.
  TITLE     Sarcalumenin plays a critical role in age-related cardiac
            dysfunction due to decreases in SERCA2a expression and activity
  JOURNAL   Cell Calcium 51 (1), 31-39 (2012)
   PUBMED   22119571
  REMARK    GeneRIF: The important role of SAR in maintaining Ca(2+) transport
            activity of SERCA2a and cardiac function in the senescent
            population, is reported.
REFERENCE   4  (bases 1 to 5007)
  AUTHORS   Niro,C., Demignon,J., Vincent,S., Liu,Y., Giordani,J., Sgarioto,N.,
            Favier,M., Guillet-Deniau,I., Blais,A. and Maire,P.
  TITLE     Six1 and Six4 gene expression is necessary to activate the
            fast-type muscle gene program in the mouse primary myotome
  JOURNAL   Dev Biol 338 (2), 168-182 (2010)
   PUBMED   19962975
REFERENCE   5  (bases 1 to 5007)
  AUTHORS   Jiao,Q., Bai,Y., Akaike,T., Takeshima,H., Ishikawa,Y. and
            Minamisawa,S.
  TITLE     Sarcalumenin is essential for maintaining cardiac function during
            endurance exercise training
  JOURNAL   Am J Physiol Heart Circ Physiol 297 (2), H576-H582 (2009)
   PUBMED   19502553
  REMARK    GeneRIF: SAR plays a critical role in maintaining cardiac function
            under physiological stresses, such as endurance exercise, by
            regulating Ca(2+) transport activity into the sarcoplasmic
            reticulum
REFERENCE   6  (bases 1 to 5007)
  AUTHORS   Shimura,M., Minamisawa,S., Takeshima,H., Jiao,Q., Bai,Y.,
            Umemura,S. and Ishikawa,Y.
  TITLE     Sarcalumenin alleviates stress-induced cardiac dysfunction by
            improving Ca2+ handling of the sarcoplasmic reticulum
  JOURNAL   Cardiovasc Res 77 (2), 362-370 (2008)
   PUBMED   18006473
  REMARK    GeneRIF: sarcalumenin-SERCA2a interaction plays an essential role
            in preserving cardiac function under biomechanical stresses such as
            pressure overload.
REFERENCE   7  (bases 1 to 5007)
  AUTHORS   Zhao,X., Yoshida,M., Brotto,L., Takeshima,H., Weisleder,N.,
            Hirata,Y., Nosek,T.M., Ma,J. and Brotto,M.
  TITLE     Enhanced resistance to fatigue and altered calcium handling
            properties of sarcalumenin knockout mice
  JOURNAL   Physiol Genomics 23 (1), 72-78 (2005)
   PUBMED   15998745
  REMARK    GeneRIF: sarcalumenin knockout mice have enhanced resistance to
            fatigue and altered calcium handling properties
REFERENCE   8  (bases 1 to 5007)
  AUTHORS   Yoshida,M., Minamisawa,S., Shimura,M., Komazaki,S., Kume,H.,
            Zhang,M., Matsumura,K., Nishi,M., Saito,M., Saeki,Y., Ishikawa,Y.,
            Yanagisawa,T. and Takeshima,H.
  TITLE     Impaired Ca2+ store functions in skeletal and cardiac muscle cells
            from sarcalumenin-deficient mice
  JOURNAL   J Biol Chem 280 (5), 3500-3506 (2005)
   PUBMED   15569689
  REMARK    GeneRIF: SAR plays important roles in improving the Ca2+ handling
            functions of the SR in striated muscle.
REFERENCE   9  (bases 1 to 5007)
  AUTHORS   Dowling,P., Doran,P. and Ohlendieck,K.
  TITLE     Drastic reduction of sarcalumenin in Dp427 (dystrophin of 427
            kDa)-deficient fibres indicates that abnormal calcium handling
            plays a key role in muscular dystrophy
  JOURNAL   Biochem J 379 (Pt 2), 479-488 (2004)
   PUBMED   14678011
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC145687.1 and AC157597.4.
