LOCUS       NM_001080974            2399 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus sorcin (Sri), transcript variant 1, mRNA.
ACCESSION   NM_001080974
VERSION     NM_001080974.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2399)
  AUTHORS   Wang,D., Shi,S., Hsieh,Y.L., Wang,J., Wang,H. and Wang,W.
  TITLE     Knockdown of sorcin increases HEI-OC1 cell damage induced by
            cisplatin in vitro
  JOURNAL   Arch Biochem Biophys 701, 108752 (2021)
   PUBMED   33675811
  REMARK    GeneRIF: Knockdown of sorcin increases HEI-OC1 cell damage induced
            by cisplatin in vitro.
REFERENCE   2  (bases 1 to 2399)
  AUTHORS   Vineeth Daniel,P., Kamthan,M., Gera,R., Dogra,S., Gautam,K.,
            Ghosh,D. and Mondal,P.
  TITLE     Chronic exposure to Pb2+ perturbs ChREBP transactivation and
            coerces hepatic dyslipidemia
  JOURNAL   FEBS Lett 593 (21), 3084-3097 (2019)
   PUBMED   31309533
  REMARK    GeneRIF: Presence of Pb(2+) ions within the hepatocytes reduces
            transcript and protein levels of sorcin, a cytosolic adaptor
            partner of ChREBP. Adenovirus-mediated overexpression of sorcin in
            Pb(2+) exposed hepatocytes and an in vivo mouse model ameliorates
            liver steatosis and hepatotoxicity. These results present evidence
            that sorcin is an essential regulator of Pb2+-induced dyslipidemia
            in the liver.
REFERENCE   3  (bases 1 to 2399)
  AUTHORS   Gupta,K., Sirohi,V.K., Kumari,S., Shukla,V., Manohar,M., Popli,P.
            and Dwivedi,A.
  TITLE     Sorcin is involved during embryo implantation via activating
            VEGF/PI3K/Akt pathway in mice
  JOURNAL   J Mol Endocrinol 60 (2), 119-132 (2018)
   PUBMED   29273681
  REMARK    GeneRIF: Sorcin is involved in the regulation of Ca(+2)-mediated
            angiogenesis via VEGF/PI3K/Akt pathway in endometrial cells.
REFERENCE   4  (bases 1 to 2399)
  AUTHORS   Chen,X., Weber,C., Farrell,E.T., Alvarado,F.J., Zhao,Y.T.,
            Gomez,A.M. and Valdivia,H.H.
  TITLE     Sorcin ablation plus beta-adrenergic stimulation generate an
            arrhythmogenic substrate in mouse ventricular myocytes
  JOURNAL   J Mol Cell Cardiol 114, 199-210 (2018)
   PUBMED   29174767
  REMARK    GeneRIF: sorcin deficiency may trigger cardiac ventricular
            arrhythmias due to Ca(2+) disturbances
REFERENCE   5  (bases 1 to 2399)
  AUTHORS   Marmugi,A., Parnis,J., Chen,X., Carmichael,L., Hardy,J., Mannan,N.,
            Marchetti,P., Piemonti,L., Bosco,D., Johnson,P., Shapiro,J.A.,
            Cruciani-Guglielmacci,C., Magnan,C., Ibberson,M., Thorens,B.,
            Valdivia,H.H., Rutter,G.A. and Leclerc,I.
  TITLE     Sorcin Links Pancreatic beta-Cell Lipotoxicity to ER Ca2+ Stores
  JOURNAL   Diabetes 65 (4), 1009-1021 (2016)
   PUBMED   26822088
  REMARK    GeneRIF: Sorcin links pancreatic beta cells lipotoxicity to calcium
            stores and provides a target for intervention in type 2 diabetes.
REFERENCE   6  (bases 1 to 2399)
  AUTHORS   Farrell,E.F., Antaramian,A., Rueda,A., Gomez,A.M. and Valdivia,H.H.
  TITLE     Sorcin inhibits calcium release and modulates
            excitation-contraction coupling in the heart
  JOURNAL   J Biol Chem 278 (36), 34660-34666 (2003)
   PUBMED   12824171
  REMARK    GeneRIF: sorcin is a potent inhibitor of both spontaneous and
            ICa-triggered RyR activity and is kinetically capable of playing a
            role in terminating the positive feedback loop of Ca2+-induced Ca2+
            release
REFERENCE   7  (bases 1 to 2399)
  AUTHORS   Meyers,M.B., Fischer,A., Sun,Y.J., Lopes,C.M., Rohacs,T.,
            Nakamura,T.Y., Zhou,Y.Y., Lee,P.C., Altschuld,R.A., McCune,S.A.,
            Coetzee,W.A. and Fishman,G.I.
  TITLE     Sorcin regulates excitation-contraction coupling in the heart
  JOURNAL   J Biol Chem 278 (31), 28865-28871 (2003)
   PUBMED   12754254
REFERENCE   8  (bases 1 to 2399)
  AUTHORS   Il'inskaia,G.V., Demidova,N.S. and Kopnin,B.P.
