LOCUS       NM_011157               1551 bp    mRNA    linear   ROD 14-FEB-2024
DEFINITION  Mus musculus serglycin (Srgn), transcript variant 1, mRNA.
ACCESSION   NM_011157
VERSION     NM_011157.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1551)
  AUTHORS   Qian,Y., Yang,L., Chen,J., Zhou,C., Zong,N., Geng,Y., Xia,S.,
            Yang,H., Bao,X., Chen,Y. and Xu,Y.
  TITLE     SRGN amplifies microglia-mediated neuroinflammation and exacerbates
            ischemic brain injury
  JOURNAL   J Neuroinflammation 21 (1), 35 (2024)
   PUBMED   38287411
  REMARK    GeneRIF: SRGN amplifies microglia-mediated neuroinflammation and
            exacerbates ischemic brain injury.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1551)
  AUTHORS   Doncheva,A.I., Norheim,F.A., Hjorth,M., Grujic,M., Paivandy,A.,
            Dankel,S.N., Hertel,J.K., Valderhaug,T.G., Bottcher,Y., Ferno,J.,
            Mellgren,G., Dalen,K.T., Pejler,G. and Kolset,S.O.
  TITLE     Serglycin Is Involved in Adipose Tissue Inflammation in Obesity
  JOURNAL   J Immunol 208 (1), 121-132 (2022)
   PUBMED   34872979
  REMARK    GeneRIF: Serglycin Is Involved in Adipose Tissue Inflammation in
            Obesity.
REFERENCE   3  (bases 1 to 1551)
  AUTHORS   Li,Z., Peirasmaki,D., Svard,S. and Abrink,M.
  TITLE     Serglycin-Deficiency Causes Reduced Weight Gain and Changed
            Intestinal Cytokine Responses in Mice Infected With Giardia
            intestinalis
  JOURNAL   Front Immunol 12, 677722 (2021)
   PUBMED   34335577
  REMARK    GeneRIF: Serglycin-Deficiency Causes Reduced Weight Gain and
            Changed Intestinal Cytokine Responses in Mice Infected With Giardia
            intestinalis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1551)
  AUTHORS   Li,H., Kurtzeborn,K., Kupari,J., Gui,Y., Siefker,E., Lu,B.,
            Matlik,K., Olfat,S., Montano-Rodriguez,A.R., Huh,S.H.,
            Costantini,F., Andressoo,J.O. and Kuure,S.
  TITLE     Postnatal prolongation of mammalian nephrogenesis by excess fetal
            GDNF
  JOURNAL   Development 148 (10) (2021)
   PUBMED   34032268
REFERENCE   5  (bases 1 to 1551)
  AUTHORS   Wu,J., Li,H., Han,L., Sun,T., Tian,Y. and Wang,X.
  TITLE     The spatiotemporal expression pattern of Syndecans in murine
            embryonic teeth
  JOURNAL   Gene Expr Patterns 36, 119109 (2020)
   PUBMED   32220631
REFERENCE   6  (bases 1 to 1551)
  AUTHORS   Avraham,S., Avraham,H., Austen,K.F. and Stevens,R.L.
  TITLE     Negative and positive cis-acting elements in the promoter of the
            mouse gene that encodes the serine/glycine-rich peptide core of
            secretory granule proteoglycans
  JOURNAL   J Biol Chem 267 (1), 610-617 (1992)
   PUBMED   1730621
REFERENCE   7  (bases 1 to 1551)
  AUTHORS   Baughman,G., Harrigan,M.T., Campbell,N.F., Nurrish,S.J. and
            Bourgeois,S.
  TITLE     Genes newly identified as regulated by glucocorticoids in murine
            thymocytes
  JOURNAL   Mol Endocrinol 5 (5), 637-644 (1991)
   PUBMED   2072923
REFERENCE   8  (bases 1 to 1551)
  AUTHORS   Angerth,T., Huang,R.Y., Aveskogh,M., Pettersson,I., Kjellen,L. and
            Hellman,L.
  TITLE     Cloning and structural analysis of a gene encoding a mouse
            mastocytoma proteoglycan core protein; analysis of its evolutionary
            relation to three cross hybridizing regions in the mouse genome
  JOURNAL   Gene 93 (2), 235-240 (1990)
   PUBMED   2121613
REFERENCE   9  (bases 1 to 1551)
  AUTHORS   Kjellen,L., Pettersson,I., Lillhager,P., Steen,M.L., Pettersson,U.,
            Lehtonen,P., Karlsson,T., Ruoslahti,E. and Hellman,L.
  TITLE     Primary structure of a mouse mastocytoma proteoglycan core protein
  JOURNAL   Biochem J 263 (1), 105-113 (1989)
   PUBMED   2532501
REFERENCE   10 (bases 1 to 1551)
  AUTHORS   Avraham,S., Stevens,R.L., Nicodemus,C.F., Gartner,M.C., Austen,K.F.
            and Weis,J.H.
  TITLE     Molecular cloning of a cDNA that encodes the peptide core of a
            mouse mast cell secretory granule proteoglycan and comparison with
            the analogous rat and human cDNA
  JOURNAL   Proc Natl Acad Sci U S A 86 (10), 3763-3767 (1989)
   PUBMED   2726751
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK151357.1, AK157945.1, AA209819.1, CJ276881.1 and BU754820.1.
            