            
            On Jun 19, 2019 this sequence version replaced NM_175347.5.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB113383.1, BC145687.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849390
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4455              BC145687.1         10-4464
            4456-5007           AC157597.4         70545-71096         c
FEATURES             Location/Qualifiers
     source          1..5007
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 2.44 cM"
     gene            1..5007
                     /gene="Srl"
                     /gene_synonym="9830004M20Rik; sar"
                     /note="sarcalumenin"
                     /db_xref="GeneID:106393"
                     /db_xref="MGI:MGI:2146620"
     exon            1..74
                     /gene="Srl"
                     /gene_synonym="9830004M20Rik; sar"
                     /inference="alignment:Splign:2.1.0"
     CDS             14..2746
                     /gene="Srl"
                     /gene_synonym="9830004M20Rik; sar"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /codon_start=1
                     /product="sarcalumenin isoform 1 precursor"
                     /protein_id="NP_780556.2"
                     /db_xref="CCDS:CCDS27918.1"
                     /db_xref="GeneID:106393"
                     /db_xref="MGI:MGI:2146620"
                     /translation="MKALLLLCCFLASLLLSGQAELQVSASGGTEDVGNLLENHFSAG
                     DASLEEKERALYADAAPGDKNLLLHYPDGREAESLEQTPAGAPSTANGQGSETEASLS
                     NTSAAESAPPGDVEGPGEEEEGPHAAGTLPPGGIEGPEEERPQFSSGKEPGQEEAGVG
                     VPTEGAASMEAEVQEGSSGVPEELQGLLGDGPMNEAAGTAESVVTQSSPPIEGKEAEG
                     EGNTGSDHQSTELDGTQDAIPAGDESEAREGAEDKPQDYSLQSEDTATPGPDHQPTDL
                     HAASDTASSGVEAEEGAEESKAEVDTESGEKVEDQGEPRPSLDAGSAIEANKQSEYTQ
                     ARETENDSPEGQVSGMSEEGLAEASSEEEGGEEDGSENGEVPFKEESGEDSGDGASSE
                     EEGSTPGEAGEPQKTPGATGHEEEGPQLDVEDLNTGFEGSKTQDIEAEASEERQQERG
                     NPVIAQWEEVEDASEEAPLRDRSHIDKTLMLNEDKPADDYSAVLQRLRKIYHTSIKPL
                     EQSYKYNELRQHEITDGEITSKPMVLFLGPWSVGKSTMINYLLGLEDTRYQLYTGAEP
                     TTSEFTVLMHGPKLKTIEGIVMAADSARSFSPLEKFGQNFLEKLIGIEVPHKLLERVT
                     FVDTPGIIENRKQQERGYPFNDVCQWFIDRADLIFVVFDPTKLDVGLELEMLFRQLKG
                     RESQIRIILNKADNLATQMLMRVYGALFWSLAPLINVTEPPRVYVSSFWPQDYKPDTH
                     RELFLKEEISLLEDLNQVIENRLENKIAFIRQHAIRVRIHALLVDRYLQTYKDKMTFF
                     SDGELVFKDIVEDPDKFYIFKTILAKTNVSKFDLPNREAYKDFFGINPISNFKLLSQQ
                     CSYMGGCFLEKIERAITQELPSLLGSIGLGKNPGAPNCDKTGCGETPKNRYKKH"
     exon            75..1385
                     /gene="Srl"
                     /gene_synonym="9830004M20Rik; sar"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..1487
                     /gene="Srl"
                     /gene_synonym="9830004M20Rik; sar"
                     /inference="alignment:Splign:2.1.0"
     exon            1488..1583
                     /gene="Srl"
                     /gene_synonym="9830004M20Rik; sar"
                     /inference="alignment:Splign:2.1.0"
     exon            1584..1700
                     /gene="Srl"
                     /gene_synonym="9830004M20Rik; sar"
                     /inference="alignment:Splign:2.1.0"
     exon            1701..1934
                     /gene="Srl"
                     /gene_synonym="9830004M20Rik; sar"