  TITLE     [Relationship between amplicon composition and cytologic type of
            structures containing amplified DNA in murine P388 cells with
            multiple drug resistance]
  JOURNAL   Genetika 31 (10), 1449-1451 (1995)
   PUBMED   8543148
REFERENCE   9  (bases 1 to 2399)
  AUTHORS   Goffinet,A.M.
  TITLE     The reeler gene: a clue to brain development and evolution
  JOURNAL   Int J Dev Biol 36 (1), 101-107 (1992)
   PUBMED   1627461
REFERENCE   10 (bases 1 to 2399)
  AUTHORS   Dernoncourt,C., Ruelle,D. and Goffinet,A.M.
  TITLE     Estimation of genetic distances between 'reeler' and nearby loci on
            mouse chromosome 5
  JOURNAL   Genomics 11 (4), 1167-1169 (1991)
   PUBMED   1783386
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK134747.1, AK168572.1 and BQ033487.1.
            
            On Oct 22, 2013 this sequence version replaced NM_001080974.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BU562693.1, SRR1660815.273466.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                AK134747.1         3-22
            21-2226             AK168572.1         2-2207
            2227-2399           BQ033487.1         83-255              c
FEATURES             Location/Qualifiers
     source          1..2399
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 3.38 cM"
     gene            1..2399
                     /gene="Sri"
                     /gene_synonym="2210417O06Rik; 2900070H08Rik; Sor"
                     /note="sorcin"
                     /db_xref="GeneID:109552"
                     /db_xref="MGI:MGI:98419"
     exon            1..98
                     /gene="Sri"
                     /gene_synonym="2210417O06Rik; 2900070H08Rik; Sor"
                     /inference="alignment:Splign:2.1.0"
     CDS             48..644
                     /gene="Sri"
                     /gene_synonym="2210417O06Rik; 2900070H08Rik; Sor"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="sorcin isoform 1"
                     /protein_id="NP_001074443.1"
                     /db_xref="CCDS:CCDS39009.1"
                     /db_xref="GeneID:109552"
                     /db_xref="MGI:MGI:98419"
                     /translation="MAYPGHPGAGGGYYPGGYGGAPGGPAFPGQTQDPLYGYFAAVAG
                     QDGQIDADELQRCLTQSGIAGGYKPFNLETCRLMVSMLDRDMSGTMGFNEFKELWAVL
                     NGWRQHFISFDSDRSGTVDPQELQKALTTMGFRLSPQTVNSVAKRYSTSGKITFDDYI
                     ACCVKLRALTDSFRRRDSGQQGVVNFSYDDFIQCVMTV"
     exon            99..182
                     /gene="Sri"
                     /gene_synonym="2210417O06Rik; 2900070H08Rik; Sor"
                     /inference="alignment:Splign:2.1.0"
     exon            183..252
                     /gene="Sri"
                     /gene_synonym="2210417O06Rik; 2900070H08Rik; Sor"
                     /inference="alignment:Splign:2.1.0"
     exon            253..296
                     /gene="Sri"
                     /gene_synonym="2210417O06Rik; 2900070H08Rik; Sor"
                     /inference="alignment:Splign:2.1.0"
     exon            297..444
                     /gene="Sri"
                     /gene_synonym="2210417O06Rik; 2900070H08Rik; Sor"
                     /inference="alignment:Splign:2.1.0"
     exon            445..558
                     /gene="Sri"
                     /gene_synonym="2210417O06Rik; 2900070H08Rik; Sor"
                     /inference="alignment:Splign:2.1.0"
     exon            559..617
                     /gene="Sri"
                     /gene_synonym="2210417O06Rik; 2900070H08Rik; Sor"
                     /inference="alignment:Splign:2.1.0"
     exon            618..2399
                     /gene="Sri"
                     /gene_synonym="2210417O06Rik; 2900070H08Rik; Sor"
                     /inference="alignment:Splign:2.1.0"
     regulatory      812..817
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sri"
                     /gene_synonym="2210417O06Rik; 2900070H08Rik; Sor"
                     /note="hexamer: AATAAA"
     polyA_site      844
                     /gene="Sri"
                     /gene_synonym="2210417O06Rik; 2900070H08Rik; Sor"