            [WARNING] On Mar 22, 2024 this sequence was replaced by
            NM_011157.4.
            
            On Dec 15, 2017 this sequence version replaced NM_011157.2.
            
            Transcript Variant: This variant (1) represents the predominant,
            but shorter, transcript. It has a transcriptional start site that
            is internal relative to that of variant 2. Variants 1 and 2 encode
            the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BY224801.1, AK151357.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-520               AK151357.1         3-522
            521-933             AK157945.1         520-932
            934-1110            AA209819.1         151-327
            1111-1111           CJ276881.1         173-173
            1112-1248           AA209819.1         328-464
            1249-1551           BU754820.1         1-303               c
FEATURES             Location/Qualifiers
     source          1..1551
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 32.42 cM"
     gene            1..1551
                     /gene="Srgn"
                     /gene_synonym="Prg; Prg1; Sgc"
                     /note="serglycin"
                     /db_xref="GeneID:19073"
                     /db_xref="MGI:MGI:97756"
     exon            1..116
                     /gene="Srgn"
                     /gene_synonym="Prg; Prg1; Sgc"
                     /inference="alignment:Splign:2.1.0"
     CDS             44..502
                     /gene="Srgn"
                     /gene_synonym="Prg; Prg1; Sgc"
                     /note="proteoglycan, secretory granule; proteoglycan 1,
                     secretory granule; gp600; mastocytoma proteoglycan core
                     protein; secretory granule proteoglycan core protein"
                     /codon_start=1
                     /product="serglycin precursor"
                     /protein_id="NP_035287.1"
                     /db_xref="CCDS:CCDS23889.1"
                     /db_xref="GeneID:19073"
                     /db_xref="MGI:MGI:97756"
                     /translation="MQVPVGSRLVLALAFVLVWGSSVQGYPARRARYQWVRCKPNGFF
                     ANCIEEKGPQFDLIDESNNIGPPMNNPVLMEGPSKDFISNYDDYGSGSGSGSGSGSGS
                     GSGSGSGFLGDMEWEYQPTDESNIVYFNYKPFDRILTEQNQDQPEDDFII"
     exon            117..261
                     /gene="Srgn"
                     /gene_synonym="Prg; Prg1; Sgc"
                     /inference="alignment:Splign:2.1.0"
     exon            262..1535
                     /gene="Srgn"
                     /gene_synonym="Prg; Prg1; Sgc"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acatttgcta atccagaggc tgagtggagc cgagctggtc aggatgcagg ttcccgtcgg
       61 cagcaggctt gtcctggctc tcgccttcgt cctggtttgg ggatcttcag tgcaaggtta
      121 tcctgctcgg agagccaggt accagtgggt ccgctgcaaa ccgaatggct tttttgcgaa
      181 ctgcatcgag gagaagggac cacagtttga cctaatagat gaatccaata acatcggccc
      241 tcccatgaat aatcctgttt tgatggaagg accctcaaaa gatttcatct ccaattatga
      301 tgactatggg tcaggttcgg gctccggctc tggctccggc tctggctcgg gttccggctc
      361 cggaagtggc ttcctaggtg acatggaatg ggaataccag ccaacagatg aaagcaatat
      421 tgtctatttc aactataagc cttttgacag gattctcact gagcaaaacc aagaccaacc
      481 agaagacgat tttattatat gaatgtgacg gtctctgtct ccccacctcc atgtggaaca
      541 atgtattcag tatacttagt gtaccacgtt taaatgacca gtctcaggat aaagagtttt
      601 acagaaaatt taaaatgcct ggaaaagact cttgaatcct gttacccctt tcctcattaa
      661 ctcgtaagga attatgcttt aatgctgtta cctatcttgt tgttctggaa aatgcctgca
      721 tttatgtgta ttgaatcaac atttaagaaa ttaacacaca cccccattat tatacaataa
      781 ctttcaaagc catactggtt ttgaaaattt taatttgata gcaagttgat gaacaatctt
      841 tcatacctaa agtgttcagg aacccaactc gcattgtgaa ttacaaatat attcctttat
      901 gtgattaaaa agaaaataaa gtgaaacaca gtggcctcct accgtggcta tgtgacatgg
      961 tttacatggt gaggggtaga tattgagctg tggccattgg atgtgacagg gaagaccaaa
     1021 tgttatcgaa aaatgttgtg ggttttttgt ttgtttgttt gtttgttttt tgttgttgtt
     1081 tttgagacag ggtttccagg acaggttgtc ctgtaactca ctctgtagac caggatggct
     1141 agattcagaa atcctcatgc ttctgcctcc caagtgctgg gattaaaggc atgcgccacc
     1201 ccccacccca cccccggggt tgttgtgggt tttaaagtta gaaacttaac gcctcaaata
     1261 acatggagtt gtggtctcaa cggctcataa tgctttacct ttgtctagat gcctgttcag
     1321 ggtcaaatgt tactccatta aagtgaacat ataaccaaag gggggagatg tcatctggaa
     1381 cttcctgttc taatccaggg aatagttact ttgaaaaaat aatcaatcat attatacata
     1441 ttaatatata ataattttat aatacagtat ataatattgg tgtaggtgat atttaatata
     1501 aataatataa taaaaagtgt atgtaattga taacaaaaaa aaaaaaaaaa a
//