                     /inference="alignment:Splign:2.1.0"
     exon            1935..5007
                     /gene="Srl"
                     /gene_synonym="9830004M20Rik; sar"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4984..4989
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Srl"
                     /gene_synonym="9830004M20Rik; sar"
                     /note="hexamer: AATAAA"
     polyA_site      5007
                     /gene="Srl"
                     /gene_synonym="9830004M20Rik; sar"
                     /note="major polyA site"
ORIGIN      
        1 cttggcagtc accatgaagg cgctgctcct gctctgctgt ttcctggcct ccctgctgct
       61 ttcaggacaa gcagaactgc aagtctctgc ttcgggtggc acggaagatg ttggcaattt
      121 gttggagaat catttctctg ctggagacgc gagtctagag gagaaggaaa gggcgcttta
      181 tgcagatgcg gcccctggag acaagaacct actccttcac tacccagacg gcagggaggc
      241 tgagagcttg gagcagactc ctgcaggggc cccttccact gccaacggcc agggctccga
      301 aaccgaagct agcctgtcca atacctcagc tgcagagtca gctccgcctg gggatgttga
      361 agggcctggg gaggaagagg agggcccaca tgcagcaggc acccttcctc caggagggat
      421 tgaagggcca gaagaagaga ggccacagtt cagttctggg aaggagccag ggcaggagga
      481 ggctggggtg ggggttccca cagagggggc tgccagtatg gaggcagaag tgcaagaggg
      541 aagtagtggg gtccctgagg aattacaggg actcttagga gatgggccta tgaatgaagc
      601 agcagggaca gcagagtctg tagtcaccca gtcctctcct cccatagagg gtaaagaggc
      661 agaaggtgag ggcaacacag gttctgatca ccaatccaca gagctagatg gaacccagga
      721 tgccatacct gccggagatg aatcggaagc cagggaggga gcagaggaca agccccagga
      781 ctactccctg cagtcagagg acacagccac tcccgggcct gatcaccagc ccacagacct
      841 acatgcagcc tctgacacgg catcttctgg agtagaggca gaagaaggtg cagaggaatc
      901 aaaggctgag gtggacacag aatctgggga gaaggttgag gaccaggggg agcctagacc
      961 tagcctggat gctggttcag ctatagaggc caataaacag tctgagtaca cccaggcaag
     1021 ggagacagag aacgactctc ctgagggcca ggtgtcaggg atgtcggagg agggcctggc
     1081 tgaggcctct tctgaagaag agggtggtga agaagatgga agtgagaatg gggaagttcc
     1141 atttaaagaa gagtctggag aagacagtgg tgatggagct agctcagaag aagaggggag
     1201 tacccctggg gaggctggag agccccagaa aacaccagga gccacaggac atgaggagga
     1261 aggtccccag cttgatgtgg aagatttgaa cacagggttc gaaggcagca agacccagga
     1321 catagaagca gaggcatccg aagagagaca acaggagaga gggaatcccg taattgctca
     1381 atgggaagag gtggaggatg cgagtgaaga ggctcccctg agggaccgct cccacattga
     1441 caaaaccctg atgctgaatg aggacaagcc agctgacgat tactcagcgg tgctgcagcg
     1501 acttcggaag atctatcata cgtccatcaa gcccctggag cagtcttaca agtacaatga
     1561 gcttcggcag catgagatca cagacgggga gattacttcc aagccaatgg tgctgttcct
     1621 gggaccgtgg agtgttggca aatccaccat gataaactac ctccttgggt tagaagatac
     1681 tcgataccaa ctttatacag gtgctgaacc taccacctct gagttcactg tccttatgca
     1741 tgggcccaag ctgaaaacca ttgagggcat cgtcatggct gctgatagtg cccgatcctt
     1801 ctcaccactg gaaaagtttg gccagaattt tctggagaag ctgattggca ttgaggttcc
     1861 ccacaagctt ctagaacgag tcacattcgt ggatacacca ggcatcattg agaaccgcaa
     1921 gcaacaagaa agaggttacc ccttcaacga tgtgtgtcag tggttcatcg acagagccga
     1981 cctcatcttc gttgtcttcg atcccacaaa gctggatgtg ggtctggagt tggagatgct
     2041 cttccgccaa ctgaagggcc gtgagtccca gataaggatc attttgaaca aggctgacaa
     2101 cctggccacg caaatgctca tgcgggtgta tggagctctc ttttggagct tggcccctct
     2161 catcaatgtc acggaacctc cacgggttta cgtcagctcc ttctggccac aggactataa
     2221 gcctgatacc caccgggaac tgttcctcaa agaagagatc tctctcttgg aagacctgaa