                     /note="major polyA site"
     regulatory      919..924
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sri"
                     /gene_synonym="2210417O06Rik; 2900070H08Rik; Sor"
                     /note="hexamer: TATAAA"
     polyA_site      945
                     /gene="Sri"
                     /gene_synonym="2210417O06Rik; 2900070H08Rik; Sor"
                     /note="major polyA site"
     regulatory      2238..2243
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sri"
                     /gene_synonym="2210417O06Rik; 2900070H08Rik; Sor"
                     /note="hexamer: AATAAA"
     polyA_site      2262
                     /gene="Sri"
                     /gene_synonym="2210417O06Rik; 2900070H08Rik; Sor"
                     /note="major polyA site"
     regulatory      2312..2317
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sri"
                     /gene_synonym="2210417O06Rik; 2900070H08Rik; Sor"
                     /note="hexamer: AATATA"
     polyA_site      2330
                     /gene="Sri"
                     /gene_synonym="2210417O06Rik; 2900070H08Rik; Sor"
ORIGIN      
        1 ggacgggcgg agcagcagac aggcagggcg gaggcgcagt ctgcaccatg gcgtatcccg
       61 ggcaccctgg cgcgggcgga gggtactacc caggcgggta tggtggggct cccggagggc
      121 ctgcgttccc tggacaaact caggatccgc tatatggtta ctttgctgct gtggctggac
      181 aggacggaca aattgatgct gacgaattgc agagatgcct aacacagtct ggcattgcgg
      241 gaggatacaa gccttttaac ctggagactt gtcgccttat ggtttcaatg ttggatagag
      301 atatgtccgg cacgatgggg ttcaatgaat tcaaagagct ctgggctgtg ctgaatggct
      361 ggagacaaca cttcatcagt ttcgatagcg ataggagtgg caccgtggat ccccaggagc
      421 tacagaaggc cctgacgact atgggattca ggttgagccc ccaaactgtg aattcagttg
      481 caaagcgata cagcaccagc gggaagatca cgtttgatga ctacattgcc tgctgtgtca
      541 aactgagggc tctcacagat agctttcgca gacgggattc gggtcaacaa ggagttgtga
      601 atttctcgta tgatgatttc atccagtgtg tcatgaccgt ctaactcaag agcaaactgt
      661 ctgaatatat tcaacattcc aactggaact cgcccttgct tcctctctgc cttcagtgct
      721 gtgtgcagac cccaccgaca gccactccct gacaaccgtt gaacgggatt atgactttat
      781 atagagccac agcttcattt ttcattttga taataaattc ctttgaagtt taatgatata
      841 aaaacaagtc tgttatacca gtcagaacct cctgagccat tatcaatcat gccttatttt
      901 cctgctaacc ctcttttata taaagtatgc aaaatgttta acatatatta catattttct
      961 tgtgatatat gaaatttttt catcttagct gttattgttt ctttccctga ggaatgtggt
     1021 taaagtttgt gtggggtatt cttaagtggc atacatccac agttgggcaa aacaaaccaa
     1081 tgaacctggc agtccacata ctagaaagta taagttttac gacttacttg ttgaaagcct
     1141 tatgacttag agatattgaa tggttactgt ctgcctccta aaaacctata gatcatgagg
     1201 ggcaaatact gtcaccaagt tcttctttgc catctacccc aaacttttgt taattatact
     1261 taaagatctt gaatactgtc agcttaaatt gtcagaaaaa gactaaagtg aagtaagaat
     1321 atattaactg tttatttttg actaataaga ttctagatga ctttaatttc ctttatatat
     1381 ttctgtatct cccaaatttt taataatgtg catgctttca ttttacaacc agatgtcagg
     1441 ggaggagaga cagctcagca atactcatgt actgctctta tggaggacta aagtccccag
     1501 cgcccatgtt gggtggctta ctactgcctc gggccccatg gtcaccttca tttcacctgc
     1561 agatatccca gtgcaaacat gcatgcacac acacaattaa aaagtaataa agaataagta
     1621 aaaccaagca ggtttcattt taaaaattgt tggcattcat ttttgaatgt catttgctca
     1681 tgatctttaa cacaagaaag gaactgaaat gaacatctta attaatgatc tgcctttaac
     1741 tacagggagt agggtcttcc ttccaactca atttccaagt attctctaat agcgtattag
     1801 gttttacaca aacacacaca cacaaaggga gagaaagaga tggggaaagg aggggaggga
     1861 gagagaaaga ggagagagag agagagagag agagagagag agagagagag agagagagag
     1921 agagagagag agagaatttt ttccaaatgt ttaatcattt ggcttgctgg aaatgccttg
     1981 ctatgtatgt gccttggaca ttttaggcaa tgacagtaca ctcaggtccc tatctttgaa
     2041 aagagaagac taattaccat taaagtagtt ctgagtatgc aaaggtatat ttgagtaaaa
     2101 agcatcccca gggttttgtt gttacagttt ggcagctaac aatggttaag tcttctctcg
     2161 ctagcaatgt atctgtcttg tttctggcac aatgtgaatc tgaccatcca agtaaacgat
     2221 tcacttacaa ctggtgaaat aaacattcca taagcatctt catcctcgtt tcacaaatat
     2281 atgttcagat agtgtttata tatatatata aaatatatgc atatattata tattcagtca
     2341 cttcatgagt atttattcat tgctaactta ctatgtgttt agttaatact taatgctca
//