     2281 ccaggtgatt gagaacaggc tagagaacaa gatcgctttt attcgacagc atgccatccg
     2341 agtccgaatt catgcccttt tagttgaccg ctatctgcag acttacaagg acaaaatgac
     2401 cttcttcagt gatggggaac tggtctttaa ggacattgtg gaagatcctg ataaattcta
     2461 tattttcaag accatcctgg caaagaccaa tgtcagcaag tttgaccttc ccaaccgtga
     2521 ggcttataag gacttctttg gcatcaaccc catttccaat ttcaaactcc tctctcagca
     2581 gtgctcctac atggggggtt gcttcctgga gaagattgaa cgagccatca cccaggagct
     2641 ccccagcctt ctgggtagca ttgggcttgg gaagaatcca ggtgctccta actgtgataa
     2701 aacaggctgt ggtgagaccc caaagaatcg ctacaagaag cactagtttc tgtgtagcta
     2761 ttcttgggtc cccactggtg aataagcttg tgtcctaact gtctcagaag tcctggcttg
     2821 ttaacccttt gagccatact ggtgacaatc agtctgcatt ggagatttgg gagttcattg
     2881 aggctggtga atcagggaag gttctaggga ggagagtggt aactgtgaat tatagtgtgc
     2941 ttgtcatatt gcttcagtta gaaggccttg acacaggcca agccagtcta caaggcttcc
     3001 tttgcttttt ctgggtcctg tcttagagag acagagagca gctaaattct aatgaataat
     3061 aagataacga gggtcaaata agctaaactc agtggaaaat tcctgagtaa tagagggttc
     3121 tcaggtctgt gtcaactcct cacacataca tcttctgttt gatccctgtc cctccttggc
     3181 tccctcctaa gcttgggttg attttcagaa gtggacagac tcttgagtct aatcttcata
     3241 aattttgagc ccaaccttgg aatcttctcc atgttttccc aaggggtggg gcatccagaa
     3301 aactaaaaca tgagttttca aattaggatg ttgatctgcc accccaagta taatttcatt
     3361 gatgtcccag ttggagagct tagatactta gttgtcccta aaaggagagt gagcgggtga
     3421 tgtactcagg tactttccct ccttatgtga cttacatgaa ggtcctggaa gcactcccgg
     3481 ggttaattgg tttgcggtgt atctttgtat gttgcatgtc tttgaaagct cagatcacag
     3541 aggtgttggg tttcagagag gacaatggag accttgctcc tagtccttgg aggcttctct
     3601 ggacagacat tctcccaagt ttcaggggaa gctgtgtcca cagcttcttt gtgggagcac
     3661 ttgatagagg acatgtctct tctggttccc agaaccatgg tttctctttt cctttcttct
     3721 ccattccctg atgcattaat acttccaact gagaaaaagt ccctgaatca gaaccagtac
     3781 cagccttggc attggcactg gtgccagata agacctgagg ttcaggttca acctgaactt
     3841 ctgcagatgc ccactgaatg cagtcaggac agccaggacc ttcaaacacc agtgaatgtg
     3901 cacttgaggg cgtcagactt gagggcacag agagaggact ccagagagtc ttgcatggca
     3961 cacatacatt gccaccttga agtgcagggg agtgagaggc tctgggagga tgaagagatt
     4021 tttgatggag cgggcaaggt gaagttcagc ctgccttgag ggctttctct gagcacagcc
     4081 agctgctttt ttgggagcaa gctctcccgg gggccttagt tgtgaggcat gggttgggat
     4141 ccgccagcac cagggtgtca tctagaacag aaggaaagta ggttggagag ctgagccagt
     4201 cattcctcct aaggatcaag taggtagcat aagcagtaat caatggagac tacatagaga
     4261 acttcaattt aggagtttgt gtttctctga attcctggca gtctggtgcc ccctcctaag
     4321 ggaggctact gctctggctc aatgtagggc ccaggatctg ccacaaatca aaagccccag
     4381 agctgccagg acaccgtttc caaggagtga gtttctcccg tcacagttat tcatggctag
     4441 ggcagatgag ctgcaatctg tcttggattt ttcttcccaa actcctcccc tcttctctct
     4501 atcatgtgct ctctggagag actgtctttc ccacccttct ccttcatgcc cctcatgcct
     4561 gtgggttttg tgtggcaaat gtttttgcag aaaccaggga aaaggttgaa ctgtacggac
     4621 cttgtcctgg ctgtcagtgc ctgcatgctt ggaggaaagc agatgacgta aggccaatta
     4681 attcttacag gatttgcatt tgggggaaga caccttacca gtagtatcct ccttttggat
     4741 ttttctccat ctatttcttc tctgtctcca ttttgctcct ctcctgccca caggccactg
     4801 actgtcagta caggttttta gcacgtatcc tttgcccagc tctgcagaga tggattctga
     4861 gcaagttctg actatgggcg tttcatccca ggagaagcat gggattcaga gatgtctgtg
     4921 cctgaacagt ggctgacctt tccagtgttc tttccattct ggtttcatca gggagaacgt
     4981 ctcaataaag ttccaatctc tcttcaa
//
